Mechanical and metabolic injury to the skin barrier leads to increased expression of murine Β-defensin-1,-3, and-14

Journal of Investigative Dermatology

Volumn 131, Issue 2, 2011, Pages 443-452

  Ahrens, Kerstin ^a   Schunck, Michael ^a   Podda, Graziella Francesca ^a   Meingassner, Josef ^b   Stuetz, Anton ^b   Schröder, Jens Michael ^a   Harder, Jürgen ^a   Proksch, Ehrhardt ^a  

^a UNIVERSITY OF KIEL   (Germany)

^b Novartis Institutes for Biomedical Research   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ACETONE; BETA DEFENSIN; BETA DEFENSIN 1; BETA DEFENSIN 14; BETA DEFENSIN 3; MESSENGER RNA; NEUTRALIZING ANTIBODY; TRANSFORMING GROWTH FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; IMMUNOHISTOLOGY; KERATINOCYTE; MALE; METABOLISM; MOUSE; NONHUMAN; PERMEABILITY BARRIER; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKIN INJURY; SKIN PERMEABILITY; UPREGULATION; WESTERN BLOTTING;

EID: 78651398373     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2010.289     Document Type: Article

References (60)

1. Aberg KM, Man MQ, Gallo RL et al. (2008) Co-regulation and interdependence of the mammalian epidermal permeability and antimicrobial barriers. J Invest Dermatol 128:917-25
2. Aberg KM, Radek KA, Choi EH et al. (2007) Psychological stress down-regulates epidermal antimicrobial peptide expression and increases severity of cutaneous infections in mice. J Clin Invest 117:3339-49
3. Ali RS, Falconer A, Ikram M et al. (2001) Expression of the peptide antibiotics human beta defensin-1 and human beta defensin-2 in normal human skin. J Invest Dermatol 117:106-11
4. Aly R, Maibach HE, Mandel A (1976) Bacterial flora in psoriasis. Br J Dermatol 95:603-6
5. Aly R, Maibach HI, Shinefield HR (1977) Microbial flora of atopic dermatitis. Arch Dermatol 113:780-2
6. Bals R, Wang X, Meegalla RL et al. (1999) Mouse beta-defensin 3 is an inducible antimicrobial peptide expressed in the epithelia of multiple organs. Infect Immun 67:3542-7
7. Bavandi A, Meingassner JG, Becker S (1992) Diet-induced dermatitis response of hairless rats to systemic treatment with cyclosporin A (Sandimmun), cyclosporin H and FK506. Exp Dermatol 1:199-205
8. Bibel DJ, Miller SJ, Brown BE et al. (1989) Antimicrobial activity of stratum-corneum lipids from normal and essential fatty acid-deficient mice. J Invest Dermatol 92:632-8
9. Burd RS, Furrer JL, SulliVan J et al. (2002) Murine beta-defensin-3 is an inducible peptide with limited tissue expression and broad-spectrum antimicrobial activity. Shock 18:461-4
10. Denda M, Sato J, Masuda Y et al. (1998) Exposure to a dry environment enhances epidermal permeability barrier function. J Invest Dermatol 111:858-63
11. Fluhr JW, Akengin A, Bornkessel A et al. (2005) Additive impairment of the barrier function by mechanical irritation, occlusion and sodium lauryl sulphate in vivo. Br J Dermatol 153:125-31
12. Fulton C, Anderson GM, Zasloff M et al. (1997) Expression of natural peptide antibiotics in human skin. Lancet 350:1750-1
13. Gallo RL, Huttner KM (1998) Antimicrobial peptides: an emerging concept in cutaneous biology. J Invest Dermatol 111:739-43
14. Gallo RL, Kim KJ, Bernfield M et al. (1997) Identification of CRAMP, a cathelin-related antimicrobial peptide expressed in the embryonic and adult mouse. J Biol Chem 272:13088-93
15. Ganz T, Lehrer RI (1994) Defensins. Curr Opin Immunol 6:584-9
16. Gläser R, Harder J, Lange H et al. (2005) Antimicrobial psoriasin (S100A7) protects human skin from Escherichia coli infection. Nat Immunol 6:57-64
17. Harder J, Bartels J, Christophers E et al. (1997) A peptide antibiotic from human skin. Nature 387:861
18. Harder J, Bartels J, Christophers E et al. (2001) Isolation and characterization of human beta -defensin-3, a novel human inducible peptide antibiotic. J Biol Chem 276:5707-13
19. Harder J, Dressel S, Wittersheim M et al. (2010) Enhanced expression and secretion of antimicrobial peptides in atopic dermatitis and after superficial skin injury. J Invest Dermatol 130:1355-64
20. Harder J, Schröder JM (2002) RNase 7, a novel innate immune defense antimicrobial protein of healthy human skin. J Biol Chem 277: 46779-84
21. Harder J, Schröder JM (2005a) Antimicrobial peptides in human skin. Chem Immunol Allergy 86:22-41
22. Harder J, Schröder JM (2005b) Psoriatic scales: a promising source for the isolation of human skin-derived antimicrobial proteins. J Leukoc Biol 77:476-86
23. Hinrichsen K, Podschun R, Schubert S et al. (2008) Mouse beta-defensin-14, an antimicrobial ortholog of human beta-defensin-3. Antimicrob Agents Chemother 52:1876-9
24. Hong SP, Kim MJ, Jung MY et al. (2008) Biopositive effects of low-dose UVB on epidermis: coordinate upregulation of antimicrobial peptides and permeability barrier reinforcement. J Invest Dermatol 128:2880-7
25. Huttner KM, Kozak CA, Bevins CL (1997) The mouse genome encodes a single homolog of the antimicrobial peptide human beta-defensin 1. FEBS Lett 413:45-9
26. Izadpanah A, Gallo RL (2005) Antimicrobial peptides. J Am Acad Dermatol 52:381-90
27. Jensen JM, Pfeiffer S, Akaki T et al. (2007) Barrier function, epidermal differentiation, and human beta-defensin 2 expression in tinea corporis. J Invest Dermatol 127:1720-7
28. Jensen JM, Schutze S, Forl M et al. (1999) Roles for tumor necrosis factor receptor p55 and sphingomyelinase in repairing the cutaneous permeability barrier. J Clin Invest 104:1761-70
29. Liou A, Elias PM, Grunfeld C et al. (1997) Amphiregulin and nerve growth factor expression are regulated by barrier status in murine epidermis. J Invest Dermatol 108:73-7
30. Liu AY, Destoumieux D, Wong AV et al. (2002) Human beta-defensin-2 production in keratinocytes is regulated by interleukin-1, bacteria, and the state of differentiation. J Invest Dermatol 118:275-81
31. Liu L, Wang L, Jia HP et al. (1998) Structure and mapping of the human beta-defensin HBD-2 gene and its expression at sites of inflammation. Gene 222:237-44
32. Lübbe J (2003) Secondary infections in patients with atopic dermatitis. Am J Clin Dermatol 4:641-54
33. Mathews M, Jia HP, Guthmiller JM et al. (1999) Production of beta-defensin antimicrobial peptides by the oral mucosa and salivary glands. Infect Immun 67:2740-5
34. Morrison GM, Davidson DJ, Kilanowski FM et al. (1998) Mouse beta defensin-1 is a functional homolog of human beta defensin-1. Mamm Genome 9:453-7
35. Morrison GM, Semple CA, Kilanowski FM et al. (2003) Signal sequence conservation and mature peptide divergence within subgroups of the murine beta-defensin gene family. Mol Biol Evol 20:460-70
36. Niyonsaba F, Ushio H, Nakano N et al. (2007) Antimicrobial peptides human beta-defensins stimulate epidermal keratinocyte migration, proliferation and production of proinflammatory cytokines and chemokines. J Invest Dermatol 127:594-604
37. Oren A, Ganz T, Liu L et al. (2003) In human epidermis, beta-defensin 2 is packaged in lamellar bodies. Exp Mol Pathol 74:180-2
38. Pazgier M, Hoover DM, Yang D et al. (2006) Human beta-defensins. Cell Mol Life Sci 63:1294-313
39. Plessner HL, Lin PL, Kohno T et al. (2007) Neutralization of tumor necrosis factor (TNF) by antibody but not TNF receptor fusion molecule exacerbates chronic murine tuberculosis. J Infect Dis 195:1643-50
40. Proksch E, Elias PM, Feingold KR (1990) Regulation of 3-hydroxy-3-methylglutaryl-coenzyme-A reductase-activity in murine epidermis- modulation of enzyme content and activation state by barrier requirements. J Clin Invest 85:874-82
41. Proksch E, Feingold KR, Elias PM (1992) Epidermal Hmg CoA reductase-activity in essential fatty-acid deficiency- barrier requirements rather than eicosanoid generation regulate cholesterol-synthesis. J Invest Dermatol 99:216-20
42. Radek KA, Lopez-Garcia B, Hupe M et al. (2008) The neuroendocrine peptide catestatin is a cutaneous antimicrobial and induced in the skin after injury. J Invest Dermatol 128:1525-34
43. Röhrl J, Yang D, Oppenheim JJ et al. (2008) Identification and biological characterization of mouse beta-defensin 14, the orthologue of human beta-defensin 3. J Biol Chem 283:5414-9
44. Schägger H, von Jagow G (1987) Tricine sodium dodecyl-sulfate polyacry-lamide-gel electrophoresis for the separation of proteins in the range from 1- to 100-Kda. Anal Biochem 166:368-79
45. Schauber J, Gallo RL (2008) Antimicrobial peptides and the skin immune defense system. J Allergy Clin Immunol 122:261-6
46. Schröder JM (1999) Epithelial antimicrobial peptides: innate local host response elements. Cell Mol Life Sci 56:32-46
47. Schröder JM, Harder J (1999) Human beta-defensin-2. Int J Biochem Cell Biol 31:645-51
48. Schröder JM, Harder J (2006) Antimicrobial skin peptides and proteins. Cell Mol Life Sci 63:469-86
49. Singh G, Marples RR, Kligman AM (1971) Experimental staphylococcus aureus infections in humans. J Invest Dermatol 57:149-62
50. Sørensen OE, Cowland JB, Theilgaard-Monch K et al. (2003) Wound healing and expression of antimicrobial peptides/polypeptides in human keratinocytes, a consequence of common growth factors. J Immunol 170:5583-9
51. Sørensen OE, Thapa DR, Rosenthal A et al. (2005) Differential regulation of beta-defensin expression in human skin by microbial stimuli. J Immunol 174:4870-9
52. Ørensen OE, Thapa DR, Roupe KM et al. (2006). Injury-induced innate immune response in human skin mediated by transactivation of the epidermal growth factor receptor. J Clin Invest 116 1878-85.
53. Taylor K, Clarke DJ, McCullough B et al. (2008) Analysis and separation of residues important for the chemoattractant and antimicrobial activities of beta-defensin 3. J Biol Chem 283:6631-9
54. Varoga D, Pufe T, Harder J et al. (2004) Production of endogenous antibiotics in articular cartilage. Arthritis Rheum 50:3526-34
55. Warner RR, Stone KJ, Boissy YL (2003) Hydration disrupts human stratum corneum ultrastructure. J Invest Dermatol 120:275-84
56. Werner S, Krieg T, Smola H (2007) Keratinocyte-fibroblast interactions in wound healing. J Invest Dermatol 127:998-1008
57. Wood LC, Elias PM, Sequeiramartin SM et al. (1994) Occlusion lowers cytokine messenger-RNA levels in essential fatty acid-deficient and normal mouse epidermis, but not after acute barrier disruption. J Invest Dermatol 103:834-8
58. Wood LC, Jackson SM, Elias PM et al. (1992) Cutaneous barrier perturbation stimulates cytokine production in the epidermis of mice. J Clin Invest 90:482-7
59. Yin C, Dang HN, Zhang HB et al. (2006) Capacity of human beta-defensin expression in gene-transduced and cytokine-induced cells. Biochem Biophys Res Commun 339:344-54
60. Zhao C, Wang I, Lehrer RI (1996) Widespread expression of beta-defensin hBD-1 in human secretory glands and epithelial cells. FEBS Lett 396:319-22