In vivo investigation of the roles of FdmM and FdmM1 in fredericamycin biosynthesis unveiling a new family of oxygenases

Journal of Biological Chemistry

Volumn 284, Issue 37, 2009, Pages 24735-24743

  Chen, Yilhua ^a   Wendt Pienkoski, Evelyn ^a   Rajski, Scott R ^a   Shen, Ben ^a,b  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICANCER DRUG; BIOSYNTHETIC GENE CLUSTER; FREDERICAMYCIN; IN-VIVO; MUTANT STRAIN; NATURAL PRODUCTS; OVER-EXPRESSION; OXYGENASES; POLYKETIDES; SEQUENCE HOMOLOGY; STREPTOMYCES GRISEUS; STRUCTURAL CHARACTERIZATION;

AROMATIC COMPOUNDS; BIOCHEMISTRY; BIOSYNTHESIS; GENES; HYDROXYLATION; PROTEINS;

FREQUENCY DIVISION MULTIPLEXING;

FREDERICAMYCIN A; FREDERICAMYCIN M; FREDERICAMYCIN M1; FREDERICAMYCIN M2; FREDERICAMYCIN M3; NATURAL PRODUCT; OXYGENASE; POLYKETIDE; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL STRAIN; BIOSYNTHESIS; CONTROLLED STUDY; ENZYME SYNTHESIS; FRAMESHIFT MUTATION; GENE CLUSTER; GENE OVEREXPRESSION; HETEROLOGOUS EXPRESSION; HYDROXYLATION; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; STREPTOMYCES ALBUS; STREPTOMYCES GRISEUS;

BACTERIAL PROTEINS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GENE DELETION; GENE EXPRESSION REGULATION, BACTERIAL; GENES, BACTERIAL; ISOQUINOLINES; MODELS, BIOLOGICAL; MODELS, CHEMICAL; MULTIGENE FAMILY; OXYGENASES; PLASMIDS; SPIRO COMPOUNDS; STREPTOMYCES;

STREPTOMYCES ALBUS; STREPTOMYCES GRISEUS;

EID: 69949151717     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.014191     Document Type: Article

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