Site-directed mutagenesis of the ATM promoter: Consequences for response to proliferation and ionizing radiation

Genes Chromosomes and Cancer

Volumn 38, Issue 2, 2003, Pages 157-167

  Gueven, Nuri ^a,b   Keating, Karen ^c   Fukao, Toshiyuki ^a,d   Loeffler, Heidi ^b   Kondo, Naomi ^d   Rodemann, H Peter ^b   Lavin, Martin F ^a,e  

^a ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

^b Sect Radiobiol/Molec Environ R   (Germany)

^c EiRx Therapeutics Ltd   (Ireland)

^d GIFU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^e UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR SP1;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; COMPUTER ANALYSIS; CONSENSUS SEQUENCE; CONTROLLED STUDY; DNA BINDING; GENE ACTIVATION; GENE SEQUENCE; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; IONIZING RADIATION; LYMPHOBLASTOID CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PROTEIN INTERACTION; SEQUENCE ANALYSIS; SITE DIRECTED MUTAGENESIS; SKIN FIBROBLAST; TRANSCRIPTION REGULATION;

ANIMALS; BINDING SITES; CELL CYCLE PROTEINS; CELL DIVISION; CELL LINE; CELL LINE, TRANSFORMED; CERCOPITHECUS AETHIOPS; CLONING, MOLECULAR; DNA-BINDING PROTEINS; GAMMA RAYS; HUMANS; INFANT, NEWBORN; MALE; MUTAGENESIS, SITE-DIRECTED; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; REGULATORY SEQUENCES, NUCLEIC ACID; SP1 TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP-1; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEINS; VERO CELLS;

ATAXIA; ATAXIA TELANGIECTASIA;

EID: 0041332880     PISSN: 10452257     EISSN: None     Source Type: Journal    
DOI: 10.1002/gcc.10261     Document Type: Article

References (41)

1. Bakkenist CJ, Kastan MB. 2003. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 421:499-506.
2. Banin S, Moyal L, Shieh S, Taya Y, Anderson CW, Chessa L, Smorodinsky NI, Prives C, Reiss Y, Shiloh Y, Ziv Y. 1998. Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science 281:1674-1677.
3. Beetz A, Peter RU, Oppel T, Kaffenberger W, Rupec RA, Meyer M, van Beuningen D, Kind P, Messer G. 2000. NF-kappaB and AP-1 are responsible for inducibility of the IL-6 promoter by ionizing radiation in HeLa cells. Int J Radiat Biol 76:1443-1453.
4. Berkovich E, Ginsberg D. 2003. ATM is a target for positive regulation by E2F-1. Oncogene 22:161-167.
5. Borja PF, Collins NK, Du P, Azizkhan-Clifford J, Mudryj M. 2001. Cyclin A-CDK phosphorylates Sp1 and enhances Sp1-mediated transcription. EMBO J 20:5737-5747.
6. Brown KD, Ziv Y, Sadanandan SN, Chessa L, Collins VS, Shiloh Y, Tagle DA. 1997. The ataxia-telangiectasia gene product, a constitutively expressed nuclear protein that is not up-regulated following genome damage. Proc Natl Acad Sci USA 94:1840-1845.
7. Byrd PJ, Cooper PR, Stankovic T, Kullar HS, Watts GDJ, Robinson PJ, Taylor AMR. 1996. A gene transcribed from the bidirectional ATM promoter coding for a serine rich protein: amino acid sequence, structure and expression studies. Hum Mol Genet 5:1785-1791.
8. Canman CE, Lim DS, Cimprich KA, Taya Y, Tamai K, Sakaguchi K, Appella E, Kastan MB, Siliciano JD. 1998. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science 281:1677-1679.
9. Castellvi-Bel S, Sheikhavandi S, Telatar M, Tai LQ, Hwang M, Wang Z, Yang Z, Cheng R, Gatti RA. 1999. New mutations, polymorphisms, and rare variants in the ATM gene detected by a novel SSCP strategy. Hum Mutat 14:156-162.
10. Chen X, Yang L, Udar N, Liang T, Uhrhammer N, Xu S, Bay JO, Wang Z, Dandakar S, Chiplunkar S, Klisak I, Telatar M, Yang H, Concannon P, Gatti RA. 1997. CAND3: a ubiquitously expressed gene immediately adjacent and in opposite transcriptional orientation to the ATM gene at 11q23.1. Mamm Genome 8:129-133.
11. Clarke RA, Kairouz R, Watters D, Lavin MF, Kearsley JH, Lee CS. 1998. Upregulation of ATM in sclerosing adenosis of the breast. Mol Pathol 51:224-226.
12. Comforth MN, Bedford JS. 1985. On the nature of a defect in cells from individuals with ataxia telangiectasia. Science 227:1589-1591.
13. Fang ZM, Lee CS, Sarris M, Kearsley JH, Murrell D, Lavin MF, Keating K, Clarke RA. 2001. Rapid radiation-induction of ATM protein levels in situ. Pathology 33:30-36.
14. Foray N, Priestley A, Alsbeih G, Badie C, Capulas EP, Arlett CF, Malaise EP. 1997. Hypersensitivity of ataxia-telangiectasia fibroblasts to ionizing radiation is associated with a repair deficiency of DNA double strand breaks. Int J Radiat Biol 72:271-283.
15. Fukao T, Kaneko H, Birrell G, Gatei M, Tashita H, Yoshida T, Cross S, Kedar P, Watters D, Khanna KK, Misko I, Kondo N, Lavin MF. 1999. ATM is upregulated during the mitogenic response in peripheral blood mononuclear cells. Blood 94:1998-2006.
16. Gatei M, Scott SP, Filippovitch I, Soronika N, Lavin MF, Weber B, Khanna KK. 2000. Role for ATM in DNA damage-induced phosphorylation of BRCA1. Cancer Res 60:3299-3304.
17. Ghee M, Baker H, Miller JC, Ziff EB. 1998. AP-1, CREB and CBP transcription factors differentially regulate the tyrosine hydrolase gene. Brain Res Mol Brain Res 55:101-114.
18. Gizang-Ginsberg E, Ziff EB. 1990. Nerve growth factor regulates tyrosine hydroxylase gene transcription through a nucleoprotein complex that contains c-Fos. Genes Dev 4:477-491.
19. Gueven N, Keating KE, Chen P, Fukao T, Khanna KK, Watters D, Rodemann HP, Lavin MF. 2001. Epidermal growth factor sensitizes cells to ionizing radiation by down-regulating protein mutated in ataxia-telangiectasia. J Biol Chem 276:8884-8891.
20. Hara T, Namba H, Yang TT, Nagayama Y, Fukata S, Kuma K, Ishikawa N, Ito K, Yamashita S. 1998. Ionizing radiation activates c-Jun NH2-terminal kinase (JNK/SAPK) via a PKC-dependent pathway in human thyroid cells. Biochem Biophys Res Commun 244:41-44.
21. Hirai Y, Hayashi T, Kubo Y, Hoki Y, Arita I, Tatsumi K, Seyama T. 2001. X-irradiation induces up-regulation of ATM gene expression in wild-type lymphoblastoid cell lines, but not in their heterozygous or homozygous ataxia-telangiectasia counterparts. Jpn J Cancer Res 92:710-717.
22. Imai T, Yamauchi M, Seki N, Sugawara T, Saito T, Matsuda Y, Ito H, Nagase T, Nomura N, Hori T. 1996. Identification and characterization of a new gene physically linked to the ATM gene. Genome Res 6:439-447.
23. Jackson SP, MacDonald JJ, Lees-Miller S, Tjian R. 1990. GC box binding induces phosphorylation of Sp1 by a DNA-dependent protein kinase. Cell 63:155-165.
24. Jishage M, Fujino T, Yamazaki Y, Kuroda H, Nakamura T. 2003. Identification of target genes for EWS/ATF-1 chimeric transcription factor. Oncogene 22:41-49.
25. Keating KE, Gueven N, Watters D, Rodemann HP, Lavin MF. 2001. Transcriptional downregulation of ATM by EGF is defective in ataxia-telangiectasia cells expressing mutant protein. Oncogene 20:4281-4290.
26. Khanna KK, Keating KE, Kozlov S, Scott S, Gatei M, Hobson K, Taya Y, Gabrielli B, Chan D, Lees-Miller SP, Lavin MF. 1998. ATM associates with and phosphorylates p53: mapping the region of interaction. Nat Genet 20:398-400.
27. Kim W-J, Vo QN, Shrivastav M, Lataxes TA, Brown KD. 2002. Aberrant methylation of the ATM promoter correlates with increased radiosensitivity in a human colorectal tumor cell line. Oncogene 21:3864-3871.
28. Kozlov S, Gueven N, Keating K, Ramsay J, Lavin MF. 2003. ATP activates ATM in vitro: importance of autophosphorylation. J Biol Chem 278:9309-9317.
29. Lakin ND, Weber P, Stankovic T, Rottinghaus ST, Taylor AM, Jackson SP. 1996. Analysis of the ATM protein in wild-type and ataxia-telangiectasia cells. Oncogene 13:2707-2716.
30. Lavin MF, Shiloh Y. 1997. The genetic defect in ataxia-telangiectasia. Ann Rev Immunol 15:177-202.
31. Lee SA, Dritschilo A, Jung M. 1998. Impaired ionizing radiation-induced activation of a nuclear signal essential for phosphorylation of c-Jun by dually phosphorylated c-Jun amino-terminal kinases in ataxia telangiectasia fibroblasts. J Biol Chem 273:32889-32894.
32. Mao P, Takimoto M, Wei G, Sakai N, Senmaru N, Fujita H, Kuzumaki N. 1997. Expression of GCF protein is dependent on the cell cycle. Nucleic Acids Symp Ser 37:119-120.
33. Marples B, Scott SD, Hendry JH, Embleton MJ, Lashford LS Margison GP. 2000. Development of synthetic promoters for radiation-mediated gene therapy. Gene Ther 7:1706.
34. Nenoi M, Ichimura S, Mita K, Yukawa O, Cartwright IL. 2001. Regulation of the catalase gene promoter by Sp1, CCAAT-recognizing factors, and a WT1/Egr-related factor in hydrogen peroxide-resistant HP100 cells. Cancer Res 61:5885-5894.
35. Raju U, Gumin GJ, Tofilon PJ. 2000. Radiation-induced transcription factor activation in the rat cerebral cortex. Int J Radiat Biol 76:1045-1053.
36. Scott SP, Bendix R, Chen P, Clark R, Dork T, Lavin MF. 2002. Missense mutations but not allelic variants alter the function of ATM by dominant interference in patients with breast cancer. Proc Natl Acad Sci USA 99:925-930.
37. Sedgwick RP, Boder E. 1991. Ataxia-telangiectasia. In: Vinken PJ, Bruyn GW, Klawans HL, editors. Hereditary neuropathies and spinocerebellar atrophies. New York: A. R. Liss. p 347-423.
38. Ueda T, Akiyama N, Sai H, Oya N, Noda M, Hiraoka M, Kizaka-Kondoh S. 2001. c-IAP2 is induced by ionizing radiation through NF-kappaB binding sites. FEBS Lett 491:40-44.
39. Watters D, Khanna KK, Beamish H, Birrell G, Spring K, Kedar P, Gatei M, Stenzel D, Hobson K, Kozlov S, Zhang N, Farrell A, Ramsay J, Gatti R, Lavin MF. 1997. Cellular localisation of the ataxia-telangiectasia (ATM) gene product and discrimination between mutated and normal forms. Oncogcne 14:1911-1921.
40. Weizman N, Shiloh Y, Barzilai A. 2003. Contribution of the Atm protein to maintaining cellular homeostasis evidenced by continuous activation of the AP-1 pathway in Atm-deficient brains. J Biol Chem 278:6741-6747.
41. Yordy JS, Muise-Helmericks RC. 2000. Signal transduction and the Ets family of transcription factors. Oncogene 19:6503-6513.