Synthesis and antibacterial activity of isomeric 15-membered azalides

Journal of Antibiotics

Volumn 59, Issue 12, 2006, Pages 753-769

  Alihodzic, Sulejman ^a   Fajdetic, Andrea ^a   Kobrehel, Gabrijela ^a   Lazarevski, Gorjana ^a   Mutak, Stjepan ^a   Pavlovic, Drazen ^a   Stimac, Vlado ^a   Cipcic, Hana ^a   Kramaric, Miroslava Dominis ^a   Erakovic, Vesna ^a   Hasenöhrl, Andreja ^a   Marsic, Natasa ^a   Schoenfeld, Wolfgang ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Acylide; Antibacterial activity; Azalide; Ketolide; Structure activity relationship

Indexed keywords

6 O ALLYL 3 OXO 8A AZA 8A HOMOERYTHROMYCIN A; 6 O ALLYL 3 OXO 9A AZA 9A HOMOERYTHROMYCIN A; 6 O ETHYL 3 O DECLADINOSYL 3 O (4 NITROPHENYL)ACETYL 8A AZA 8A HOMOERYTHROMYCIN A; 6 O ETHYL 3 O DECLADINOSYL 3 O (4 NITROPHENYL)ACETYL 9A AZA 9A HOMOERYTHROMYCIN A; 6 O ETHYL 3 OXO 8A AZA 8A HOMOERYTHROMYCIN A; 6 O ETHYL 3 OXO 9A AZA 9A HOMOERYTHROMYCIN A; 6 O METHYL 3 O DECLADINOSYL 3 O (4 METHYOXYPHENYL)ACETYL 8A AZA 8A HOMOERYTHROMYCIN A; 6 O METHYL 3 O DECLADINOSYL 3 O (4 NITROPHENYL)ACETYL 8A AZA 8A HOMOERYTHROMYCIN A; 6 O METHYL 3 O DECLADINOSYL 3 O (4 NITROPHENYL)ACETYL 8A AZA 8A HOMOERYTHROMYCIN A 11,12 CYCLIC CARBONIC ACID; 6 O METHYL 3 O DECLADINOSYL 3 O (4 NITROPHENYL)ACETYL 9A AZA 9A HOMOERYTHROMYCIN A; 6 O METHYL 3 O DECLADINOSYL 3 O (4 NITROPHENYL)ACETYL 9A AZA 9A HOMOERYTHROMYCIN A 11,12 CYCLIC CARBONIC ACID; 6 O METHYL 3 O DECLADINOSYL 3 O (4 NITROPHENYL)ACRYLOYL 8A AZA 8A HOMOERYTHROMYCIN A; 6 O METHYL 3 O DECLADINOSYL 3 O (4 NITROPHENYLCARBAMOYL) 8A AZA 8A HOMOERYTHROMYCIN A; 6 O METHYL 3 O DECLADINOSYL 3 O (4 PHENYLBUTYRYL) 8A AZA 8A HOMOERYTHROMYCIN A; 6 O METHYL 3 O DECLADINOSYL 3 O (4 PYRIDIN 3 YLIMIDAZOL 1 YL)ACETYL 8A AZA 8A HOMOERYTHROMYCIN A; 6 O METHYL 3 O DECLADINOSYL 3 O (NAPHTHALENE 1 YL)ACETYL 8A AZA 8A HOMOERYTHROMYCIN A; 6 O METHYL 3 O DECLADINOSYL 3 O (PYRIDIN 3 YL)ACETYL 8A AZA 8A HOMOERYTHROMYCIN A; 6 O METHYL 3 O DECLADINOSYL 3 O (PYRIDIN 4 YL)ACETYL 8A AZA 8A HOMOERYTHROMYCIN A; 6 O METHYL 3 O DECLADINOSYL 3 O (PYRIDIN 4YL SULFANYL)ACETYL 8A AZA 8A HOMOERYTHROMYCIN A; 6 O METHYL 3 O DECLADINOSYL 3 O (R PHENYLPROPIONYL) 8A AZA 8A HOMOERYTHROMYCIN A; 6 O METHYL 3 O DECLADINOSYL 3 O [(5 QUINOLIN 3 YL)PENT 3 ENOYL] 8A AZA 8A HOMOERYTHROMYCIN A; 6 O METHYL 3 O DECLADINOSYL 3 O PHENYLACETYL 8A AZA 8A HOMOERYTHROMYCIN A; 6 O METHYL 3 OXO 8A AZA 8A HOMOERYTHROMYCIN A; 6 O METHYL 3 OXO 9A AZA 9A HOMOERYTHROMYCIN A; 6 O METHYL 8A LACTAM; AZITHROMYCIN; ERYTHROMYCIN DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; AREA UNDER THE CURVE; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG POTENCY; DRUG SYNTHESIS; DRUG TISSUE LEVEL; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; IN VITRO STUDY; IN VIVO STUDY; ISOMERISM; MALE; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEPTICEMIA; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-BACTERIAL AGENTS; BACTERIAL INFECTIONS; MACROLIDES; MICE; MICROBIAL SENSITIVITY TESTS; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP;

MUS; NEGIBACTERIA; POSIBACTERIA;

EID: 33846815536     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.1038/ja.2006.100     Document Type: Article

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