Discovery of artemisinin (Qinghaosu)

Molecules

Volumn 14, Issue 12, 2009, Pages 5362-5366

  Liao, Fulong ^a  

^a INSTITUTE OF CHINESE MATERIA MEDICA   (China)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 73849093637     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules14125362     Document Type: Review

References (56)

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2. Collaboration research group for Qinghaosu. A new sesquiterpene lactone-Qinghaosu (in Chinese). Kexue Tongbao 1977, 3, 142.
3. Liu, J.; Ni, M., Fan, J.; Tu, Y. Wu, Z.; Wu, Y.; Zhou, W. Structure and reaction of Qinghaosu (in Chinese). Acta Chim. Sinica 1979, 37, 129-143.
4. Collaboration research group for Qinghaosu. Studies on new anti-malarial drug Qinghaosu (in Chinese). Yaoxue Tongbao 1979, 14, 49-53.
5. Collaboration research group for Qinghaosu. Antimalarial studies on Qinghaosu (in Chinese). Chin. Med. J. 1979, 92, 811-816
6. Tu, Y. The awarded Chinese invention: Antimalarial drug Qinghaosu (in Chinese). Rev. World Invent. 1981, 1, 6.
7. Tu, Y.; Ni, M.; Zhong, Y.; Li, L.; Cui, S.; Zhang, M.; Wang, X.; Liang, X. Studies on the constituents of Artemisia annua L (in Chinese). Yao Xue Xue Bao 1981, 16, 366-368.
8. Tu, Y.; Ni, M.; Zhong, Y.; Li, L. Studies on the constituents of Artemisia annua L. and derivatives of artemisinin (in Chinese). Zhongguo Zhong Yao Za Zhi 1981, 6, 31-32.
9. Tu, Y.; Ni, M.; Zhong, Y.; Li, L.; Cui, S.; Zhang, M.; Wang, X.; Ji, Z.; Liang, X. Studies on the constituents of Artemisia annua L. (II). Planta Med. 1982, 44, 143-145.
10. Collaboration research group for Qinghaosu. Chemical studies on Qinghaosu. J. Tradit. Chin. Med. 1982, 2 (1), 3-8.
11. Xiao, Y.; Tu, Y. Isolation and identification of the lipophilic constituents from Artemisia anomala S. Moore (in Chinese). Yao Xue Xue Bao 1984, 19, 909-913.
12. Tu, Y.; Yin, J.; Ji, L.; Huang, M.; Liang, X. Studies on the constituents of Artemisia annua L. (III) (in Chinese). Chin. Tradit. Herbal Drugs 1985, 16, 200-201.
13. Wu, C.; Tu, Y. Studies on the constituents of Artemisia apiacea Honce (in Chinese). Chin. Tradit. Herbal Drugs 1985, 6, 2-3.
14. Tu, Y. Zhu, Q.; Shen, X. Studies on the constituents of Young Artemisia annua L. (in Chinese). Zhongguo Zhong Yao Za Zhi 1985, 10, 419-420.
15. Wu, C.; Tu, Y. Studies on the constituents of Artemisia gmelinii Web.exstechm (in Chinese). Chin. Bull. Bot. 1985, 8, 34-35.
16. Wu, C.; Tu, Y. Studies on the constituents of Artemisia argyi Levl et vant (in Chinese). Zhongguo Zhong Yao Za Zhi 1985, 10, 31-32.
17. Xiao, Y.; Tu, Y. Isolation and identification of the lipophilic constituents from Artemisia anomala S. Moore (in Chinese). Acta Bot. Sinica 1986, 28, 307-310.
18. Tu, Y. To inherit and to develop the heritage of traditional Chinese medicine for the honor of the motherland (in Chinese). Zhongguo Zhong Xi Yi Jie He Za Zhi 1986, 6, 174-176.
19. Tu, Y. Study on authentic species of Chinese herbal drug Qinghao (in Chinese). Bull. Chin. Mater.Med. 1987, 12, 2-5.
20. Yin, J.; Tu, Y. Studies on the constituents of Artemisia eriopoda Bunge (in Chinese). Chin. Tradit. Herbal Drugs 1989, 20, 149-150.
21. Gu, Y.; Tu, Y. Studies on Chemical Constituents of Artemisia japonica Thunb (in Chinese). Chin. Tradit. Herbal Drugs 1993, 24, 122-124.
22. Sun, X.; Xie, S.; Long, Z.; Zhang, Z.; Tu, Y. Experimental study on the immunosuppressive effects of Qinghaosu and its derivatives (in Chinese). Zhongguo Zhong Xi Yi Jie He Za Zhi 1991, 11, 37-38.
23. Yang, S.; Xie, S.; Ma, D.; Long, Z.; Tu, Y. Immunologic enhancement and reconstitution by Qinghaosu and its derivatives (in Chinese). Chin. Bull. Pharm. 1992, 9, 61-63.
24. Chen, P.; Tu, Y.; Wang, F.; Li, F.; Yang, Lan. Effect of DihydroQinghaosu on the Development of Plasmodium Yoelii in Anopheles Stephensi (in Chinese). Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 1998, 16, 421-424.
25. Huang, L.; Liu, J.; Liu, L.; Li, D.; Zhang, Y.; Nui, H.; Song, H.; Zhang, C.; Liu, X.; Tu, Y. Studies on the Antipyretic and Anti-inflammatory Effects of Artemisia annua L (in Chinese). Zhongguo Zhong Yao Za Zhi 1993, 18, 44-48.
26. Tu, Y. The development of new antimalarial drugs: Qinghaosu and Dihydro-Qinghaosu. Chin. Med. J. 1999, 112, 976-977.
27. Xu, L.; Chen, X.; Tu, Y. Effect of Hydroartemisinin on Lupus BXSB Mice (in Chinese). Chin. J. Dermatovenerol. Integr. Tradit. West. Med. 2002, 1, 19-20.
28. Dong, Y.; Li, W.; Tu, Y. Effect of Dihydro-Qinghaosu on Auto-antibody Production, TNFα Secretion and Pathologic Change of Lupus Nephritis in BXSB Mice (in Chinese). Zhongguo Zhong Xi Yi Jie He Za Zhi 2003, 23, 676-679.
29. Dong, Y.; Li, W.; Tu, Y.; Zhang, H.; Zou, W.; Yang, L.; Lin, Z. The effects of DQHS on the pathologic changes in BXSB mice lupus nephritis and the effect mechanism (in Chinese). Chin. Pharmacol. Bull. 2003, 19, 1125-1128.
30. Tu, Y. The development of the antimalarial drugs with new type of chemical structure: Qinghaosu and DihydroQinghaosu. Southeast Asian J. Trop. Med. Public Health 2004, 35, 250-251.
31. Tu, Y. The journey of antimalarial drug-Qinghaosu. In A Collection of Memories for the Fifty Years (1955-2005) of the Institute of Chinese Materia Medica (in Chinese); Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences: Beijing, China; pp. 4-10.
32. Yang, L.; Wang, M.; Zhang, D.; Tu, Y. Determination of Scopoletin in Qinghao by HPLC (in Chinese). Chin. J. Exp. Tradit. Med. Formulae 2006, 12, 10-11.
33. Li, W.; Dong, Y.; Tu, Y.; Lin, Z. Dihydroarteannuin ameliorates lupus symptom of BXSB mice by inhibiting production of TNF-alpha and blocking the signaling pathway NF-kappa B translocation. Int. Immunopharmacol. 2006, 6, 1243-1250.
34. Zhang, D.; Yang, L.; Yang, L.; Wang, M.; Tu, Y. Determination of artemisinin, arteannuin B and artemisinic acid in Artemisia Annua by HPLC-UV-ELSD (in Chinese). Yao Xue Xue Bao 2007, 42, 978-981.
35. Tu, Y., Ed. Qinghao Ji Qinghaosulei Yaowu (Artemisia annua L., Artemisinin and Its Alikes) (in Chinese); Publisher of Chemical Industry: Beijing, China, 2009.
36. Klayman, D.L. Qinghaosu (artemisinin): An antimalarial drug from China. Science 1985, 228, 1049-1055
37. New Drug Certificate (86 X-01) for Qinghaosu, issued by the Ministry of Health, China.
38. New Drug Certicicate (92 X66,67) for Dihydro-Qinghaosu issued by the Ministry of Health.
39. New Drug Certicicate (H20030344) for Qinghaosu Tablet issued by State Food & Drug Administration (SFDA).
40. New Drug Certicicate (H20030341) for Suppositories of Dihydro-Qinghaosu issued by SFDA.
41. Antimalarial New Drug - Compound Recipe of Dihydro-Qinghaosu. Chin. Pat. Invent. ZL99109669.X, 2004.
42. Drugs Containing Dihydro-Qinghaosu for Treatment of Lupus Erythematosus and Photoallergic Diseases. Chin. Pat. Invent. ZL99103346.9, 2004.
43. Clinical Approval of Dihydro-Qinghaosu for Treatment of Lupus Erythematosus (2004L02089) issued by SFDA, June 2004.
44. Award for progress in anti-malarial research achieved by "Project 523" Scientific Team, by National Congress of Science and Technology, 1978
45. National Scientific Discovery Award for Antimalaria Drug - Qinghaosu, by the Committee of Science and Technology, China, 1979.
46. Invention Award (Tu as the first inventor), by National Congress for Awards in Science and Technology, 1982.
47. Young and Middle-aged Experts with Outstanding Contribution, by National Ministry of Personnel, 1984.
48. Dihydro-Qinghaosu and its Tablet were awarded as the Top Ten National Achievements for Progress in Science and Technology by National Committee of Science and Technology in 1992.
49. Quality Studies on commonly used Chinese Matria Medica (Artemisia annua L. is one of them), First-rate Award of National Achievements in Science and Technology, National Award Committee for Advances in Science and Technology, 1992.
50. National Model Worker, by the State Council, 1995.
51. Award for Outstanding Achievement in Traditional Chinese Medicine, by Guangzhou Zhongjing Award Foundation for Traditional Chinese Medicine, 1995.
52. Outstanding Scientific Achievement Award, by Qiu Shi Science and Technologies Foundation of Hong Kong, 1996.
53. Dihydro-Qinghaosu and its Tablet was awarded as the Top Ten Health Achievements in New China, by Ministry of Health in 1997.
54. Woman Inventor of the New Century, by National Bureau of Intellectual Property, 2002.
55. th National Invention Exhibition, by National Bureau of Intellectual Property, 2003.
56. Award for Development of Chinese Materia Medica, Cyrus Chung Ying Tang Foundation, 2009.