The combined toxicity of dibutyl phthalate and benzo(a)pyrene on the reproductive system of male Sprague Dawley rats in vivo

Journal of Hazardous Materials

Volumn 186, Issue 1, 2011, Pages 835-841

  Chen, Xuemei ^a   An, Hui ^b   Ao, Lin ^b   Sun, Lei ^b   Liu, Wenbin ^b   Zhou, Ziyuan ^b   Wang, Yingxiong ^a   Cao, Jia ^b  

^a CHONGQING MEDICAL UNIVERSITY   (China)

^b THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Benzo(a)pyrene; Combined toxicity; Dibutyl phthalate; Reproductive toxicity

Indexed keywords

ADDITIVE EFFECTS; ADVERSE EFFECT; BENZO(A)PYRENE; BIOCHEMICAL ANALYSIS; CHONGQING; COMBINED TOXICITY; DIBUTYL PHTHALATE; DIBUTYL PHTHALATES; ENDOCRINE DISRUPTOR; GLUTATHIONE PEROXIDASE; IN-VIVO; IRREGULAR ARRANGEMENT; MALE RATS; REPRODUCTIVE SYSTEMS; REPRODUCTIVE TOXICITY; SERUM TESTOSTERONE; SINGLE-DOSE; SPRAGUE-DAWLEY RATS; SUPER OXIDE DISMUTASE; WATER SAFETY;

EMERGENCY ROOMS; ESTERS; OXYGEN; RATS; WATER POLLUTION;

TOXICITY;

BENZO[A]PYRENE; ENDOCRINE DISRUPTOR; GLUTATHIONE PEROXIDASE; PHTHALIC ACID DIBUTYL ESTER; SUPEROXIDE DISMUTASE; TESTOSTERONE;

BIOCHEMISTRY; DOSE-RESPONSE RELATIONSHIP; ENDOCRINE DISRUPTOR; ENVIRONMENTAL STRESS; ENZYME ACTIVITY; EXPERIMENTAL STUDY; PAH; REPRODUCTIVE BIOLOGY; RIVER POLLUTION; RODENT; SPERM; TESTOSTERONE; TOXICITY;

ADVERSE OUTCOME; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHEMICAL ANALYSIS; CHINA; CONTROLLED STUDY; ENZYME ACTIVITY; GENITAL SYSTEM; HORMONE DETERMINATION; LONG TERM EXPOSURE; MALE; NONHUMAN; OXIDATIVE STRESS; RAT; REPRODUCTIVE TOXICITY; SEMINIFEROUS TUBULE EPITHELIUM; SPERMATOGENESIS; SPERMATOZOON COUNT; TESTOSTERONE BLOOD LEVEL; WATER CONTAMINATION; WATER QUALITY; WATER SAFETY;

ANIMALS; BENZO(A)PYRENE; DIBUTYL PHTHALATE; MALE; RATS; RATS, SPRAGUE-DAWLEY; SOIL POLLUTANTS;

CHINA; CHONGQING; JIALING RIVER; YANGTZE RIVER;

RATTUS;

EID: 79551559162     PISSN: 03043894     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhazmat.2010.11.078     Document Type: Article

References (53)

1. Swan S.H., Kruse R.L., Liu F., Barr D.B., Drobnis E.Z., Redmon J.B., Wang C., Brazil C., Overstreet J.W. Semen quality in relation to biomarkers of pesticide exposure. Environ. Health Perspect. 2003, 111:1478-1484.
2. Weidner I.S., Moller H., Jensen T.K., Skakkebaek N.E. Cryptorchidism and hypospadias in sons of gardeners and farmers. Environ. Health Perspect. 1998, 106:793-796.
3. Hanke W., Jurewicz J. The risk of adverse reproductive and developmental disorders due to occupational pesticide exposure: an overview of current epidemiological evidence. Int. J. Occup. Med. Environ. Health 2004, 17:223-243.
4. Kumar S. Occupational exposure associated with reproductive dysfunction. J. Occup. Health 2004, 46:1-19.
5. Adibi J.J., Perera F.P., Jedrychowski W., Camann D.E., Barr D., Jacek R., Whyatt R.M. Prenatal exposures to phthalates among women in New York City and Krakow, Poland. Environ. Health Perspect. 2003, 111:1719-1722.
6. Koch H.M., Rossbach B., Drexler H., Angerer J. Internal exposure of the general population to DEHP and other phthalates-determination of secondary and primary phthalate monoester metabolites in urine. Environ. Res. 2003, 93:177-185.
7. Blount B.C., Silva M.J., Caudill S.P., Needham L.L., Pirkle J.L., Sampson E.J., Lucier G.W., Jackson R.J., Brock J.W. Levels of seven urinary phthalate metabolites in a human reference population. Environ. Health Perspect. 2000, 108:979-982.
8. Matsumoto M., Hirata-Koizumi M., Ema M. Potential adverse effects of phthalic acid esters on human health: a review of recent studies on reproduction. Regul. Toxicol. Pharmacol. 2008, 50:37-49.
9. Wine R.N., Li L.H., Barnes L.H., Gulati D.K., Chapin R.E. Reproductive toxicity of di-n-butyl phthalate in a continuous breeding protocol in Sprague-Dawley rats. Environ. Health Perspect. 1997, 105:102-107.
10. Mylchreest E., Wallace D.G., Cattley R.C., Foster P.M. Dose-dependent alterations in androgen-regulated male reproductive development in rats exposed to Di(n-butyl) phthalate during late gestation. Toxicol. Sci. 2000, 55:143-151.
11. Mylchreest E., Sar M., Wallace D.G., Foster P.M. Fetal testosterone insufficiency and abnormal proliferation of Leydig cells and gonocytes in rats exposed to di(n-butyl) phthalate. Reprod. Toxicol. 2002, 16:19-28.
12. Mahood I.K., Scott H.M., Brown R., Hallmark N., Walker M., Sharpe R.M. In utero exposure to di(n-butyl) phthalate and testicular dysgenesis: comparison of fetal and adult end points and their dose sensitivity. Environ. Health Perspect. 2007, 115(Suppl. 1):55-61.
13. Ramesh A., Walker S.A., Hood D.B., Guillen M.D., Schneider K., Weyand E.H. Bioavailability and risk assessment of orally ingested polycyclic aromatic hydrocarbons. Int. J. Toxicol. 2004, 23:301-333.
14. Yauk C.L., Berndt M.L., Williams A., Rowan-Carroll A., Douglas G.R., Stampfli M.R. Mainstream tobacco smoke causes paternal germ-line DNA mutation. Cancer Res. 2007, 67:5103-5106.
15. Mukherjee J.J., Sikka H.C. Attenuation of BPDE-induced p53 accumulation by TPA is associated with a decrease in stability and phosphorylation of p53 and downregulation of NFκB activation: role of p38 MAP kinase. Carcinogenesis 2006, 27:631-638.
16. Knuckles M.E., Inyang F., Ramesh A. Acute and subchronic oral toxicities of benzo[a]pyrene in F-344 rats. Toxicol. Sci. 2001, 61:382-388.
17. Archibong A.E., Inyang F., Ramesh A., Greenwood M., Nayyar T., Kopsombut P., Hood D.B., Nyanda A.M. Alteration of pregnancy related hormones and fetal survival in F-344 rats exposed by inhalation to benzo(a)pyrene. Reprod. Toxicol. 2002, 16:801-808.
18. Revel A., Raanani H., Younglai E., Xu J., Han R., Savouret J.F., Casper R.F. Resveratrol, a natural aryl hydrocarbon receptor antagonist, protects sperm from DNA damage and apoptosis caused by benzo(a)pyrene. Reprod. Toxicol. 2001, 15:479-486.
19. Ramesh A., Inyang F., Lunstra D.D., Niaz M.S., Kopsombut P., Jones K.M., Hood D.B., Hills E.R., Archibong A.E. Alteration of fertility endpoints in adult male F-344 rats by subchronic exposure to inhaled benzo(a)pyrene. Exp. Toxicol. Pathol. 2008, 60:269-280.
20. Bouayed J., Desor F., Soulimani R. Subacute oral exposure to benzo[alpha]pyrene (B[alpha]P) increases aggressiveness and affects consummatory aspects of sexual behaviour in male mice. J. Hazard. Mater. 2009, 169:581-585.
21. Cui Z.H., Liu J., Li P., Cao B., Luo C., Cao J. Biomonitoring of detoxifying activity as measured by CYP1A1 induction in Yangtze and Jialing Rivers in Chongqing City in China. J. Toxicol. Environ. Health A 2009, 72:782-788.
22. Tian H.J., Shu W.Q., Zhang X. Organic pollutants in source water in river Jialing River and Yangtze River (Chongqing section). Resour. Environ. Yangtze Basin 2003, 12:118-123.
23. Wang W.D., Huang Y.M., Shu W.Q., Cao J. Multiwalled carbon nanotubes as adsorbents of solid-phase extraction for determination of polycyclic aromatic hydrocarbons in environmental waters coupled with high-performance liquid chromatography. J. Chromatogr. A 2007, 1173:27-36.
24. Yu Y., Xu J., Wang P., Sun H., Dai S. Sediment-porewater partition of polycyclic aromatic hydrocarbons (PAHs) from Lanzhou Reach of Yellow River, China. J. Hazard. Mater. 2009, 165:494-500.
25. Li J., Shang X., Zhao Z., Tanguay R.L., Dong Q., Huang C. Polycyclic aromatic hydrocarbons in water, sediment, soil, and plants of the Aojiang River waterway in Wenzhou, China. J. Hazard. Mater. 2010, 173:75-81.
26. Cao B., Ren Q., Cui Z., Li P., Cao J. Evaluation of reproductive toxicity in rats caused by organic extracts of Jialing River water of Chongqing, China. Environ. Toxicol. Pharmacol. 2009, 27:357-365.
27. Narayana K., D'Souza U.J., Seetharama Rao K.P. Ribavirin-induced sperm shape abnormalities in Wistar rat. Mutat. Res. 2002, 513:193-196.
28. Wang Y.B., Song L., Zhu Z.P., Chen J.F., Wang X.R. Effects of dibutyl phthalate on sertoli cells of rat testis. Zhonghua Yu Fang Yi Xue Za Zhi 2005, 39:179-181.
29. Kohn M.C., Parham F., Masten S.A., Portier C.J., Shelby M.D., Brock J.W., Needham L.L. Human exposure estimates for phthalates. Environ. Health Perspect. 2000, 108:A440-A442.
30. Phillips D.H. Polycyclic aromatic hydrocarbons in the diet. Mutat. Res. 1999, 443:139-147.
31. Jeng H.A., Yu L. Alteration of sperm quality and hormone levels by polycyclic aromatic hydrocarbons on airborne particulate particles. J. Environ. Sci. Health A: Tox. Hazard. Subst. Environ. Eng. 2008, 43:675-681.
32. Selevan S.G., Borkovec L., Zudova Z., Hajnova R., Rubes R.J., Perreault S.D. Semen quality in young men and air pollution in two Czech communities. Epidemiology 1995, 6:S85.
33. Sram R.J., Binkova B., Rossner P., Rubes J., Topinka J., Dejmek J. Adverse reproductive outcomes from exposure to environmental mutagens. Mutat. Res. 1999, 428:203-215.
34. Santodonato J. Review of the estrogenic and antiestrogenic activity of polycyclic aromatic hydrocarbons: relationship to carcinogenicity. Chemosphere 1997, 34:835-848.
35. Singh R., Sram R.J., Binkova B., Kalina I., Popov T.A., Georgieva T., Garte S., Taioli E., Farmer P.B. The relationship between biomarkers of oxidative DNA damage, polycyclic aromatic hydrocarbon DNA adducts, antioxidant status and genetic susceptibility following exposure to environmental air pollution in humans. Mutat. Res. 2007, 620:83-92.
36. Dohle G.R., Smit M., Weber R.F. Androgens and male fertility. World J. Urol. 2003, 21:341-345.
37. Shultz V.D., Phillips S., Sar M., Foster P.M., Gaido K.W. Altered gene profiles in fetal rat testes after in utero exposure to di(n-butyl) phthalate. Toxicol. Sci. 2001, 64:233-242.
38. Akingbemi B.T., Ge R., Klinefelter G.R., Zirkin B.R., Hardy M.P. Phthalate-induced Leydig cell hyperplasia is associated with multiple endocrine disturbances. Proc. Natl. Acad. Sci. U.S.A. 2004, 101:775-780.
39. Wang Y., Song L., Hong X., Cui L., Zhang Z., Xiao H., Zhou J., Wang X. Low concentrations mono-butyl phthalate stimulates steroidogenesis by facilitating steroidogenic acute regulatory protein expression in mouse Leydig tumor cells (MLTC-1). Chem. Biol. Interact. 2006, 164:15-24.
40. Wang Y.B., Song L., Cui L.B., Hong X., Zhang Z.D., Wang X.R. Monobutyl phthalate inhibits steroidogenesis by downregulating steroidogenic acute regulatory protein expression in mouse Leydig tumor cells (MLTC-1). J. Toxicol. Environ. Health A 2007, 70:947-955.
41. Calabrese E.J., Baldwin L.A. Chemical hormesis: its historical foundations as a biological hypothesis. Hum. Exp. Toxicol. 2000, 19:2-31.
42. Conolly R.B., Lutz W.K. Nonmonotonic dose-response relationships: mechanistic basis, kinetic modeling, and implications for risk assessment. Toxicol. Sci. 2004, 77:151-157.
43. Thayer K.A., Melnick R., Burns K., Davis D., Huff J. Fundamental flaws of hormesis for public health decisions. Environ. Health Perspect. 2005, 113:1271-1276.
44. Calabrese E.J., Baldwin L.A. Toxicology rethinks its central belief. Nature 2003, 421:691-692.
45. Kaiser J. Hormesis. A healthful dab of radiation?. Science 2003, 302:378.
46. Kinoshita A., Wanibuchi H., Morimura K., Wei M., Shen J., Imaoka S., Funae Y., Fukushima S. Phenobarbital at low dose exerts hormesis in rat hepatocarcinogenesis by reducing oxidative DNA damage, altering cell proliferation, apoptosis and gene expression. Carcinogenesis 2003, 24:1389-1399.
47. Weltje L., vom Saal F.S., Oehlmann J. Reproductive stimulation by low doses of xenoestrogens contrasts with the view of hormesis as an adaptive response. Hum. Exp. Toxicol. 2005, 24:431-437.
48. Ramesh A., Inyang F., Knuckles M.E. Modulation of adult rat benzo(a)pyrene (BaP) metabolism and DNA adduct formation by neonatal diethylstilbestrol (DES) exposure. Exp. Toxicol. Pathol. 2004, 56:129-138.
49. Aitken R.J., Roman S.D. Antioxidant systems and oxidative stress in the testes. Oxid. Med. Cell Longev. 2008, 1(1):15-24.
50. Agarwal A., Saleh R.A., Bedaiwy M.A. Role of reactive oxygen species in the pathophysiology of human reproduction. Fertil. Steril. 2003, 79:829-843.
51. Hemachand T., Shaha C. Functional role of sperm surface glutathione S-transferases and extracellular glutathione in the haploid spermatozoa under oxidative stress. FEBS Lett. 2003, 538:14-18.
52. Vernet P., Aitken R.J., Drevet J.R. Antioxidant strategies in the epididymis. Mol. Cell. Endocrinol. 2004, 216:31-39.
53. Li X.L., Xu G., Chen T., Wong Y.S., Zhao H.L., Fan R.R., Gu X.M., Tong P.C., Chan J.C. Phycocyanin protects INS-1E pancreatic beta cells against human islet amyloid polypeptide-induced apoptosis through attenuating oxidative stress and modulating JNK and p38 mitogen-activated protein kinase pathways. Int. J. Biochem. Cell Biol. 2009, 41:1526-1535.