Mechanisms of cell death induced by 2-chloroadenosine in leukemic B-cells

Biochemical Pharmacology

Volumn 75, Issue 7, 2008, Pages 1451-1460

  Bastin Coyette, Laurent ^a   Smal, Caroline ^a   Cardoen, Sabine ^a   Saussoy, Pascale ^b   Van Den Neste, Eric ^a,b   Bontemps, Françoise ^a  

^a DE DUVE INSTITUTE   (Belgium)

^b CLINIQUES UNIVERSITAIRES SAINT LUC   (Belgium)

Author keywords

2 Chloroadenosine; ATP; B CLL; Mcl 1; Mitochondrial pathway

Indexed keywords

2 CHLOROADENOSINE; 2 CHLOROADENOSINE 5' TRIPHOSPHATE; 5 IODOTUBERCIDIN; ADENOSINE DERIVATIVE; ADENOSINE KINASE INHIBITOR; ADENOSINE RECEPTOR; ADENOSINE RECEPTOR STIMULATING AGENT; ADENOSINE TRIPHOSPHATE; CASPASE 3; CELL DNA; COFORMYCIN; CYTOCHROME C; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN MCL 1; PROTEIN P53; RNA;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; B CELL LEUKEMIA; CANCER CELL CULTURE; CANCER INHIBITION; CELL DEATH; CONTROLLED STUDY; DNA FRAGMENTATION; DNA SYNTHESIS INHIBITION; DRUG CYTOTOXICITY; DRUG METABOLISM; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; LEUKEMIA CELL; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION;

2-CHLOROADENOSINE; APOPTOSIS; CELL DEATH; CELLS, CULTURED; HUMANS; LEUKEMIA, B-CELL;

EID: 40649106920     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2007.12.007     Document Type: Article

References (52)

1. Clarke D.A., Davoll J., Philips F.S., and Brown G.B. Enzymatic deamination and vasodepressor effects of adenosine analogs. J Pharmacol Exp Ther 106 (1952) 291-302
2. Daly J.W. Adenosine receptors: targets for future drugs. J Med Chem 25 (1982) 197-207
3. Yamanaka H., Kamatani N., Nishida Y., Nishioka K., and Mikanagi K. Relationship between phosphorylation and cytotoxicity of 2-chloroadenosine and 6-methylmercaptopurine riboside in human cells. Biochim Biophys Acta 798 (1984) 291-294
4. Claeyssens S., Hamet M., Chedeville A., Basuyau J.P., and Lavoinne A. Influence of 2-chloroadenosine on the nucleotide content of isolated rat hepatocytes. FEBS Lett 232 (1988) 317-322
5. Kizaki H., Suzuki K., Tadakuma T., and Ishimura Y. Adenosine receptor-mediated accumulation of cyclic AMP-induced T-lymphocyte death through internucleosomal DNA cleavage. J Biol Chem 265 (1990) 5280-5284
6. Szondy Z. Adenosine stimulates DNA fragmentation in human thymocytes by Ca(2+)-mediated mechanisms. Biochem J 304 (1994) 877-885
7. Szondy Z. The 2-chlorodeoxyadenosine-induced cell death signalling pathway in human thymocytes is different from that induced by 2-chloroadenosine. Biochem J 311 (1995) 585-588
8. Abbracchio M.P., Ceruti S., Barbieri D., Franceschi C., Malorni W., Biondo L., et al. A novel action for adenosine: apoptosis of astroglial cells in rat brain primary cultures. Biochem Biophys Res Commun 213 (1995) 908-915
9. Ceruti S., Franceschi C., Barbieri D., Malorni W., Camurri A., Giammarioli A.M., et al. Apoptosis induced by 2-chloro-adenosine and 2-chloro-2′-deoxy-adenosine in a human astrocytoma cell line: differential mechanisms and possible clinical relevance. J Neurosci Res 60 (2000) 388-400
10. Barbieri D., Abbracchio M.P., Salvioli S., Monti D., Cossarizza A., Ceruti S., et al. Apoptosis by 2-chloro-2′-deoxy-adenosine and 2-chloro-adenosine in human peripheral blood mononuclear cells. Neurochem Int 32 (1998) 493-504
11. Szondy Z. Methylprednisolone and 2-chloroadenosine induce DNA fragmentation at different stages of human T-lymphocyte development. Immunol Lett 58 (1997) 59-65
12. Ceruti S., Giammarioli A.M., Camurri A., Falzano L., Rufini S., Frank C., et al. Adenosine- and 2-chloro-adenosine-induced cytopathic effects on myoblastic cells and myotubes: involvement of different intracellular mechanisms. Neuromuscul Disord 10 (2000) 436-446
13. 2 myotubes. Biochem Biophys Res Commun 277 (2000) 546-551
14. Koshiba M., Kosaka H., Nakazawa T., Hayashi N., Saura R., Kitamura N., et al. 2-Chloroadenosine but not adenosine induces apoptosis in rheumatoid fibroblasts independently of cell surface adenosine receptor signalling. Br J Pharmacol 135 (2002) 1477-1486
15. Minelli A., Bellezza I., Agostini M., Bracarda S., and Culig Z. Mechanism of 2-chloroadenosine toxicity to PC3 cell line. Prostate 66 (2006) 1425-1436
16. Ceruti S., Beltrami E., Matarrese P., Mazzola A., Cattabeni F., Malorni W., et al. A key role for caspase-2 and caspase-3 in the apoptosis induced by 2-chloro-2′-deoxy-adenosine (cladribine) and 2-chloro-adenosine in human astrocytoma cells. Mol Pharmacol 63 (2003) 1437-1447
17. Van Den Neste E., Cardoen S., Offner F., and Bontemps F. Old and new insights into the mechanisms of action of two nucleoside analogs active in lymphoid malignancies: fludarabine and cladribine (review). Int J Oncol 27 (2005) 1113-1124
18. Saltman D., Bansal N.S., Ross F.M., Ross J.A., Turner G., and Guy K. Establishment of a karyotypically normal B-chronic lymphocytic leukemia cell line; evidence of leukemic origin by immunoglobulin gene rearrangement. Leuk Res 14 (1990) 381-387
19. Bontemps F., Delacauw A., Cardoen S., Van Den Neste E., and Van Den Berghe G. Metabolism and cytotoxic effects of 2-chloroadenine, the major catabolite of 2-chloro-2′-deoxyadenosine. Biochem Pharmacol 59 (2000) 1237-1243
20. Smal C., Lisart S., Maerevoet M., Ferrant A., Bontemps F., and Van Den Neste E. Pharmacological inhibition of the MAPK/ERK pathway increases sensitivity to 2-chloro-2′-deoxyadenosine (CdA) in the B-cell leukemia cell line EHEB. Biochem Pharmacol 73 (2007) 351-358
21. Huang P., Robertson L.E., Wright S., and Plunkett W. High molecular weight DNA fragmentation: a critical event in nucleoside analogue-induced apoptosis in leukemia cells. Clin Cancer Res 1 (1995) 1005-1013
22. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72 (1976) 248-254
23. Pastor-Anglada M., Felipe A., and Casado F.J. Transport and mode of action of nucleoside derivatives used in chemical and antiviral therapies. Trends Pharmacol Sci 19 (1998) 424-430
24. Henderson J.F., Paterson A.R., Caldwell I.C., Paul B., Chan M.C., and Lau K.F. Inhibitors of nucleoside and nucleotide metabolism. Cancer Chemother Rep 2 3 (1972) 71-85
25. Hengartner M.O. The biochemistry of apoptosis. Nature 407 (2000) 770-776
26. Borner C. The Bcl-2 protein family: sensors and checkpoints for life-or-death decisions. Mol Immunol 39 (2003) 615-647
27. Chapman A.G., and Atkinson D.E. Stabilization of adenylate energy charge by the adenylate deaminase reaction. J Biol Chem 248 (1973) 8309-8312
28. Van den Berghe G., Bronfman M., Vanneste R., and Hers H.G. The mechanism of adenosine triphosphate depletion in the liver after a load of fructose. A kinetic study of liver adenylate deaminase. Biochem J 162 (1977) 601-609
29. Van den Berghe G., Bontemps F., and Hers H.G. Purine catabolism in isolated rat hepatocytes. Influence of coformycin. Biochem J 188 (1980) 913-920
30. King A.E., Ackley M.A., Cass C.E., Young J.D., and Baldwin S.A. Nucleoside transporters: from scavengers to novel therapeutic targets. Trends Pharmacol Sci 27 (2006) 416-425
31. Albertioni F., Lindemalm S., Reichelova V., Pettersson B., Eriksson S., Juliusson G., et al. Pharmacokinetics of cladribine in plasma and its 5′-monophosphate and 5′-triphosphate in leukemic cells of patients with chronic lymphocytic leukemia. Clin Cancer Res 4 (1998) 653-658
32. Krett N.L., Davies K.M., Ayres M., Ma C., Nabhan C., Gandhi V., et al. 8-Amino-adenosine is a potential therapeutic agent for multiple myeloma. Mol Cancer Ther 3 (2004) 1411-1420
33. Huang P., and Plunkett W. Action of 9-beta-D-arabinofuranosyl-2-fluoroadenine on RNA metabolism. Mol Pharmacol 39 (1991) 449-455
34. Stellrecht C.M., Rodriguez Jr. C.O., Ayres M., and Gandhi V. RNA-directed actions of 8-chloro-adenosine in multiple myeloma cells. Cancer Res 63 (2003) 7968-7974
35. Yang-Yen H.F. Mcl-1: a highly regulated cell death and survival controller. J Biomed Sci 13 (2006) 201-204
36. Balakrishnan K., Wierda W.G., Keating M.J., and Gandhi V. Mechanisms of cell death of chronic lymphocytic leukemia lymphocytes by RNA-directed agent, 8-NH2-adenosine. Clin Cancer Res 11 (2005) 6745-6752
37. Balakrishnan K., Stellrecht C.M., Genini D., Ayres M., Wierda W.G., Keating M.J., et al. Cell death of bioenergetically compromised and transcriptionally challenged CLL lymphocytes by chlorinated ATP. Blood 105 (2005) 4455-4462
38. de Vries J.F., Falkenburg J.H., Willemze R., and Barge R.M. The mechanisms of Ara-C-induced apoptosis of resting B-chronic lymphocytic leukemia cells. Haematologica 91 (2006) 912-919
39. MacCallum D.E., Melville J., Frame S., Watt K., Anderson S., Gianella-Borradori A., et al. Seliciclib (CYC202, R-Roscovitine) induces cell death in multiple myeloma cells by inhibition of RNA polymerase II-dependent transcription and down-regulation of Mcl-1. Cancer Res 65 (2005) 5399-5407
40. Gojo I., Zhang B., and Fenton R.G. The cyclin-dependent kinase inhibitor flavopiridol induces apoptosis in multiple myeloma cells through transcriptional repression and down-regulation of Mcl-1. Clin Cancer Res 8 (2002) 3527-3538
41. Chen R., Keating M.J., Gandhi V., and Plunkett W. Transcription inhibition by flavopiridol: mechanism of chronic lymphocytic leukemia cell death. Blood 106 (2005) 2513-2519
42. Zhang B., Gojo I., and Fenton R.G. Myeloid cell factor-1 is a critical survival factor for multiple myeloma. Blood 99 (2002) 1885-1893
43. Moulding D.A., Giles R.V., Spiller D.G., White M.R., Tidd D.M., and Edwards S.W. Apoptosis is rapidly triggered by antisense depletion of MCL-1 in differentiating U937 cells. Blood 96 (2000) 1756-1763
44. Hussain S.R., Cheney C.M., Johnson A.J., Lin T.S., Grever M.R., Caligiuri M.A., et al. Mcl-1 is a relevant therapeutic target in acute and chronic lymphoid malignancies: down-regulation enhances rituximab-mediated apoptosis and complement-dependent cytotoxicity. Clin Cancer Res 13 (2007) 2144-2150
45. Petlickovski A., Laurenti L., Li X., Marietti S., Chiusolo P., Sica S., et al. Sustained signaling through the B-cell receptor induces Mcl-1 and promotes survival of chronic lymphocytic leukemia B cells. Blood 105 (2005) 4820-4827
46. Gandhi V., Ayres M., Halgren R.G., Krett N.L., Newman R.A., and Rosen S.T. 8-Chloro-cAMP and 8-chloro-adenosine act by the same mechanism in multiple myeloma cells. Cancer Res 61 (2001) 5474-5479
47. Mlejnek P., and Dolezel P. Apoptosis induced by N6-substituted derivatives of adenosine is related to intracellular accumulation of corresponding mononucleotides in HL-60 cells. Toxicol In Vitro 19 (2005) 985-990
48. Skulachev V.P. Bioenergetic aspects of apoptosis, necrosis and mitoptosis. Apoptosis 11 (2006) 473-485
49. Izyumov D.S., Avetisyan A.V., Pletjushkina O.Y., Sakharov D.V., Wirtz K.W., Chernyak B.V., et al. Wages of fear: transient threefold decrease in intracellular ATP level imposes apoptosis. Biochim Biophys Acta 1658 (2004) 141-147
50. Seto S., Carrera C.J., Kubota M., Wasson D.B., and Carson D.A. Mechanism of deoxyadenosine and 2-chlorodeoxyadenosine toxicity to nondividing human lymphocytes. J Clin Invest 75 (1985) 377-383
51. Martin D.S., Spriggs D., and Koutcher J.A. A concomitant ATP-depleting strategy markedly enhances anticancer agent activity. Apoptosis 6 (2001) 125-131
52. Chandra D., Bratton S.B., Person M.D., Tian Y., Martin A.G., Ayres M., et al. Intracellular nucleotides act as critical prosurvival factors by binding to cytochrome c and inhibiting apoptosome. Cell 125 (2006) 1333-1346