A dual role of Cdk2 in DNA damage response

Cell Division

Volumn 4, Issue , 2009, Pages

  Satyanarayana, Ande ^b   Kaldis, Philipp ^a  

^a INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 67449149014     PISSN: None     EISSN: 17471028     Source Type: Journal    
DOI: 10.1186/1747-1028-4-9     Document Type: Review

References (27)

1. Morgan DO Cyclin-dependent kinases: Engines, clocks, and microprocessors Annu Rev Cell Dev Biol 1997, 13:261-291. 10.1146/ annurev.cellbio.13.1.261 9442875
2. Sherr CJ Roberts JM Cdk inhibitors: Positive and negative regulators of G1-phase progression Genes Dev 1999, 13:1501-1512. 10.1101/ gad.13.12.1501 10385618
3. Sherr CJ Roberts JM Living with or without cyclins and cyclin-dependent kinases Genes Dev 2004, 18:2699-2711. 10.1101/gad.1256504 15545627
4. Weinberg RA The Retinoblstoma protein and cell cycle control Cell 1995, 81:323-330. 10.1016/0092-8674(95)90385-2 7736585
5. Dyson N The regulation of E2F by pRB-family proteins Genes & Dev 1998, 12:2245-2262. 10.1101/gad.12.15.2245 9694791
6. Riabowol K Draetta G Brizuela L Vandre D Beach D The cdc2 kinase is a nuclear protein that is essential for mitosis in mammalian cells Cell 1989, 57:393-401. 10.1016/0092-8674(89)90914-8 2541912
7. Heuvel van den S Harlow E Distinct roles for cyclin-dependent kinases in cell cycle control Science 1993, 262:2050-2054. 10.1126/science.8266103 8266103
8. Aleem E Kiyokawa H Kaldis P Cdc2-cyclin E complexes regulate the G1/S phase transition Nat Cell Biol 2005, 7:831-836. 10.1038/ncb1284 16007079
9. Berthet C Aleem E Coppola V Tessarollo L Kaldis P Cdk2 knockout mice are viable Curr Biol 2003, 13:1775-1785. 10.1016/j.cub.2003.09.024 14561402
10. Ortega S Prieto I Odajima J Martin A Dubus P Sotillo R Barbero JL Malumbres M Barbacid M Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice Nat Genet 2003, 35:25-31. 10.1038/ng1232 12923533
11. Santamaria D Barriere C Cerqueira A Hunt S Tardy C Newton K Caceres JF Dubus P Malumbres M Barbacid M Cdk1 is sufficient to drive the mammalian cell cycle Nature 2007, 448:811-815. 10.1038/nature06046 17700700
12. O'Connor PM Mammalian G1 and G2 phase checkpoints Cancer Surv 1997, 29:151-182. 9338101
13. Vaziri H Benchimol S From telomere loss to p53 induction and activation of a DNA-damage pathway at senescence: The telomere loss/DNA damage model of cell aging Exp Gerontol 1996, 31:295-301. 10.1016/ 0531-5565(95)02025-X 8706799
14. Aprelikova O Xiong Y Liu ET Both p16 and p21 families of cyclin-dependent kinase (CDK) inhibitors block the phosphorylation of cyclin-dependent kinases by the CDK-activating kinase J Biol Chem 1995, 270:18195-18197. 10.1074/jbc.270.31.18195 7629134
15. Toyoshima H Hunter T p27, a novel inhibitor of G1 cyclin-cdk protein kinase activity, is related to p21 Cell 1994, 78:67-74. 10.1016/ 0092-8674(94)90573-8 8033213
16. Weinert TA Hartwell LH The RAD9 gene controls the cell cycle response to DNA damage in Saccharomyces cerevisiae Science 1988, 241:317-322. 10.1126/science.3291120 3291120
17. Giono LE Manfredi JJ The p53 tumor suppressor participates in multiple cell cycle checkpoints J Cell Physiol 2006, 209:13-20. 10.1002/jcp.20689 16741928
18. O'Connell MJ Cimprich KA G2 damage checkpoints: What is the turn-on? J Cell Sci 2005, 118:1-6. 10.1242/jcs.01626 15615778
19. Satyanarayana A Hilton MB Kaldis P p21 Inhibits Cdk1 in the Absence of Cdk2 to Maintain the G1/S Phase DNA Damage Checkpoint Mol Biol Cell 2008, 19:65-77. 2174178 17942597 10.1091/mbc.E07-06-0525
20. Esashi F Christ N Gannon J Liu Y Hunt T Jasin M West SC CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair Nature 2005, 434:598-604. 10.1038/nature03404 15800615
21. Thorslund T West SC BRCA2: A universal recombinase regulator Oncogene 2007, 26:7720-7730. 10.1038/sj.onc.1210870 18066084
22. Muller-Tidow C Ji P Diederichs S Potratz J Baumer N Kohler G Cauvet T Choudary C Meer Van Der T Chan WY The cyclin A1-Cdk2 complex regulates DNA double-strand break repair Mol Cell Biol 2004, 24:8917-8928. 517883 15456866 10.1128/MCB.24.20.8917-8928.2004
23. Deans AJ Khanna KK McNees CJ Mercurio C Heierhorst J McArthur GA Cyclin-dependent kinase 2 functions in normal DNA repair and is a therapeutic target in BRCA1-deficient cancers Cancer Res 2006, 66:8219-8226. 10.1158/0008-5472.CAN-05-3945 16912201
24. Sanchez Y Bachant J Wang H Hu F Liu D Tetzlaff M Elledge SJ Control of the DNA damage checkpoint by Chk1 and Rad53 protein kinases through distinct mechanisms Science 1999, 286:1166-1171. 10.1126/ science.286.5442.1166 10550056
25. Ira G Pellicioli A Balijja A Wang X Fiorani S Carotenuto W Liberi G Bressan D Wan L Hollingsworth NM DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1 Nature 2004, 431:1011-1017. 10.1038/nature02964 15496928
26. Huang H Regan KM Lou Z Chen J Tindall DJ CDK2-Dependent Phosphorylation of FOXO1 as an Apoptotic Response to DNA Damage Science 2006, 314:294-297. 10.1126/science.1130512 17038621
27. Fu Z Tindall DJ FOXOs, cancer and regulation of apoptosis Oncogene 2008, 27:2312-2319. 10.1038/onc.2008.24 18391973