Cellular accumulation of the new ketolide RU 64004 by human neutrophils: Comparison with that of azithromycin and roxithromycin

Antimicrobial Agents and Chemotherapy

Volumn 41, Issue 10, 1997, Pages 2099-2107

  Vazifeh, D ^a   Abdelghaffar, H ^a   Labro, M T ^a  

^a BICHAT HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AZITHROMYCIN; CALCIUM; DRUG CARRIER; HMR 3004; MACROLIDE; NICKEL; ROXITHROMYCIN; SODIUM ION; UNCLASSIFIED DRUG; VERAPAMIL;

ARTICLE; DRUG ACCUMULATION; DRUG TRANSPORT; DRUG UPTAKE; HUMAN; HUMAN CELL; NEUTROPHIL; NORMAL HUMAN; PRIORITY JOURNAL; SODIUM CALCIUM EXCHANGE; TRANSPORT KINETICS;

EID: 0030840528     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.41.10.2099     Document Type: Article

References (35)

1. Agouridas, C., A. Bonnefoy, K. Braham, P. Collette, M. Guitton, A. Hochet, P. Mauvais, and J. F. Chantot. 1995. RU 004: uptake by phagocytes, intracellular bioactivity and other immunomodulatory effects, abstr. F175, p. 143. In Program and abstracts of the 35th Interscience Conference on Antimicrobial Agents and Chemotherapy. American Society for Microbiology, Washington, D.C.
2. Agouridas, C., Y. Benedetti, A. Denis, O. Le Martret, and J. F. Chantot. 1995. Ketolides: a new distinct class of macrolide antibacterials. Synthesis and structural characteristics of RU 004, abstr. F157, p. 140. In Program and abstracts of the 35th Interscience Conference on Antimicrobial Agents and Chemotherapy. American Society for Microbiology, Washington, D.C.
3. 3H-chloroquine. Am. J. Pathol. 67:277-280.
4. Arceci, R. J., K. Stieglitz, and B. E. Bierer. 1992. Immunosuppressants FK506 and rapamycin function as reversal agents of the multidrug resistance phenotype. Blood 80:1528-1536.
5. Bergmeyer, H. U., and E. Bernt. 1963. Lactate dehydrogenase, p. 737-739. In H. U. Bergmeyer (ed.), Methods in enzymatic analysis. Academic Press, Inc., New York, N.Y.
6. Bonnet, M., and P. Van der Auwera. 1992. In vitro and in vivo intraleukocytic accumulation of azithromycin (CP-62, 993) and its influence on ex vivo leukocyte chemiluminescence. Antimicrob. Agents Chemother. 36:1302-1309.
7. Bornstein, N., H. Behr, Y. Brun, and J. Fleurette. 1995. In vitro activity of RU 004 on Legionella species, abstr. F166, p. 142. In Program and abstracts of the 35th Interscience Conference on Antimicrobial Agents and Chemotherapy. American Society for Microbiology, Washington, D.C.
8. Carlier, M. B., A. Zenebergh, and P. M. Tulkens. 1987. Cellular uptake and subcellular distribution of roxithromycin and erythromycin in phagocytic cells. J. Antimicrob. Chemother. 20(Suppl. B):47-56.
9. Carlier, M. B., I. Garcia-Luque, J. P. Montenez, P. M. Tulkens, and J. Piret. 1994. Accumulation, release and subcellular localization of azithromycin in phagocytic and non-phagocytic cells in culture. Int. J. Tiss. React. 16:211-220.
10. Crosta, L., V. Candiloro, M. Meli, M. Tolomeo, L. Rausa, and L. Dusonchet. 1994. Lacidipine and josamycin: two new multidrug resistance modulators. Anticancer Res. 14:2685-2690.
11. De Duve, C., T. H. De Barsy, B. Poole, A. Trouet, P. M. Tulkens, and F. Van Hoof. 1974. Lysosomotropic agents. Biochem. Pharmacol. 23:2495-2531.
12. 2+ changes, cyclic AMP and protein kinase C. Biochim. Biophys. Acta 845:223-236.
13. Endicott, J. A., and V. Ling. 1989. The biochemistry of P-glycoprotein-mediated multidrug resistance. Annu. Rev. Biochem. 58:137-171.
14. Fernandes, P. B. 1987. The macrolide revival: thirty five years after erythromycin. Antimicrob. Newsl. 4:25-34.
15. Haider, F., F. Eb, and J. Orfila. 1995. Ketolides and Chlamydia: in vitro evaluation of RU 004, abstr. F165, p. 142. In Program and abstracts of the 35th Interseience Conference on Antimicrobial Agents and Chemotherapy. American Society for Microbiology, Washington, D.C.
16. Hand, W. L., N. King-Thompson, and J. W. Holman. 1987. Entry of roxithromycin (RU 965), imipenem, cefotaxime, trimethoprim, and metronidazole into human polymorphonuclear leukocytes. Antimicrob. Agents Chemother. 31:1553-1557.
17. Henry, P. D. 1980. Comparative pharmacology of calcium antagonists: nifedipine, verapamil and diltiazem. Am. J. Cardiol. 46:1047-1058.
18. Inderlied, C. B., L. E. Bermudez, L. B. Barbara-Burnham, M. Wu, and L. S. Young. 1996. In vitro and macrophage activity of ketolide derivatives against the Mycobacterium avium complex (MAC), abstr. F223, p. 138. In Program and abstracts of the 35th Interscience Conference on Antimicrobial Agents and Chemotherapy. American Society for Microbiology, Washington, D.C.
19. Kirst, H. A., and G. D. Sides. 1989. New directions for macrolide antibiotics: pharmacokinetics and clinical efficacy. Antimicrob. Agents Chemother. 33: 1419-1422.
20. Klimecki, W. T., B. W. Futscher, T. M. Grogan, and W. S. Dalton. 1994. P-glycoprotein expression and function in circulating blood cells from normal volunteers. Blood 83:2451-2458.
21. Labro, M. T. 1997. Effects of macrolides on leukocytes and inflammation, p. 101-116. In S. Zinner, L. Young, and J. Acar (ed.), Expanding indications of the new macrolides, azalides and streptogramins. Marcel Dekker, Inc., New York, N.Y.
22. Labro, M. T., H. Abdelghaffar, and A. Bryskier. 1996. Characteristics of the cellular accumulation of RU 004 by human neutrophils (PMN). Comparison with azithromycin and roxithromycin, abstr. F224, p. 139. In Program and abstracts of the 36th Interscience Conference on Antimicrobial Agents and Chemotherapy. American Society for Microbiology, Washington, D.C.
23. Labro, M. T., H. Abdelghaffar, D. Vazifeh, and A. Bryskier. 1996. Roxithromycin uptake by human neutrophils is mediated by a protein kinase A-dependent mechanism, abstr. 110-018, p. 278. In Program and abstracts of the 7th International Congress on Infectious Diseases.
24. Laufen, H., A. Wildfeuer, and P. Lach. 1989. Kinetics of the uptake of antimicrobial agents by human polymorphonuclear leucocytes. Arzneim.-Forsch. 39:233-235.
25. Laufen, H., A. Wildfeuer, and P. Lach. 1990. Mechanism of azithromycin uptake in human polymorphonuclear leucocytes. Arzneim.-Forsch. 40:686-689.
26. Litwack, G. 1995. Photometric determination of lysozyme activity. Proc. Soc. Exp. Biol. Med. 89:401-403.
27. Mtairag, E. M., H. Abdelghaffar, and M. T. Labro. 1994. Investigation of dirithromycin and erythromycylamine uptake by human neutrophils in vitro. J. Antimicrob. Chemother. 33:523-536.
28. Mtairag, E. M., H. Abdelghaffar, C. Douhet, and M. T. Labro. 1995. Role of extracellular calcium in in vitro uptake and intraphagocytic location of macrolides. Antimicrob. Agents Chemother. 39:1676-1682.
29. Nichterlein, T., M. Kretschman, M. Siegsmund, and H. Hof. 1995. Erythromycin is ineffective against Listeria monocytogenes in multidrug resistant cells. J. Chemother. 7:184-188.
30. Pastan, I., and M. M. Gottesman. 1991. Multidrug resistance. Annu. Rev. Med. 42:277-286.
31. Schentag, J. J., and C. H. Ballow. 1991. Tissue-directed pharmacokinetics. Am. J. Med. 91(Suppl. 3A):5S-11S.
32. Schram, M., and R. Towart. 1985. Modulation of calcium channel function by drugs. Life Sci. 37:1843-1860.
33. Styrt, B., and M. S. Klempner. 1986. Inhibition of neutrophil oxidative metabolism by lysomotropic weak bases. Blood 67:334-342.
34. Talalay, P., W. H. Fishman, and C. Huggins. 1946. Chromogenic substrate. II. Phenolphthalein glucuronic acid as substrate for the assay of glucuronidase activity. J. Biol. Chem. 166:756-772.
35. Truffot-Pernot, C., N. Lounis, J. F. Chantot, and J. Grosset. 1995. In vitro activity of ketolide RU 004 against non tuberculous mycobacteria, abstr. F167, p. 142. In Program and abstracts of the 35th Interscience Conference on Antimicrobial Agents and Chemotherapy. American Society for Microbiology, Washington, D.C.