Monobutyl phthalate inhibits steroidogenesis by downregulating steroidogenic acute regulatory protein expression in mouse Leydig tumor cells (MLTC-1)

Journal of Toxicology and Environmental Health - Part A: Current Issues

Volumn 70, Issue 11, 2007, Pages 947-955

  Wang, Yu Bang ^a   Song, Ling ^a   Cui, Lun Biao ^a   Hong, Xia ^a   Zhang, Zheng Dong ^a   Wang, Xin Ru ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; ANDROGEN RECEPTOR; CHOLERA TOXIN; CHOLESTEROL MONOOXYGENASE (SIDE CHAIN CLEAVING); CHORIONIC GONADOTROPIN; ENDOCRINE DISRUPTOR; MESSENGER RNA; PHTHALIC ACID BUTYL ESTER; PHTHALIC ACID DIBUTYL ESTER; PHTHALIC ACID ESTER; PREGNENOLONE; STEROIDOGENIC ACUTE REGULATORY PROTEIN; UNCLASSIFIED DRUG;

ANALYSIS OF VARIANCE; ANIMAL CELL; BINDING AFFINITY; BIOSYNTHESIS; CELL CULTURE; CELL VIABILITY; CHOLESTEROL TRANSPORT; CONFERENCE PAPER; CONTROLLED STUDY; DNA SYNTHESIS; ILLICIUM VERUM; INHIBITION KINETICS; LEYDIG CELL TUMOR; MALE; METABOLITE; MITOCHONDRION; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROGESTERONE RELEASE; PROTEIN EXPRESSION; REGULATORY MECHANISM; STATISTICAL ANALYSIS; STEROID RELEASE; STEROIDOGENESIS;

8-BROMO CYCLIC ADENOSINE MONOPHOSPHATE; ANIMALS; CELL LINE, TUMOR; CELL SURVIVAL; CHOLERA TOXIN; CHORIONIC GONADOTROPIN; CYCLIC AMP; DNA REPLICATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; DRUG COMBINATIONS; ENDOCRINE DISRUPTORS; HUMANS; HYDROXYCHOLESTEROLS; LEYDIG CELL TUMOR; MALE; MICE; MITOCHONDRIA; PHOSPHOPROTEINS; PHTHALIC ACIDS; PREGNENOLONE; PROGESTERONE; RNA, MESSENGER; TESTICULAR NEOPLASMS;

EID: 34247887422     PISSN: 15287394     EISSN: 10872620     Source Type: Journal    
DOI: 10.1080/15287390701290717     Document Type: Conference Paper

References (55)

1. Ascoli, M., Fanelli, F., and Segaloff, D. L. 2002. The lutropin/choriogonadotropin receptor, A 2002 perspective. Endocr. Rev. 23:141-174.
2. Ascoli, M., and Segaloff, D. L. 1989. Regulation of the differentiated functions of Leydig tumor cells by epidermal growth factor. Ann. NY Acad. Sci. 564:99-115.
3. Barlow, N. J., Phillips, S. L., Wallace, D. G., Sar, M., Gaido, K. W., and Foster, P. M. 2003. Quantitative changes in gene expression in fetal rat testes following exposure to di(n-butyl) phthalate. Toxicol. Sci. 73:431-441.
4. Blount, B. C., Silva, M. J., Caudill, S. P., Needham, L. L., Pirkle, J. L., Sampson, E. J., Lucier, G. W., Jackson, R. J., and Brock, J. W. 2000. Levels of seven urinary phthalate metabolites in a human reference population. Environ. Health Perspect. 108:979-982.
5. Boujrad, N., Vidic, B., Gazouli, M., Culty, M., and Papadopoulos, V. 2000. The peroxisome proliferator perfluorodecanoic acid inhibits the peripheral-type benzodiazepine receptor (PBR) expression and hormone-stimulated mitochondrial cholesterol transport and steroid formation in Leydig cells. Endocrinology 141:3137-3148.
6. Caron, K. M., Soo, S. C., Wetsel, W. C., Stocco, D. M., Clark, B. J., and Parker, K. L. 1997. Targeted disruption of the mouse gene encoding steroidogenic acute regulatory protein provides insights into congenital lipoid adrenal hyperplasia. Proc. Natl. Acad. Sci. USA 94:11540-11545.
7. Chen, C. W. 2001. Assessment of endocrine disruptors: approaches, issues, and uncertainties. Folia Histochem. Cytobiol. 39(suppl. 2):20-23.
8. Chen, J., Chen, H., Liu, R., Song, L., Bian, Q., Xu, L., Zhou, J., Xiao, H., Dai, G., Chang, H. C., and Wang, X. 2005. Effects of fenvalerate on progesterone production in cultured rat granulosa cells. Reprod. Toxicol. 20:195-202.
9. Chiao, Y. C., Cho, W. L. and Wang, P. S. 2002. Inhibition of testosterone production by propylthiouracil in rat Leydig cells. Biol. Reprod. 67:416-422.
10. Clark, B. J., Soo, S. C., Caron, K. M., Ikeda, Y., Parker, K. L., and Stocco, D. M. 1995. Hormonal and developmental regulation of the steroidogenic acute regulatory (StAR) protein. Mol. Endocrinol. 9:1346-1355.
11. Clark, B. J., Wells, J., King, S. R., and Stocco, D. M. 1994. The purification, cloning, and expression of a novel luteinizing hormone-induced mitochondrial protein in MA-10 mouse Leydig tumor cells. Characterization of the steroidogenic acute regulatory protein (StAR). J. Biol. Chem. 269:28314-28322.
12. Clem, B. F., Hudson, E. A., and Clark, B. J. 2005. Cyclic adenosine 3′,5′-monophosphate (cAMP) enhances cAMP-responsive element binding (CREB) protein phosphorylation and phospho-CREB interaction with the mouse steroidogenic acute regulatory protein gene promoter. Endocrinology 146:1348-1356.
13. DeRosa, C., Richter, P., Pohl, H., and Jones, D. E. 1998. Environmental exposures that affect the endocrine system: Health implications. J. Toxicol. Environ. Health B 1:3-26.
14. Fisher, J. S. 2004. Environmental anti-androgens and male reproductive health: Focus on phthalates and testicular dysgenesis syndrome. Reproduction 127:305-315.
15. Foster, P. M., Mylchreest, E., Gaido, K. W., and Sar, M. 2001. Effects of phthalate esters on the developing reproductive tract of male rats. Hum. Reprod. Update 7:231-235.
16. Hedger, M. P., and Culler, M. D. 1997. Comparison of LHRH-peptidase and plasminogen activator activity in rat testis extracts. Reprod. Fertil. Dev. 9:659-664.
17. Higuchi, T. T., Palmer, J. S., Gray, L. E., and Veeramachaneni, D. N. 2003. Effects of dibutyl phthalate in male rabbits following in utero, adolescent, or postpubertal exposure. Toxicol. Sci. 72:301-313.
18. Khan, S. A., Keck, C., Gudermann, T., and Nieschlag, E. 1990. Isolation of a protein from human ovarian follicular fluid which exerts major stimulatory effects on in vitro steroid production of testicular, ovarian, and adrenal cells. Endocrinology 126:3043-3052.
19. Kim, H. S., Kim, T. S., Shin, J.-H., Moon, H. J., Kang, I. H., Kim, I. Y., Oh, J. Y. and Han, S. Y. 2004. Neonatal exposure to di(n-butyl) phthalate (DBP) alters male reproductive tract development. J. Toxicol. Environ. Health A 67:2045-2060.
20. Kohn, M. C., Parham, F., Masten, S. A., Portier, C. J., Shelby, M. D., Broch, J. W., and Needham, L. L. 2000. Human exposure estimates for phthalates. Environ. Health Perspect. 108:A440-442.
21. Koch, H. M., Rossbach, B., Drexler, H., and Angerer, J. 2003. Internal exposure of the general population to DEHP and other phthalates - Determination of secondary and primary phthalate monoester metabolites in urine. Environ. Res. 93:177-185.
22. Koo, H. J., and Lee, B. M. 2004. Estimated exposure to phthalates in cosmetics and risk assessment. J. Toxicol. Environ. Health A 67:1901-1914.
23. Koo, H. J., and Lee, B. M. 2005. Human monitoring of phthalates and risk assessment. J. Toxicol. Environ. Health A 68:1379-1392.
24. Kumar, S., Blumberg, D. L., Canas, J. A., and Maddaiah, V. T. 1994. Human chorionic gonadotropin (hCG) increases cytosolic free calcium in adult rat Leydig cells. Cell Calcium 15:349-355.
25. Lin, D., Sugawara, T., Strauss III, J. F., Clark, B. J., Stocco, D. M., Saenger, P., Rogol, A., and Miller, W. L. 1995. Role of steroidogenic acute regulatory protein in adrenal and gonadal steroidogenesis. Science 267:1828-1831.
26. Lin, T., Wang, D., Hu, J., and Stocco, D. M. 1998. Upregulation of human chorionic gonadotrophin-induced steroidogenic acute regulatory protein by insulin-like growth factor-I in rat Leydig cells. Endocrine 8:73-78.
27. Maness, S. C., McDonnell, D. P., and Gaido, K. W. 1998. Inhibition of androgen receptor-dependent transcriptional activity by DDT isomers and methoxychlor in HepG12 human hepatoma cells. Toxicol. Appl. Pharmacol. 151:135-142.
28. Manna, P. R., Eubank, D. W., Lalli, E., Sassone-Corsi, P., and Stocco, D. M. 2003. Transcriptional regulation of the mouse steroidogenic acute regulatory protein gene by the cAMP response-element binding protein and steroidogenic factor 1. J. Mol. Endocrinol. 30:381-397.
29. Manna, P. R., Eubank, D. W., and Stocco, D. M. 2004a. Assessment of the role of activator protein-1 on transcription of the mouse steroidogenic acute regulatory protein gene. Mol. Endocrinol. 18:558-573.
30. Manna, P. R., Huhtaniemi, I. T., and Stocco, D. M. 2004b. Detection of hCG responsive expression of the steroidogenic acute regulatory protein in mouse Leydig cells. Biol. Proc. Online 6:83-93.
31. Manna, P. R., Huhtaniemi, I. T., Wang, X. J., Eubank, D. W., and Stocco, D. M. 2002. Mechanisms of epidermal growth factor signaling: Regulation of steroid biosynthesis and the steroidogenic acute regulatory protein in mouse Leydig tumor cells. Biol. Reprod. 67:1393-1404.
32. Manna, P. R., Pakarinen, P., El-Hefnawy, T., and Huhtaniemi, I. T. 1999. Functional assessment of the calcium messenger system in cultured mouse Leydig tumor cells: Regulation of human chorionic gonadotropin-induced expression of the steroidogenic acute regulatory protein. Endocrinology 140:1739-1751.
33. Manna, P. R., and Stocco, D. M. 2005. Regulation of the steroidogenic acute regulatory protein expression: Functional and physiological consequences. Curr. Drug Targets Immune Endocr. Metabol. Disord. 5:93-108.
34. Mylchreest, E., Cattley, R. C., and Foster, P. M. 1998. Male reproductive tract malformations in rats following gestational and lactational exposure to di(n-butyl) phthalate: An antiandrogenic mechanism?. Toxicol. Sci. 43:47-60.
35. Mylchreest, E., Sar, M., Cattley, R. C., and Foster, P. M. 1999. Disruption of androgen regulated male reproductive development by di(n-butyl) phthalate during late gestation in rats is different from flutamide. Toxicol. Appl. Pharmacol. 156:81-95.
36. Mylchreest, E., Sar, M., Wallace, D. G., and Foster, P. M. 2002. Fetal testosterone insufficiency and abnormal proliferation of Leydig cells and gonodocytes in rats exposed to di(n-butyl) phthalate. Reprod. Toxicol. 16:19-28.
37. Parks, L. G., Ostby, J. S., Lambright, C. R., Abbott, B. D., Klinefelter, G. R., Barlow, N. J., and Gray, L. E. 2000. The plasticizer diethylhexyl phthalate induces malformations by decreasing fetal testosterone synthesis during sexual differentiation in the male rat. Toxicol. Sci. 58:339-349.
38. Qiu, C., Shan, L., Yu, M., and Snyderwine, E. G. 2003. Deregulation of the cyclin d1/cdk4 retinoblastoma pathway in rat mammary gland carcinomas induced by the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine. Cancer Res. 63:5674-5678.
39. Richards, J. S. 2001. New signaling pathways for hormones and cyclic adenosine 3′,5′-monophosphate action in endocrine cells. Mol. Endocrinol. 15:209-218.
40. Shono, T. and Suita, S. 2003. Dose-dependent effect of phthalate ester on testicular descent in pre- and post natal rats. Urol. Res. 31:293-296.
41. Shultz, V. D., Phillips, S., Sar, M., Foster, P. M., and Gaido K. W. 2001. Altered gene profiles in fetal rat testes after in utero exposure to di(n-butyl) phthalate. Toxicol. Sci. 64:233-242.
42. Silva, M. J., Barr, D. B., Reidy, J. A., Malek, N. A., Hodge, C. C., Caudill, S. P., Brock, J. W., Needham, L. L., and Calafat, A. M. 2004. Urinary levels of seven phthalate metabolites in the U.S. population from the National Health and Nutrition Examination Survey (NHANES) 1999-2000. Environ. Health Perspect. 112:331-338.
43. Stocco, D. M. 2000. Intramitochondrial cholesterol transfer. Biochim. Biophys. Acta 1486:184-197.
44. Stocco, D. M. 2002. Clinical disorders associated with abnormal cholesterol transport: Mutations in the steroidogenic acute regulatory protein. Mol. Cell Endocrinol. 191:19-25.
45. Stocco, D. M., and Clark, B. J. 1993. The requirement of phosphorylation on a threonine residue in the acute regulation of steroidogenesis in MA-10 mouse Leydig cells. J. Steroid Biochem. Mol. Biol. 46:337-347.
46. Stocco, D. M., and Clark, B. J. 1996. Regulation of the acute production of steroids in steroidogenic cells. Endocr. Rev. 17:221-244.
47. Stocco, D. M., and Khan, S. A. 1992. Effects of steroidogenesis inducing protein (SIP) on steroid production in MA-10 mouse Leydig tumor cells: Utilization of a non-cAMP second messenger pathway. Mol. Cell Endocrinol. 84:185-194.
48. Thompson, C. J., Ross, S. M., and Gaido, K. W. 2004. Di(n-butyl) phthalate impairs cholesterol transport and steroidogenesis in the fetal rat testis through a rapid and reversible mechanism. Endocrinology 145:1227-1237.
49. Verhoeven, G., Cailleau, J., Van, D. J., and Billiau, A. 1988. Interleukin-1 stimulates steroidogenesis in cultured rat Leydig cells. Mol. Cell Endocrinol. 57:51-60.
50. Walsh, L. P., McCormick, C., Martin, C., and Stocco, D. M. 2000a. Roundup inhibits steroidogenesis by disrupting steroidogenic acute regulatory (StAR) protein expression. Environ. Health Perspect. 108:769-776.
51. Walsh, L. P., and Stocco, D. M. 2000. Effects of lindane on steroidogenesis and steroidogenic acute regulatory protein expression. Biol. Reprod. 63:1024-1033.
52. Walsh, L. P., Webster, D. R., and Stocco, D. M. 2000b. Dimethoate inhibits steroidogenesis by disrupting transcription of the steroidogenic acute regulatory (StAR) gene. J. Endocrinol. 167:253-263.
53. Wooton-Kee, C. R., and Clark, B. J. 2000. Steroidogenic factor-1 influences protein-deoxyribonucleic acid interactions within the cyclic adenosine 3,5-monophosphate-responsive regions of the murine steroidogenic acute regulatory protein gene. Endocrinology 141:1345-1355.
54. Wu, C. S., Leu, S. F., Yang, H. Y., and Huang, B. M. 2001. Melatonin inhibits the expression of steroidogenic acute regulatory protein and steroidogenesis in MA-10 cells. J. Androl. 22:245-254.
55. Zirkin, B. R., and Chen, H. 2000. Regulation of Leydig cell steroidogenic function during aging. Biol. Reprod. 63:977-981.