New function of CDC13 in positive telomere length regulation

Molecular and Cellular Biology

Volumn 21, Issue 13, 2001, Pages 4233-4245

  Meier, B ^a   Driller, L ^a   Jaklin, S ^a   Feldmann, H M ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CDC13 PROTEIN; CELL CYCLE PROTEIN; TELOMERASE; UNCLASSIFIED DRUG;

ARTICLE; CHROMOSOME; HUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SACCHAROMYCES CEREVISIAE; STEADY STATE; TELOMERE;

BLOTTING, SOUTHERN; CYCLIN B; DNA, FUNGAL; DNA-BINDING PROTEINS; FUNGAL PROTEINS; GALACTOSE; GENE TARGETING; GLUCOSE; MUTATION; PHENOTYPE; PLASMIDS; PRECIPITIN TESTS; RECOMBINANT FUSION PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TELOMERASE; TELOMERE;

SACCHAROMYCES CEREVISIAE;

EID: 0034978934     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.21.13.4233-4245.2001     Document Type: Article

References (60)

1. The succinate/fumarate transporter Acr1p of Saccharomyces cerevisiae is part of the gluconeogenic pathway and its expression is regulated by Cat8p
2. Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing
3. Identification of a Saccharomyces cerevisiae Ku80 homologue: Roles in DNA double strand break rejoining and in telomeric maintenance
4. Saccharomyces cerevisiae Ku70 potentiates illegitimate DNA double-strand break repair and serves as a barrier to error-prone DNA repair pathways
5. Sir proteins, Rif proteins, and Cdc13p bind Saccharomyces telomeres in vivo
6. Telomerase in yeast
7. RAP1 protein interacts with yeast telomeres in vivo: Overproduction alters telomere structure and decreases chromosome stability
8. The catalytic subunit of yeast telomerase
9. Yeast G1 cyclins CLN1 and CLN2 and a GAP-like protein have a role in bud formation
10. Telomerase-mediated telomere addition in vivo requires DNA primase and DNA polymerases alpha and delta
11. Cell cycle-regulated generation of single-stranded G-rich DNA in the absence of telomerase
12. Est1 and Cdc13 as comediators of telomerase access
13. Mutations in the RNA polymerase II transcription machinery suppress the hyperrecombination mutant hpr1 delta of Saccharomyces cerevisiae
14. HDF2, the second subunit of the Ku homologue from Saccharomyces cerevisiae
15. A putative homologue of the human autoantigen Ku from Saccharomyces cerevisiae
16. Single-stranded DNA arising at telomeres in cdc13 mutants may constitute a specific signal for the RAD9 checkpoint
17. A novel protein complex promoting formation of functional alpha- and gamma-tubulin
18. Cdc13 cooperates with the yeast Ku proteins and Stn1 to regulate telomerase recruitment
19. Yeast Ku as a regulator of chromosomal DNA end structure
20. TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene
21. A RAP1-interacting protein involved in transcriptional silencing and telomere length regulation
22. An overhanging 3′ terminus is a conserved feature of telomeres
23. Identification of the single-strand telomeric DNA binding domain of the Saccharomyces cerevisiae Cdc13 protein
24. All gene-sized DNA molecules in four species of hypotrichs have the same terminal sequence and an unusual 3′ terminus
25. The yeast telomere length regulator TEL2 encodes a protein that binds to telomeric DNA
26. Cloning by function: An alternative approach for identifying yeast homologs of genes from other organisms
27. RAD50 and RAD51 define two pathways that collaborate to maintain telomeres in the absence of telomerase
28. Senescence mutants of Saccharomyces cerevisiae with a defect in telomere replication identify three additional EST genes
29. The Saccharomyces CDC13 protein is a single-strand TG1-3 telomeric DNA-binding protein in vitro that affects telomere behavior in vivo
30. Three ever shorter telomere (EST) genes are dispensable for in vitro yeast telomerase activity
31. Mutational analysis defines a C-terminal tail domain of RAP1 essential for telomeric silencing in Saccharomyces cerevisiae
32. Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae
33. - senescence
34. A mutant with a defect in telomere elongation leads to senescence in yeast
35. Identification of yeast mutants with altered telomere structure
36. Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening
37. Progressive cis-inhibition of telomerase upon telomere elongation
38. A protein-counting mechanism for telomere length regulation in yeast
39. The terminal DNA structure of mammalian chromosomes
40. Cdc13p: A single-strand telomeric DNA-binding protein with a dual role in yeast telomere maintenance
41. The telomerase reverse transcriptase: Components and regulation
42. Genetic applications of yeast transformation with linear and gapped plasmids
43. Cdc13 delivers separate complexes to the telomere for end protection and replication
44. The DNA-binding protein Hdf1p (a putative Ku homologue) is required for maintaining normal telomere length in Saccharomyces cerevisiae
45. The Saccharomyces telomere-binding protein Cdc13p interacts with both the catalytic subunit of DNA polymerase alpha and the telomerase-associated est1 protein
46. The yeast telomere length counting machinery is sensitive to sequences at the telomere-nontelomere junction
47. The Mre1 1p/Rad50p/Xrs2p complex and the tel 1p function in a single pathway for telomere maintenance in yeast
48. TEL2, an essential gene required for telomere length regulation and telomere position effect in Saccharomyces cerevisiae
49. Loss of a yeast telomere: Arrest, recovery, and chromosome loss
50. High efficiency transformation of intact yeast cells using single stranded nucleic acids as a carrier
51. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae
52. TLC1: Template RNA component of Saccharomyces cerevisiae telomerase
53. Telomere-telomere recombination is an efficient bypass pathway for telomere maintenance in Saccharomyces cerevisiae
54. TRF2 protects human telomeres from end-to-end fusions
55. New heterologous modules for classical or PCR-based gene disruptions in Saccharomyces cerevisiae
56. Cell cycle arrest of cdc mutants and specificity of the RAD9 checkpoint
57. Evidence for a new step in telomere maintenance
58. Saccharomyces telomeres acquire single-strand TG1-3 tails late in S phase
59. A novel Rap1p-interacting factor, Rif2p, cooperates with Rif1p to regulate telomere length in Saccharomyces cerevisiae
60. Normal human chromosomes have long G-rich telomeric overhangs at one end