Frontiers in targeting glioma stem cells

European Journal of Cancer

Volumn 47, Issue 4, 2011, Pages 496-507

  Frosina, Guido ^a  

^a UNIVERSITY OF GENOA   (Italy)

Author keywords

Cancer; CD133; Glioma; Resistance; Stem

Indexed keywords

12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; 2 MORPHOLINO 6 (1 THIANTHRENYL) 4 PYRANONE; A 443654; ABC TRANSPORTER; ANTINEOPLASTIC AGENT; BEVACIZUMAB; CASPASE 8; CETUXIMAB; CYCLOOXYGENASE 2; DOUBLECORTIN; ERLOTINIB; GANCICLOVIR; GEFITINIB; NIMOTUZUMAB; NOTCH RECEPTOR; TEMOZOLOMIDE; UNCLASSIFIED DRUG;

AUTOPHAGY; CANCER RESISTANCE; DNA DAMAGE; DOWN REGULATION; GLIOMA CELL; HUMAN; INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; REVIEW; SIGNAL TRANSDUCTION; STEM CELL; VIROTHERAPY;

ANTINEOPLASTIC AGENTS; BRAIN NEOPLASMS; DRUG RESISTANCE, NEOPLASM; GLIOBLASTOMA; GLIOMA; HUMANS; IMMUNOTHERAPY; NEOPLASM RECURRENCE, LOCAL; NEOPLASTIC STEM CELLS;

EID: 79851507486     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejca.2010.11.017     Document Type: Article

References (92)

1. T.W. Abel, C. Clark, and B. Bierie GFAP-cre-mediated activation of oncogenic K-ras results in expansion of the subventricular zone and infiltrating glioma Mol Cancer Res 7 5 2009 645 653
2. C.D. Stiles, and D.H. Rowitch Glioma stem cells: a midterm exam Neuron 58 6 2008 832 846 (Pubitemid 351842757)
3. D.M. Park, and J.N. Rich Biology of glioma cancer stem cells Mol Cells 28 1 2009 7 12
4. G. Frosina The bright and the dark sides of DNA repair in stem cells J Biomed Biotechnol 2010 2010 845396
5. D. Bexell, S. Gunnarsson, P. Siesjo, J. Bengzon, and A. Darabi CD133+ and nestin+ tumor-initiating cells dominate in N29 and N32 experimental gliomas Int J Cancer 125 1 2009 15 22
6. M. Ropolo, A. Daga, and F. Griffero Comparative analysis of DNA repair in stem and nonstem glioma cell cultures Mol Cancer Res 7 3 2009 383 392
7. G. Frosina DNA repair and resistance of gliomas to chemotherapy and radiotherapy Mol Cancer Res 7 7 2009 989 999
8. D. Beier, P. Hau, and M. Proescholdt CD133(+) and CD133(-) glioblastoma-derived cancer stem cells show differential growth characteristics and molecular profiles Cancer Res 67 9 2007 4010 4015 (Pubitemid 46815044)
9. H.S. Gunther, N.O. Schmidt, and H.S. Phillips Glioblastoma-derived stem cell-enriched cultures form distinct subgroups according to molecular and phenotypic criteria Oncogene 27 20 2008 2897 2909 (Pubitemid 351620450)
10. L. Prestegarden, A. Svendsen, and J. Wang Glioma cell populations grouped by different cell type markers drive brain tumor growth Cancer Res 70 11 2010 4274 4279
11. K. Nishide, Y. Nakatani, H. Kiyonari, and T. Kondo Glioblastoma formation from cell population depleted of Prominin1-expressing cells PLoS One 4 8 2009 e6869
12. S.G. Piccirillo, R. Combi, and L. Cajola Distinct pools of cancer stem-like cells coexist within human glioblastomas and display different tumorigenicity and independent genomic evolution Oncogene 28 15 2009 1807 1811
13. G. Shen, F. Shen, and Z. Shi Identification of cancer stem-like cells in the C6 glioma cell line and the limitation of current identification methods In Vitro Cell Dev Biol Anim 44 7 2008 280 289
14. M.K. Kang, and S.K. Kang Tumorigenesis of chemotherapeutic drug-resistant cancer stem-like cells in brain glioma Stem Cells Dev 16 5 2007 837 847
15. M.K. Kang, B.I. Her, and M.H. Ko Potential identity of multi-potential cancer stem-like subpopulation after radiation of cultured brain glioma BMC Neurosci 9 1 2008 15
16. A.T. Ogden, A.E. Waziri, and R.A. Lochhead Identification of A2B5+ tumor-initiating cells in adult human gliomas Neurosurgery 62 2 2008 505 514 [discussion 514-5] (Pubitemid 351489297)
17. D. Beier, S. Rohrl, and D.R. Pillai Temozolomide preferentially depletes cancer stem cells in glioblastoma Cancer Res 68 14 2008 5706 5715
18. G.L. Gallia, B.M. Tyler, and C.L. Hann Inhibition of akt inhibits growth of glioblastoma and glioblastoma stem-like cells Mol Cancer Ther 8 2 2009 386 393
19. A.M. McCord, M. Jamal, E.S. Williams, K. Camphausen, and P.J. Tofilon CD133+ glioblastoma stem-like cells are radiosensitive with a defective DNA damage response compared with established cell lines Clin Cancer Res 15 16 2009 5145 5153
20. N. Serakinci, R. Christensen, and J. Graakjaer Ectopically hTERT expressing adult human mesenchymal stem cells are less radiosensitive than their telomerase negative counterpart Exp Cell Res 313 5 2007 1056 1067 (Pubitemid 46273450)
21. A. Shervington, C. Lu, R. Patel, and L. Shervington Telomerase downregulation in cancer brain stem cell Mol Cell Biochem 331 1-2 2009 153 159
22. P.Y. Wen, and S. Kesari Malignant gliomas in adults N Engl J Med 359 5 2008 492 507
23. K. Qin, X. Jiang, and Y. Zou Study on the proliferation and drug-resistance of human brain tumor stem-like cells Cell Mol Neurobiol 30 6 2010 955 960
24. S.L. Lomonaco, S. Finniss, and C. Xiang The induction of autophagy by gamma-radiation contributes to the radioresistance of glioma stem cells Int J Cancer 125 3 2009 717 722
25. B. Annabi, C. Laflamme, A. Sina, M.P. Lachambre, and R. Beliveau A MT1-MMP/NF-kappaB signaling axis as a checkpoint controller of COX-2 expression in CD133+ U87 glioblastoma cells J Neuroinflammation 6 2009 8
26. B. Annabi, M.P. Lachambre, K. Plouffe, H. Sartelet, and R. Beliveau Modulation of invasive properties of CD133+ glioblastoma stem cells: a role for MT1-MMP in bioactive lysophospholipid signaling Mol Carcinog 48 10 2009 910 919
27. D. Capper, T. Gaiser, and C. Hartmann Stem-cell-like glioma cells are resistant to TRAIL/Apo2L and exhibit down-regulation of caspase-8 by promoter methylation Acta Neuropathol 117 4 2009 445 456
28. Y. Jin, Z.Q. Bin, and H. Qiang ABCG2 is related with the grade of glioma and resistance to mitoxantone, a chemotherapeutic drug for glioma J Cancer Res Clin Oncol 135 10 2009 1369 1376
29. A.M. Bleau, D. Hambardzumyan, and T. Ozawa PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells Cell Stem Cell 4 3 2009 226 235
30. A.M. Bleau, J.T. Huse, and E.C. Holland The ABCG2 resistance network of glioblastoma Cell Cycle 8 18 2009 2936 2944
31. A.I. Persson, and W.A. Weiss The side story of stem-like glioma cells Cell Stem Cell 4 3 2009 191 192
32. E. Nakai, K. Park, and T. Yawata Enhanced MDR1 expression and chemoresistance of cancer stem cells derived from glioblastoma Cancer Invest 27 9 2009 901 908
33. L. Qiang, Y. Yang, and Y.J. Ma Isolation and characterization of cancer stem like cells in human glioblastoma cell lines Cancer Lett 279 1 2009 13 21
34. V. Martin, J. Xu, and S.K. Pabbisetty Tie2-mediated multidrug resistance in malignant gliomas is associated with upregulation of ABC transporters Oncogene 28 24 2009 2358 2363
35. S. Hitoshi, R.M. Seaberg, and C. Koscik Primitive neural stem cells from the mammalian epiblast differentiate to definitive neural stem cells under the control of notch signaling Genes Dev 18 15 2004 1806 1811 (Pubitemid 39025091)
36. M. Kanamori, T. Kawaguchi, and J.M. Nigro Contribution of notch signaling activation to human glioblastoma multiforme J Neurosurg 106 3 2007 417 427 (Pubitemid 46354295)
37. X.P. Zhang, G. Zheng, and L. Zou Notch activation promotes cell proliferation and the formation of neural stem cell-like colonies in human glioma cells Mol Cell Biochem 307 1-2 2008 101 108 (Pubitemid 350238652)
38. X. Fan, W. Matsui, and L. Khaki Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors Cancer Res 66 15 2006 7445 7452 (Pubitemid 44289197)
39. E. Vlashi, W.H. McBride, and F. Pajonk Radiation responses of cancer stem cells J Cell Biochem 108 2 2009 339 342
40. H.C. Reinhardt, and M.B. Yaffe Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2 Curr Opin Cell Biol 21 2 2009 245 255
41. E. Bolderson, D.J. Richard, B.B. Zhou, and K.K. Khanna Recent advances in cancer therapy targeting proteins involved in DNA double-strand break repair Clin Cancer Res 15 20 2009 6314 6320
42. S. Bao, Q. Wu, and R.E. McLendon Glioma stem cells promote radioresistance by preferential activation of the DNA damage response Nature 444 7120 2006 756 760 (Pubitemid 44949604)
43. J. Dietrich, R. Han, Y. Yang, M. Mayer-Proschel, and M. Noble CNS progenitor cells and oligodendrocytes are targets of chemotherapeutic agents in vitro and in vivo J Biol 5 7 2006 22
44. R. Han, Y.M. Yang, and J. Dietrich Systemic 5-fluorouracil treatment causes a syndrome of delayed myelin destruction in the central nervous system J Biol 7 4 2008 12
45. D.D. Correa Neurocognitive function in brain tumors Curr Neurol Neurosci Rep 10 3 2010 232 239
46. B. Herrington, and M.W. Kieran Small molecule inhibitors in children with malignant gliomas Pediatr Blood Cancer 53 3 2009 312 317
47. M. Glantz, S. Kesari, L. Recht, G. Fleischhack, and A. Van Horn Understanding the origins of gliomas and developing novel therapies: Cerebrospinal fluid and subventricular zone interplay Semin Oncol 36 4 Suppl. 2 2009 S17 S24
48. N. Golestaneh, and B. Mishra TGF-beta, neuronal stem cells and glioblastoma Oncogene 24 37 2005 5722 5730 (Pubitemid 43086132)
49. S. Penuelas, J. Anido, and R.M. Prieto-Sanchez TGF-beta increases glioma-initiating cell self-renewal through the induction of LIF in human glioblastoma Cancer Cell 15 4 2009 315 327
50. H.A. Fine Glioma stem cells: not all created equal Cancer Cell 15 4 2009 247 249
51. H. Ikushima, T. Todo, and Y. Ino Autocrine TGF-beta signaling maintains tumorigenicity of glioma-initiating cells through sry-related HMG-box factors Cell Stem Cell 5 5 2009 504 514
52. S.G. Piccirillo, B.A. Reynolds, and N. Zanetti Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells Nature 444 7120 2006 761 765 (Pubitemid 44949605)
53. J. Lee, M.J. Son, and K. Woolard Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells Cancer Cell 13 1 2008 69 80 (Pubitemid 350309742)
54. K. Yuki, A. Natsume, and H. Yokoyama Induction of oligodendrogenesis in glioblastoma-initiating cells by IFN-mediated activation of STAT3 signaling Cancer Lett 284 1 2009 71 79
55. M. Gadji, A.M. Crous, and D. Fortin EGF receptor inhibitors in the treatment of glioblastoma multiform: old clinical allies and newly emerging therapeutic concepts Eur J Pharmacol 625 1-3 2009 23 30
56. F. Griffero, A. Daga, and D. Marubbi Different response of human glioma tumor-initiating cells to epidermal growth factor receptor kinase inhibitors J Biol Chem 284 11 2009 7138 7148
57. P.C. De Witt Hamer Small molecule kinase inhibitors in glioblastoma: a systematic review of clinical studies Neuro Oncol 12 3 2010 304 316
58. B. Neyns, J. Sadones, and E. Joosens Stratified phase II trial of cetuximab in patients with recurrent high-grade glioma Ann Oncol 20 9 2009 1596 1603
59. J. Wang, T.P. Wakeman, and J.D. Lathia Notch promotes radioresistance of glioma stem cells Stem Cells 28 1 2010 17 28
60. P. Xu, M. Qiu, and Z. Zhang The oncogenic roles of Notch1 in astrocytic gliomas in vitro and in vivo J Neurooncol 97 1 2010 41 51
61. I. Hickson, Y. Zhao, and C.J. Richardson Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM Cancer Res 64 24 2004 9152 9159 (Pubitemid 39665530)
62. E.A. Kohn, C.J. Yoo, and A. Eastman The protein kinase C inhibitor Go6976 is a potent inhibitor of DNA damage-induced S and G2 cell cycle checkpoints Cancer Res 63 1 2003 31 35 (Pubitemid 36070415)
63. J. Bain, L. Plater, and M. Elliott The selectivity of protein kinase inhibitors: a further update Biochem J 408 3 2007 297 315
64. C.C. Chen, R.D. Kennedy, S. Sidi, A.T. Look, and A. D'Andrea CHK1 inhibition as a strategy for targeting fanconi anemia (FA) DNA repair pathway deficient tumors Mol Cancer 8 2009 24
65. Y. Pereg, S. Lam, and A. Teunisse Differential roles of ATM- and Chk2-mediated phosphorylations of hdmx in response to DNA damage Mol Cell Biol 26 18 2006 6819 6831 (Pubitemid 44387632)
66. E. Crescenzi, G. Palumbo, J. de Boer, and H.J. Brady Ataxia telangiectasia mutated and p21CIP1 modulate cell survival of drug-induced senescent tumor cells: Implications for chemotherapy Clin Cancer Res 14 6 2008 1877 1887 (Pubitemid 351469475)
67. D.O. Azorsa, I.M. Gonzales, and G.D. Basu Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer J Transl Med 7 2009 43
68. T. Di Tomaso, S. Mazzoleni, and E. Wang Immunobiological characterization of cancer stem cells isolated from glioblastoma patients Clin Cancer Res 16 3 2010 800 813
69. J. Wei, J. Barr, and L.Y. Kong Glioma-associated cancer-initiating cells induce immunosuppression Clin Cancer Res 16 2 2010 461 473
70. H. Wang, J.D. Lathia, and Q. Wu Targeting interleukin 6 signaling suppresses glioma stem cell survival and tumor growth Stem Cells 27 10 2009 2393 2404
71. C.E. Brown, R. Starr, and C. Martinez Recognition and killing of brain tumor stem-like initiating cells by CD8+ cytolytic T cells Cancer Res 69 23 2009 8886 8893
72. R. Ueda, K. Ohkusu-Tsukada, and N. Fusaki Identification of HLA-A2- and A24-restricted T-cell epitopes derived from SOX6 expressed in glioma stem cells for immunotherapy Int J Cancer 126 4 2010 919 929
73. R. Castriconi, A. Daga, and A. Dondero NK cells recognize and kill human glioblastoma cells with stem cell-like properties J Immunol 182 6 2009 3530 3539
74. A. Diaz Miqueli, J. Rolff, and M. Lemm Radiosensitisation of U87MG brain tumours by anti-epidermal growth factor receptor monoclonal antibodies Br J Cancer 100 6 2009 950 958
75. S. Bao, Q. Wu, and S. Sathornsumetee Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor Cancer Res 66 16 2006 7843 7848 (Pubitemid 44299144)
76. C. Folkins, Y. Shaked, and S. Man Glioma tumor stem-like cells promote tumor angiogenesis and vasculogenesis via vascular endothelial growth factor and stromal-derived factor 1 Cancer Res 69 18 2009 7243 7251
77. A.D. Norden, G.S. Young, and K. Setayesh Bevacizumab for recurrent malignant gliomas: efficacy, toxicity, and patterns of recurrence Neurology 70 10 2008 779 787
78. M. Dey, I.V. Ulasov, and M.S. Lesniak Virotherapy against malignant glioma stem cells Cancer Lett 289 1 2010 1 10
79. G. Frosina Prophylaxis of oxidative DNA damage by formamidopyrimidine-DNA glycosylase Int J Cancer 119 1 2006 1 7
80. A.P. Kyritsis, C. Sioka, and J.S. Rao Viruses, gene therapy and stem cells for the treatment of human glioma Cancer Gene Ther 16 10 2009 741 752
81. H. Wakimoto, S. Kesari, and C.J. Farrell Human glioblastoma-derived cancer stem cells: establishment of invasive glioma models and treatment with oncolytic herpes simplex virus vectors Cancer Res 69 8 2009 3472 3481
82. B.J. Passer, C.L. Wu, S. Wu, S.D. Rabkin, and R.L. Martuza Analysis of genetically engineered oncolytic herpes simplex viruses in human prostate cancer organotypic cultures Gene Ther 16 12 2009 1477 1482
83. P.C. Huszthy, T. Giroglou, and O. Tsinkalovsky Remission of invasive, cancer stem-like glioblastoma xenografts using lentiviral vector-mediated suicide gene therapy PLoS One 4 7 2009 e6314
84. M. Santra, X. Zheng, and C. Roberts Single doublecortin gene therapy significantly reduces glioma tumor volume J Neurosci Res 88 2 2010 304 314
85. M. Santra, X. Zhang, S. Santra, F. Jiang, and M. Chopp Ectopic doublecortin gene expression suppresses the malignant phenotype in glioblastoma cells Cancer Res 66 24 2006 11726 11735 (Pubitemid 46098830)
86. F.J. Swartling, M. Ferletta, M. Kastemar, W.A. Weiss, and B. Westermark Cyclic GMP-dependent protein kinase II inhibits cell proliferation, Sox9 expression and akt phosphorylation in human glioma cell lines Oncogene 28 35 2009 3121 3131
87. C.J. Chang, C.C. Hsu, and M.C. Yung Enhanced radiosensitivity and radiation-induced apoptosis in glioma CD133-positive cells by knockdown of SirT1 expression Biochem Biophys Res Commun 380 2 2009 236 242
88. G. Frosina DNA repair in normal and cancer stem cells, with special reference to the central nervous system Curr Med Chem 16 7 2009 854 866
89. P.B. Dirks Brain tumor stem cells: bringing order to the chaos of brain cancer J Clin Oncol 26 17 2008 2916 2924
90. A. Dupre, L. Boyer-Chatenet, and R.M. Sattler A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex Nat Chem Biol 4 2 2008 119 125
91. J. Won, M. Kim, and N. Kim Small molecule-based reversible reprogramming of cellular lifespan Nat Chem Biol 2 7 2006 369 374 (Pubitemid 43936937)
92. J. Won, M. Kim, and N. Kim Retraction: small molecule-based reversible reprogramming of cellular lifespan Nat Chem Biol 4 7 2008 431