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Volumn 6, Issue 2, 2011, Pages 167-175

Expression of human melanocortin 4 receptor in Saccharomyces cerevisiae

Author keywords

functional screens; G protein coupled receptors; melanocortin receptors; Saccharomyces cerevisiae

Indexed keywords

MAMMALIA; SACCHAROMYCES CEREVISIAE;

EID: 79651471506     PISSN: 1895104X     EISSN: 16443632     Source Type: Journal    
DOI: 10.2478/s11535-011-0002-3     Document Type: Article
Times cited : (3)

References (40)
  • 3
    • 0027227288 scopus 로고
    • Molecular cloning, expression, and gene localization of a fourth melanocortin receptor
    • Gantz I., Miwa H., Konda Y., Shimoto Y., Tashiro T., Watson S. J., et al. Molecular cloning, expression, and gene localization of a fourth melanocortin receptor, J. Biol. Chem., 1993, 268, 15174-15179.
    • (1993) J. Biol. Chem. , vol.268 , pp. 15174-15179
    • Gantz, I.1    Miwa, H.2    Konda, Y.3    Shimoto, Y.4    Tashiro, T.5    Watson, S.J.6
  • 4
    • 0026800892 scopus 로고
    • The cloning of a family of genes that encode the melanocortin receptors
    • Mountjoy K. G., Robbins L. S., Mortrud M. T., Cone R. D., The cloning of a family of genes that encode the melanocortin receptors, Science, 1992, 257, 1248-1251.
    • (1992) Science , vol.257 , pp. 1248-1251
    • Mountjoy, K.G.1    Robbins, L.S.2    Mortrud, M.T.3    Cone, R.D.4
  • 5
    • 0018696441 scopus 로고
    • Concomitant synthesis of betaendorphin and alpha-melanotropin from two forms of pro-opiomelanocortin in the rat pars intermedia
    • Crine P., Gossard F., Seidah N. G., Blanchette L., Lis M., Chretien M., Concomitant synthesis of betaendorphin and alpha-melanotropin from two forms of pro-opiomelanocortin in the rat pars intermedia, Proc. Natl. Acad. Sci. USA, 1979, 76, 5085-5089.
    • (1979) Proc. Natl. Acad. Sci. USA , vol.76 , pp. 5085-5089
    • Crine, P.1    Gossard, F.2    Seidah, N.G.3    Blanchette, L.4    Lis, M.5    Chretien, M.6
  • 7
    • 0018693511 scopus 로고
    • Synthesis and secretion of corticotropins, melanotropins, and endorphins by rat intermediate pituitary cells
    • Mains R. E., Eipper B. A., Synthesis and secretion of corticotropins, melanotropins, and endorphins by rat intermediate pituitary cells, J. Biol. Chem., 1979, 254, 7885-7894.
    • (1979) J. Biol. Chem. , vol.254 , pp. 7885-7894
    • Mains, R.E.1    Eipper, B.A.2
  • 10
    • 0028134706 scopus 로고
    • Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain
    • Mountjoy K. G., Mortrud M. T., Low M. J., Simerly R. B., Cone R. D., Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain, Mol. Endocrinol., 1994, 8, 1298-1308.
    • (1994) Mol. Endocrinol. , vol.8 , pp. 1298-1308
    • Mountjoy, K.G.1    Mortrud, M.T.2    Low, M.J.3    Simerly, R.B.4    Cone, R.D.5
  • 11
    • 0036125112 scopus 로고    scopus 로고
    • Proopiomelanocortin processing in the hypothalamus: impact on melanocortin signalling and obesity
    • Pritchard L. E., Turnbull A. V., White A., Proopiomelanocortin processing in the hypothalamus: impact on melanocortin signalling and obesity, J. Endocrinol., 2002, 172, 411-421.
    • (2002) J. Endocrinol. , vol.172 , pp. 411-421
    • Pritchard, L.E.1    Turnbull, A.V.2    White, A.3
  • 12
    • 0029848043 scopus 로고    scopus 로고
    • Distribution of cDNA for melanocortin receptor subtypes in human tissues
    • Chhajlani V., Distribution of cDNA for melanocortin receptor subtypes in human tissues, Biochem. Mol. Biol. Int., 1996, 38, 73-80.
    • (1996) Biochem. Mol. Biol. Int. , vol.38 , pp. 73-80
    • Chhajlani, V.1
  • 14
    • 0035851851 scopus 로고    scopus 로고
    • The hypothalamus and the control of energy homeostasis: different circuits, different purposes
    • Williams G., Bing C., Cai X. J., Harrold J. A., King P. J., Liu X. H., The hypothalamus and the control of energy homeostasis: different circuits, different purposes, Physiol. Behav., 2001, 74, 683-701.
    • (2001) Physiol. Behav. , vol.74 , pp. 683-701
    • Williams, G.1    Bing, C.2    Cai, X.J.3    Harrold, J.A.4    King, P.J.5    Liu, X.H.6
  • 16
    • 31544465224 scopus 로고    scopus 로고
    • The melanocortin system and energy balance
    • Butler A. A., The melanocortin system and energy balance, Peptides, 2006, 27, 281-290.
    • (2006) Peptides , vol.27 , pp. 281-290
    • Butler, A.A.1
  • 17
    • 0033818103 scopus 로고    scopus 로고
    • Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass
    • Chen A. S., Marsh D. J., Trumbauer M. E., Frazier E. G., Guan X. M., Yu H., et al., Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass, Nat. Genet., 2000, 26, 97-102.
    • (2000) Nat. Genet. , vol.26 , pp. 97-102
    • Chen, A.S.1    Marsh, D.J.2    Trumbauer, M.E.3    Frazier, E.G.4    Guan, X.M.5    Yu, H.6
  • 18
    • 27644559821 scopus 로고    scopus 로고
    • Molecular interactions of nonpeptide agonists and antagonists with the melanocortin-4 receptor
    • Fleck B. A., Chen C., Yang W., Huntley R., Markison S., Nickolls S. A., et al., Molecular interactions of nonpeptide agonists and antagonists with the melanocortin-4 receptor, Biochemistry, 2005, 44, 14494-14508.
    • (2005) Biochemistry , vol.44 , pp. 14494-14508
    • Fleck, B.A.1    Chen, C.2    Yang, W.3    Huntley, R.4    Markison, S.5    Nickolls, S.A.6
  • 19
    • 32344446277 scopus 로고    scopus 로고
    • Mapping the binding site of melanocortin 4 receptor agonists: a hydrophobic pocket formed by I3.28(125), I3.32(129), and I7.42(291) is critical for receptor activation
    • Hogan K., Peluso S., Gould S., Parsons I., Ryan D., Wu L., et al. Mapping the binding site of melanocortin 4 receptor agonists: a hydrophobic pocket formed by I3. 28(125), I3. 32(129), and I7. 42(291) is critical for receptor activation, J. Med. Chem., 2006, 49, 911-922.
    • (2006) J. Med. Chem. , vol.49 , pp. 911-922
    • Hogan, K.1    Peluso, S.2    Gould, S.3    Parsons, I.4    Ryan, D.5    Wu, L.6
  • 20
    • 0037371579 scopus 로고    scopus 로고
    • Molecular determinants of melanocortin 4 receptor ligand binding and MC4/MC3 receptor selectivity
    • Nickolls S. A., Cismowski M. I., Wang X., Wolff M., Conlon P. J., Maki R. A., Molecular determinants of melanocortin 4 receptor ligand binding and MC4/MC3 receptor selectivity, J. Pharmacol. Exp. Ther., 2003, 304, 1217-1227.
    • (2003) J. Pharmacol. Exp. Ther. , vol.304 , pp. 1217-1227
    • Nickolls, S.A.1    Cismowski, M.I.2    Wang, X.3    Wolff, M.4    Conlon, P.J.5    Maki, R.A.6
  • 21
    • 19444381366 scopus 로고    scopus 로고
    • Functional selectivity of melanocortin 4 receptor peptide and nonpeptide agonists: evidence for ligand-specific conformational states
    • Nickolls S. A., Fleck B., Hoare S. R., Maki R. A., Functional selectivity of melanocortin 4 receptor peptide and nonpeptide agonists: evidence for ligand-specific conformational states, J. Pharmacol. Exp. Ther., 2005, 313, 1281-1288.
    • (2005) J. Pharmacol. Exp. Ther. , vol.313 , pp. 1281-1288
    • Nickolls, S.A.1    Fleck, B.2    Hoare, S.R.3    Maki, R.A.4
  • 22
    • 0033546392 scopus 로고    scopus 로고
    • Conformation of the core sequence in melanocortin peptides directs selectivity for the melanocortin MC3 and MC4 receptors
    • Oosterom J., Nijenhuis W. A., Schaaper W. M., Slootstra J., Meloen R. H., Gispen W. H., et al., Conformation of the core sequence in melanocortin peptides directs selectivity for the melanocortin MC3 and MC4 receptors, J. Biol. Chem., 1999, 274, 16853-16860.
    • (1999) J. Biol. Chem. , vol.274 , pp. 16853-16860
    • Oosterom, J.1    Nijenhuis, W.A.2    Schaaper, W.M.3    Slootstra, J.4    Meloen, R.H.5    Gispen, W.H.6
  • 23
    • 11144358080 scopus 로고    scopus 로고
    • Identification of putative agouti-related protein(87-132)-melanocortin-4 receptor interactions by homology molecular modeling and validation using chimeric peptide ligands
    • Wilczynski A., Wang X. S., Joseph C. G., Xiang Z., Bauzo R. M., Scott J. W., et al., Identification of putative agouti-related protein(87-132)-melanocortin-4 receptor interactions by homology molecular modeling and validation using chimeric peptide ligands, J. Med. Chem., 2004, 47, 2194-2207.
    • (2004) J. Med. Chem. , vol.47 , pp. 2194-2207
    • Wilczynski, A.1    Wang, X.S.2    Joseph, C.G.3    Xiang, Z.4    Bauzo, R.M.5    Scott, J.W.6
  • 24
    • 0034610311 scopus 로고    scopus 로고
    • Molecular determinants of ligand binding to the human melanocortin-4 receptor
    • Yang Y. K., Fong T. M., Dickinson C. J., Mao C., Li J. Y., Tota M. R., et al., Molecular determinants of ligand binding to the human melanocortin-4 receptor, Biochemistry, 2000, 39, 14900-14911.
    • (2000) Biochemistry , vol.39 , pp. 14900-14911
    • Yang, Y.K.1    Fong, T.M.2    Dickinson, C.J.3    Mao, C.4    Li, J.Y.5    Tota, M.R.6
  • 25
    • 0035918601 scopus 로고    scopus 로고
    • Structure activity studies of the melanocortin-4 receptor by in vitro mutagenesis: identification of agouti-related protein (AGRP), melanocortin agonist and synthetic peptide antagonist interaction determinants
    • Haskell-Luevano C., Cone R. D., Monck E. K., Wan Y. P., Structure activity studies of the melanocortin-4 receptor by in vitro mutagenesis: identification of agouti-related protein (AGRP), melanocortin agonist and synthetic peptide antagonist interaction determinants, Biochemistry, 2001, 40, 6164-6179.
    • (2001) Biochemistry , vol.40 , pp. 6164-6179
    • Haskell-Luevano, C.1    Cone, R.D.2    Monck, E.K.3    Wan, Y.P.4
  • 26
    • 0033025734 scopus 로고    scopus 로고
    • C5a receptor activation. Genetic identification of critical residues in four transmembrane helices
    • Baranski T. J., Herzmark P., Lichtarge O., Gerber B. O., Trueheart J., Meng E. C., et al., C5a receptor activation. Genetic identification of critical residues in four transmembrane helices, J. Biol. Chem., 1999, 274, 15757-15765.
    • (1999) J. Biol. Chem. , vol.274 , pp. 15757-15765
    • Baranski, T.J.1    Herzmark, P.2    Lichtarge, O.3    Gerber, B.O.4    Trueheart, J.5    Meng, E.C.6
  • 27
    • 1342329641 scopus 로고    scopus 로고
    • Random mutagenesis of the human adenosine A2B receptor followed by growth selection in yeast. Identification of constitutively active and gain of function mutations
    • Beukers M. W., van Oppenraaij J., van der Hoorn P. P., Blad C. C., den Dulk H., Brouwer J., et al., Random mutagenesis of the human adenosine A2B receptor followed by growth selection in yeast. Identification of constitutively active and gain of function mutations, Mol. Pharmacol., 2004, 65, 702-710.
    • (2004) Mol. Pharmacol. , vol.65 , pp. 702-710
    • Beukers, M.W.1    van Oppenraaij, J.2    van der Hoorn, P.P.3    Blad, C.C.4    den Dulk, H.5    Brouwer, J.6
  • 28
    • 0035800798 scopus 로고    scopus 로고
    • Single amino acid substitutions and deletions that alter the G protein coupling properties of the V2 vasopressin receptor identified in yeast by receptor random mutagenesis
    • Erlenbach I., Kostenis E., Schmidt C., Serradeil-Le Gal C., Raufaste D., Dumont M. E., et al., Single amino acid substitutions and deletions that alter the G protein coupling properties of the V2 vasopressin receptor identified in yeast by receptor random mutagenesis, J. Biol. Chem., 2001, 276, 29382-29392.
    • (2001) J. Biol. Chem. , vol.276 , pp. 29382-29392
    • Erlenbach, I.1    Kostenis, E.2    Schmidt, C.3    Serradeil-Le gal, C.4    Raufaste, D.5    Dumont, M.E.6
  • 29
    • 0036510377 scopus 로고    scopus 로고
    • Functional expression of heteromeric calcitonin gene-related peptide and adrenomedullin receptors in yeast
    • Miret J. J., Rakhilina L., Silverman L., Oehlen B., Functional expression of heteromeric calcitonin gene-related peptide and adrenomedullin receptors in yeast, J. Biol. Chem., 2002, 277, 6881-6887.
    • (2002) J. Biol. Chem. , vol.277 , pp. 6881-6887
    • Miret, J.J.1    Rakhilina, L.2    Silverman, L.3    Oehlen, B.4
  • 31
    • 0042530487 scopus 로고    scopus 로고
    • Random mutagenesis of the M3 muscarinic acetylcholine receptor expressed in yeast. Identification of point mutations that "silence" a constitutively active mutant M3 receptor and greatly impair receptor/G protein coupling
    • Schmidt C., Li B., Bloodworth L., Erlenbach I., Zeng F. Y., Wess J., Random mutagenesis of the M3 muscarinic acetylcholine receptor expressed in yeast. Identification of point mutations that "silence" a constitutively active mutant M3 receptor and greatly impair receptor/G protein coupling, J. Biol. Chem., 2003, 278, 30248-30260.
    • (2003) J. Biol. Chem. , vol.278 , pp. 30248-30260
    • Schmidt, C.1    Li, B.2    Bloodworth, L.3    Erlenbach, I.4    Zeng, F.Y.5    Wess, J.6
  • 32
    • 25144437063 scopus 로고    scopus 로고
    • Techniques: how to boost GPCR mutagenesis studies using yeast
    • Beukers M. W., Ijzerman A. P., Techniques: how to boost GPCR mutagenesis studies using yeast, Trends Pharmacol. Sci., 2005, 26, 533-539.
    • (2005) Trends Pharmacol. Sci. , vol.26 , pp. 533-539
    • Beukers, M.W.1    Ijzerman, A.P.2
  • 33
    • 0031543433 scopus 로고    scopus 로고
    • G-protein-coupled receptors in Saccharomyces cerevisiae: high-throughput screening assays for drug discovery
    • Pausch M. H., G-protein-coupled receptors in Saccharomyces cerevisiae: high-throughput screening assays for drug discovery, Trends Biotechnol., 1997, 15, 487-494.
    • (1997) Trends Biotechnol. , vol.15 , pp. 487-494
    • Pausch, M.H.1
  • 34
    • 0028586017 scopus 로고
    • Regulatable promoters of Saccharomyces cerevisiae: comparison of transcriptional activity and their use for heterologous expression
    • Mumberg D., Muller R., Funk M., Regulatable promoters of Saccharomyces cerevisiae: comparison of transcriptional activity and their use for heterologous expression, Nucl. Acids Res., 1994, 22, 5767-5768.
    • (1994) Nucl. Acids Res. , vol.22 , pp. 5767-5768
    • Mumberg, D.1    Muller, R.2    Funk, M.3
  • 35
    • 0032809011 scopus 로고    scopus 로고
    • Characterization of melanocortin receptor ligands on cloned brain melanocortin receptors and on grooming behavior in the rat
    • Adan R. A., Szklarczyk A. W., Oosterom J., Brakkee J. H., Nijenhuis W. A., Schaaper W. M., et al., Characterization of melanocortin receptor ligands on cloned brain melanocortin receptors and on grooming behavior in the rat, Eur. J. Pharmacol., 1999, 378, 249-258.
    • (1999) Eur. J. Pharmacol. , vol.378 , pp. 249-258
    • Adan, R.A.1    Szklarczyk, A.W.2    Oosterom, J.3    Brakkee, J.H.4    Nijenhuis, W.A.5    Schaaper, W.M.6
  • 36
    • 3242749765 scopus 로고    scopus 로고
    • Synthesis and biological activity of new potential agonists for the human adenosine A2A receptor
    • Bosch M. P., Campos F., Niubo I., Rosell G., Diaz J. L., Brea J., et al., Synthesis and biological activity of new potential agonists for the human adenosine A2A receptor, J. Med. Chem., 2004, 47, 4041-4053.
    • (2004) J. Med. Chem. , vol.47 , pp. 4041-4053
    • Bosch, M.P.1    Campos, F.2    Niubo, I.3    Rosell, G.4    Diaz, J.L.5    Brea, J.6
  • 37
    • 0037057558 scopus 로고    scopus 로고
    • Design and pharmacology of N-[(3R)-1,2,3,4-tetrahydroisoquinolinium-3-ylcarbonyl]-(1R)-1-(4-chlorobenzyl)-2-[4-cyclohexyl-4-(1H-1,2,4-triazol-1-ylmethyl)piperidin-1-yl]-2-oxoethylamine (1), a potent, selective, melanocortin subtype-4 receptor agonist
    • Sebhat I. K., Martin W. J., Ye Z., Barakat K., Mosley R. T., Johnston D. B., et al., Design and pharmacology of N-[(3R)-1, 2, 3, 4-tetrahydroisoquinolinium-3-ylcarbonyl]-(1R)-1-(4-chlorobenzyl)-2-[4-cyclohexyl-4-(1H-1, 2, 4-triazol-1-ylmethyl)piperidin-1-yl]-2-oxoethylamine (1), a potent, selective, melanocortin subtype-4 receptor agonist, J. Med. Chem., 2002, 45, 4589-4593.
    • (2002) J. Med. Chem. , vol.45 , pp. 4589-4593
    • Sebhat, I.K.1    Martin, W.J.2    Ye, Z.3    Barakat, K.4    Mosley, R.T.5    Johnston, D.B.6
  • 38
    • 0034634690 scopus 로고    scopus 로고
    • Genetic mapping of the human C5a receptor. Identification of transmembrane amino acids critical for receptor function
    • Geva A., Lassere T. B., Lichtarge O., Pollitt S. K., Baranski T. J., Genetic mapping of the human C5a receptor. Identification of transmembrane amino acids critical for receptor function, J. Biol. Chem., 2000, 275, 35393-35401.
    • (2000) J. Biol. Chem. , vol.275 , pp. 35393-35401
    • Geva, A.1    Lassere, T.B.2    Lichtarge, O.3    Pollitt, S.K.4    Baranski, T.J.5
  • 39
    • 34247640671 scopus 로고    scopus 로고
    • Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand
    • Armbruster B. N., Li X., Pausch M. H., Herlitze S., Roth B. L., Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand, Proc. Natl. Acad. Sci. USA, 2007, 104, 5163-5168.
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 5163-5168
    • Armbruster, B.N.1    Li, X.2    Pausch, M.H.3    Herlitze, S.4    Roth, B.L.5
  • 40
    • 9644279627 scopus 로고    scopus 로고
    • Constitutive activity of the melanocortin-4 receptor is maintained by its N-terminal domain and plays a role in energy homeostasis in humans
    • Srinivasan S., Lubrano-Berthelier C., Govaerts C., Picard F., Santiago P., Conklin B. R., et al., Constitutive activity of the melanocortin-4 receptor is maintained by its N-terminal domain and plays a role in energy homeostasis in humans, J. Clin. Invest., 2004, 114, 1158-1164.
    • (2004) J. Clin. Invest. , vol.114 , pp. 1158-1164
    • Srinivasan, S.1    Lubrano-Berthelier, C.2    Govaerts, C.3    Picard, F.4    Santiago, P.5    Conklin, B.R.6


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