Telomerase recruitment in Saccharomyces cerevisiae is not dependent on Tel1-mediated phosphorylation of Cdc13

Genetics

Volumn 186, Issue 4, 2010, Pages 1147-1159

  Gao, Hua ^a,b,d   Toro, Tasha B ^a,b,e   Paschini, Margherita ^a,c   Braunstein Ballew, Bari ^a,c   Cervantes, Rachel B ^a   Lundblad, Victoria ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^e BURNHAM INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; CDC13 PROTEIN; DOUBLE STRANDED DNA; SERINE; TEL1 PROTEIN; TELOMERASE; UNCLASSIFIED DRUG;

ARTICLE; CHROMOSOME SIZE; DOUBLE STRANDED DNA BREAK; GENE FUNCTION; GENE LOCUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; SACCHAROMYCES CEREVISIAE; TELOMERE;

HEMOSTASIS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN ISOFORMS; PROTEIN TRANSPORT; PROTEIN-SERINE-THREONINE KINASES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TELOMERASE; TELOMERE; TELOMERE-BINDING PROTEINS;

SACCHAROMYCES CEREVISIAE;

EID: 79251551669     PISSN: 00166731     EISSN: 00166731     Source Type: Journal    
DOI: 10.1534/genetics.110.122044     Document Type: Article

References (45)

1. ABDALLAH, P., P. LUCIANO, K. W. RUNGE, M. LISBY, V. GELI et al., 2009 A two-step model for senescence triggered by a single critically short telomere. Nat. Cell. Biol. 11: 988-993.
2. ANDERSON, C. M., D. KORKIN, D. L. SMITH, S. MAKOVETS, J. J. SEIDEL et al., 2008 Tel2 mediates activation and localization of ATM/Tel1 kinase to a double-strand break. Genes Dev. 22: 854-859.
3. ANDERSON, E. M., W. A. HALSEY and D. S. WUTTKE, 2003 Site-directed mutagenesis reveals the thermodynamic requirements for single-stranded DNA recognition by the telomere-binding protein Cdc13. Biochemistry 42: 3751-3758.
4. ARNERIC, M., and J. LINGNER, 2007 Tel1 kinase and subtelomere-bound Tbf1 mediate preferential elongation of short telomeres by telomerase in yeast. EMBO Rep. 8: 1080-1085.
5. BIANCHI, A., and D. SHORE, 2007 Increased association of telomerase with short telomeres in yeast. Genes Dev. 21: 1726-1730. (Pubitemid 47076472)
6. BIANCHI, A., S. NEGRINI AND D. SHORE, 2004 Delivery of yeast telomerase to a DNA break depends on the recruitment functions of Cdc13 and Est1. Mol. Cell 16: 139-146.
7. BUCKLEY, K., 2005 Investigating the recruitment of telomerase to the telomere in Saccharomyces cerevisiae. Ph.D. Thesis, Baylor College of Medicine, Houston, Texas.
8. CHAN, A., J. B. BOULE and V. A. ZAKIAN, 2008 Two pathways recruit telomerase to Saccharomyces cerevisiae telomeres. PLoS Genet. 4: 1-11.
9. CHAN, S. W., J. CHANG, J. PRESCOTT and E. H. BLACKBURN, 2001 Altering telomere structure allows telomerase to act in yeast lacking ATM kinases. Curr. Biol. 11: 1240-1250.
10. CHANDRA, A., T. R. HUGHES, C. I. NUGENT AND V. LUNDBLAD, 2001 Cdc13 both positively and negatively regulates telomere replication. Genes Dev. 15: 404-414.
11. CHANG, M., M. ARNERIC and J. LINGNER, 2007 Telomerase repeat addition processivity is increased at critically short telomeres in a Tel1-dependent manner in Saccharomyces cerevisiae. Genes Dev. 21: 2485-2494.
12. CHEN, S. H., C. P. ALBUQUERQUE, J. LIANG, R. T. SUHANDYNATA and H. ZHOU, 2010 A proteome-wide analysis of kinase-substrate network in the DNA damage response. J. Biol. Chem. 285: 12803-12812.
13. EVANS, S. K., and V. LUNDBLAD, 1999 Est1 and Cdc13 as comediators of telomerase access. Science 286: 117-120.
14. FRANK, C. J., M. HYDE and C. W. GREIDER, 2006 Regulation of telomere elongation by the cyclin-dependent kinase CDK1. Mol. Cell 24: 423-432.
15. GAO, H., R. B. CERVANTES, E. K. MANDELL, J. H. OTERO and V. LUNDBLAD, 2007 RPA-like proteins mediate yeast telomere function. Nat. Struct. Mol. Biol. 14: 208-214.
16. GELINAS, A. D., M. PASCHINI, F. E. REYES, A. HEROUX, R. T. BATEY et al., 2009 Telomere capping proteins are structurally related to RPA with an additional telomere-specific domain. Proc. Natl. Acad. Sci. USA 106: 19298-19303.
17. GOUDSOUZIAN, L. K., C. T. TUZON and V. A. ZAKIAN, 2006 S. cerevisiae Tel1p and Mre11p are required for normal levels of Est1p and Est2p telomere association. Mol. Cell 24: 603-610.
18. HECTOR, R. E., R. L. SHTOFMAN, A. RAY, B. R. CHEN, T. NYUN et al., 2007 Tel1p preferentially associates with short telomeres to stimulate their elongation. Mol. Cell 27: 851-858.
19. KIM, S. T., D. S. LIM, C. E.CANMAN and M. B. KASTAN, 1999 Substrate specificities and identification of putative substrates of ATMkinase family members. J. Biol. Chem. 274: 37538-37543.
20. LARRIVEE, M., C. LEBEL and R. J. WELLINGER, 2004 The generation of proper constitutive G-tails on yeast telomeres is dependent on the MRX complex. Genes Dev. 18: 1391-1396.
21. LENDVAY, T. S., D. K. MORRIS, J. SAH, B. BALASUBRAMANIAN and V. LUNDBLAD, 1996 Senescence mutants of Saccharomyces cerevisiae with a defect in telomere replication identify three additional EST genes. Genetics 144: 1399-1412.
22. LI, S., S. MAKOVETS, T.MATSUGUCHI, J. D. BLETHROW, K.M. SHOKAT et al., 2009 Cdk1-dependent phosphorylation of Cdc13 coordinates telomere elongation during cell-cycle progression. Cell 136: 50-61.
23. LUNDBLAD, V., and J.W. SZOSTAK, 1989 A mutant with a defect in telomere elongation leads to senescence in yeast. Cell 57: 633-643.
24. LUSTIG, A. J., and T. D. PETES, 1986 Identification of yeast mutants with altered telomere structure. Proc. Natl. Acad. Sci. USA 83: 1398-1402.
25. MALLORY, J. C., and T. D. PETES, 2000 Protein kinase activity of Tel1p and Mec1p, two Saccharomyces cerevisiae proteins relates to the human ATM protein kinase. Proc. Natl. Acad. Sci. USA 97: 13749-13754.
26. MANTIERO, D., M. CLERICI, G. LUCCHINI and M. P. LONGHESE, 2007 Dual role for Saccharomyces cerevisiae Tel1 in the checkpoint response to double-strand breaks. EMBO Rep. 8: 380-387.
27. MARCAND, S., V. BREVET, C. MANN and E. GILSON, 2000 Cell cycle restriction of telomere elongation. Curr. Biol. 10: 487-490.
28. MEIER, B., L. DRILLER, S. JAKLIN and H. M. FELDMANN, 2001 New function of CDC13 in positive telomere length regulation. Mol. Cell. Biol. 21: 4233-4245.
29. NUGENT, C. I., T. R. HUGHES, N. F. LUE and V. LUNDBLAD, 1996 Cdc13p: a single-strand telomeric DNA-binding protein with a dual role in yeast telomere maintenance. Science 274: 249-252.
30. NUGENT, C. I., G. BOSCO, L.O. ROSS, S.K. EVANS, A. P. SALINGER et al., 1998 Telomere maintenance is dependent on activities required for end repair of double-strand breaks. Curr. Biol. 8: 657-660.
31. PASCHINI, M.,E.K.MANDELL and V. LUNDBLAD, 2010 Structure prediction- driven genetics in Saccharomyces cerevisiae identifies an interface between the t-RPA proteins Stn1 and Ten1. Genetics 185: 11-21.
32. PENNOCK, E., K. BUCKLEY and V. LUNDBLAD, 2001 Cdc13 delivers separate complexes to the telomere for end protection and replication. Cell 104: 387-396.
33. QI, H., and V. A. ZAKIAN, 2000 The Saccharomyces telomere-binding protein Cdc13p interacts with both the catalytic subunit of DNA polymerase a and the telomerase-associated Est1 protein. Genes Dev. 14: 1777-1788.
34. RITCHIE, K. B., and T. D. PETES, 2000 The Mre11p/Rad50p/Xrs2p complex and the Tel1p function in a single pathway for telomere maintenance in yeast. Genetics 155: 475-479.
35. RITCHIE, K. B., J. C. MALLORY and T. D. PETES, 1999 Interactions of TLC1 (which encodes the RNA subunit of telomerase), TEL1, and MEC1 in regulating telomere length in the yeast Saccharomyces cerevisiae. Mol. Cell. Biol. 19: 6065-6075.
36. RIZKI, A., and V. LUNDBLAD, 2001 Defects in mismatch repair promote telomerase-independent proliferation. Nature 411: 713-716. (Pubitemid 32531679)
37. SABOURIN, M., C. T. TUZON and V. A. ZAKIAN, 2007 Telomerase and Tel1p preferentially associate with short telomeres in S. cerevisiae. Mol. Cell 27: 550-561.
38. SMOLKA, M. B., C. P. ALBUQUERQUE, S. H. CHEN and H. ZHOU, 2007 Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases. Proc. Natl. Acad. Sci. USA 104: 10364-10369.
39. SUN, J., E. Y. YU, Y. YANG, L. A. CONFER, S. H. SUN et al., 2009 Stn1-Ten1 is an Rpa2-Rpa3-like complex at telomeres. Genes Dev. 23: 2900-2914.
40. TAKATA, H., Y. KANOH, N. GUNGE, K. SHIRAHIGE and A. MATSUURA, 2004 Reciprocal association of the budding yeast ATM-related proteins Tel1 and Mec1 with telomeres in vivo. Mol. Cell 14: 515-522.
41. TAKATA, H., Y. TANAKA and A. MATSUURA, 2005 Late S phasespecific recruitment of Mre11 complex triggers hierarchical assembly of telomere replication proteins in Saccharomyces cerevisiae. Mol. Cell 17: 573-583.
42. TEIXEIRA, M. T., M. ARNERIC, P. SPERISEN and J. LINGNER, 2004 Telomere length homeostasis is achieved via a switch between telomerase-extendible and -nonextendible states. Cell 117: 323-335.
43. TRAVEN, A., and J. HEIERHORST, 2005 SQ/TQ cluster domains: concentrated ATM/ATR kinase phosphorylation site regions in DNA-damage-response proteins. Bioessays 27: 397-407.
44. TSENG, S. F., J. J. LIN and S. C. TENG, 2006 The telomeraserecruitment domain of the telomere binding protein Cdc13 is regulated by Mec1p/Tel1p-dependent phosphorylation. Nucleic Acids Res. 34: 6327-6336.
45. ZHANG, W., and D. DUROCHER, 2010 De novo telomere formation is suppressed by the Mec1-dependent inhibition of Cdc13 accumulation at DNA breaks. Genes Dev. 24: 502-515.