The PY motif of ENaC, mutated in liddle syndrome, regulates channel internalization, sorting and mobilization from subapical pool

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Volumn 8, Issue 9, 2007, Pages 1246-1264

  Lu, Chen ^a   Pribanic, Sandra ^a   Debonneville, Anne ^a   Jiang, Chong ^a   Rotin, Daniela ^a  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

ENaC; Endocytosis; Liddle syndrome; Nedd4; Ubiquitin ligase; WW domain

Indexed keywords

CYCLIC AMP; MUTANT PROTEIN; PROTEIN SUBUNIT; SODIUM CHANNEL; SODIUM CHLORIDE; UBIQUITIN PROTEIN LIGASE NEDD4;

ANIMAL CELL; APICAL MEMBRANE; ARTICLE; BINDING SITE; BLOOD PRESSURE REGULATION; CELL SELECTION; CELL STRAIN; CELL SURFACE; CONTROLLED STUDY; ENDOSOME; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE MUTATION; HEREDITARY HYPERTENSION; IMAGING; INTERNALIZATION; KIDNEY TUBULE ABSORPTION; LIDDLE SYNDROME; LYSOSOME; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN MOTIF; UBIQUITINATION;

1-METHYL-3-ISOBUTYLXANTHINE; AMINO ACID MOTIFS; ANIMALS; CELL LINE; CELL MEMBRANE; CYCLIC AMP; ENDOCYTOSIS; ENZYME INHIBITORS; EPITHELIAL CELLS; EPITHELIAL SODIUM CHANNEL; HUMANS; HYPERTENSION; KINETICS; MICROSCOPY, CONFOCAL; MICROVILLI; MODELS, BIOLOGICAL; MUTATION; PROTEIN TRANSPORT; RECOMBINANT FUSION PROTEINS; SYNDROME; THIONUCLEOTIDES; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES;

EID: 34547830212     PISSN: 13989219     EISSN: 16000854     Source Type: Journal    
DOI: 10.1111/j.1600-0854.2007.00602.x     Document Type: Article

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