Regulation of voltage-gated ion channels in excitable cells by the ubiquitin ligases Nedd4 and Nedd4-2

Channels

Volumn 5, Issue 1, 2011, Pages 79-88

  Bongiorno, Daria ^a   Schuetz, Friderike ^b   Poronnik, Philip ^a   Adams, David J ^a,b  

^a RMIT UNIVERSITY   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Chloride channels; KCNQ channels; Nedd4; Nedd4 2; Ubiquitin ligase; Voltage gated ion channels; Voltage gated potassium channels; Voltage gated sodium channels

Indexed keywords

POTASSIUM CHANNEL; POTASSIUM CHANNEL KCNE1; POTASSIUM CHANNEL KCNE2; POTASSIUM CHANNEL KCNQ; POTASSIUM CHANNEL KCNQ2; POTASSIUM CHANNEL KCNQ3; POTASSIUM CHANNEL KV1.3; POTASSIUM CHANNEL KV7.1; POTASSIUM CHANNEL KV7.2; POTASSIUM CHANNEL KV7.3; SERUM AND GLUCOCORTICOID REGULATED KINASE 1; SODIUM CHANNEL NAV1.1; SODIUM CHANNEL NAV1.2; SODIUM CHANNEL NAV1.3; SODIUM CHANNEL NAV1.4; SODIUM CHANNEL NAV1.5; SODIUM CHANNEL NAV1.6; SODIUM CHANNEL NAV1.7; SODIUM CHANNEL NAV1.8; UBIQUITIN PROTEIN LIGASE; UBIQUITIN PROTEIN LIGASE NEDD4; UBIQUITIN PROTEIN LIGASE NEDD4 2; UNCLASSIFIED DRUG; VOLTAGE GATED SODIUM CHANNEL;

ENZYME MECHANISM; HUMAN; INTRACELLULAR TRANSPORT; NONHUMAN; PROTEIN FUNCTION; PROTEIN STRUCTURE; REGULATORY MECHANISM; REVIEW; UBIQUITINATION;

EID: 79551479336     PISSN: 19336950     EISSN: 19336969     Source Type: Journal    
DOI: 10.4161/chan.5.1.13967     Document Type: Review

References (122)

1. Catterall WA, Goldin AL, Waxman SG. International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels. Pharmacol Rev 2005; 57:397-409.
2. Duran C, Thompson CH, Xiao Q, Hartzell HC. Chloride channels: often enigmatic, rarely predictable. Annu Rev Physiol 2010; 72:95-121.
3. Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, et al. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. Pharmacol Rev 2005; 57:473-508.
4. Thomas EA, Reid CA, Berkovic SF, Petrou S. Prediction by modeling that epilepsy may be caused by very small functional changes in ion channels. Arch Neurol 2009; 66:1225-32.
5. Dib-Hajj SD, Black JA, Waxman SG. Voltage-gated sodium channels: therapeutic targets for pain. Pain Med 2009; 10:1260-9.
6. Isom L, De Jongh K, Patton D, Reber B, Offord J, Charbonneau H, et al. Primary structure and functional expression of the β1 subunit of the rat brain sodium channel. Science 1992; 256:839-42.
7. Isom LL, Ragsdale DS, De Jongh KS, Westenbroek RE, Reber BF, Scheuer T, Catterall WA. Structure and function of the β2 subunit of brain sodium channels, a transmembrane glycoprotein with a CAM motif. Cell 1995; 83:433-42.
8. Carr G, Simmons N, Sayer J. A role for CBS domain 2 in trafficking of chloride channel CLC-5. Biochem Biophys Res Commun 2003; 310:600-5.
9. Sile S, Vanoye CG, George AL Jr. Molecular physiology of renal ClC chloride channels/transporters. Curr Opin Nephrol Hypertens 2006; 15:511-6. (Pubitemid 44246401)
10. Sík A, Smith RL, Freund TF. Distribution of chloride channel-2-immunoreactive neuronal and astrocytic processes in the hippocampus. Neuroscience 2000; 101:51-65.
11. Schulz DJ, Temporal S, Barry DM, Garcia ML. Mechanisms of voltage-gated ion channel regulation: from gene expression to localization. Cell Mol Life Sci 2008; 65:2215-31.
12. Okuse K, Malik-Hall M, Baker M, Poon W, Kong H, Chao M, Wood J. Annexin II light chain regulates sensory neuron-specific sodium channel expression. Nature 2002; 417:653-6.
13. Shao D, Okuse K, Djamgoz MBA. Protein-protein interactions involving voltage-gated sodium channels: post-translational regulation, intracellular trafficking and functional expression. Int J Biochem Cell Biol 2009; 41:1471-81.
14. V1.5 on the surface of cardiomyocytes. Proc Natl Acad Sci USA 2004; 101:17533-8.
15. V channel targeting in the heart requires an ankyrin-G-dependent cellular pathway. J Cell Biol 2008; 180:173-86.
16. Kretschmer T, Nguyen DH, Beuerman RW, Happel LT, England JD, Tiel RL, Kline DG. Painful human neuromas: a potential role for a structural transmembrane protein, ankyrin G. J Neurosurg 2002; 97:1424-31.
17. 2+-sensitivity? Biochemistry 2000; 39:1316-23.
18. 2+/calmodulin-dependent protein kinase II in guinea-pig ventricular myocytes. Cardiovasc Res 2010; 85:454-63.
19. Yuill KH, Smirnov SV. Calcium-dependent regulation of voltage-gated sodium channels in cardiac myocytes: just the beginning? Cardiovasc Res 2010; 85:411-2.
20. V1.4 current: role of binding to the carboxyl terminus. J Gen Physiol 2008; 131:197-209.
21. Hallaq H, Yang Z, Viswanathan PC, Fukuda K, Shen W, Wang DW, et al. Quantitation of protein kinase A-mediated trafficking of cardiac sodium channels in living cells. Cardiovasc Res 2006; 72:250-61. (Pubitemid 44511919)
22. Cusdin FS, Clare JJ, Jackson AP. Trafficking and cellular distribution of voltage-gated sodium channels. Traffic 2008; 9:17-26.
23. V1.5 in atrial myocytes. J Biol Chem 2007; 282:29612-20.
24. Vacher H, Mohapatra DP, Misonou H, Trimmer JS. Regulation of KV1 channel trafficking by the mamba snake neurotoxin dendrotoxin K. FASEB J 2007; 21:906-14. (Pubitemid 46348263)
25. V1 channel trafficking. Biochem Biophys Res Commun 2004; 322:577-84.
26. Etxeberria A, Aivar P, Rodriguez-Alfaro JA, Alaimo A, Villace P, Gomez-Posada JC, et al. Calmodulin regulates the trafficking of KCNQ2 potassium channels. FASEB J 2008; 22:1135-43.
27. Choi WS, Khurana A, Mathur R, Viswanathan V, Steele DF, Fedida D. KV1.5 surface expression is modulated by retrograde trafficking of newly endocytosed channels by the dynein motor. Circ Res 2005; 97:363-71.
28. V1.2 potassium channel trafficking by cyclic AMP. J Biol Chem 2008; 283:3445-53.
29. + channels. J Neurosci 2010; 30:2311-23.
30. + channels. Physiol Rev 2010; 90:755-96.
31. Hernandez CC, Zaika O, Tolstykh GP, Shapiro MS. Regulation of neural KCNQ channels: signalling pathways, structural motifs and functional implications. J Physiol 2008; 586:1811-21.
32. Haitin Y, Attali B. The C-terminus of KV7 channels: a multifunctional module. J Physiol 2008; 586:1803-10.
33. Nakajo K, Kubo Y. Second coiled-coil domain of KCNQ channel controls current expression and subfamily specific heteromultimerization by salt bridge networks. J Physiol 2008; 586:2827-40. (Pubitemid 351837279)
34. Haug K, Warnstedt M, Alekov AK, Sander T, Ramirez A, Poser B, et al. Mutations in CLCN2 encoding a voltage-gated chloride channel are associated with idiopathic generalized epilepsies. Nat Genet 2003; 33:527-32.
35. Pusch M. Myotonia caused by mutations in the muscle chloride channel gene CLCN1. Human Mutat 2002; 19:423-34.
36. Pickart CM. Mechanisms underlying ubiquitation. Annu Rev Biochem 2001; 70:503-33.
37. Hershko A, Ciechanover A. The ubiquitin system. Annu Rev Biochem 1998; 67:425-79.
38. Yang B, Kumar S. Nedd4 and Nedd4-2: closely related ubiquitin-protein ligases with distinct physiological functions. Cell Death Differ 2010; 17:68-77.
39. Rotin D, Kumar S. Physiological functions of the HECT family of ubiquitin ligases. Nat Rev Mol Cell Biol 2009; 10:398-409.
40. Ciechanover A. Proteolysis: from the lysosome to ubiquitin and the proteasome. Nat Rev Mol Cell Biol 2005; 6:79-87.
41. Ciechanover A. Intracellular protein degradation: from a vague idea thru the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting. Hematology 2006; 2006:1-12.
42. Kahle PJ, Haass C. How does parkin ligate ubiquitin to Parkinson's disease? EMBO Rep 2004; 5:681-5.
43. Sone J, Niwa Ji, Kawai K, Ishigaki S, Yamada Si, Adachi H, et al. Dorfin ameliorates phenotypes in a transgenic mouse model of amyotrophic lateral sclerosis. J Neurosci Res 2010; 88:123-35.
44. Whitaker WRJ, Faull RLM, Dragunow M, Mee EW, Emson PC, Clare JJ. Changes in the mRNAs encoding voltage-gated sodium channel types II and III in human epileptic hippocampus. Neuroscience 2001; 106:275-85.
45. Hains BC, Waxman SG, John TW, Andrew IRM. Sodium channel expression and the molecular pathophysiology of pain after SCI. Prog Brain Res 2007; 161:195-203.
46. Devor M. Sodium channels and mechanisms of neuropathic pain. J Pain 2006; 7:3-12.
47. Ohno K, Yokota A, Hirofuji S, Kanbara K, Ohtsuka H, Kinoshita M. Altered expression of sodium channel distribution in the dorsal root ganglion after gradual elongation of rat sciatic nerves. J Orthop Res 2010; 28:481-6.
48. Kumar S, Tomooka Y, Noda M. Identification of a set of genes with developmentally downregulated expression in the mouse brain. Biochem Biophys Res Commun 1992; 185:1155-61.
49. Harvey KF, Kumar S. Nedd4-like proteins: an emerging family of ubiquitin-protein ligases implicated in diverse cellular functions. Trends Cell Biol 1999; 9:166-9. (Pubitemid 129750027)
50. Kumar S, Harvey KF, Kinoshita M, Copeland NG, Noda M, Jenkins NA. cDNA cloning, expression analysis and mapping of the mouse Nedd4 gene. Genomics 1997; 40:435-43.
51. Lu PJ, Zhou XZ, Shen M, Lu KP. Function of WW domains as phosphoserine- or phosphothreonine-binding modules. Science 1999; 283:1325-8.
52. Kaneis V, Bruce M, Skrynnikov N, Rotin D, Forman-Kay J. Structural determinants for high-affinity binding in a Nedd4 WW3* domain-comm PY motif complex. Structure 2006; 14:543-53. (Pubitemid 43363487)
53. Eaton DC, Malik B, Bao HF, Yu L, Jain L. Regulation of epithelial sodium channel trafficking by ubiquitination. Proc Am Thorac Soc 2010; 7:54-64.
54. Lu C, Pribanic S, Debonneville A, Jiang C, Rotin D. The PY motif of ENaC, mutated in Liddle syndrome, regulates channel internalization, sorting and mobilization from subapical pool. Traffic 2007; 8:1246-64.
55. Rauh R, Dinudom A, Fotia A, Paulides M, Kumar S, Korbmacher C, Cook D. Stimulation of the epithelial sodium channel (ENaC) by the serum- and glucocorticoid- inducible kinase (Sgk) involves the PY motifs of the channel but is independent of sodium feedback inhibition. Pflügers Archiv 2006; 452:290-9.
56. Fotia AB, Dinudom A, Shearwin KE, Koch JP, Korbmacher C, Cook DI, Kumar S. The role of individual Nedd4-2 (KIAA0439) WW domains in binding and regulating epithelial sodium channels. FASEB J 2003; 17:70-2.
57. Persaud A, Alberts P, Amsen EM, Xiong X, Wasmuth J, Saadon Z, et al. Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. Mol Syst Biol 2009; 5:333-7.
58. Cao XR, Lill NL, Boase N, Shi PP, Croucher DR, Shan H, et al. Nedd4 controls animal growth by regulating IGF-1 signaling. Sci Signal 2008; 1:5.
59. Chan W, Tian R, Lee YF, Sit ST, Lim L, Manser E. Downregulation of active ACK1 is mediated by association with the E3 ubiquitin ligase Nedd4-2. J Biol Chem 2009; 284:8185-94.
60. Lin Q, Wang J, Childress C, Sudol M, Carey DJ, Yang W. HECT E3 ubiquitin ligase Nedd4-1 ubiquitinates ACK and regulates epidermal growth factor (EGF)-induced degradation of EGF receptor and ACK. Mol Cell Biol 2010; 30:1541-54.
61. Murdaca J, Treins C, Monthouël-Kartmann MN, Pontier-Bres R, Kumar S, Van Obberghen E, Giorgetti- Peraldi S. Grb10 prevents Nedd4-mediated vascular endothelial growth factor receptor-2 degradation. J Biol Chem 2004; 279:26754-61.
62. Kwak YD, Wang B, Pan W, Xu H, Jiang X, Liao FF. Functional interaction of phosphatase and tensin homologue (PTEN) with the E3 ligase NEDD4-1 during neuronal response to zinc. J Biol Chem 2010; 285:9847-57.
63. Drinjakovic J, Jung H, Campbell DS, Strochlic L, Dwivedy A, Holt CE. E3 ligase Nedd4 promotes axon branching by downregulating PTEN. Neuron 2010; 65:341-57.
64. Vina-Vilaseca A, Sorkin A. Lysine 63-linked polyubiquitination of the dopamine transporter requires WW3 and WW4 domains of Nedd4-2 and UBE2D ubiquitin-conjugating enzymes. J Biol Chem 2008; 285:7645-56.
65. Sorkina T, Miranda M, Dionne KR, Hoover BR, Zahniser NR, Sorkin A. RNA interference screen reveals an essential role of Nedd4-2 in dopamine transporter ubiquitination and endocytosis. J Neurosci 2006; 26:8195-205.
66. Boehmer C, Henke G, Schniepp R, Palmada M, Rothstein JD, Bröer S, Lang F. Regulation of the glutamate transporter EAAT1 by the ubiquitin ligase Nedd4-2 and the serum and glucocorticoid-inducible kinase isoforms SGK1/3 and protein kinase B. J Neurochem 2003; 86:1181-8. (Pubitemid 37022194)
67. Boehmer C, Palmada M, Rajamanickam J, Schniepp R, Amara S, Lang F. Post-translational regulation of EAAT2 function by co-expressed ubiquitin ligase Nedd4-2 is impacted by SGK kinases. J Neurochem 2006; 97:911-21.
68. Kuratomi G, Komuro A, Goto K, Shinozaki M, Miyazawa K, Miyazono K, Imamura T. Nedd4-2 (neural precursor cell expressed, developmentally downregulated 4-2) negatively regulates TGFβ (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGFβ type I receptor. Biochem J 2005; 386:461-70.
69. Arevalo JC, Waite J, Rajagopal R, Beyna M, Chen ZY, Lee FS, Chao MV. Cell survival through Trk neurotrophin receptors is differentially regulated by ubiquitination. Neuron 2006; 50:549-59.
70. He Y, Hryciw DH, Carroll ML, Myers SA, Whitbread AK, Kumar S, et al. The ubiquitin-protein ligase Nedd4-2 differentially interacts with and regulates members of the Tweety family of chloride ion channels. J Biol Chem 2008; 283:24000-10.
71. Jespersen T, Membrez M, Nicolas CS, Pitard B, Staub O, Olesen SP, et al. The KCNQ1 potassium channel is downregulated by ubiquitylating enzymes of the Nedd4/Nedd4-like family. Cardiovasc Res 2007; 74:64-74.
72. + channels KCNQ2/3 and KCNQ3/5 by ubiquitination. J Biol Chem 2007; 282:12135-42.
73. V1.3 by the ubiquitin ligase Nedd4-2 and the serum and glucocorticoid inducible kinase SGK1. J Cell Physiol 2004; 199:194-9.
74. V4.3 by serum- and glucocorticoid- inducible kinase isoforms in Xenopus oocytes. Pflügers Archiv 2005; 450:26-33.
75. Fotia AB, Ekberg J, Adams DJ, Cook DI, Poronnik P, Kumar S. Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2. J Biol Chem 2004; 279:28930-5.
76. Rougier JS, van Bemmelen MX, Bruce MC, Jespersen T, Gavillet B, Apotheloz F, et al. Molecular determinants of voltage-gated sodium channel regulation by the Nedd4/Nedd4-like proteins. Am J Physiol Cell Physiol 2005; 288:692-701.
77. V1.5 is regulated by Nedd4-2 mediated ubiquitination. Circ Res 2004; 95:284-91.
78. + channels in pain pathways. Trends Pharmacol Sci 2001; 22:27-31.
79. V1.5. Brain 2010; 133:835-46.
80. V1.5 sodium channel. J Cardiovasc Electrophysiol 2010; 21:107-15.
81. Chen Q, Kirsch GE, Zhang D, Brugada R, Brugada J, Brugada P, et al. Genetic basis and molecular mechanism for idiopathic ventricular fibrillation. Nature 1998; 392:293-6.
82. + channel (H1) by the ubiquitin-protein ligase Nedd4. FEBS Lett 2000; 466:377-80.
83. Palmada M, Dieter M, Boehmer C, Waldegger S, Lang F. Serum and glucocorticoid inducible kinases functionally regulate ClC-2 channels. Biochem Biophys Res Commun 2004; 321:1001-6. (Pubitemid 39044408)
84. Hryciw DH, Ekberg J, Lee A, Lensink IL, Kumar S, Guggino WB, et al. Nedd4-2 functionally interacts with ClC-5: involvement in constitutive albumin endocytosis in proximal tubule cells. J Biol Chem 2004; 279:54996-5007.
85. Rickheit G, Wartosch L, Schaffer S, Stobrawa SM, Novarino G, Weinert S, Jentsch TJ. Role of ClC-5 in renal endocytosis is unique among ClC exchangers and does not require PY-motif-dependent ubiquitylation. J Biol Chem 2010; 285:17595-603.
86. Pongs O. Regulation of excitability by potassium channels. Results Probl Cell Differ 2008; 44:145-61.
87. V1.4 channel at Ser229 through protein kinase A1. J Neurochem 2005; 94:1512-22.
88. Brown D. M-currents. In: Narahashi T, Ed. Ion channels. New York: Plenum Press 1988; 44.
89. V1.3) ion channel half-life and surface expression. Neuroscience 2007; 144:531-46.
90. Douglas C, Vyazovskiy V, Southard T, Chiu SY, Messing A, Tononi G, Cirelli C. Sleep in Kcna2 knockout mice. BMC Biol 2007; 5:42.
91. V1.6 influence excitability of rat visceral sensory neurons. J Physiol 2002; 541:467-82.
92. V1.6 by p38 MAPK. J Biol Chem 2010; 26149-61.
93. V channel expression. Am J Physiol Cell Physiol 2001; 281:290-9.
94. Singh NA, Otto JF, Jill Dahle E, Pappas C, Leslie JD, Vilaythong A, et al. Mouse models of human KCNQ2 and KCNQ3 mutations for benign familial neonatal convulsions show seizures and neuronal plasticity without synaptic reorganization. J Physiol 2008; 586:3405-23.
95. Volkers L, Rook MB, Das JHG, Verbeek NE, Groenewegen WA, van Kempen MJA, et al. Functional analysis of novel KCNQ2 mutations found in patients with benign familial neonatal convulsions. Neurosci Lett 2009; 462:24-9.
96. V4. J Biol Chem 2002; 277:14965-75.
97. Webster MK, Goya L, Ge Y, Maiyar AC, Firestone GL. Characterization of sgk, a novel member of the serine/threonine protein kinase gene family which is transcriptionally induced by glucocorticoids and serum. Mol Cell Biol 1993; 13:2031-40.
98. Lang F, Bohmer C, Palmada M, Seebohm G, Strutz-Seebohm N, Vallon V. (Patho)physiological significance of the serum- and glucocorticoid-inducible kinase isoforms. Physiol Rev 2006; 86:1151-78.
99. + channels. J Biol Chem 1999; 274:16973-8.
100. Imaizumi K, Tsuda M, Wanaka A, Tohyama M, Takagi T. Differential expression of sgk mRNA, a member of the Ser/Thr protein kinase gene family, in rat brain after CNS injury. Brain Res Mol Brain Res 1994; 26:189-96.
101. Nishida Y, Nagata T, Takahashi Y, Sugahara-Kobayashi M, Murata A, Asai S. Alteration of serum/glucocorticoid regulated kinase-1 (sgk-1) gene expression in rat hippocampus after transient global ischemia. Brain Res Mol Brain Res 2004; 123:121-5.
102. Hollister RD, Page KJ, Hyman BT. Distribution of the messenger RNA for the extracellularly regulated kinases 1, 2 and 3 in rat brain: effects of excitotoxic hippocampal lesions. Neuroscience 1997; 79:1111-9.
103. Murata S, Yoshiara T, Lim CR, Sugino M, Kogure M, Ohnuki T, et al. Psychophysiological stress-regulated gene expression in mice. FEBS Lett 2005; 579:2137-42.
104. Tsai KJ, Chen SK, Ma YL, Hsu WL, Lee EH. sgk, a primary glucocorticoid-induced gene, facilitates memory consolidation of spatial learning in rats. Proc Natl Acad Sci USA 2002; 99:3990-5.
105. Waldegger S, Barth P, Raber G, Lang F. Cloning and characterization of a putative human serine/threonine protein kinase transcriptionally modified during anisotonic and isotonic alterations of cell volume. Proc Natl Acad Sci USA 1997; 94:4440-5.
106. Shanmugam I, Cheng G, Terranova P, Thrasher J, Thomas C, Li B. Serum/glucocorticoid-induced protein kinase-1 facilitates androgen receptor-dependent cell survival. Cell Death Differ 2007; 14:2085-94.
107. Kumari S, Liu X, Nguyen T, Zhang X, D'Mello SR. Distinct phosphorylation patterns underlie Akt activation by different survival factors in neurons. Mol Brain Res 2001; 96:157-62.
108. de la Rosa DA, Zhang P, Náray-Fejes-Tóth A, Fejes-Tóth G, Canessa CM. The serum and glucocorticoid kinase sgk increases the abundance of epithelial sodium channels in the plasma membrane of Xenopus oocytes. J Biol Chem 1999; 274:37834-9.
109. Loffing J, Zecevic M, Feraille E, Kaissling B, Asher C, Rossier BC, et al. Aldosterone induces rapid apical translocation of ENaC in early portion of renal collecting system: possible role of SGK. Am J Physiol Renal Physiol 2001; 280:675-82.
110. Lang F, Strutz-Seebohm N, Seebohm G, Lang U. Significance of SGK1 in the regulation of neuronal function. J Physiol 2010; 588:1688-97.
111. Putz U, Howitt J, Lackovic J, Foot N, Kumar S, Silke J, Tan SS. Nedd4 family-interacting protein 1 (Ndfip1) is required for the exosomal secretion of Nedd4 family proteins. J Biol Chem 2008; 283:32621-7.
112. Howitt J, Putz U, Lackovic J, Doan A, Dorstyn L, Cheng H, et al. Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons. Proc Natl Acad Sci USA 2009; 106:15489-94.
113. Fu H, Subramanian RR, Masters SC. 14-3-3 Proteins: structure, function and regulation. Annu Rev Pharmacol Toxicol 2000; 40:617-47.
114. + channels. Biochemistry 2006; 45:6733-40.
115. + Channels by phosphorylation- dependent interaction with Nedd4-2 ubiquitin ligase. J Biol Chem 2005; 280:13187-94.
116. Bhalla V, Daidie D, Li H, Pao AC, LaGrange LP, Wang J, et al. Serum- and glucocorticoid-regulated kinase 1 regulates ubiquitin ligase neural precursor cell-expressed, developmentally downregulated protein 4-2 by inducing interaction with 14-3-3. Mol Endocrinol 2005; 19:3073-84.
117. Liang X, Peters KW, Butterworth MB, Frizzell RA. 14-3-3 isoforms are induced by aldosterone and participate in its regulation of epithelial sodium channels. J Biol Chem 2006; 281:16323-32.
118. Amerik AY, Hochstrasser M. Mechanism and function of deubiquitinating enzymes. Biochimica et Biophysica Acta 2004; 1695:189-207.
119. Setsuie R, Wada K. The functions of UCH-L1 and its relation to neurodegenerative diseases. Neurochem Int 2007; 51:105-11.
120. Hussain S, Zhang Y, Galardy P. DUBs and cancer: The role of deubiquitinating enzymes as oncogenes, nononcogenes and tumor suppressors. Cell Cycle 2009; 8:1688-97.
121. Catterall WA, Dib-Hajj S, Meisler MH, Pietrobon D. Inherited neuronal ion channelopathies: new windows on complex neurological diseases. J Neurosci 2008; 28:11768-77.
122. V7 disorders: breakdown of a subthreshold brake. J Physiol 2008; 586:1791-801.