메뉴 건너뛰기




Volumn 19, Issue 2, 2011, Pages 222-232

Regulation of mechanical stress-induced MMP-13 and ADAMTS-5 expression by RUNX-2 transcriptional factor in SW1353 chondrocyte-like cells

Author keywords

ADAMTS; Aggrecanase; Chondrocyte; Mechanical stress; RUNX 2

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ADAMTS 9 PROTEIN; AGGRECANASE 1; AGGRECANASE 2; COLLAGENASE 3; METALLOPROTEINASE; MITOGEN ACTIVATED PROTEIN KINASE; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG;

EID: 79151483757     PISSN: 10634584     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.joca.2010.11.004     Document Type: Article
Times cited : (119)

References (52)
  • 2
    • 0028245650 scopus 로고
    • The effects of matrix compression on proteoglycan metabolism in articular cartilage explants
    • Guilak F., Meyer B.C., Ratcliffe A., Mow V.C. The effects of matrix compression on proteoglycan metabolism in articular cartilage explants. Osteoarthritis Cartilage 1994, 2:91-101.
    • (1994) Osteoarthritis Cartilage , vol.2 , pp. 91-101
    • Guilak, F.1    Meyer, B.C.2    Ratcliffe, A.3    Mow, V.C.4
  • 3
    • 0028969111 scopus 로고
    • Ultrastructural observations on fibril profiles in normal and degenerative human articular cartilage
    • Curtin W.A., Reville W.J. Ultrastructural observations on fibril profiles in normal and degenerative human articular cartilage. Clin Orthop Relat Res 1995, 224-230.
    • (1995) Clin Orthop Relat Res , pp. 224-230
    • Curtin, W.A.1    Reville, W.J.2
  • 4
    • 0029731750 scopus 로고    scopus 로고
    • Regulating expression of the gene for matrix metalloproteinase-1 (collagenase): mechanisms that control enzyme activity, transcription, and mRNA stability
    • Vincenti M.P., White L.A., Schroen D.J., Benbow U., Brinckerhoff C.E. Regulating expression of the gene for matrix metalloproteinase-1 (collagenase): mechanisms that control enzyme activity, transcription, and mRNA stability. Crit Rev Eukaryot Gene Expr 1996, 6:391-411.
    • (1996) Crit Rev Eukaryot Gene Expr , vol.6 , pp. 391-411
    • Vincenti, M.P.1    White, L.A.2    Schroen, D.J.3    Benbow, U.4    Brinckerhoff, C.E.5
  • 5
    • 0029852094 scopus 로고    scopus 로고
    • Aggrecan is degraded by matrix metalloproteinases in human arthritis. Evidence that matrix metalloproteinase and aggrecanase activities can be independent
    • Fosang A.J., Last K., Maciewicz R.A. Aggrecan is degraded by matrix metalloproteinases in human arthritis. Evidence that matrix metalloproteinase and aggrecanase activities can be independent. J Clin Invest 1996, 98:2292-2299.
    • (1996) J Clin Invest , vol.98 , pp. 2292-2299
    • Fosang, A.J.1    Last, K.2    Maciewicz, R.A.3
  • 6
    • 0031025218 scopus 로고    scopus 로고
    • Membrane type 1 matrix metalloproteinase digests interstitial collagens and other extracellular matrix macromolecules
    • Ohuchi E., Imai K., Fujii Y., Sato H., Seiki M., Okada Y. Membrane type 1 matrix metalloproteinase digests interstitial collagens and other extracellular matrix macromolecules. J Biol Chem 1997, 272:2446-2451.
    • (1997) J Biol Chem , vol.272 , pp. 2446-2451
    • Ohuchi, E.1    Imai, K.2    Fujii, Y.3    Sato, H.4    Seiki, M.5    Okada, Y.6
  • 7
    • 33748940904 scopus 로고    scopus 로고
    • Overexpression of Runx2 directed by the matrix metalloproteinase-13 promoter containing the AP-1 and Runx/RD/Cbfa sites alters bone remodeling in vivo
    • Selvamurugan N., Jefcoat S.C., Kwok S., Kowalewski R., Tamasi J.A., Partridge N.C. Overexpression of Runx2 directed by the matrix metalloproteinase-13 promoter containing the AP-1 and Runx/RD/Cbfa sites alters bone remodeling in vivo. J Cell Biochem 2006, 99:545-557.
    • (2006) J Cell Biochem , vol.99 , pp. 545-557
    • Selvamurugan, N.1    Jefcoat, S.C.2    Kwok, S.3    Kowalewski, R.4    Tamasi, J.A.5    Partridge, N.C.6
  • 8
    • 0345211445 scopus 로고    scopus 로고
    • Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins
    • Tortorella M.D., Burn T.C., Pratta M.A., Abbaszade I., Hollis J.M., Liu R., et al. Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins. Science 1999, 284:1664-1666.
    • (1999) Science , vol.284 , pp. 1664-1666
    • Tortorella, M.D.1    Burn, T.C.2    Pratta, M.A.3    Abbaszade, I.4    Hollis, J.M.5    Liu, R.6
  • 9
    • 0033551844 scopus 로고    scopus 로고
    • Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family
    • Abbaszade I., Liu R.Q., Yang F., Rosenfeld S.A., Ross O.H., Link J.R., et al. Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family. J Biol Chem 1999, 274:23443-23450.
    • (1999) J Biol Chem , vol.274 , pp. 23443-23450
    • Abbaszade, I.1    Liu, R.Q.2    Yang, F.3    Rosenfeld, S.A.4    Ross, O.H.5    Link, J.R.6
  • 12
    • 0038237345 scopus 로고    scopus 로고
    • Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1
    • Somerville R.P., Longpre J.M., Jungers K.A., Engle J.M., Ross M., Evanko S., et al. Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1. J Biol Chem 2003, 278:9503-9513.
    • (2003) J Biol Chem , vol.278 , pp. 9503-9513
    • Somerville, R.P.1    Longpre, J.M.2    Jungers, K.A.3    Engle, J.M.4    Ross, M.5    Evanko, S.6
  • 13
    • 15844413814 scopus 로고    scopus 로고
    • Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis
    • Glasson S.S., Askew R., Sheppard B., Carito B., Blanchet T., Ma H.L., et al. Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis. Nature 2005, 434:644-648.
    • (2005) Nature , vol.434 , pp. 644-648
    • Glasson, S.S.1    Askew, R.2    Sheppard, B.3    Carito, B.4    Blanchet, T.5    Ma, H.L.6
  • 14
    • 15844384854 scopus 로고    scopus 로고
    • ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro
    • Stanton H., Rogerson F.M., East C.J., Golub S.B., Lawlor K.E., Meeker C.T., et al. ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro. Nature 2005, 434:648-652.
    • (2005) Nature , vol.434 , pp. 648-652
    • Stanton, H.1    Rogerson, F.M.2    East, C.J.3    Golub, S.B.4    Lawlor, K.E.5    Meeker, C.T.6
  • 15
    • 4043154293 scopus 로고    scopus 로고
    • Characterization of and osteoarthritis susceptibility in ADAMTS-4-knockout mice
    • Glasson S.S., Askew R., Sheppard B., Carito B.A., Blanchet T., Ma H.L., et al. Characterization of and osteoarthritis susceptibility in ADAMTS-4-knockout mice. Arthritis Rheum 2004, 50:2547-2558.
    • (2004) Arthritis Rheum , vol.50 , pp. 2547-2558
    • Glasson, S.S.1    Askew, R.2    Sheppard, B.3    Carito, B.A.4    Blanchet, T.5    Ma, H.L.6
  • 16
    • 36048985974 scopus 로고    scopus 로고
    • Double-knockout of ADAMTS-4 and ADAMTS-5 in mice results in physiologically normal animals and prevents the progression of osteoarthritis
    • Majumdar M.K., Askew R., Schelling S., Stedman N., Blanchet T., Hopkins B., et al. Double-knockout of ADAMTS-4 and ADAMTS-5 in mice results in physiologically normal animals and prevents the progression of osteoarthritis. Arthritis Rheum 2007, 56:3670-3674.
    • (2007) Arthritis Rheum , vol.56 , pp. 3670-3674
    • Majumdar, M.K.1    Askew, R.2    Schelling, S.3    Stedman, N.4    Blanchet, T.5    Hopkins, B.6
  • 17
    • 1642280932 scopus 로고    scopus 로고
    • Altered proteolytic activities of ADAMTS-4 expressed by C-terminal processing
    • Kashiwagi M., Enghild J.J., Gendron C., Hughes C., Caterson B., Itoh Y., et al. Altered proteolytic activities of ADAMTS-4 expressed by C-terminal processing. J Biol Chem 2004, 279:10109-10119.
    • (2004) J Biol Chem , vol.279 , pp. 10109-10119
    • Kashiwagi, M.1    Enghild, J.J.2    Gendron, C.3    Hughes, C.4    Caterson, B.5    Itoh, Y.6
  • 18
    • 35148882630 scopus 로고    scopus 로고
    • Expression of ADAMTS4 (aggrecanase-1) in human osteoarthritic cartilage
    • Naito S., Shiomi T., Okada A., Kimura T., Chijiiwa M., Fujita Y., et al. Expression of ADAMTS4 (aggrecanase-1) in human osteoarthritic cartilage. Pathol Int 2007, 57:703-711.
    • (2007) Pathol Int , vol.57 , pp. 703-711
    • Naito, S.1    Shiomi, T.2    Okada, A.3    Kimura, T.4    Chijiiwa, M.5    Fujita, Y.6
  • 19
    • 14944371238 scopus 로고    scopus 로고
    • Analysis of ADAMTS4 and MT4-MMP indicates that both are involved in aggrecanolysis in interleukin-1-treated bovine cartilage
    • Patwari P., Gao G., Lee J.H., Grodzinsky A.J., Sandy J.D. Analysis of ADAMTS4 and MT4-MMP indicates that both are involved in aggrecanolysis in interleukin-1-treated bovine cartilage. Osteoarthritis Cartilage 2005, 13:269-277.
    • (2005) Osteoarthritis Cartilage , vol.13 , pp. 269-277
    • Patwari, P.1    Gao, G.2    Lee, J.H.3    Grodzinsky, A.J.4    Sandy, J.D.5
  • 20
    • 18644370594 scopus 로고    scopus 로고
    • ADAMTS-9 is synergistically induced by interleukin-1beta and tumor necrosis factor alpha in OUMS-27 chondrosarcoma cells and in human chondrocytes
    • Demircan K., Hirohata S., Nishida K., Hatipoglu O.F., Oohashi T., Yonezawa T., et al. ADAMTS-9 is synergistically induced by interleukin-1beta and tumor necrosis factor alpha in OUMS-27 chondrosarcoma cells and in human chondrocytes. Arthritis Rheum 2005, 52:1451-1460.
    • (2005) Arthritis Rheum , vol.52 , pp. 1451-1460
    • Demircan, K.1    Hirohata, S.2    Nishida, K.3    Hatipoglu, O.F.4    Oohashi, T.5    Yonezawa, T.6
  • 21
    • 2442531856 scopus 로고    scopus 로고
    • Mechanical compression of cartilage explants induces multiple time-dependent gene expression patterns and involves intracellular calcium and cyclic AMP
    • Fitzgerald J.B., Jin M., Dean D., Wood D.J., Zheng M.H., Grodzinsky A.J. Mechanical compression of cartilage explants induces multiple time-dependent gene expression patterns and involves intracellular calcium and cyclic AMP. J Biol Chem 2004, 279:19502-19511.
    • (2004) J Biol Chem , vol.279 , pp. 19502-19511
    • Fitzgerald, J.B.1    Jin, M.2    Dean, D.3    Wood, D.J.4    Zheng, M.H.5    Grodzinsky, A.J.6
  • 22
    • 0035085049 scopus 로고    scopus 로고
    • Cyclic tensile strain suppresses catabolic effects of interleukin-1beta in fibrochondrocytes from the temporomandibular joint
    • Agarwal S., Long P., Gassner R., Piesco N.P., Buckley M.J. Cyclic tensile strain suppresses catabolic effects of interleukin-1beta in fibrochondrocytes from the temporomandibular joint. Arthritis Rheum 2001, 44:608-617.
    • (2001) Arthritis Rheum , vol.44 , pp. 608-617
    • Agarwal, S.1    Long, P.2    Gassner, R.3    Piesco, N.P.4    Buckley, M.J.5
  • 23
    • 0030684749 scopus 로고    scopus 로고
    • Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts
    • Komori T., Yagi H., Nomura S., Yamaguchi A., Sasaki K., Deguchi K., et al. Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 1997, 89:755-764.
    • (1997) Cell , vol.89 , pp. 755-764
    • Komori, T.1    Yagi, H.2    Nomura, S.3    Yamaguchi, A.4    Sasaki, K.5    Deguchi, K.6
  • 24
    • 33746938803 scopus 로고    scopus 로고
    • Contribution of runt-related transcription factor 2 to the pathogenesis of osteoarthritis in mice after induction of knee joint instability
    • Kamekura S., Kawasaki Y., Hoshi K., Shimoaka T., Chikuda H., Maruyama Z., et al. Contribution of runt-related transcription factor 2 to the pathogenesis of osteoarthritis in mice after induction of knee joint instability. Arthritis Rheum 2006, 54:2462-2470.
    • (2006) Arthritis Rheum , vol.54 , pp. 2462-2470
    • Kamekura, S.1    Kawasaki, Y.2    Hoshi, K.3    Shimoaka, T.4    Chikuda, H.5    Maruyama, Z.6
  • 25
    • 0141750631 scopus 로고    scopus 로고
    • Cyclic tensile strain and cyclic hydrostatic pressure differentially regulate expression of hypertrophic markers in primary chondrocytes
    • Wong M., Siegrist M., Goodwin K. Cyclic tensile strain and cyclic hydrostatic pressure differentially regulate expression of hypertrophic markers in primary chondrocytes. Bone 2003, 33:685-693.
    • (2003) Bone , vol.33 , pp. 685-693
    • Wong, M.1    Siegrist, M.2    Goodwin, K.3
  • 26
    • 33746676272 scopus 로고    scopus 로고
    • Involvement of SA channels in orienting response of cultured endothelial cells to cyclic stretch
    • Naruse K., Yamada T., Sokabe M. Involvement of SA channels in orienting response of cultured endothelial cells to cyclic stretch. Am J Physiol 1998, 274:H1532-H1538.
    • (1998) Am J Physiol , vol.274
    • Naruse, K.1    Yamada, T.2    Sokabe, M.3
  • 27
    • 37249020517 scopus 로고    scopus 로고
    • Effects of tensile and compressive strains on response of a chondrocytic cell line embedded in type I collagen gel
    • Hirano Y., Ishiguro N., Sokabe M., Takigawa M., Naruse K. Effects of tensile and compressive strains on response of a chondrocytic cell line embedded in type I collagen gel. J Biotechnol 2008, 133:245-252.
    • (2008) J Biotechnol , vol.133 , pp. 245-252
    • Hirano, Y.1    Ishiguro, N.2    Sokabe, M.3    Takigawa, M.4    Naruse, K.5
  • 28
    • 69449087164 scopus 로고    scopus 로고
    • Mechanical stretch stimulates integrin alphaVbeta3-mediated collagen expression in human anterior cruciate ligament cells
    • Tetsunaga T., Furumatsu T., Abe N., Nishida K., Naruse K., Ozaki T. Mechanical stretch stimulates integrin alphaVbeta3-mediated collagen expression in human anterior cruciate ligament cells. J Biomech 2009, 42:2097-2103.
    • (2009) J Biomech , vol.42 , pp. 2097-2103
    • Tetsunaga, T.1    Furumatsu, T.2    Abe, N.3    Nishida, K.4    Naruse, K.5    Ozaki, T.6
  • 29
    • 17344392308 scopus 로고    scopus 로고
    • A new mathematical model for relative quantification in real-time RT-PCR
    • Pfaffl M.W. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 2001, 29:e45.
    • (2001) Nucleic Acids Res , vol.29
    • Pfaffl, M.W.1
  • 31
    • 8444234314 scopus 로고    scopus 로고
    • Role of NF-kappaB transcription factors in antiinflammatory and proinflammatory actions of mechanical signals
    • Agarwal S., Deschner J., Long P., Verma A., Hofman C., Evans C.H., et al. Role of NF-kappaB transcription factors in antiinflammatory and proinflammatory actions of mechanical signals. Arthritis Rheum 2004, 50:3541-3548.
    • (2004) Arthritis Rheum , vol.50 , pp. 3541-3548
    • Agarwal, S.1    Deschner, J.2    Long, P.3    Verma, A.4    Hofman, C.5    Evans, C.H.6
  • 32
    • 0028793281 scopus 로고
    • Chondrocyte and chondrosarcoma cell integrins with affinity for collagen type II and their response to mechanical stress
    • Holmvall K., Camper L., Johansson S., Kimura J.H., Lundgren-Akerlund E. Chondrocyte and chondrosarcoma cell integrins with affinity for collagen type II and their response to mechanical stress. Exp Cell Res 1995, 221:496-503.
    • (1995) Exp Cell Res , vol.221 , pp. 496-503
    • Holmvall, K.1    Camper, L.2    Johansson, S.3    Kimura, J.H.4    Lundgren-Akerlund, E.5
  • 33
    • 0032981665 scopus 로고    scopus 로고
    • Cyclic mechanical stress induces extracellular matrix degradation in cultured chondrocytes via gene expression of matrix metalloproteinases and interleukin-1
    • Fujisawa T., Hattori T., Takahashi K., Kuboki T., Yamashita A., Takigawa M. Cyclic mechanical stress induces extracellular matrix degradation in cultured chondrocytes via gene expression of matrix metalloproteinases and interleukin-1. J Biochem 1999, 125:966-975.
    • (1999) J Biochem , vol.125 , pp. 966-975
    • Fujisawa, T.1    Hattori, T.2    Takahashi, K.3    Kuboki, T.4    Yamashita, A.5    Takigawa, M.6
  • 35
    • 0033064916 scopus 로고    scopus 로고
    • Orientation change of cardiocytes induced by cyclic stretch stimulation: time dependency and involvement of protein kinases
    • Kada K., Yasui K., Naruse K., Kamiya K., Kodama I., Toyama J. Orientation change of cardiocytes induced by cyclic stretch stimulation: time dependency and involvement of protein kinases. J Mol Cell Cardiol 1999, 31:247-259.
    • (1999) J Mol Cell Cardiol , vol.31 , pp. 247-259
    • Kada, K.1    Yasui, K.2    Naruse, K.3    Kamiya, K.4    Kodama, I.5    Toyama, J.6
  • 36
    • 33847010576 scopus 로고    scopus 로고
    • Aggrecan degradation in human articular cartilage explants is mediated by both ADAMTS-4 and ADAMTS-5
    • Song R.H., Tortorella M.D., Malfait A.M., Alston J.T., Yang Z., Arner E.C., et al. Aggrecan degradation in human articular cartilage explants is mediated by both ADAMTS-4 and ADAMTS-5. Arthritis Rheum 2007, 56:575-585.
    • (2007) Arthritis Rheum , vol.56 , pp. 575-585
    • Song, R.H.1    Tortorella, M.D.2    Malfait, A.M.3    Alston, J.T.4    Yang, Z.5    Arner, E.C.6
  • 37
    • 33847183465 scopus 로고    scopus 로고
    • Molecular targets in osteoarthritis: metalloproteinases and their inhibitors
    • Burrage P.S., Brinckerhoff C.E. Molecular targets in osteoarthritis: metalloproteinases and their inhibitors. Curr Drug Targets 2007, 8:293-303.
    • (2007) Curr Drug Targets , vol.8 , pp. 293-303
    • Burrage, P.S.1    Brinckerhoff, C.E.2
  • 39
    • 35148831210 scopus 로고    scopus 로고
    • Characterization of the human ADAMTS-5 (aggrecanase-2) gene promoter
    • Thirunavukkarasu K., Pei Y., Wei T. Characterization of the human ADAMTS-5 (aggrecanase-2) gene promoter. Mol Biol Rep 2007, 34:225-231.
    • (2007) Mol Biol Rep , vol.34 , pp. 225-231
    • Thirunavukkarasu, K.1    Pei, Y.2    Wei, T.3
  • 40
    • 41049087212 scopus 로고    scopus 로고
    • Expression and activity of Runx2 mediated by hyaluronan during chondrocyte differentiation
    • Tanne Y., Tanimoto K., Tanaka N., Ueki M., Lin Y.Y., Ohkuma S., et al. Expression and activity of Runx2 mediated by hyaluronan during chondrocyte differentiation. Arch Oral Biol 2008, 53:478-487.
    • (2008) Arch Oral Biol , vol.53 , pp. 478-487
    • Tanne, Y.1    Tanimoto, K.2    Tanaka, N.3    Ueki, M.4    Lin, Y.Y.5    Ohkuma, S.6
  • 41
    • 0034840936 scopus 로고    scopus 로고
    • The role of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) in a model of cartilage degradation
    • Tortorella M.D., Malfait A.M., Deccico C., Arner E. The role of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) in a model of cartilage degradation. Osteoarthritis Cartilage 2001, 9:539-552.
    • (2001) Osteoarthritis Cartilage , vol.9 , pp. 539-552
    • Tortorella, M.D.1    Malfait, A.M.2    Deccico, C.3    Arner, E.4
  • 42
    • 0036467471 scopus 로고    scopus 로고
    • Expression and regulation of aggrecanase in arthritis: the role of TGF-beta
    • Yamanishi Y., Boyle D.L., Clark M., Maki R.A., Tortorella M.D., Arner E.C., et al. Expression and regulation of aggrecanase in arthritis: the role of TGF-beta. J Immunol 2002, 168:1405-1412.
    • (2002) J Immunol , vol.168 , pp. 1405-1412
    • Yamanishi, Y.1    Boyle, D.L.2    Clark, M.3    Maki, R.A.4    Tortorella, M.D.5    Arner, E.C.6
  • 43
    • 23644459677 scopus 로고    scopus 로고
    • Mechanical injury of cartilage explants causes specific time-dependent changes in chondrocyte gene expression
    • Lee J.H., Fitzgerald J.B., Dimicco M.A., Grodzinsky A.J. Mechanical injury of cartilage explants causes specific time-dependent changes in chondrocyte gene expression. Arthritis Rheum 2005, 52:2386-2395.
    • (2005) Arthritis Rheum , vol.52 , pp. 2386-2395
    • Lee, J.H.1    Fitzgerald, J.B.2    Dimicco, M.A.3    Grodzinsky, A.J.4
  • 44
    • 0036222734 scopus 로고    scopus 로고
    • The modulation of matrix metalloproteinase and ADAM gene expression in human chondrocytes by interleukin-1 and oncostatin M: a time-course study using real-time quantitative reverse transcription-polymerase chain reaction
    • Koshy P.J., Lundy C.J., Rowan A.D., Porter S., Edwards D.R., Hogan A., et al. The modulation of matrix metalloproteinase and ADAM gene expression in human chondrocytes by interleukin-1 and oncostatin M: a time-course study using real-time quantitative reverse transcription-polymerase chain reaction. Arthritis Rheum 2002, 46:961-967.
    • (2002) Arthritis Rheum , vol.46 , pp. 961-967
    • Koshy, P.J.1    Lundy, C.J.2    Rowan, A.D.3    Porter, S.4    Edwards, D.R.5    Hogan, A.6
  • 45
    • 33847686338 scopus 로고    scopus 로고
    • Adenoviral gene transfer of the endogenous inhibitor IkappaBalpha into human osteoarthritis synovial fibroblasts demonstrates that several matrix metalloproteinases and aggrecanases are nuclear factor-kappaB-dependent
    • Bondeson J., Lauder S., Wainwright S., Amos N., Evans A., Hughes C., et al. Adenoviral gene transfer of the endogenous inhibitor IkappaBalpha into human osteoarthritis synovial fibroblasts demonstrates that several matrix metalloproteinases and aggrecanases are nuclear factor-kappaB-dependent. J Rheumatol 2007, 34:523-533.
    • (2007) J Rheumatol , vol.34 , pp. 523-533
    • Bondeson, J.1    Lauder, S.2    Wainwright, S.3    Amos, N.4    Evans, A.5    Hughes, C.6
  • 46
    • 33745623947 scopus 로고    scopus 로고
    • Differential regulation of cytokine-induced MMP-1 and MMP-13 expression by p38 kinase inhibitors in human chondrosarcoma cells: potential role of Runx2 in mediating p38 effects
    • Pei Y., Harvey A., Yu X.P., Chandrasekhar S., Thirunavukkarasu K. Differential regulation of cytokine-induced MMP-1 and MMP-13 expression by p38 kinase inhibitors in human chondrosarcoma cells: potential role of Runx2 in mediating p38 effects. Osteoarthritis Cartilage 2006, 14:749-758.
    • (2006) Osteoarthritis Cartilage , vol.14 , pp. 749-758
    • Pei, Y.1    Harvey, A.2    Yu, X.P.3    Chandrasekhar, S.4    Thirunavukkarasu, K.5
  • 47
    • 34547906444 scopus 로고    scopus 로고
    • Mechanical stress-mediated Runx2 activation is dependent on Ras/ERK1/2 MAPK signaling in osteoblasts
    • Kanno T., Takahashi T., Tsujisawa T., Ariyoshi W., Nishihara T. Mechanical stress-mediated Runx2 activation is dependent on Ras/ERK1/2 MAPK signaling in osteoblasts. J Cell Biochem 2007, 101:1266-1277.
    • (2007) J Cell Biochem , vol.101 , pp. 1266-1277
    • Kanno, T.1    Takahashi, T.2    Tsujisawa, T.3    Ariyoshi, W.4    Nishihara, T.5
  • 48
    • 0037811204 scopus 로고    scopus 로고
    • Induction of matrix metalloproteinase-13 gene expression by TNF-alpha is mediated by MAP kinases, AP-1, and NF-kappaB transcription factors in articular chondrocytes
    • Liacini A., Sylvester J., Li W.Q., Huang W., Dehnade F., Ahmad M., et al. Induction of matrix metalloproteinase-13 gene expression by TNF-alpha is mediated by MAP kinases, AP-1, and NF-kappaB transcription factors in articular chondrocytes. Exp Cell Res 2003, 288:208-217.
    • (2003) Exp Cell Res , vol.288 , pp. 208-217
    • Liacini, A.1    Sylvester, J.2    Li, W.Q.3    Huang, W.4    Dehnade, F.5    Ahmad, M.6
  • 49
    • 0035284754 scopus 로고    scopus 로고
    • Oncostatin M-induced matrix metalloproteinase and tissue inhibitor of metalloproteinase-3 genes expression in chondrocytes requires Janus kinase/STAT signaling pathway
    • Li W.Q., Dehnade F., Zafarullah M. Oncostatin M-induced matrix metalloproteinase and tissue inhibitor of metalloproteinase-3 genes expression in chondrocytes requires Janus kinase/STAT signaling pathway. J Immunol 2001, 166:3491-3498.
    • (2001) J Immunol , vol.166 , pp. 3491-3498
    • Li, W.Q.1    Dehnade, F.2    Zafarullah, M.3
  • 50
    • 33747203059 scopus 로고    scopus 로고
    • Early responses of osteoblast-like cells to different mechanical signals through various signaling pathways
    • Liu J., Liu T., Zheng Y., Zhao Z., Liu Y., Cheng H., et al. Early responses of osteoblast-like cells to different mechanical signals through various signaling pathways. Biochem Biophys Res Commun 2006, 348:1167-1173.
    • (2006) Biochem Biophys Res Commun , vol.348 , pp. 1167-1173
    • Liu, J.1    Liu, T.2    Zheng, Y.3    Zhao, Z.4    Liu, Y.5    Cheng, H.6
  • 51
    • 67650418103 scopus 로고    scopus 로고
    • Central and peripheral region tibial plateau chondrocytes respond differently to in vitro dynamic compression
    • Bevill S.L., Briant P.L., Levenston M.E., Andriacchi T.P. Central and peripheral region tibial plateau chondrocytes respond differently to in vitro dynamic compression. Osteoarthritis Cartilage 2009, 17:980-987.
    • (2009) Osteoarthritis Cartilage , vol.17 , pp. 980-987
    • Bevill, S.L.1    Briant, P.L.2    Levenston, M.E.3    Andriacchi, T.P.4
  • 52
    • 72149105318 scopus 로고    scopus 로고
    • Mechanical loading regimes affect the anabolic and catabolic activities by chondrocytes encapsulated in PEG hydrogels
    • Nicodemus G.D., Bryant S.J. Mechanical loading regimes affect the anabolic and catabolic activities by chondrocytes encapsulated in PEG hydrogels. Osteoarthritis Cartilage 2010, 18:126-137.
    • (2010) Osteoarthritis Cartilage , vol.18 , pp. 126-137
    • Nicodemus, G.D.1    Bryant, S.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.