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Volumn 6, Issue 11, 2005, Pages 2048-2054

Enantiomeric 1,2,4-trioxanes display equivalent in vitro antimalarial activity versus Plasmodium falciparum malaria parasites: Implications for the molecular mechanism of action of the artemisinins

(9) O'Neill, Paul M a Rawe, Sarah L a Borstnik, Kristina c Miller, Alison a Ward, Stephen A b Bray, Patrick G b Davies, Jill b Oh, Chang Ho d Posner, Gary H c

a UNIVERSITY OF LIVERPOOL (United Kingdom)

b LIVERPOOL SCHOOL OF TROPICAL MEDICINE (United Kingdom)

c JOHNS HOPKINS UNIVERSITY (United States)

d Hanyang University (South Korea)

Author keywords

Artemisinin; Asymmetric synthesis; Chirality; Drug design; Medicinal chemistry

Indexed keywords

1,2,4 TRIOXANE DERIVATIVE; ARTEMISININ DERIVATIVE;

ANTIMALARIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG SYNTHESIS; ENANTIOMER; MALARIA FALCIPARUM; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN TARGETING; STEREOCHEMISTRY; STRAIN IDENTIFICATION;

ANIMALS; ANTIMALARIALS; ARTEMISININS; DRUG DESIGN; HETEROCYCLIC COMPOUNDS; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; PARASITIC SENSITIVITY TESTS; PLASMODIUM FALCIPARUM; STEREOISOMERISM;

PLASMODIUM FALCIPARUM;

EID: 27744592680 PISSN: 14394227 EISSN: None Source Type: Journal
DOI: 10.1002/cbic.200500048 Document Type: Article

Times cited : (59)

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