Ketosynthases in the initiation and elongation modules of aromatic polyketide synthases have orthogonal acyl carrier protein specificity

Biochemistry

Volumn 42, Issue 21, 2003, Pages 6588-6595

  Tang, Yi ^a   Lee, Taek Soon ^b   Kobayashi, Seiji ^a   Khosla, Chaitan ^a,b  

^a Stanford University   (United States)

^b STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; CARBOXYLATION; CATALYSIS; DIMERS; MUTAGENESIS; PROTEINS; SUBSTRATES;

CHAIN INITIATION;

AROMATIC POLYMERS;

ACETIC ACID; ACYL CARRIER PROTEIN; ACYL CARRIER PROTEIN TRANSACYLASE; KETOSYNTHASE; MALONYL COENZYME A; POLYKETIDE SYNTHASE; SYNTHETASE; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; BIOSYNTHESIS; CATALYSIS; CHEMICAL STRUCTURE; COMPLEX FORMATION; DECARBOXYLATION; DIMERIZATION; DISSOCIATION; ENZYME SPECIFICITY; ENZYME SYNTHESIS; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RNA TRANSLATION; SITE DIRECTED MUTAGENESIS;

ACYL CARRIER PROTEIN; ACYL-CARRIER PROTEIN S-MALONYLTRANSFERASE; ACYLTRANSFERASES; AMINO ACID SEQUENCE; DIMERIZATION; DNA; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; KINETICS; MODELS, CHEMICAL; MOLECULAR SEQUENCE DATA; MULTIENZYME COMPLEXES; MUTAGENESIS, SITE-DIRECTED; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; STREPTOMYCES; TIME FACTORS;

BACTERIA (MICROORGANISMS);

EID: 0037714370     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0341962     Document Type: Article

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