Total synthesis of (+)-lactacystin

Journal of the American Chemical Society

Volumn 118, Issue 15, 1996, Pages 3584-3590

  Nagamitsu, Tohru ^a,b   Sunazuka, Toshiaki ^a,b   Tanaka, Haruo ^a,b   Omura, Satoshi ^a,b   Sprengeler, Paul A ^c,d   Smith III, Amos B ^c,d  

^a KITASATO INSTITUTE   (Japan)

^b KITASATO UNIVERSITY   (Japan)

^c MONELL CHEMICAL SENSES CENTER   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXYLEUCINE; CYTOTOXIC AGENT; DECARBOXYLACTACYSTIN; LACTACYSTIN; UNCLASSIFIED DRUG;

ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; MASS SPECTROMETRY; NERVE CELL; NEURITE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; STEREOISOMERISM;

EID: 0029995939     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja9541544     Document Type: Article

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52. 4 and deuterium oxide are reported relative to the methanol peak at 331 ppm and the deuterium peak at 4.76 ppm, respectively Mass spectra were obtained with a JMS-D100 or JMS-D300 instrument. Elemental analyses were performed by YANACO CHN Corder MT-5. Optical rotations were measured with a JASCO DIP-370 digital polarimeter.