Human hepatocytes express an array of proinflammatory cytokines after agonist stimulation or bacterial invasion

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 273, Issue 2 36-2, 1997, Pages

  Rowell, Diana L ^c   Eckmann, Lars ^c   Dwinell, Michael B ^c   Carpenter, Susan P ^c   Raucy, Judy L ^c   Yang, Suk Kyun ^a   Kagnoff, Martin F ^b  

^a University of Ulsan College of Medicine   (South Korea)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c NONE

Author keywords

Chemokines; Hematopoietic growth factors; Inflammation; Interleukins; Salmonella

Indexed keywords

COLONY STIMULATING FACTOR 1; CYTOKINE; EPITHELIAL DERIVED NEUTROPHIL ACTIVATING FACTOR 78; ERYTHROPOIETIN; GAMMA INTERFERON; HEMOPOIETIC GROWTH FACTOR; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 11; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 15; INTERLEUKIN 2; INTERLEUKIN 3; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; INTERLEUKIN 7; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN 3; RANTES; STEM CELL FACTOR; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; BACTERIAL COLONIZATION; BACTERIAL INFECTION; GENE AMPLIFICATION; HEPATITIS; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; INFLAMMATORY INFILTRATE; LIVER CELL CULTURE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0030882523     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.1997.273.2.g322     Document Type: Article

References (21)

1. Baggiolini, M., B. Dewald, and B. Moser. Interleukin-8 and related chemotactic cytokines: CXC and CG chemokines. Adv. Immunol. 55: 97-179, 1994.
2. Carpenter, S. P., J. M. Lasker, and J. L. Raucy. Expression, induction, and catalytic activity of the ethanol-inducible cytochrome P450 (CYP2E1) in human fetal liver and hepatocytes. Mol. Pharmacol. 49: 260-268, 1996.
3. Chikami, G. K., J. Fierer, and D. G. Guiney. Plasmid-mediated virulence in Salmonella dublin demonstrated by use of a Tn5-oriT construct. Infect. Immun. 50: 420-424, 1985.
4. Decker, K. Biologically active products of stimulated liver macrophages (Kupffer cells). Eur. J. Biochem. 192: 245-261, 1990.
5. Eckmann, L., H. C. Jung, C. Schurer-Maly, A. Panja, E. Morzycka-Wroblewska, and M. F. Kagnoff. Differential cytokine expression by human intestinal epithelial cell lines: regulated expression of interleukin 8. Gastroenterology 105: 1689-1697, 1993.
6. Eckmann, L., M. F. Kagnoff, and J. Fierer. Epithelial cells secrete the chemokine interleukin-8 in response to bacterial entry. Infect. Immun. 61: 4569-4574, 1993.
7. 2α production. J. Clin. Invest. In press.
8. Fandrey, J., and H. F. Bunn. In vivo and in vitro regulation of erythropoietin mRNA: measurement by competitive polymerase chain reaction. Blood 81: 617-623, 1993.
9. Fandrey, J., A. Huwiler, S. Frede, J. Pfeilschifter, and W. Jelkmann. Distinct signaling pathways mediate phorbolester-induced and cytokine-induced inhibition of erythropoietin gene expression. Eur. J. Biochem. 226: 335-340, 1994.
10. Gilmour, S. M., S. Yang, D. Malkin, and E. A. Roberts. "Hot spot" mutation in p53 contributes to tumorigenicity of human hepatocyte lines (Abstract). Can. J. Gastroenterol. 11, Suppl. A: 65A, 1997.
11. Goldberg, M. A., G. A. Glass, J. M. Cunningham, and H. F. Bunn. The regulated expression of erythropoietin by two human hepatoma cell lines. Proc. Natl. Acad. Sci. USA 84: 7972-7976, 1987.
12. Gumucio, J. J., and C. M. Berkowitz. Structural organization of the liver and function of the hepatic acinus. In: Liver and Biliary Diseases, edited by N. Kaplowitz. Baltimore, MD: Williams & Wilkins, 1992, p. 2-17.
13. Healy, A. M., and T. D. Gelehrter. Induction of plasminogen activator inhibitor-1 in HepG2 human hepatoma cells by mediators of the acute phase response. J. Biol. Chem. 269: 19095-19100, 1994.
14. Hechtman, D. H., M. I. Cybulsky, H. J. Fuchs, J. B. Baker, and M. A. Gimbrone, Jr. Inhibitor of polymorphonuclear leukocyte accumulation at sites of acute inflammation. J. Immunol. 147: 883-892, 1991.
15. Herkens, C., M. Wolff, J. Fandrey, F. Schuler, and W. Jelkmann. Immunocytochemical demonstration of erythropoietin in hypoxic human hepatoma cultures. Histochemistry 100: 303-309, 1993.
16. Hoedemakers, R. M. J., G. L. Scherphof, and T. Daemen. Proliferation of rat liver macrophages in vitro: influence of hemopoietic growth factors. Hepatology 19: 666-674, 1994.
17. Honda, Y., K. Takahashi, M. Naito, and S. Fujiyama. The role of macrophage colony-stimulating factor in the differentiation and proliferation of Kupffer cells in the liver of protein-deprived mice. Lab. Invest. 72: 696-706, 1995.
18. Jones, A. L., and J. Altorfer. Immunological functions of the liver. In: Immunology of the Gastrointestinal Tract and Liver, edited by M. F. Heyworth and A. L. Jones. New York: Raven, 1988, p. 159-171.
19. Jung, H. C., L. Eckmann, S. Yang, A. Panja, J. Fierer, E. Morzycka-Wroblewska, and M. F. Kagnoff. A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasion. J. Clin. Invest. 95: 55-65, 1995.
20. Knowles, B. B., C. C. Howe, and D. P. Aden. Human hepatocellular carcinoma cell lines secrete the major plasma proteins and hepatitis B surface antigen. Science 209: 497-499, 1980.
21. Kobsel, N., and G. Ramadori. Human hepatoma cells synthesize and secrete lysozyme: modulation by cytokines. Hepatology 19: 1182-1188, 1994.