Mouse beta defensin-1 is a functional homolog of human beta defensin-1

Mammalian Genome

Volumn 9, Issue 6, 1998, Pages 453-457

  Morrison, Gillian M ^a   Davidson, Donald J ^a   Kilanowski, Fiona M ^a   Borthwick, Duncan W ^a   Crook, Ken ^a   Maxwell, Alison I ^b   Govan, John R W ^b   Dorin, Julia R ^a  

^a WESTERN GENERAL HOSPITAL   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BETA DEFENSIN 1; PEPTIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIMICROBIAL ACTIVITY; ARTICLE; BURKHOLDERIA CEPACIA; CHROMOSOME 8; CYSTIC FIBROSIS; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PEPTIDE MAPPING; PROTEIN EXPRESSION; PSEUDOMONAS AERUGINOSA; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; ANIMALS; BETA-DEFENSINS; BLOOD PROTEINS; CHROMOSOME MAPPING; DEFENSINS; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; RESTRICTION MAPPING;

ANIMALIA; BURKHOLDERIA; BURKHOLDERIA CEPACIA; EUKARYOTA; INSECTA; PSEUDOMONAS; PSEUDOMONAS AERUGINOSA;

EID: 0031874723     PISSN: 09388990     EISSN: None     Source Type: Journal    
DOI: 10.1007/s003359900795     Document Type: Article

References (20)

1. Beckman W, Lessie TG (1979) Response of Pseudomonas cepacia to β-lactam antibiotics: utilization of penicillin G as the carbon source. J Bacteriol 140, 1126-1128
2. Diamond G, Zasloff M, Eck H, Brasseur M, Maloy WL et al. (1991) Tracheal antimicrobial peptide, a cysteine-rich peptide from mammalian tracheal mucosa: peptide isolation and cloning of a cDNA. Proc Natl Acad Sci USA 88, 3952-3956
3. Fantes JA, Oghene K, Boyle S, Danes S, Fletcher JM et al. (1995) A high-resolution integrated physical, cytogenetic, and genetic map of human Chromosome 11: distal p13 to proximal p15.1. Genomics 25, 447-461
4. Gilljam H, Ellin A, Strandvik B (1989) Increased bronchial chloride concentration in cystic fibrosis. Scand J Clin Lab Invest 49, 121-124
5. Goldman MJ, Anderson GM, Stolzenberg ED, Kari UP, Zasloff M et al. (1997) Human β-defensin-1 is a salt-sensitive antibiotic in lung that is inactivated in cystic fibrosis. Cell 88, 553-560
6. Govan JRW, Nelson JW (1992) Microbiology of lung infection in cystic fibrosis. Br Med Bull 48, 912-930
7. Govan JRW, Brown PH, Maddison J, Doherty CJ, Nelson JW et al. (1993) Evidence for transmission of Pseudomonas cepacia by social contact in cystic fibrosis. Lancet 342, 15-19
8. Govan JRW, Hughes JE, Vandamme P (1996) Burkholderia cepacia: medical, laxonomic and ecological issues. J Med Microbiol 45, 395-407
9. Hancock REW (1997) Peptide antibiotics. Lancet 349, 418-422
10. Harder J, Bartels J, Christophers E, Schroder J-M (1997a). A peptide antibiotic from human skin. Nature 387, 861
11. Harder J, Siebert R, Zhang Y, Matthiesen P, Christophers E et al. (1997b) Mapping of the gene encoding human β-defensin-2 (DEFB2) to Chromosome region 8p22-p23.1. Genomics 46, 472-475
12. Huttner KM, Selsted ME, Ouellette AJ (1994) Structure and diversity of the murine cryptdin gene family. Genomics 19, 448-453
13. Huttner KM, Kozak CA, Bevins CL (1997) The mouse genome encodes a single homolog of the antimicrobial peptide human β-defensin-1. FEBS Lett 413, 45-49
14. Joris L, Dab L, Quinton PM (1993) Elemental composition of human airway surface fluid in healthy and diseased airways. Am Rev Respir Dis 148, 1633-1637
15. Lui L, Zhao C, Heng HHQ, Ganz T (1997) The human β-defensin-1 and α-defensins are encoded by adjacent genes: two peptide families with differing disulfide topology share a common ancestry. Genomics 43, 316-320
16. McCray PB, Bentley L (1997) Human airway epithelia express a beta-defensin. Am J Respir Cell Mol Biol 16, 343-349
17. Nehls M, Pfeifer D, Boehm T (1994) Exon amplification from complete libraries of genomic DNA using a novel phage vector with automatic plasmid excision facility: application to the mouse neurofibromatosis-1 locus. Oncogene 9, 2169-2175
18. Schonwetter BS, Stolzenberg ED, Zasloff MA (1995) Epithelial antibiotics induced at sites of inflammation. Science 267, 1645-1648
19. Singh P, Welsh MJ (1997) Components of airway surface fluid have synergistic antimicrobial activity. Ped Pulm Supl 14, 323
20. Smith JJ, Travis SM, Greenberg EP, Welsh MJ (1996) Cystic fibrosis airway epithelia fail to kill bacteria because of abnormal airway surface fluid. Cell 85, 229-236