Kupffer cells participate in early clearance of syngeneic hepatocytes transplanted in the rat liver

Gastroenterology

Volumn 123, Issue 5, 2002, Pages 1677-1685

  Joseph, Brigid ^a,c   Malhi, Harmeet ^a,c   Bhargava, Kuldeep K ^d   Palestro, Christopher J ^d   McCuskey, Robert S ^e   Gupta, Sanjeev ^a,b,c,f  

^a MARION BESSIN LIVER RESEARCH CENTER   (United States)

^b Comprehensive Cancer Research Center ^*  (United States)

^c Department of Medicine ^*  (United States)

^d Long Island Jewish Hospital   (United States)

^e UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^f ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON; DIPEPTIDYL PEPTIDASE IV; GADOLINIUM CHLORIDE; RETRORSINE; TECHNETIUM SULFUR COLLOID TC 99M;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL FUNCTION; CELL INTERACTION; CELL KINETICS; CELL POPULATION; CELL PROLIFERATION; CELL SURVIVAL; CELL TRANSPLANTATION; CONTROLLED STUDY; HISTOCHEMISTRY; INTRAHEPATIC BILE DUCT; ISOGRAFT; KUPFFER CELL; LIVER CELL; LIVER CELL DAMAGE; LIVER HILUS; LIVER PARENCHYMA; LIVER SINUSOID; LIVER TRANSPLANTATION; NONHUMAN; PHAGOCYTE; PORTAL VEIN; PRIORITY JOURNAL; RAT; RECIPIENT;

EID: 0036830258     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/gast.2002.36592     Document Type: Article

References (27)

1. Gupta S, Rajvanshi P, Lee C-D. Integration of transplanted hepatocytes in host liver plates demonstrated with dipeptidyl peptidase IV deficient rats. Proc Natl Acad Sci U S A 1995;92:5860-5864.
2. Sokhi RP, Rajvanshi P, Gupta S. Transplanted reporter cells help in defining onset of hepatocyte proliferation during the life of F344 rats. Am J Physiol Gastrointest Liver Physiol 2000;279: G631-G640.
3. Vemuru RP, Davidson A, Aragona E, Burk RD, Roy Chowdhury J, Gupta S. Immune tolerance to a defined heterologous antigen following intrasplenic hepatocyte transplantation: Implications for human gene therapy. FASEB J 1992;6:2836-2842.
4. Gupta S, Rajvanshi P, Sokhi R, Vaidya S, Irani AN, Gorla GR, Position-specific gene expression in the liver lobule is directed by the microenvironment and not by the previous cell differentiation state. J Biol Chem 1999;274:2157-2165.
5. Rhim JA, Sandgren EP, Degen JL, Palmiter RD, Brinster RL. Replacement of diseased mouse liver by hepatic cell transplantation. Science 1994;263:1149-1152.
6. Overturf K, Al-Dhalimy M, Ou C-N, Finegold M, Grompe M. Serial transplantation reveals the stem-cell-like regenerative potential of adult mouse hepatocytes. Am J Pathol 1997;151:1273-1280.
7. Laconi E, Oren R, Mukhopadhyay DK, Hurston H, Laconi S, Pani P, Dabeva M, Shafritz DA. Long-term, near-total liver replacement by transplantation of isolated hepatocytes in rats treated with retrorsine. Am J Pathol 1998;153:319-329.
8. Mignon A, Guidotti JE, Mitchell C, Fabre M, Wernet A, de La Coste A, Soubrane O, Gilgenkrantz H, Kahn A. Selective repopulation of normal mouse liver by Fas/CD95-resistant hepatocytes. Nat Med 1998;10:1185-1188.
9. Malhi H, Gorla GR, Irani AN, Annamaneni P, Gupta S. Cell transplantation after oxidative hepatic preconditioning with radiation and ischemia-reperfusion leads to extensive liver repopulation. Proc Natl Acad Sci U S A 2002;99:13114-13119.
10. Gupta S, Rajvanshi P, Sokhi RP, Slehria S, Yam A, Kerr A, Novikoff PM. Entry and integration of transplanted hepatocytes in liver plates occur by disruption of hepatic sinusoidal endothelium. Hepatology 1999;29:509-519.
11. Gupta S, Rajvanshi P, Malhi H, Sokhi RP, Slehria S, Vasa SRG, Dabeva M, Shafritz DA, Kerr A. Cell transplantation causes loss of gap junctions and activates GGT expression permanently in host liver. Am J Physiol Gastrointest Liver Physiol 2000;279: G815-G826.
12. Slehria S, Rajvanshi P, Ito Y, Sokhi R, Bhargava KK, Palestro CJ, McCuskey RS, Gupta S. Hepatic sinusoidal vasodilators improve transplanted cell engraftment and ameliorate microcirculatory perturbations in the liver. Hepatology 2002;35:1320-1328.
13. Lemasters JJ, Thurman RG. Reperfusion injury after liver preservation for transplantation. Annu Rev Pharmacol Toxicol 1997;37:327-338.
14. Serracino-Inglott F, Habib NA, Mathie RT. Hepatic ischemia-reperfusion injury. Am J Surg 2001;181:160-166.
15. Thompson NL, Hixson DC, Callanan H, Panzica M, Flanagan D, Faris RA, Hong WJ, Hartel-Schenk S, Doyle D. A Fischer rat substrain deficient in dipeptidyl peptidase IV activity makes normal steady-state RNA levels and an altered protein. Use as a liver-cell transplantation model. Biochem J 1991;273:497-502.
16. Lindert KA, Caldwell-Kenkel JC, Nukina S, Lemasters JJ, Thurman RG. Activation of Kupffer cells on reperfusion following hypoxia: Particle phagocytosis in a low-flow, reflow model, Am J Physiol 1992;262:G345-350.
17. Hardonk MJ, Dijkhuis FW, Hulstaert CE, Koudstaal J. Heterogeneity of rat liver and spleen macrophages in gadolinium chloride-induced elimination and repopulation. J Leukoc Biol 1992;52:296-302.
18. Holmberg SB, Hafstrom L, Jacobsson L. Phagocytosis and dynamic RES scintigraphy: An evaluation of commercial colloids in rats. Nucl Med Commun 1987;8:335-346.
19. Malhi H, Annamaneni P, Slehria S, Joseph B, Bhargava KK, Palestro CJ, Novikoff PM, Gupta S. Cyclophosphamide disrupts hepatic sinusoidal endothelium and improves transplanted cell engraftment in rat liver. Hepatology 2002;36:112-121.
20. Hoebe KH, Witkamp RF, Fink-Gremmels J, Van Miert AS, Monshouwer M. Direct cell-to-cell contact between Kupffer cells and hepatocytes augments endotoxin-induced hepatic injury. Am J Physiol Gastrointest Liver Physiol 2001;280:G720-728.
21. Nakagawa, K, Miller FN, Simms DE, Lentsch AB, Miyazaki M, Edwards MJ. Mechanisms of interleukin-2-induced hepatic toxicity. Cancer Res 1996;56:507-510.
22. Yan SF, Tritto I, Pinsky D, Liao H, Huang J, Fuller G, Brett J, May L, Stern D. Induction of interleukin 6 (IL-6) by hypoxia in vascular cells. Central role of the binding site for nuclear factor-IL-6. J Biol Chem 1995;270:11463-11471.
23. Rose ML, Germolec DR, Schoonhoven R, Thurman RG. Kupffer cells are causally responsible for the mitogenic effect of peroxisome proliferators. Carcinogenesis 1997;18:1453-1456.
24. Funyu J, Mochida S, Inao M, Matsui A, Fujiwara K. VEGF can act as vascular permeability factor in the hepatic sinusoids through upregulation of porosity of endothelial cells. Biochem Biophys Res Commun 2001;19:280:481-485.
25. Rajvanshi P, Kerr A, Bhargava KK, Burk RD, Gupta S. Efficacy and safety of repeated hepatocyte transplantation for significant liver repopulation in rodents. Gastroenterology 1996;111:1092-1102.
26. Michalopoulos GK, DeFrances MC. Liver regeneration. Science 1997;4:276:60-66.
27. Rudiger HA, Clavien PA. Tumor necrosis factor alpha, but not Fas, mediates hepatocellular apoptosis in the murine ischemic liver. Gastroenterology 2002;122:202-210.