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The use of the mini-mental state examination to assess cognitive functioning in cancer trials: No ifs, ands, buts, or sensitivity
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Meyers CA, Wefel JS: The use of the mini-mental state examination to assess cognitive functioning in cancer trials: no ifs, ands, buts, or sensitivity. J Clin Oncol 2003; 21:3557-3558.
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J Clin Oncol
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Nordal RA, Wong CS: Molecular targets in radiation-induced blood-brain barrier disruption. Int J Radiat Oncol Biol Phys 2005, 62:279-287.
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6
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This is an excellent paper describing in vitro and in vivo (mice) studies demonstrating that common chemotherapy agents caused increased cell death and decreased cell division in the subventricular zone and in the dentate gyrus of the hippocampus (regions involved in neurogenesis). These effects were seen in doses that were not effective in causing cell death in tumor cell lines
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•• Dietrich J, Han R, Yang Y, et al.: CNS progenitor cells and oligodendrocytes are targets of chemotherapeutic agents in vitro and vivo. J Biol 2006, 5:1-23. This is an excellent paper describing in vitro and in vivo (mice) studies demonstrating that common chemotherapy agents caused increased cell death and decreased cell division in the subventricular zone and in the dentate gyrus of the hippocampus (regions involved in neurogenesis). These effects were seen in doses that were not effective in causing cell death in tumor cell lines.
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Dietrich, J.1
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7
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This article provides a comprehensive review of empiric studies using pharmacologic interventions to treat and prevent cognitive impairment in brain tumor patients; studies using cognitive rehabilitation techniques also are reviewed
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•• Gehring K, Sitskoorn MM, Aaronson NK, et al.: Interventions for cognitive deficits in adults with brain tumours. Lancet Neurol 2008, 7:548-560. This article provides a comprehensive review of empiric studies using pharmacologic interventions to treat and prevent cognitive impairment in brain tumor patients; studies using cognitive rehabilitation techniques also are reviewed.
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Gehring, K.1
Sitskoorn, M.M.2
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8
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2642510727
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Neuropsychological dysfunction associated with cancer and cancer therapies: A conceptual review of an emerging target
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Wefel JS, Kayl AE, Meyers CA: Neuropsychological dysfunction associated with cancer and cancer therapies: a conceptual review of an emerging target. Br J Cancer 2004, 90:1691-1696.
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Br J Cancer
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Wefel, J.S.1
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9
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Role and relevance of neurocognitive assessments in clinical trials of patients with CNS tumors
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This study outlines the rationale for performing prospective neuropsychological evaluations at diagnosis and following treatment in patients with brain tumors. A brief test battery including standardized cognitive tests and quality-of-life questionnaires is suggested for use in neurooncology trials
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• Meyers CA, Brown PD: Role and relevance of neurocognitive assessments in clinical trials of patients with CNS tumors. J Clin Oncol 2006, 24:1305-1309. This study outlines the rationale for performing prospective neuropsychological evaluations at diagnosis and following treatment in patients with brain tumors. A brief test battery including standardized cognitive tests and quality-of-life questionnaires is suggested for use in neurooncology trials.
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J Clin Oncol
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Meyers, C.A.1
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10
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This article provides a comprehensive review of cognitive studies in PCNSL patients. It also proposes the use of a standardized cognitive test battery in future collaborative studies
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• Correa DD, Maron L, Harder H, et al.: Cognitive functions in primary central nervous system lymphoma: literature review and assessment guidelines. Ann Oncol 2007, 18:1145-1151. This article provides a comprehensive review of cognitive studies in PCNSL patients. It also proposes the use of a standardized cognitive test battery in future collaborative studies.
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National Cancer Institute, National Institute of Neurological Disorders and Stroke: Report of the Brain Tumor Progress Review Group, November 2000. Available at http://osp.nci.nih.gov/Prg-assess/PRG/BTPGR.
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12
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Regine WF, Schmitt FA, Scott CB, et al.: Feasibility of neurocognitive outcome evaluations in patients with brain metastases in a multi-institutional cooperative group setting: results of Radiation Therapy Oncology Group trial BR-0018. Int J Radiat Oncol 2004, 58:1346-1352.
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Meyers CA, Smith JA, Bezjak A, et al.: Neurocognitive function and progression in patients with brain metastases treated with whole-brain radiation and motexafin gadolinium: results of a randomized phase III trial. J Clin Oncol 2004, 22:157-165.
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14
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Correa DD, Rocco-Donovan M, DeAngelis LM, et al.: Prospective cognitive follow-up in primary CNS lymphoma patients treated with chemotherapy and reduced-dose radiotherapy. J Neurooncol 2009, 91:315-321.
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16
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Does brain tumor histology influence cognitive function?
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Kayl AE, Meyers CA: Does brain tumor histology influence cognitive function? Neuro Oncol 2003, 5:255-260.
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Hahn CA, Dunn RH, Logue PE, et al.: Prospective study of neuropsychologic testing and quality-of-life assessment of adults with primary malignant brain tumors. Int J Radiat Oncol Biol Phys 2003, 55:992-999.
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Lupien SJ, Gillin CJ, Hauger RL: Working memory is more sensitive than declarative memory to the acute effects of corticosteroids: a dose-response study in humans. Behav Neurosci 1999, 113:420-430.
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This article discusses the role of antiepileptic drugs in the management of seizures in brain tumor patients. Prophylactic use was not suggested, and interactions with chemotherapeutic agents and cognitive side effects are among the issues to consider in decision making
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• van Breemen MSM, Wilms EB, Vecht CJ: Epilepsy in patients with brain tumors: epidemiology, mechanisms, and management. Lancet Neurol 2007, 6:421-430. This article discusses the role of antiepileptic drugs in the management of seizures in brain tumor patients. Prophylactic use was not suggested, and interactions with chemotherapeutic agents and cognitive side effects are among the issues to consider in decision making.
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Lancet Neurol
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Van Breemen, M.S.M.1
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20
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34047226861
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The course of neurocognitive functioning in high grade glioma patients
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This study describes the results of longitudinal cognitive follow-up before and after treatment with RT in highgrade gliomas. Tumor progression and antiepileptic agents were associated with neurocognitive decline
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• Bosma I, Vos MJ, Heimans JJ, et al.: The course of neurocognitive functioning in high grade glioma patients. Neuro Oncol 2007, 9:53-62. This study describes the results of longitudinal cognitive follow-up before and after treatment with RT in highgrade gliomas. Tumor progression and antiepileptic agents were associated with neurocognitive decline.
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Neuro Oncol
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edn 2. Edited by DeAngelis LM, Posner JB. New York: Oxford University Press
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•• Fike JR, Rosi SR, Limoli CL: Neural precursor cells and central nervous system radiation sensitivity. Sem Radiat Oncol 2009, 19:122-132. This article describes the current knowledge on potential mechanisms for radiation injury to the brain.
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The authors provide a review of cognitive, imaging, and biological changes associated with chemotherapy and RT in cancer patients
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These investigators reported deficits in several tasks associated with learning and memory in mice administered methotrexate and 5- fluorouracil
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• Winocur G, Vardy J, Binns MA, et al.: The effects of anti-cancer drugs, methotrexate and 5-fluorouracil, on cognitive function in mice. Pharmacol Biochem Behav 2006, 85:66-75. These investigators reported deficits in several tasks associated with learning and memory in mice administered methotrexate and 5- fluorouracil.
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Meyers CA, Hess KR: Multifaceted end points in brain tumor clinical trials: cognitive deterioration precedes MRI progression. Neuro Oncol 2003, 5:89-95.
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This article reports the findings of a randomized trial comparing focal RT with supportive care in elderly patients (70 years or older) with high-grade tumors. RT was associated with a modest improvement in survival without significant neurocognitive decline at a median follow-up of 21 weeks
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• Keime-Guibert F, Chinot O, Tailandier L, et al.: Radiotherapy for glioblastoma in the elderly. N Engl J Med 2007, 356:1527-1535. This article reports the findings of a randomized trial comparing focal RT with supportive care in elderly patients (70 years or older) with high-grade tumors. RT was associated with a modest improvement in survival without significant neurocognitive decline at a median follow-up of 21 weeks.
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Herman MA, Tremont-Lukats I, Meyers CA, et al.: Neurocognitive and functional assessment of patients with brain metastases. Am J Clin Oncol 2003, 26:273-279.
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Am J Clin Oncol
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41
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doi:10.1097/COC.0b013e318194f744). This article provides an overview of the most widely used therapies for brain metastases and discusses strategies to maintain or improve cognitive functions in these patients
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• Platta CS, Khuntia D, Mehta MP, Suh JH: Current treatment strategies for brain metastasis and complications from therapeutic techniques.AmJ Clin Oncol (doi:10.1097/COC.0b013e318194f744). This article provides an overview of the most widely used therapies for brain metastases and discusses strategies to maintain or improve cognitive functions in these patients.
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• Brown PD, Asher AL, Farace E: Adjuvant whole brain radiotherapy: strong emotions decide but rational studies are needed. Int J Radiat Oncol Biol Phys 2008, 70:1305-1309. This article discusses recent studies involving patients with brain metastases treated with wholebrain RT with regard to treatment efficacy and neurocognitive side effects. It emphasizes the importance of including serial neurocognitive assessment in large clinical trials to further elucidate the risks and benefits of ongoing and newly developed therapies.
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