Perturbations in ataxia telangiectasia mutant signaling pathways after drug-induced acute liver failure and their reversal during rescue of animals by cell therapy

American Journal of Pathology

Volumn 178, Issue 1, 2011, Pages 161-174

  Bandi, Sriram ^a   Joseph, Brigid ^a   Berishvili, Ekaterine ^a,b   Singhania, Rohit ^a,c   Wu, Yao Ming ^a,d   Cheng, Kang ^a,e   Gupta, Sanjeev ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b TBILISI STATE MEDICAL UNIVERSITY   (Georgia)

^c ST LUKE S ROOSEVELT HOSPITAL CENTER   (United States)

^d NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^e LONG ISLAND JEWISH MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; CASPASE 8; CHAPERONIN; CYCLIN D1; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLIN G1; CYTOCHROME P450 1B1; CYTOCHROME P450 2A5; CYTOCHROME P450 2B9; CYTOCHROME P450 3A11; CYTOCHROME P450 3A4; EARLY GROWTH RESPONSE FACTOR 1; FAS LIGAND; GLUTATHIONE PEROXIDASE 2; GLUTATHIONE TRANSFERASE; HEME OXYGENASE 1; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 6; LIPOCORTIN 5; MONOCROTALINE; PHENYTOIN; PROTEIN BCL 2; PROTEIN KINASE; RIFAMPICIN; URACIL DNA GLYCOSIDASE;

ACUTE LIVER FAILURE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CYCLE ARREST; CELL GROWTH; CELL THERAPY; CELL TRANSPLANTATION; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; GENE EXPRESSION REGULATION; GENE MUTATION; HISTOPATHOLOGY; HUMAN; LIVER CELL; LIVER INJURY; METABOLIC STRESS; MOUSE; NONHUMAN; OXIDATIVE STRESS; PERITONEAL CAVITY; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

EID: 79251501338     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2010.11.001     Document Type: Article

References (44)

1. Murray KF, Hadzic N, Wirth S, Bassett M, Kelly D: Drug-related hepatotoxicity and acute liver failure. J Pediatr Gastroenterol Nutr 2008, 47:395-405
2. Jaeschke H: Innate immunity and acetaminophen-induced liver injury: why so many controversies? Hepatology 2008, 48:699-701
3. Avraham Y, Grigoriadis NC, Magen I, Poutahidis T, Vorobiav L, Zolotarev O, Ilan Y, Mechoulam R, Berry EM: Capsaicin affects brain function in a model of hepatic encephalopathy associated with fulminant hepatic failure in mice. Br J Pharmacol 2009, 158:896-906
4. Bémeur C, Vaquero J, Desjardins P, Butterworth RF: N-acetylcysteine attenuates cerebral complications of non-acetaminophen-induced acute liver failure in mice: antioxidant and anti-inflammatory mechanisms. Metab Brain Dis 2010, 25:241-249
5. Shinohara M, Ybanez MD, Win S, Than TA, Jain S, Gaarde WA, Han D, Kaplowitz N: Silencing glycogen synthase kinase-3beta inhibits acetaminophen hepatotoxicity and attenuates JNK activation and loss of glutamate cysteine ligase and myeloid cell leukemia sequence 1. J Biol Chem 2010, 285:8244-8255
6. Wu YM, Joseph B, Berishvili E, Kumaran V, Gupta S: Hepatocyte transplantation and drug-induced perturbations in liver cell compartments. Hepatology 2008, 47:279-287
7. Fisher RA, Strom SC: Human hepatocyte transplantation: worldwide results. Transplantation 2006, 82:441-449
8. Gupta S, Rajvanshi P, Irani AN, Palestro CJ, Bhargava KK: Integration and proliferation of transplanted cells in hepatic parenchyma following D-galactosamine-induced acute injury in F344 rats. J Pathol 2000, 190:203-210
9. Gupta S, Vemuru RP, Lee C-D, Yerneni P, Aragona E, Burk RD: Hepatocytes exhibit superior transgene expression after transplantation into liver and spleen compared with peritoneal cavity or dorsal fat pad: implications for hepatic gene therapy. Human Gene Ther 1994, 5:959-967 (Pubitemid 24304757)
10. Rajvanshi P, Kerr A, Bhargava KK, Burk RD, Gupta S: Studies of liver repopulation using the dipeptidyl peptidase IV deficient rat and other rodent recipients: cell size and structure relationships regulate capacity for increased transplanted hepatocyte mass in the liver lobule. Hepatology 1996, 23:482-496
11. Gupta S, Rajvanshi P, Malhi H, Sokhi RP, Slehria S, Vasa SRG, Dabeva M, Shafritz DA, Kerr A: Cell transplantation causes loss of gap junctions and activates GGT expression permanently in host liver. Am J Physiol Gastroint Liver Physiol 2000, 279:G815-G826
12. Slehria S, Rajvanshi P, Ito Y, Sokhi RP, Bhargava KK, Palestro CJ, McCuskey RS, Gupta S: Hepatic sinusoidal vasodilators improve transplanted cell engraftment and ameliorate microcirculatory perturbations in the liver. Hepatology 2002, 35:1320-1328 (Pubitemid 34966886)
13. Joseph B, Malhi H, Bhargava KK, Palestro CJ, McCuskey RS, Gupta S: Kupffer cells participate in early clearance of syngeneic hepatocytes transplanted in the rat liver. Gastroenterology 2002, 123:1677-1685
14. Krohn N, Kapoor S, Enami Y, Follenzi A, Bandi S, Joseph B, Gupta S: Hepatocyte transplantation-induced liver inflammation is driven by cytokines-chemokines associated with neutrophils and Kupffer cells. Gastroenterology 2009, 136:1806-1817
15. Demetriou AA, Whiting JF, Feldman D, Levenson SM, Chowdhury NR, Moscioni AD, Kram M, Chowdhury JR: Replacement of liver function in rats by transplantation of microcarrier-attached hepatocytes. Science 1986, 233:1190-1192
16. Kumaran V, Benten D, Follenzi A, Joseph B, Sarkar R, Gupta S: Transplantation of endothelial cells corrects the phenotype in hemophilia A mice. J Thromb Haemost 2005, 3:2022-2031 (Pubitemid 43086060)
17. Guide for the Care and Use of Laboratory Animals. Institute of Laboratory Animal Resources, Commission on Life Sciences, National Research Council, National Academy Press, Washinton, D.C., 1996.
18. Gagandeep S, Ott M, Sokhi R, Gupta S: Rapid clearance of syngeneic transplanted hepatocytes following transduction with E-1-deleted adenovirus indicates early host immune responses and offers novel ways for studying viral vector, target cell and host interactions. Gene Ther 1999, 6:729-736
19. Morishita K, Mizukawa Y, Kasahara T, Okuyama M, Takashima K, Toritsuka N, Miyagishima T, Nagao T, Urushidani T: Gene expression profile in liver of differing ages of rats after single oral administration of acetaminophen. J Toxicol Sci 2006, 31:491-507
20. Quaglia A: Auxiliary transplantation for acute liver failure: histopathological study of native liver regeneration. Liver Transpl 2008, 14: 1437-1448
21. Fulop GM, Phillips RA: The scid mutation in mice causes a general defect in DNA repair. Nature 1990, 347:479-482
22. Jhappan C, Morse HC 3rd, Fleischmann RD, Gottesman MM, Merlino G: DNA-PKcs: a T-cell tumour suppressor encoded at the mouse scid locus. Nat Genet 1997, 17:483-486
23. De Lazzari E, León A, Arnaiz JA, Martinez E, Knobel H, Negredo E, Clotet B, Montaner J, Storfer S, Asenjo MA, Mallolas J, Miró JM, Gatell JM: Hepatotoxicity of nevirapine in virologically suppressed patients according to gender and CD4 cell counts. HIV Med 2008, 9:221-226
24. Geisert EE, Lu L, Freeman-Anderson NE, Templeton JP, Nassr M, Wang X, Gu W, Jiao Y, Williams RW: Gene expression in the mouse eye: an online resource for genetics using 103 strains of mice. Mol Vis 2009, 15:1730-1763
25. Cheng J, Ma X, Krausz KW, Idle JR, Gonzalez FJ: Rifampicin-activated human pregnane X receptor and CYP3A4 induction enhance acetaminophen-induced toxicity. Drug Metab Dispos 2009, 37:1611-1621
26. Lu S, Shen KC, Wang Y, Brooks SC, Wang YA: Impaired hepatocyte survival and liver regeneration in Atm-deficient mice. Hum Mol Genet 2005, 14:3019-3025 (Pubitemid 41535467)
27. Bhuller Y, Jeng W, Wells PG: Variable in vivo embryoprotective role for ataxia-telangiectasia-mutated against constitutive and phenytoin-enhanced oxidative stress in Atm knockout mice. Toxicol Sci 2006, 93:146-155
28. Ravi D, Muniyappa H, Das KC: Caffeine inhibits UV-mediated NF-kappaB activation in A2058 melanoma cells: an ATM-PKCdelta-p38 MAPK-dependent mechanism. Mol Cell Biochem 2008, 308:193-200
29. Sato C, Izumi N: Mechanism of increased hepatotoxicity of acetaminophen by the simultaneous administration of caffeine in the rat. J Pharmacol Exp Ther 1989, 248:1243-1247
30. Gueven N, Keating K, Fukao T, Loeffler H, Kondo N, Rodemann HP, Lavin MF: Site-directed mutagenesis of the ATM promoter: consequences for response to proliferation and ionizing radiation. Genes Chromosomes Cancer 2003, 38:157-167
31. Gueven N, Keating KE, Chen P, Fukao T, Khanna KK, Watters D, Rodemann PH, Lavin MF: Epidermal growth factor sensitizes cells to ionizing radiation by down-regulating protein mutated in ataxia-telangiectasia. J Biol Chem 2001, 276:8884-8891 (Pubitemid 33650457)
32. Maroni P, Bendinelli P, Matteucci E, Desiderio MA: GF induces CXCR4 and CXCL12-mediated tumor invasion through Ets1 and NF-kappaB. Carcinogenesis 2007, 28:267-279
33. Hou XW, Jiang Y, Wang LF, Xu HY, Lin HM, He XY, He JJ, Zhang S: Protective role of granulocyte colony-stimulating factor against adriamycin induced cardiac, renal and hepatic toxicities. Toxicol Lett 2009, 187:40-44
34. Gatei M, Young D, Cerosaletti KM, Desai-Mehta A, Spring K, Kozlov S, Lavin MF, Gatti RA, Concannon P, Khanna K: ATM-dependent phosphorylation of nibrin in response to radiation exposure. Nat Genet 2000, 25:115-119
35. Kanu N, Behrens A: ATMINistrating ATM signalling: regulation of ATM by ATMIN. Cell Cycle 2008, 7:3483-3486
36. Kuribayashi K, El-Deiry WS: Regulation of programmed cell death by the p53 pathway. Adv Exp Med Biol 2008, 615:201-221
37. Li DQ, Pakala SB, Reddy SD, Ohshiro K, Peng SH, Lian Y, Fu SW, Kumar R: Revelation of p53-independent function of MTA1 in DNA damage response via modulation of the p21 WAF1-proliferating cell nuclear antigen pathway. J Biol Chem 2010, 285:10044-10052
38. Zhang J, Chen X: Posttranscriptional regulation of p53 and its targets by RNA-binding proteins. Curr Mol Med 2008, 8:845-849
39. Gagandeep S, Sokhi R, Slehria S, Gorla GR, Furgiuele J, DePinho RA, Gupta S: Hepatocyte transplantation improves survival in mice with liver toxicity induced by hepatic overexpression of Mad1 transcription factor. Mol Ther 2000, 1:358-365
40. Braun KM, Degen JL, Sandgren EP: Hepatocyte transplantation in a model of toxin-induced liver disease: variable therapeutic effect during replacement of damaged parenchyma by donor cells. Nat Med 2000, 6:320-326
41. Habibullah CM, Syed IH, Qamar A, Taher-Uz Z: Human fetal hepatocyte transplantation in patients with fulminant hepatic failure. Transplantation 1994, 58:951-952
42. Demidenko ZN, Zubova SG, Bukreeva EI, Pospelov VA, Pospelova TV, Blagosklonny MV: Rapamycin decelerates cellular senescence. Cell Cycle 2009, 8:1888-1895
43. Rowell DL, Eckmann L, Dwinell MB, Carpenter SP, Raucy JL, Yang SK, Kagnoff MF: Human hepatocytes express an array of proinflammatory cytokines after agonist stimulation or bacterial invasion. Am J Physiol 1997, 273:G322-G332
44. Cho J, Joseph B, Sappal BS, Giri RK, Wang R, Ludlow J, Susick R, Gupta S: Analysis of the functional integrity of cryopreserved human liver cells including xenografting in immunodeficient mice to address suitability for clinical applications. Liver Int 2004, 24:361-370 (Pubitemid 39162076)