Tel1 kinase and subtelomere-bound Tbf1 mediate preferential elongation of short telomeres by telomerase in yeast

EMBO Reports

Volumn 8, Issue 11, 2007, Pages 1080-1085

  Arnerić, Milica ^a   Lingner, Joachim ^a  

^a EPFL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATIDYLINOSITOL 3 KINASE; TEL1 KINASE; TELOMERASE; TELOMERE BINDING PROTEIN; TELOMERE BINDING PROTEIN 1; UNCLASSIFIED DRUG;

ARTICLE; CHROMOSOME; CONTROLLED STUDY; HOMEOSTASIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; TELOMERE; WILD TYPE; YEAST;

DNA-BINDING PROTEINS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; PROTEIN-SERINE-THREONINE KINASES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TELOMERASE; TELOMERE;

EID: 35748941663     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1038/sj.embor.7401082     Document Type: Article

References (31)

1. 2 telomere in yeast. EMBO J 22: 1688-1696
2. Berthiau AS, Yankulov K, Bah A, Revardel E, Luciano P, Wellinger PJ, Geli V, Gilson E (2006) Subtelomeric proteins negatively regulate telomere elongation in budding yeast. EMBO J 25: 846-856
3. Bianchi A, Shore D (2007) Increased association of telomerase with short telomeres in yeast. Genes Dev 21: 1726-1730
4. Brevet V, Berthiau AS, Civitelli L, Donini P, Schramke V, Geli V, Ascenzioni F, Gilson E (2003) The number of vertebrate repeats can be regulated at yeast telomeres by Rap1-independent mechanisms. EMBO J 22: 1697-1706
5. Chan SW, Chang J, Prescott J, Blackburn EH (2001) Altering telomere structure allows telomerase to act in yeast lacking ATM kinases. Curr Biol 11: 1240-1250
6. Cooper JP, Nimmo ER, Allshire RC, Cech TR (1997) Regulation of telomere length and function by a Myb-domain protein in fission yeast. Nature 385: 744-747
7. Crabbe L, Veraun RE, Haggblom CI, Karlseder J (2004) Defective telomere. lagging strand synthesis in cells lacking WRN helicase activity. Science 306: 1951-1953
8. Craven RJ, Greenwell PW, Dominska M, Petes TD (2002) Regulation of genome stability by TEL1 and MEC1 yeast homologs of the mammalian ATM and ATR genes. Genetics 161: 493-507
9. Evans SK, Lundblad V (1999) Est1 and Cdc13 as comediators of telomerase access. Science 286: 117-120
10. Fisher TS, Taggart AK, Zakian VA (2004) Cell cycle-dependent regulation of yeast telomerase by Ku. Nat Struct Mol Biol 11: 1198-1205
11. Forstemann K, Lingner J (2001) Molecular basis for telomere repeat divergence in budding yeast. Mol Cell Biol 21: 7277-7286
12. Forstemann K, Hoss M, Ligner J (2000) Telomerase-dependent repeat divergence at the 3′ ends of yeast telomeres. Nucleic Acids Res 28: 2690-2694
13. Goudsouzian LK, Tuzon CT, Zakian VA (2006) S. cerevisiae Tel1p and Mre11p are required for normal levels of Est1p and Est2p telomere association. Mol Cell 24: 603-610
14. Greenwell PW, Kronmal SL, Porter SE, Gassenhuber J, Obermaier B, Petes TD (1995) TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene. Cell 42: 823-829
15. Ivessa AS, Zhou JQ, Schulz VP, Monson EK, Zakian VA (2002) Saccharomyces Rrm3p, a 5′ to 3′ DNA helicase that promotes replication fork progression through telomeric and subtelomeric DNA. Genes Dev 16: 1383-1396
16. Koering CE, Fourel G, Binet-Brasselet E, Laroche T, Klein F, Gilson E (2000) Identification of high affinity Tbf1p-binding sites within the budding yeast genome. Nucleic Acids Res 28: 2519-2526
17. Krauskopf A, Blackburn EH (1996) Control of telomere growth by interactions of RAP1 with the most distal telomeric repeat. Nature 383: 354-357
18. Kyrion G, Boakye KA, Lustig AJ (1992) C-termimal truncation of RAP1 results in the deregulation of telomere size, stability, and function in Saccharomyces cerevisiae. Mol Cell Biol 12: 5159-5173
19. Lundblad V, Szostak JW (1989) A mutant with a defect in telomere elongation leads to senescence in yeast. Cell 57: 633-643
20. Marcand S, Gilson E, Shore D (1997) A protein-counting mechanism for telomere length regulation in yeast. Science 275: 986-990
21. Pennock E, Buckley K, Lundblad V (2001) Cdc13 delivers separate complexes to the telomere for end protection and replication. Cell 104: 387-396
22. Ray A, Runge KW (1999) Varying the number of telomere-bound proteins does not alter telomere length in tel1Δ cells. Proc Natl Acad Sci USA 96: 15044-15049
23. Ritchie KB, Mallory JC, Petes TD (1999) Interactions of TLC1 (which encodes the RNA subunit of telomerase), TEL1, and MEC1 in regulating telomere length in the yeast Saccharomyces cerevisiae. Mol Cell Biol 19: 6065-6075
24. Sabourin M, Tuzon CT, Zakian VA (2007) Telomerase and Tel1p preferentially associate with short telomeres in S. cerevisiae. Mol Cell 27: 550-561
25. Singer MS, Gottschling DE (1994) TLC1: Template RNA component of Saccharomyces cerevisiae telomerase. Science 266: 404-409
26. Teixeira MT, Forstemann K, Gasser SM, Lingner J (2002) Intracellular trafficking of yeast telomerase components. EMBO Rep 3: 652-659
27. Teixeira MT, Arneric M, Sperisen P, Lingner J (2004) Telomere length homeostasis is achieved via a switch between telomerase-extendible and -nonextendible states. Cell 117: 323-335
28. Tseng SF, Lin JJ, Teng SC (2006) The telomerase-recruitment domain of the telomere binding protein Cdc13 is regulated by Mec1p/Tel1p-dependent phosphorylation. Nucleic Acids Res 34: 6327-6336
29. Tsukamoto Y, Taggart AK, Zakian VA (2001) The role of the Mre11-Rad50-Xrs2 complex in telomerase-mediated lengthening of Saccharomyces cerevisiae telomeres. Curr Biol 11: 1328-1335
30. Wotton D, Shore D (1997) A novel Rap1p-interacting factor, Rif2p, cooperates with Rif1p to regulate telomere length in Saccharomyces cerevisiae. Genes Dev 11: 748-760
31. Zhao X, Chabes A, Domkin V, Thelander L, Rothstein R (2001) The ribonucleotide reductase inhibitor Sml1 is a new target of the Mec1/ Rad53 kinase cascade during growth and in response to DNA damage. EMBO J 120: 3544-3553