Proteasome-mediated degradation of p21 via N-terminal ubiquitinylation

Cell

Volumn 115, Issue 1, 2003, Pages 71-82

  Bloom, Joanna ^a   Amador, Virginia ^a   Bartolini, Francesca ^a   DeMartino, George ^b   Pagano, Michele ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS AT DALLAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LYSINE; METHIONINE; MUTANT PROTEIN; PROTEASOME; PROTEIN P21; UBIQUITIN;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN PROCESSING; PROTEIN STRUCTURE; REGULATORY MECHANISM; STRUCTURE ANALYSIS; WILD TYPE;

ANIMALIA;

EID: 0141987892     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(03)00755-4     Document Type: Article

References (25)

1. Aviel S., Winberg G., Massucci M., Ciechanover A. Degradation of the Epstein-Barr virus latent membrane protein 1 (LMP1) by the ubiquitin-proteasome pathway. Targeting via ubiquitination of the N-terminal residue. J. Biol. Chem. 275:2000;23491-23499.
2. Bornstein G., Bloom J., Sitry-Shevah D., Nakayama K., Pagano M., Hershko A. Role of SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 during S-phase. J. Biol. Chem. 278:2003;25752-25757.
3. Breitschopf K., Bengal E., Ziv T., Admon A., Ciechanover A. A novel site for ubiquitination. the N-terminal residue, and not internal lysines of MyoD, is essential for conjugation and degradation of the protein EMBO J. 17:1998;5964-5973.
4. Carrano A.C., Pagano M. Role of the F-box protein Skp2 in adhesion-dependent cell cycle progression. J. Cell Biol. 153:2001;1381-1389.
5. Carrano A.C., Eytan E., Hershko A., Pagano M. Skp2 is required for the ubiquitin-mediated degradation of the Cdk-inhibitor p27. Nat. Cell Biol. 1:1999;193-199.
6. Cayrol C., Ducommun B. Interaction with cyclin-dependent kinases and PCNA modulates proteasome-dependent degradation of p21. Oncogene. 17:1998;2437-2444.
7. Fukuchi K., Hagiwara T., Nakamura K., Ichimura S., Tatsumi K., Gomi K. Identification of the regulatory region required for ubiquitination of the cyclin kinase inhibitor, p21. Biochem. Biophys. Res. Commun. 293:2002;120-125.
8. Guardavaccaro D., Kudo Y., Boulaire J., Barchi M., Busino L., Donzelli M., Margottin-Goguet F., Jackson P.K., Yamasaki L., Pagano M. Control of meiotic and mitotic progression by the F box protein beta-Trcp1 in vivo. Dev. Cell. 4:2003;799-812.
9. Handeli S., Weintraub H. The ts41 mutation in Chinese hamster cells leads to successive S phases in the absence of intervening G2, M, and G1. Cell. 71:1992;599-611.
10. Hershko A. Ubiquitin-mediated protein degradation. J. Biol. Chem. 263:1988;15237-15240.
11. Jariel-Encontre I., Pariat M., Martin F., Carillo S., Salvat C., Piechaczyk M. Ubiquitinylation is not an absolute requirement for degradation of c-Jun protein by the 26 S proteasome. J. Biol. Chem. 270:1995;11623-11627.
12. Kriwacki R.W., Hengst L., Tennant L., Reed S.I., Wright P.E. Structural studies of p21Waf1/Cip1/Sdi1 in the free and Cdk2-bound state. conformational disorder mediates binding diversity Proc. Natl. Acad. Sci. USA. 93:1996;11504-11509.
13. Li X., Coffino P. Regulated degradation of ornithine decarboxylase requires interaction with the polyamine-inducible protein antizyme. Mol. Cell. Biol. 12:1992;3556-3562.
14. Liu C.W., Corboy M.J., DeMartino G.N., Thomas P.J. Endoproteolytic activity of the proteasome. Science. 299:2003;408-411.
15. Maki C., Howley P. Ubiquitination of p53 and p21 are differentially affected by ionizing and UV radiation. Mol. Cell. Biol. 17:1997;355-363.
16. Maki C.G., Huibregtse J.M., Howley P.M. In vivo ubiquitination and proteasome-mediated degradation of p53(1). Cancer Res. 56:1996;2649-2654.
17. Montagnoli A., Fiore F., Eytan E., Carrano A.C., Draetta G., Hershko A., Pagano M. Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation. Genes Dev. 13:1999;1181-1189.
18. Nishimoto T., Takahashi T., Basilico C. A temperature-sensitive mutation affecting S-phase progression can lead to accumulation of cells with a G2 DNA content. Somatic Cell Genet. 6:1980;465-476.
19. Petroski M.D., Deshaies R.J. Context of multiubiquitin chain attachment influences the rate of Sic1 degradation. Mol. Cell. 11:2003;1435-1444.
20. Querido E., Blanchette P., Yan Q., Kamura T., Morrison M., Boivin D., Kaelin W.G., Conaway R.C., Conaway J.W., Branton P.E. Degradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complex. Genes Dev. 15:2001;3104-3117.
21. Reinstein E., Scheffner M., Oren M., Ciechanover A., Schwartz A. Degradation of the E7 human papillomavirus oncoprotein by the ubiquitin-proteasome system. targeting via ubiquitination of the N-terminal residue Oncogene. 19:2000;5944-5950.
22. Rousseau D., Cannella D., Boulaire J., Fitzgerald P., Fotedar A., Fotedar R. Growth inhibition by CDK-cyclin and PCNA binding domains of p21 occurs by distinct mechanisms and is regulated by ubiquitin-proteasome pathway. Oncogene. 18:1999;4313-4325.
23. Sheaff R.J., Singer J.D., Swanger J., Smitherman M., Roberts J.M., Clurman B.E. Proteasomal turnover of p21Cip1 does not require p21Cip1 ubiquitination. Mol. Cell. 5:2000;403-410.
24. Sherr C.J., Roberts J.M. CDK inhibitors. positive and negative regulators of G1-phase progression Genes Dev. 13:1999;1501-1512.
25. Touitou R., Richardson J., Bose S., Nakanishi M., Rivett J., Allday M.J. A degradation signal located in the C-terminus of p21WAF1/CIP1 is a binding site for the C8 alpha-subunit of the 20S proteasome. EMBO J. 20:2001;2367-2375.