Nucleoside analogs induce proteasomal down-regulation of p21 in chronic lymphocytic leukemia cell lines

Biochemical Pharmacology

Volumn 81, Issue 5, 2011, Pages 586-593

  Bastin Coyette, L ^a   Cardoen, S ^a   Smal, C ^a   De Viron, E ^a   Arts, A ^a   Amsailale, R ^a   Van Den Neste, E ^a,b   Bontemps, F ^a  

^a DE DUVE INSTITUTE   (Belgium)

^b CLINIQUES UNIVERSITAIRES SAINT LUC   (Belgium)

Author keywords

Cdk2; CLL; Nucleoside analogs; p21 depletion; p53; PCNA monoubiquitination

Indexed keywords

BETA ACTIN; CYCLIN DEPENDENT KINASE 2; CYCLINE; CYTARABINE; ETOPOSIDE; FLUDARABINE; GEMCITABINE; MESSENGER RNA; NUCLEOSIDE ANALOG; NUTLIN 3; PROTEASOME; PROTEIN P21; PROTEIN P53; UBIQUITIN;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CHRONIC LYMPHATIC LEUKEMIA; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG MECHANISM; ENZYME ACTIVITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN INDUCTION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CLADRIBINE; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DOWN-REGULATION; ENZYME ACTIVATION; HUMANS; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; PROLIFERATING CELL NUCLEAR ANTIGEN; PROTEASOME ENDOPEPTIDASE COMPLEX; PURINE NUCLEOSIDES; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITINATION; UP-REGULATION; VIDARABINE;

EID: 79551492981     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2010.12.009     Document Type: Article

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