Different response of human glioma tumor-initiating cells to epidermal growth factor receptor kinase inhibitors

Journal of Biological Chemistry

Volumn 284, Issue 11, 2009, Pages 7138-7148

  Griffero, Fabrizio ^a,b   Daga, Antonio ^a   Marubbi, Daniela ^b   Capra, Maria Cristina ^a   Melotti, Alice ^a,b   Pattarozzi, Alessandra ^b   Gatti, Monica ^b   Bajetto, Adriana ^b   Porcile, Carola ^b   Barbieri, Federica ^b   Favoni, Roberto E ^a   Lo Castro, Michele ^a   Zona, Gianluigi ^b   Spaziante, Renato ^b   Florio, Tullio ^b   Corte, Giorgio ^a,b  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AKT PHOSPHORYLATION; ANTI-EGFR; ANTI-PROLIFERATIVE; ANTIPROLIFERATIVE EFFECT; BASAL CONDITIONS; CONCENTRATION-DEPENDENT; EPIDERMAL GROWTH FACTOR RECEPTORS; ERLOTINIB; GEFITINIB; GLIOBLASTOMAS; IN-VITRO; IN-VIVO; KINASE INHIBITORS; MOLECULAR DETERMINANTS; NEURAL STEM CELL; RADIOLIGAND BINDING; STEM CELL; TUMORIGENICITY;

BIOACTIVITY; CELL DEATH; CELL MEMBRANES; CONCENTRATION (PROCESS); PEPTIDES; TECHNOLOGICAL FORECASTING; TEMPERATURE INDICATING CAMERAS; TUMORS;

CELL CULTURE;

CD133 ANTIGEN; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; ERLOTINIB; GEFITINIB; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NESTIN; PHOSPHATASE; PROTEIN KINASE B; RADIOLIGAND; TENSIN; TUMOR MARKER; ACTIN BINDING PROTEIN; EGFR PROTEIN, HUMAN; PROTEIN KINASE INHIBITOR; QUINAZOLINE DERIVATIVE; TENSINS;

ADULT; AGED; ARTICLE; CANCER CELL CULTURE; CANCER STEM CELL; CARCINOGENICITY; CELL DEATH; CELL DIFFERENTIATION; CELL ISOLATION; CELL SURVIVAL; CLINICAL ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; DOSE TIME EFFECT RELATION; DOWN REGULATION; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FEMALE; GLIOBLASTOMA; GLIOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; LIGAND BINDING; MALE; NEURAL STEM CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEQUENCE HOMOLOGY; ANIMAL; BIOSYNTHESIS; DRUG ANTAGONISM; DRUG EFFECT; GENE EXPRESSION REGULATION; METABOLISM; MIDDLE AGED; MOUSE; MOUSE MUTANT; NONOBESE DIABETIC MOUSE; PHOSPHORYLATION; TIME; TUMOR CELL CULTURE;

AGED; ANIMALS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIOMA; HUMANS; MALE; MICE; MICE, INBRED NOD; MICE, SCID; MICROFILAMENT PROTEINS; MIDDLE AGED; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NEOPLASTIC STEM CELLS; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; QUINAZOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; TIME FACTORS; TUMOR CELLS, CULTURED;

EID: 65449188718     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M807111200     Document Type: Article

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