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Volumn 9, Issue 18, 2008, Pages 3231-3242

Developing clinical role of a CCR5 co-receptor antagonist in HIV-1 infection

Author keywords

CCR5; chemokine coreceptor antagonist; HIV 1 infection; maraviroc; UK 427857

Indexed keywords

ANTIRETROVIRUS AGENT; CHEMOKINE RECEPTOR CCR5; CYCLOHEXANE DERIVATIVE; HUMAN IMMUNODEFICIENCY VIRUS FUSION INHIBITOR; MARAVIROC; TRIAZOLE DERIVATIVE;

EID: 59449093055     PISSN: 14656566     EISSN: 17447666     Source Type: Journal    
DOI: 10.1517/14656560802576324     Document Type: Article
Times cited : (12)

References (59)
  • 1
    • 84871869890 scopus 로고    scopus 로고
    • DHHS Panel on Antiretroviral Guidelines for Adults and Adolescents Panel Roster Last accessed on 23 August 2008
    • DHHS Panel on Antiretroviral Guidelines for Adults and Adolescents Panel Roster. Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents. Available from: http://aidsinfo.nih.gov/contentfiles/ AdultandAdolescentGL.pdf. [Last accessed on 23 August 2008[
    • Guidelines for the Use of Antiretroviral Agents in HIV-1-infected Adults and Adolescents
  • 2
    • 44949194170 scopus 로고    scopus 로고
    • European AIDS Clinical Society Executive Committee, European AIDS Clinical Society (EACS) [Last accessed 23 August 2008[
    • European AIDS Clinical Society Executive Committee, European AIDS Clinical Society (EACS). Guidelines for the clinical management and treatment of HIV infected adults in Europe. Available from: http://www.eacs.eu/guide/index. htm [Last accessed 23 August 2008[
    • Guidelines for the Clinical Management and Treatment of HIV Infected Adults in Europe
  • 3
    • 48949097660 scopus 로고    scopus 로고
    • Antiretroviral treatment of adult HIV infection 2008 recommendations of the international AIDS Society-USA Panel
    • Hammer SM, Eron JJ, Reiss P, et al. Antiretroviral treatment of adult HIV infection 2008 recommendations of the international AIDS Society-USA Panel. JAMA 2008;300(5):555-70
    • (2008) JAMA , vol.300 , Issue.5 , pp. 555-570
    • Hammer, S.M.1    Eron, J.J.2    Reiss, P.3
  • 4
    • 80051726264 scopus 로고    scopus 로고
    • Isentress
    • [Last accessed 24 August 2008[
    • Isentress. EPARs for authorised medicinal products for human use. EMEA. Available from: http://www.emea.europa.eu/humandocs/Humans/EPAR/isentress/ isentress.htm [Last accessed 24 August 2008[
    • EPARs for Authorised Medicinal Products for Human Use. EMEA
  • 5
    • 80051757570 scopus 로고    scopus 로고
    • Celsentri
    • [Last accessed 24 August 2008[
    • Celsentri. EPARs for authorised medicinal products for human use. EMEA. Available from: http://www.emea.europa.eu/humandocs/Humans/EPAR/celsentri/ celsentri.htm [Last accessed 24 August 2008[
    • EPARs for Authorised Medicinal Products for Human Use. EMEA
  • 6
    • 80051729481 scopus 로고    scopus 로고
    • Rockville MD. Public Health Service. FDA/Department of Health and Human Services [Last accessed 24 August 2008[
    • Cox E. Maraviroc approval letter. Rockville, MD. Public Health Service. FDA/Department of Health and Human Services. Available from: http://www.fda.gov/cder/foi/appletter/2007/022128s000ltr.pdf [Last accessed 24 August 2008[
    • Maraviroc Approval Letter
    • Cox, E.1
  • 7
    • 80051742123 scopus 로고    scopus 로고
    • Rockville MD. Public Health Service. FDA/Department of Health and Human Services [Last accessed 24 August 2008[
    • Cox E. Raltegravir approval letter. Rockville, MD. Public Health Service. FDA/Department of Health and Human Services. Available from: http://www.fda.gov/cder/foi/appletter/2007/022145s000tr.pdf [Last accessed 24 August 2008[
    • Raltegravir Approval Letter
    • Cox, E.1
  • 8
    • 80051758855 scopus 로고    scopus 로고
    • Rockville MD. Public Health Service. FDA/Department of Health and Human Services [Last accessed 24 August 2008[
    • Cox E. Etravirine approval letter. Rockville, MD. Public Health Service. FDA/Department of Health and Human Services. Available from: http://www.fda.gov/cder/foi/appletter/2008/022187s000ltr.pdf [Last accessed 24 August 2008[
    • Etravirine Approval Letter
    • Cox, E.1
  • 9
    • 34347379935 scopus 로고    scopus 로고
    • Phase 2 study of the safety and efficacy of vicriviroc, a CCR5 inhibitor, in HIV-1-infected, treatment-experienced patients: AIDS Clinical Trials Group 5211
    • Gulick RM, Su Z, Flexner C, et al. Phase 2 study of the safety and efficacy of vicriviroc, a CCR5 inhibitor, in HIV-1-infected, treatment-experienced patients: AIDS Clinical Trials Group 5211. J Infect Dis 2007;196:304-12
    • (2007) J Infect Dis , vol.196 , pp. 304-312
    • Gulick, R.M.1    Su, Z.2    Flexner, C.3
  • 10
    • 54749134143 scopus 로고    scopus 로고
    • Phase II study of vicriviroc versus efavirenz (both with zidovudine/lamivudine) in treatment-naïve subjects with HIV-1 infection
    • Landovitz RJ, Angel JB, Hoffman C, et al. Phase II study of vicriviroc versus efavirenz (both with zidovudine/lamivudine) in treatment-naïve subjects with HIV-1 infection. J Infect Dis 2008;198:1113-22
    • (2008) J Infect Dis , vol.198 , pp. 1113-1122
    • Landovitz, R.J.1    Angel, J.B.2    Hoffman, C.3
  • 11
    • 27644510382 scopus 로고    scopus 로고
    • Maraviroc (UK-427, 857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type 1 activity
    • Dorr P, Westby M, Dobbs S, et al. Maraviroc (UK-427,857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type 1 activity. Antimicrob Agents Chemother 2005;49(11):4721-32
    • (2005) Antimicrob Agents Chemother , vol.49 , Issue.11 , pp. 4721-4732
    • Dorr, P.1    Westby, M.2    Dobbs, S.3
  • 12
    • 40849098660 scopus 로고    scopus 로고
    • Molecular interactions of CCR5 with major classes of small-molecule anti-HIV CCR5 antagonists
    • Kondru R, Zhang J, Ji C, et al. Molecular interactions of CCR5 with major classes of small-molecule anti-HIV CCR5 antagonists. Mol Pharmacol 2006;73:789-800
    • (2006) Mol Pharmacol , vol.73 , pp. 789-800
    • Kondru, R.1    Zhang, J.2    Ji, C.3
  • 13
    • 33749839996 scopus 로고    scopus 로고
    • Safety and efficacy of maraviroc a novel CCR5 antagonist when used in combination with optimized background therapy for the treatment of antiretroviral-experienced subjects infected with dual/mixed tropic HIV-1: 24-week results of a phase 2b exploratory trial
    • August 13-18 Toronto, Canada. Abstract THLB0215. Available from [Last accessed 13 Oct 2008[
    • Mayer H, Van Der Ryst E, Saag M, et al. Safety and efficacy of maraviroc, a novel CCR5 antagonist, when used in combination with optimized background therapy for the treatment of antiretroviral-experienced subjects infected with dual/mixed tropic HIV-1: 24-week results of a phase 2b exploratory trial. Program and abstracts of the XVI International AIDS Conference; August 13-18, 2006; Toronto, Canada. Abstract THLB0215. Available from: http://www.aids2006. org/PAG/Abstracts. aspx?AID = 50985 [Last accessed 13 Oct 2008[
    • (2006) Program and Abstracts of the XVI International AIDS Conference
    • Mayer, H.1    Van Der Ryst, E.2    Saag, M.3
  • 14
    • 14844333093 scopus 로고    scopus 로고
    • Epidemiology and predictive factors for chemokine receptor use in HIV-1 infection
    • Moyle GJ, Wildfire A, Mandalia S, et al. Epidemiology and predictive factors for chemokine receptor use in HIV-1 infection. J Infect Dis 2005;191:866-72
    • (2005) J Infect Dis , vol.191 , pp. 866-872
    • Moyle, G.J.1    Wildfire, A.2    Ss, M.3
  • 15
    • 40549135975 scopus 로고    scopus 로고
    • Assessment of the pharmacokinetics, safety and tolerability of maraviroc, a novel CCR5 antagonist, in healthy volunteers
    • Abel S, Van Der Ryst E, Rosario MC, et al. Assessment of the pharmacokinetics, safety and tolerability of maraviroc, a novel CCR5 antagonist, in healthy volunteers. Br J Clin Pharmacol 2008;65(s1):5-18
    • (2008) Br J Clin Pharmacol , vol.65 , Issue.S1 , pp. 5-18
    • Abel, S.1    Van Der Ryst, E.2    Rosario, M.C.3
  • 16
    • 40549102421 scopus 로고    scopus 로고
    • Assessment of the absorption, metabolism and absolute bioavailability of maraviroc in healthy male subjects
    • Abel S, Russell D, Whitlock LA, et al. Assessment of the absorption, metabolism and absolute bioavailability of maraviroc in healthy male subjects. Br J Clin Pharmacol 2008;65(s1):60-7
    • (2008) Br J Clin Pharmacol , vol.65 , Issue.S1 , pp. 60-67
    • Abel, S.1    Russell, D.2    Whitlock, L.A.3
  • 17
    • 40549127134 scopus 로고    scopus 로고
    • Effects of CYP3A4 inhibitors on the pharmacokinetics of maraviroc in healthy volunteers
    • Abel S, Russell D, Taylor-Worth RJ, et al. Effects of CYP3A4 inhibitors on the pharmacokinetics of maraviroc in healthy volunteers. Br J Clin Pharmacol 2008;65(s1):27-37
    • (2008) Br J Clin Pharmacol , vol.65 , Issue.S1 , pp. 27-37
    • Abel, S.1    Russell, D.2    Taylor-Worth, R.J.3
  • 18
    • 48549083877 scopus 로고    scopus 로고
    • New York City NY: Pfizer Inc; August
    • Selzentry [package insert]. New York City, NY: Pfizer Inc; August 2007
    • (2007) Selzentry [Package Insert]
  • 19
    • 80051732240 scopus 로고    scopus 로고
    • Efficacy and safety of maraviroc plus optimized background therapy in viremic ART-experienced patients infected with CCR5-tropic HIV-1 in Europe Australia and North America: 24-week results [abstract 104aLB]
    • February 25-28 2007; Los Angeles California [Last accessed 26 July 2008]
    • Nelson M, Fätkenheuer G, Konourina I, et al. Efficacy and safety of maraviroc plus optimized background therapy in viremic, ART-experienced patients infected with CCR5-tropic HIV-1 in Europe, Australia, and North America: 24-week results [abstract 104aLB]. Program and abstracts of the 14th Conference on Retroviruses and Opportunistic Infections; February 25-28, 2007; Los Angeles, California. Available from: http://www.retroconference.org/2007/Abstracts/ 30636.htm [Last accessed 26 July 2008]
    • Program and Abstracts of the 14th Conference on Retroviruses and Opportunistic Infections
    • Nelson, M.1    Fätkenheuer, G.2    Konourina, I.3
  • 20
    • 34249089383 scopus 로고    scopus 로고
    • Efficacy and safety of maraviroc plus optimized background therapy in viremic ART-experienced patients infected with CCR5-tropic HIV-1: 24-week results of a phase 2b/3 study in the US and Canada [abstract 104bLB]
    • February 25-28 2007; Los Angeles California [Last accessed 26 July 2008]
    • Lalezari J, Goodrich J, De Jesus E, et al. Efficacy and safety of maraviroc plus optimized background therapy in viremic, ART-experienced patients infected with CCR5-tropic HIV-1: 24-week results of a phase 2b/3 study in the US and Canada [abstract 104bLB]. Program and abstracts of the 14th Conference on Retroviruses and Opportunistic Infections; February 25-28, 2007; Los Angeles, California. Available from: http://www.retroconference. org/2007/Abstracts/ 30635.htm [Last accessed 26 July 2008]
    • Program and Abstracts of the 14th Conference on Retroviruses and Opportunistic Infections
    • Lalezari, J.1    Goodrich, J.2    De Jesus, E.3
  • 21
    • 80051779181 scopus 로고    scopus 로고
    • Efficacy and safety of maraviroc in antiretroviral treatment-experienced patients infected with CCR5-tropic HIV-1: 48-week results of MOTIVATE 1 [abstract H-718a]
    • the MOTIVATE 1 Study Team September 17-20 2007; Chicago Illinois [Last accessed 26 July 2008]
    • Lalezari J, Mayer H, the MOTIVATE 1 Study Team. Efficacy and safety of maraviroc in antiretroviral treatment-experienced patients infected with CCR5-tropic HIV-1: 48-week results of MOTIVATE 1 [abstract H-718a]. Program and abstracts of the 47th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy; September 17-20, 2007; Chicago, Illinois. Available from: http://www.abstractsonline.com/viewer/viewAbstractPrintFriendly asp?CKey ={471F844E-DCF9-4D36-B713-6C6AC2D47CA8}& SKey = {5F5FCA3D-1CD2-4AA3-A93F- 73B4E8E75F71}& MKey ={D52CF5B5-E7A0-40B1-B430-CE0AC26BBA9E}& AKey ={32093528-52DC-4EBE-9D80-29DAD84C92CE}',%20500,%20400); [Last accessed 26 July 2008]
    • Program and Abstracts of the 47th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy
    • Lalezari, J.1    Mayer, H.2
  • 22
    • 55049103539 scopus 로고    scopus 로고
    • Efficacy and safety of maraviroc (MVC) plus optimized background therapy (OBT) in viremic, antiretroviral treatment-experienced patients infected with CCR5-tropic (R5) HIV-1 in Europe, Australia and North America (MOTIVATE 2): 48-week results [abstract PS3/5]
    • Madrid [Last accessed 26 July 2008]
    • Fätkenheuer G, Konourina I, Nelson M, et al. Efficacy and safety of maraviroc (MVC) plus optimized background therapy (OBT) in viremic, antiretroviral treatment-experienced patients infected with CCR5-tropic (R5) HIV-1 in Europe, Australia and North America (MOTIVATE 2): 48-week results [abstract PS3/5]. 11th European AIDS Conference/EACS, Madrid, 2007. Available from: http://www.eacs.eu/conference/madrid07/pdf2.php?pdf=ABS00015 [Last accessed 26 July 2008]
    • (2007) 11th European AIDS Conference/EACS
    • Fätkenheuer, G.1    Konourina, I.2    Nelson, M.3
  • 23
    • 33646443202 scopus 로고    scopus 로고
    • Emergence of CXCR4-using human immunodeficiency virus type 1 (HIV-1) variants in a minority of HIV-1-infected patients following treatment with the CCR5 antagonist maraviroc is from a pretreatment CXCR4-using virus reservoir
    • Westby M, Lewis M, Whitcomb J, et al. Emergence of CXCR4-using human immunodeficiency virus type 1 (HIV-1) variants in a minority of HIV-1-infected patients following treatment with the CCR5 antagonist maraviroc is from a pretreatment CXCR4-using virus reservoir. J Virol 2006;80(10):4909-20
    • (2006) J Virol , vol.80 , Issue.10 , pp. 4909-4920
    • Westby, M.1    Lewis, M.2    Whitcomb, J.3
  • 25
    • 64549114389 scopus 로고    scopus 로고
    • Changes in HIV-1 co-receptor tropism for patients participating in the maraviroc MOTIVATE 1 and 2 clinical trials [abstract H-715]
    • September 17-20 Chicago, Illinois [Last accessed 24 July 2008[
    • Van Der Ryst E, Westby M. Changes in HIV-1 co-receptor tropism for patients participating in the maraviroc MOTIVATE 1 and 2 clinical trials [abstract H-715]. Program and abstracts of the 47th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy; September 17-20, 2007; Chicago, Illinois. Available from: http://www.abstractsonline.com/viewer/ viewAbstractPrintFriendly.asp? CKey ={935091CF-D3E2-4A6C-A28C-FBC03FE760C7}& SKey ={5F5FCA3D-1CD2-4AA3-A93F-73B4E8E75F71}& MKey ={D52CF5B5-E7A0-40B1- B430-CE0AC26BBA9E}& AKey ={32093528-52DC-4EBE-9D80-29D [Last accessed 24 July 2008[
    • (2007) Program and Abstracts of the 47th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy
    • Van Der Ryst, E.1    Westby, M.2
  • 26
    • 40649110404 scopus 로고    scopus 로고
    • Characterization of maraviroc resistance in patients failing treatment with CCR5-tropic virus in MOTIVATE 1 and MOTIVATE 2 [abstract 10]
    • June 12-16 Barbados [Last accessed 24 July 2008]
    • Mori J, Mosley M, Lewis M, et al. Characterization of maraviroc resistance in patients failing treatment with CCR5-tropic virus in MOTIVATE 1 and MOTIVATE 2 [abstract 10]. Program and abstracts of the 16th International HIV Drug Resistance Workshop; June 12-16, 2007; Barbados. Available from: http://www.intmedpress. com/Journal%20Management/display.cfm? viewinfo = 3F7451620345260A0143070F4 D22491C33782751545247000B5606510 B330C15050003421A48470455096B00 [Last accessed 24 July 2008]
    • (2007) Program and Abstracts of the 16th International HIV Drug Resistance Workshop
    • Mori, J.1    Mosley, M.2    Lewis, M.3
  • 27
    • 12144289333 scopus 로고    scopus 로고
    • Genetic and phenotypic analyses of human immunodeficiency virus type 1 escape from a small-molecule CCR5 inhibitor
    • Kuhmann SE, Pugach P, Kunstman KJ, et al. Genetic and phenotypic analyses of human immunodeficiency virus type 1 escape from a small-molecule CCR5 inhibitor. J Virol 2004;78(6):2790-807
    • (2004) J Virol , vol.78 , Issue.6 , pp. 2790-2807
    • Kuhmann, S.E.1    Pugach, P.2    Kunstman, K.J.3
  • 28
    • 35548983281 scopus 로고    scopus 로고
    • A multicenter randomized double-blind comparative trial of a novel CCR5 antagonist maraviroc vs efavirenz both in combination with Combivir (zidovudine [ZDV]/lamivudine [3TC]) for the treatment of antiretroviral naive patients infected with R5 HIV 1: Week 48 results of the MERIT study [abstract WESS104]
    • July 22-25 Sydney, Australia [Last accessed 24 July 2008[
    • Saag M, Ive P, Heera J, et al. A multicenter, randomized, double-blind, comparative trial of a novel CCR5 antagonist, maraviroc vs efavirenz, both in combination with Combivir (zidovudine [ZDV]/lamivudine [3TC]), for the treatment of antiretroviral naive patients infected with R5 HIV 1: week 48 results of the MERIT study [abstract WESS104]. Program and abstracts of the 4th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention; July 22-25, 2007; Sydney, Australia. Available from: http://www.ias2007.org/pag/ Abstracts.aspx?SID =150& AID=5557 [Last accessed 24 July 2008[
    • (2007) Program and Abstracts of the 4th International AIDS Society Conference on HIV Pathogenesis Treatment and Prevention
    • Saag, M.1    Ive, P.2    Heera, J.3
  • 29
    • 2342537759 scopus 로고    scopus 로고
    • Triple-nucleoside regimens versus efavirenz-containing regimens for the initial treatment of HIV-1 infection
    • Gulick RM, Ribaudo HJ, Shikuma CM, et al. Triple-nucleoside regimens versus efavirenz-containing regimens for the initial treatment of HIV-1 infection. N Engl J Med 2004;350:1850-61
    • (2004) N Engl J Med , vol.350 , pp. 1850-1861
    • Gulick, R.M.1    Ribaudo, H.J.2    Shikuma, C.M.3
  • 30
    • 0027537480 scopus 로고
    • Prognostic value of HIV-1 syncytium-inducing phenotype for rate of CD4+ cell depletion and progression to AIDS
    • Koot M, Keet IP, Vos AH, et al. Prognostic value of HIV-1 syncytium-inducing phenotype for rate of CD4+ cell depletion and progression to AIDS. Ann Intern Med 1993; 118:681-8
    • (1993) Ann Intern Med , vol.118 , pp. 681-688
    • Koot, M.1    Keet, I.P.2    Vos, A.H.3
  • 31
    • 56549123524 scopus 로고    scopus 로고
    • Virological correlates associated with treatment failure at week 48 in the Phase 3 study of maraviroc in treatment-naive patients [abstract 40LB]
    • February 3-6 Boston, Massachusetts [Last accessed 24 July 2006[
    • Heera J, Saag M, Ive P, et al. Virological correlates associated with treatment failure at week 48 in the Phase 3 study of maraviroc in treatment-naive patients [abstract 40LB]. Program and abstracts of the 15th Conference on Retroviruses and Opportunistic Infections; February 3-6, 2008; Boston, Massachusetts. Available from: http://www.retroconference.org/2008/ Abstracts/33388.htm [Last accessed 24 July 2006[
    • (2008) Program and Abstracts of the 15th Conference on Retroviruses and Opportunistic Infections
    • Heera, J.1    Saag, M.2    Ive, P.3
  • 32
    • 30344464412 scopus 로고    scopus 로고
    • Naïve and memory cell turnover as drivers of CCR5-to-CXCR4 tropism switch in human immunodeficiency virus type 1: Implications for therapy
    • Ribeiro RM, Hazenger MD, Perelson AS, Davenport MP. Naïve and memory cell turnover as drivers of CCR5-to-CXCR4 tropism switch in human immunodeficiency virus type 1: implications for therapy J Virol 2006;80:802-9
    • (2006) J Virol , vol.80 , pp. 802-809
    • Ribeiro, R.M.1    Hazenger, M.D.2    Perelson, A.S.3    Davenport, M.P.4
  • 33
    • 75449114153 scopus 로고    scopus 로고
    • Antiviral Drugs Advisory Committee Briefing Document. April 24 [Last accessed 24 July 2008[
    • Maraviroc tablets NDA 22-128. Antiviral Drugs Advisory Committee Briefing Document. April 24, 2007. Available from: http://www.fda.gov/OHRMS/DOCKETS/AC/ 07/briefing/2007-4283b1-01-Pfizer.pdf [Last accessed 24 July 2008[
    • (2007) Maraviroc Tablets NDA 22-128
  • 34
    • 40549121937 scopus 로고    scopus 로고
    • Hepatotoxicity observed in clinical trials of aplaviroc (GW873140)
    • Nichols WG, Steel HM, Bonny T, et al. Hepatotoxicity observed in clinical trials of aplaviroc (GW873140). Antimicrob Agents Chemother 2008;52(3):858-65
    • (2008) Antimicrob Agents Chemother , vol.52 , Issue.3 , pp. 858-865
    • Nichols, W.G.1    Steel, H.M.2    Bonny, T.3
  • 35
    • 0037456351 scopus 로고    scopus 로고
    • Cardiovascular and cerebrovascular events in patients treated for human immunodeficiency virus infection
    • Bozzette SA, Ake CF, Tam HK, et al. Cardiovascular and cerebrovascular events in patients treated for human immunodeficiency virus infection. N Engl J Med 2003;348:702-10
    • (2003) N Engl J Med , vol.348 , pp. 702-710
    • Bozzette, S.A.1    Ake, C.F.2    Tam, H.K.3
  • 37
    • 0036133520 scopus 로고    scopus 로고
    • Ischemic cardiovascular disease in persons with human immunodeficiency virus infection
    • David MH, Hornung R, Fichtenbaum CJ. Ischemic cardiovascular disease in persons with human immunodeficiency virus infection. Clin Infect Dis 2002;34:98-102
    • (2002) Clin Infect Dis , vol.34 , pp. 98-102
    • David, M.H.1    Hornung, R.2    Fichtenbaum, C.J.3
  • 38
    • 13844254117 scopus 로고    scopus 로고
    • Coronary heart disease risk, dyslipidemia, and management in HIV-infected persons
    • Fichtenbaum CJ. Coronary heart disease risk, dyslipidemia, and management in HIV-infected persons. HIV Clin Trials 2004;5(6):416-33
    • (2004) HIV Clin Trials , vol.5 , Issue.6 , pp. 416-433
    • Fichtenbaum, C.J.1
  • 39
    • 80051735841 scopus 로고    scopus 로고
    • Fasted lipid changes after administration of maraviroc or efavirenz in combination with zidovudine and lamivudine for 48 weeks to treatment-naive HIV-infected patients [abstract 929]
    • February 3-6 Boston, Massachusetts [Last accessed 25 July 2008[
    • De Jesus E, Walmsley S, Cohen C, et al. Fasted lipid changes after administration of maraviroc or efavirenz in combination with zidovudine and lamivudine for 48 weeks to treatment-naive HIV-infected patients [abstract 929]. Program and abstracts of the 15th Conference on Retroviruses and Opportunistic Infections; February 3-6, 2008; Boston, Massachusetts. Available from: http://www.retroconference.org/2008/PDFs/929.pdf [Last accessed 25 July 2008[
    • (2008) Program and Abstracts of the 15th Conference on Retroviruses and Opportunistic Infections
    • De Jesus, E.1    Walmsley, S.2    Cohen, C.3
  • 40
    • 0032530664 scopus 로고    scopus 로고
    • CXCR4 and CCR5 on human thymocytes: Biological function and role in HIV-1 infection
    • Zaitseva MB, Lee S, Rabin RL, et al. CXCR4 and CCR5 on human thymocytes: biological function and role in HIV-1 infection. J Immunol 1998;161:3103-13
    • (1998) J Immunol , vol.161 , pp. 3103-3113
    • Zaitseva, M.B.1    Lee, S.2    Rabin, R.L.3
  • 41
    • 0032837669 scopus 로고    scopus 로고
    • Genetics of HIV-1 infection: Chemokine receptor CCR5 polymorphism and its consequences
    • Carrington M, Dean M, Martin MP, O'Brien SJ. Genetics of HIV-1 infection: chemokine receptor CCR5 polymorphism and its consequences. Hum Mol Genet 1999;8(10):1939-45
    • (1999) Hum Mol Genet , vol.8 , Issue.10 , pp. 1939-1945
    • Carrington, M.1    Dean, M.2    Martin, M.P.3    O'Brien, S.J.4
  • 42
    • 33748512788 scopus 로고    scopus 로고
    • CCR5 expression and duration of high risk sexual activity among HIV-seronegative men who have sex with men
    • Thomas SM, Tse DB, Ketner DS, et al. CCR5 expression and duration of high risk sexual activity among HIV-seronegative men who have sex with men. AIDS 2006;20(14):1879-83
    • (2006) AIDS , vol.20 , Issue.14 , pp. 1879-1883
    • Thomas, S.M.1    Tse, D.B.2    Ketner, D.S.3
  • 43
    • 50649104801 scopus 로고    scopus 로고
    • Impact of Delta 32-CCR5 heterozygosity on HIV-1 genetic evolution and variability-a study of 4 individuals infected with closely related HIV-1 strains
    • Chalmet K, Van Wanzeele F, Demecheleer E, et al. Impact of Delta 32-CCR5 heterozygosity on HIV-1 genetic evolution and variability-a study of 4 individuals infected with closely related HIV-1 strains. Virology 2008;379(2):213-22
    • (2008) Virology , vol.379 , Issue.2 , pp. 213-222
    • Chalmet, K.1    Van Wanzeele, F.2    Demecheleer, E.3
  • 44
    • 35548993029 scopus 로고    scopus 로고
    • ACTG 5211: Phase II study of the safety and efficacy of vicriviroc (VCV) in HIV+ treatment-experienced subjects: 48-week results [abstract TUAB102]
    • July 22-25 Sydney, Australia [Last accessed 25 July 2008[
    • Gulick R, et al. ACTG 5211: Phase II study of the safety and efficacy of vicriviroc (VCV) in HIV+ treatment-experienced subjects: 48-week results [abstract TUAB102]. Program and abstracts of the 4th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention; July 22-25, 2007; Sydney, Australia. Available from: http://www.ias2007.org/pag/Abstracts.aspx?SID =48& AID=1623 [Last accessed 25 July 2008[
    • (2007) Program and Abstracts of the 4th International AIDS Society Conference on HIV Pathogenesis Treatment and Prevention
    • Gulick, R.1
  • 45
    • 31344465937 scopus 로고    scopus 로고
    • CCR5 deficiency increases risk of symptomatic West Nile Virus Infection
    • Glass WG, Mc Dermott DH, Lim JK, et al. CCR5 deficiency increases risk of symptomatic West Nile Virus Infection. J Exp Med 2006;203:35-40
    • (2006) J Exp Med , vol.203 , pp. 35-40
    • Glass, W.G.1    Mc Dermott, D.H.2    Lim, J.K.3
  • 46
    • 40549124307 scopus 로고    scopus 로고
    • The effects of cotrimoxazole or tenofovir co-administration on the pharmacokinetics of maraviroc in health volunteers
    • Abel S, Russell D, Whitlock LA, et al. The effects of cotrimoxazole or tenofovir co-administration on the pharmacokinetics of maraviroc in health volunteers. Br J Clin Pharmacol 2008;65(Suppl 1):47-53
    • (2008) Br J Clin Pharmacol , vol.65 , Issue.SUPPL. 1 , pp. 47-53
    • Abel, S.1    Russell, D.2    Whitlock, L.A.3
  • 47
    • 40549095691 scopus 로고    scopus 로고
    • A novel probe drug interaction study to investigate the effect of selected antiretroviral combinations on the pharmacokinetics of a single oral dose of maraviroc in HIV-positive subjects
    • Posniak AL, Boffito M, Russell D, et al. A novel probe drug interaction study to investigate the effect of selected antiretroviral combinations on the pharmacokinetics of a single oral dose of maraviroc in HIV-positive subjects. Br J Clin Pharmacol 2008;65(Suppl 1):54-9
    • (2008) Br J Clin Pharmacol , vol.65 , Issue.SUPPL. 1 , pp. 54-59
    • Posniak, A.L.1    Boffito, M.2    Russell, D.3
  • 48
    • 40549090550 scopus 로고    scopus 로고
    • Effect of maraviroc on the pharmacokinetics of midazolam, lamivudine/zidovudine, and ethinyloestradiol/levonorgestrel in health volunteers
    • Abel S, Russell D, Whitlock LA, et al. Effect of maraviroc on the pharmacokinetics of midazolam, lamivudine/zidovudine, and ethinyloestradiol/ levonorgestrel in health volunteers. Br J Clin Pharmacol 2008;65(Suppl 1):19-26
    • (2008) Br J Clin Pharmacol , vol.65 , Issue.SUPPL. 1 , pp. 19-26
    • Abel, S.1    Russell, D.2    Whitlock, L.A.3
  • 49
    • 40549086936 scopus 로고    scopus 로고
    • Effects of CYP3A4 inducers with and without CYP3A4 inhibitors on the pharmacokinetics of maraviroc in health volunteers
    • Abel S, Jenkins TM, Whitlock LA, et al. Effects of CYP3A4 inducers with and without CYP3A4 inhibitors on the pharmacokinetics of maraviroc in health volunteers. Br J Clin Pharmacol 2008;65(Suppl 1):38-46
    • (2008) Br J Clin Pharmacol , vol.65 , Issue.SUPPL. 1 , pp. 38-46
    • Abel, S.1    Jenkins, T.M.2    Whitlock, L.A.3
  • 50
    • 44049098954 scopus 로고    scopus 로고
    • Whitehouse Station NJ: Merck; October
    • Isentress [package insert]. Whitehouse Station, NJ: Merck; October 2007
    • (2007) Isentress [Package Insert]
  • 51
    • 65549153833 scopus 로고    scopus 로고
    • Raritan Inc: Tibotec Therapeutics January
    • Intelence [package insert]. Raritan, Inc: Tibotec Therapeutics; January 2008
    • (2008) Intelence [Package Insert]
  • 52
    • 43749098454 scopus 로고    scopus 로고
    • 48-week results from BENCHMRK-1 a Phase III study of raltegravir (RAL) in patients failing antiretroviral therapy (ART) with triple-class resistant HIV-1 [Poster 788]
    • February 3-6 Boston, Massachusetts [Last accessed 17 Oct 2008[
    • Cooper RA, Gatell J, Rockstroh H, et al. 48-week results from BENCHMRK-1, a Phase III study of raltegravir (RAL) in patients failing antiretroviral therapy (ART) with triple-class resistant HIV-1 [Poster 788]. Program and abstracts of the 15th Conference on Retroviruses and Opportunistic Infections; February 3-6, 2008; Boston, Massachusetts. Available from: http://www. retroconference.org/2008/PDFs/788.pdf [Last accessed 17 Oct 2008[
    • (2008) Program and Abstracts of the 15th Conference on Retroviruses and Opportunistic Infections
    • Cooper, R.A.1    Gatell, J.2    Rockstroh, H.3
  • 53
    • 43749103048 scopus 로고    scopus 로고
    • DUET-2: Week 48 results of a Phase III randomized double-blind trial to evaluate the efficacy and safety of etravirine (ETR; TMC125) versus placebo in 591 treatment-experienced HIV-1-infected patients [Poster 791]
    • February 3-6 Boston, Massachusetts [Last accessed 17 Oct 2008[
    • Johnson M, Campbell T, Clotet B, et al. DUET-2: week 48 results of a Phase III randomized double-blind trial to evaluate the efficacy and safety of etravirine (ETR; TMC125) versus placebo in 591 treatment-experienced HIV-1-infected patients [Poster 791]. Program and abstracts of the 15th Conference on Retroviruses and Opportunistic Infections; February 3-6, 2008; Boston, Massachusetts. Available from: http://www.retroconference.org/2008/PDFs/ 791.pdf [Last accessed 17 Oct 2008[
    • (2008) Program and Abstracts of the 15th Conference on Retroviruses and Opportunistic Infections
    • Johnson, M.1    Campbell, T.2    Clotet, B.3
  • 54
    • 49849103584 scopus 로고    scopus 로고
    • Severe rhabdomyolysis associated with raltegravir use [Correspondence]
    • Zembower TR, Cerzenshtein L, Coleman K, Palella FJ. Severe rhabdomyolysis associated with raltegravir use [Correspondence]. AIDS 2008;22(11):1382-4
    • (2008) AIDS , vol.22 , Issue.11 , pp. 1382-1384
    • Zembower, T.R.1    Cerzenshtein, L.2    Coleman, K.3    Palella, F.J.4
  • 55
    • 39549094435 scopus 로고    scopus 로고
    • CD4-dependent characteristics of coreceptor use and HIV type 1 V3 sequence in a large population of therapy-naive individuals
    • Low AJ, Marchant D, Brumme CJ, et al. CD4-dependent characteristics of coreceptor use and HIV type 1 V3 sequence in a large population of therapy-naive individuals. AIDS Res Hum Retroviruses 2008;24(2): 219-28
    • (2008) AIDS Res Hum Retroviruses , vol.24 , Issue.2 , pp. 219-228
    • Low, A.J.1    Marchant, D.2    Brumme, C.J.3
  • 56
    • 80051725878 scopus 로고    scopus 로고
    • Maraviroc pharmacokinetics in blood plasma genital tract fluid and tissue in healthy female volunteers [abstract 135LB]
    • February 3-6 Boston, Massachusetts [Last accessed on 13 Oct 2008[
    • Dumond JB, Patterson KB, Pecha A, et al. Maraviroc pharmacokinetics in blood plasma, genital tract fluid, and tissue in healthy female volunteers [abstract 135LB]. Program and abstracts of the 15 th Conference on Retroviruses and Opportunistic Infections; February 3-6, 2008; Boston, Massachusetts. Available from: http://img.thebody.com/confs/retro2008/slides/135LB%20Dumond%20 slides.pdf [Last accessed on 13 Oct 2008[
    • (2008) Th Conference on Retroviruses and Opportunistic Infections
    • Dumond, J.B.1    Patterson, K.B.2    Pecha, A.3
  • 57
    • 33846623260 scopus 로고    scopus 로고
    • Development and characterization of a novel singly-cycle recombinant-virus assay to determine human immunodeficiency virus type 1 coreceptor tropism
    • Whitcomb JM, Huang W, Fransen S, et al. Development and characterization of a novel singly-cycle recombinant-virus assay to determine human immunodeficiency virus type 1 coreceptor tropism. Antimicrob Agents Chemother 2007;512:566-75
    • (2007) Antimicrob Agents Chemother , vol.512 , pp. 566-575
    • Whitcomb, J.M.1    Huang, W.2    Fransen, S.3
  • 58
    • 55049098292 scopus 로고    scopus 로고
    • Comparison of results from the SensiTrop vs Trofile assays on 100 samples from the maraviroc expanded access program [abstract 920a]
    • February 3-6 Boston, Massachusetts [Last accessed 28 July 2008[
    • Tressler R, Valdez H, Van Der Ryst E, et al. Comparison of results from the SensiTrop vs Trofile assays on 100 samples from the maraviroc expanded access program [abstract 920a]. Program and abstracts of the 15th Conference on Retroviruses and Opportunistic Infections; February 3-6, 2008; Boston, Massachusetts. Available from: http://www.retroconference.org/2008/PDFs/920a.pdf [Last accessed 28 July 2008[
    • (2008) Program and Abstracts of the 15th Conference on Retroviruses and Opportunistic Infections
    • Tressler, R.1    Valdez, H.2    Van Der Ryst, E.3
  • 59
    • 48449104735 scopus 로고    scopus 로고
    • An enhanced version of the Trofile HIV co-receptor tropism assay predicts emergence of CXCR4 use in ACTG5211 vicriviroc trial samples [abstract 869]
    • February 3-6 Boston Massachusetts [Last accessed on 28 July 2008]
    • Reeves J, Han D, Wilkin T, et al. An enhanced version of the Trofile HIV co-receptor tropism assay predicts emergence of CXCR4 use in ACTG5211 vicriviroc trial samples [abstract 869]. Program and abstracts of the 15th Conference on Retroviruses and Opportunistic Infections; February 3-6, 2008; Boston, Massachusetts. Available from: http://www.retroconference. org/2008/Abstracts/ 33252.htm [Last accessed on 28 July 2008]
    • (2008) Program and Abstracts of the 15th Conference on Retroviruses and Opportunistic Infections
    • Reeves, J.1    Han, D.2    Wilkin, T.3


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