Reproductive stimulation by low doses of xenoestrogens contrasts with the view of hormesis as an adaptive response

Human and Experimental Toxicology

Volumn 24, Issue 9, 2005, Pages 431-437

  Weltje, Lennart ^a   Vom Saal, Frederick S ^b   Oehlmann, Jörg ^a  

^a GOETHE UNIVERSITY   (Germany)

^b UNIVERSITY OF MISSOURI   (United States)

Author keywords

Bisphenol A; Dynamic energy budget; Endocrine disruption; Hormesis; Inverted U; Xenoestrogen

Indexed keywords

4 TERT OCTYLPHENOL; 4,4' ISOPROPYLIDENEDIPHENOL; DIETHYLSTILBESTROL; ENDOCRINE DISRUPTOR; ESTROGEN; UNCLASSIFIED DRUG; XENOESTROGEN;

ARTICLE; CAENORHABDITIS ELEGANS; DETOXIFICATION; DOSE RESPONSE; DRUG INHIBITION; FEMINIZATION; FITNESS; HORMESIS; NEMATODE; NONHUMAN; PRIORITY JOURNAL; PROSTATE HYPERTROPHY; REPRODUCTION; RISK ASSESSMENT; SNAIL; SPERMATOZOON DENSITY; STRESS; UTERINE TUBE OCCLUSION;

ANIMALS; CAENORHABDITIS ELEGANS; DIETHYLSTILBESTROL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOCRINE DISRUPTORS; ESTRADIOL CONGENERS; MICE; NO-OBSERVED-ADVERSE-EFFECT LEVEL; PHENOLS; REPRODUCTION; RISK ASSESSMENT; SNAILS; STIMULATION, CHEMICAL; XENOBIOTICS;

EID: 26444448345     PISSN: 09603271     EISSN: None     Source Type: Journal    
DOI: 10.1191/0960327105ht551oa     Document Type: Article

References (37)

1. Calabrese EJ, Baldwin LA. Defining hormesis. Hum Exp Toxicol 2002; 21: 91-97.
2. Calabrese EJ, Baldwin LA. Toxicology rethinks its central belief: hormesis demands a reappraisal of the way risks are assessed. Nature 2003; 421: 691-92.
3. Kaiser J. Sipping from a poisoned chalice. Science 2003; 302: 376-78.
4. Stebbing ARD. Hormesis - the stimulation of growth by low levels of inhibitors. Sci Total Environ 1982; 22: 213-34.
5. Welshons WV, Thayer KA, Judy BM, Taylor JA, Curran EM, vom Saal FS. Large effects from small exposures. I. Mechanisms for endocrine-disrupting chemicals with estrogenic activity: Environ Health Perspect 2003; 111: 994-1006.
6. vom Saal FS, Hughes C. An extensive new literature concerning low-dose effects of bisphenol A shows the need for a new risk assessment. Environ Health Perspect 2005; 113: 926-33.
7. Duft M, Schulte-Oehlmann U, Weltje L, Tillmann M, Oehlmann J. Stimulated embryo production as a parameter of estrogenic exposure via sediments in the freshwater mudsnail Potamopyrgus antipodarum. Aquat Toxicol 2003; 64: 437-49.
8. Jobling S, Casey D, Rodgers-Gray T, Oehlmann J, Schulte-Oehlmann U, Pawlowski S, Braunbeck T, Turner AP, Tyler CR. Comparative responses of molluscs and fish to environmental estrogens and an estrogenic effluent. Aquat Toxicol 2004; 66: 207-22.
9. Oehlmann J, Schulte-Oehlmann U, Tillmann M, Markert B. Effects of endocrine disruptors on prosobranch snails (Mollusca: Gastropoda) in the laboratory. Part I: Bisphenol A and octylphenol as xeno-estrogens. Ecotoxicology 2000; 9: 383-97.
10. Shelby MD, Newbold RR, Tully DB, Chae K, Davis VL. Assessing environmental chemicals for estrogenicity using a combination of in vitro and in vivo assays. Environ Health Perspect 1996; 104: 1296-300.
11. Alworth LC, Howdeshell KL, Ruhlen RL, Day JK, Huang H-M, Besch Williford C, Lubahn DB, vom Saal FS. Imprinting of uterine response to estradiol and ribosomal gene methylation due to fetal exposure to diethylstilbestrol and methoxychlor in CD-1 mice: opposite effects of low and high doses. Toxicol Appl Pharmacol 2002; 183: 10-22.
12. Newbold RR, Jefferson WN, Padilla-Banks E, Haseman J. Developmental exposure to diethylstilbestrol (DES) alters uterine response to estrogens in prepubescent mice: low versus high dose effects. Reprod Toxicol 2004; 18: 399-406.
13. Sakaue M, Ohsako S, Ishimura R, Kurosawa S, Kurohmaru M, Hayashi Y, Aoki Y, Yonemoto J, Tohyama C. Bisphenol A affects spermatogenesis in the adult rat even at a low dose. J Occup Health 2001; 43: 185-90.
14. vom Saal FS, Cooke PS, Buchanan DL, Palanza P, Thayer KA, Nagel SC, Parmigiani S, Welshons WV. A physiologically based approach to the study of bisphenol A and other estrogenic chemicals on the size of reproductive organs, daily sperm production, and behavior. Toxicol Ind Health 1998; 14: 239-60.
15. Hood TE, Calabrese EJ, Zuckerman BM. Detection of an estrogen receptor in two nematode species and inhibition of binding and development by environmental chemicals. Ecotoxicol Environ Saf 2000; 47: 74-81.
16. Kooijman SALM. Dynamic energy and mass budgets in biological systems, second edition. Cambridge, UK: Cambridge University Press, 2000.
17. Oehlmann J, Schulte-Oehlmann U, Bachmann J, Oetken M, Lutz I, Kloas W, Ternes TA. Bisphenol A induces superfeminization in the ramshorn snail Marisa cornuarietis (Gastropoda: Prosobranchia) at environmentally relevant concentrations. Environ Health Perspect 2005; in press.
18. vom Saal FS, Timms BG, Montano MM, Palanza P, Thayer KA, Nagel SC, Dhar MD, Ganjam VK, Parmigiani S, Welshons WV. Prostate enlargement in mice due to fetal exposure to low doses of estradiol or diethylstilbestrol and opposite effects at high doses. Proc Natl Acad Sci USA 1997; 94: 2056-61.
19. Gupta C. Reproductive malformation of the male offspring following maternal exposure to estrogenic chemicals. Proc Soc Exp Biol Med 2000; 224: 61-68.
20. Timms BG, Howdeshell KL, Barton L, Bradley S, Richter CA, vom Saal FS. Estrogenic chemicals in plastic and oral contraceptives disrupt development of the fetal mouse prostate and urethra. Proc Natl Acad Sci USA 2005, 102: 7014-19.
21. Markey CM, Luque EH, Munoz De Toro M, Sonnenschein C, Soto AM. In utero exposure to bisphenol A alters the development and tissue organization of the mouse mammary gland. Biol Reprod 2001; 65: 1215-23.
22. Schönfelder G, Wittfoht W, Hopp H, Talsness C, Paul M, Chahoud I. Parent bisphenol A accumulation in human maternal-fetal-placental unit. Environ Health Perspect 2002; 110: A703-707.
23. Takeuchi T, Tsutsumi O. Serum bisphenol A concentrations showed gender differences, possibly linked to androgen levels. Biochem Biophys Res Commun 2002; 291: 76-78.
24. IRIS. 2004. Bisphenol A. (CASRN 80-05-7). US-EPA Integrated Risk Information System (IRIS) Substance. Retrieved December, 2004, from: http://www.epa.gov/iris/subst/0356.htm.
25. Levy G, Lutz I, Kruger A, Kloas W. Bisphenol A induces feminization in Xenopus laevis tadpoles. Environ Res 2004; 94: 102-11.
26. Talsness C, Fialkowski O, Gericke C, Merker H-J, Chahoud I. The effects of low and high doses of bisphenol A on the reproductive system of female and male rat offspring. Congenit Anom 2000; 40: S94-107.
27. Andersen HR, Halling-Sorensen B, Kusk KO. A parameter for detecting estrogenic exposure in the cope-pod Acartia tonsa. Ecotoxicol Environ Saf 1999; 44: 56-61.
28. Giesy JP, Pierens SL, Snyder EM, Miles-Richardson S, Kramer VJ, Snyder SA, Nichols, KM, Villeneuve DA. Effects of 4-nonylphenol on fecundity and biomarkers of estrogenicity in fathead minnows (Pimephales promelas). Environ Toxicol Chem 2000; 19: 1368-77.
29. Schulte-Oehlmann U, Tillmann M, Casey D, Duft M, Markert B, Oehlmann J. Xeno-estrogenic effects of bisphenol A in prosobranch snails (Mollusca: Gastropoda: Prosobranchia). Umwelt-wissenschaften und Schadstoff-Forschung Zeitschrift für Umweltchemie und Ökotoxikologie 2001; 13: 319-33.
30. Howdeshell KL, Hotchkiss AK, Thayer KA, Vandenbergh JG, vom Saal FS. Exposure to bisphenol A advances puberty. Nature 1999; 401: 763-64.
31. Rubin BS, Murray MK, Bamassa DA, King JC, Soto AM. Perinatal exposure to low doses of bisphenol A affects body weight, patterns of estrous cyclicity, and plasma LH levels. Environ Health Perspect 2001; 109: 657-80.
32. Schönfelder G, Flick B, Mayr L, Talsness C, Paul M, Chahoud I. In utero exposure to low doses of bisphenol A lead to long-term deleterious effects in the vagina. Neoplasia 2002; 4: 98-102.
33. Steinmetz R, Brown NG, Allen DL, Bigsby RM, Ben-Jonathan N. The environmental estrogen bisphenol A stimulates prolactin release in vitro and in vivo. Endocrinology 1997; 138: 1780-86.
34. Wang H-S, vom Saal FS. Maternal age influences traits of offspring. Nature 1999; 407: 469-70.
35. Coser KR, Chesnes J, Hur J, Ray S, Isselbacher KJ, Shioda T. Global analysis of ligand sensitivity of estrogen inducible and suppressible genes in MCF7/BUS breast cancer cells by DNA microarray. Proc Natl Acad Sci USA 2003; 100: 13994-99.
36. Sheehan DM, Willingham E, Gaylor D, Bergeron JM, Crews D. No threshold dose for estradiol-induced sex reversal of turtle embryos: how little is too much? Environ Health Perspect 1999; 107: 155-59.
37. vom Saal FS, Sheehan DM. Challenging risk assessment. Forum Appl Res Public Policy 1998; 13: 11-18.