Wound healing and expression of antimicrobial peptides/polypeptides in human keratinocytes, a consequence of common growth factors

Journal of Immunology

Volumn 170, Issue 11, 2003, Pages 5583-5589

  Sorensen, Ole E ^a,b   Cowland, Jack B ^a   Theilgaard Mönch, Kim ^a   Liu, Lide ^b   Ganz, Tomas ^b   Borregaard, Niels ^a  

^a Rigshospitalet   (Denmark)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA DEFENSIN; BETA DEFENSIN 3; CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; CATIONIC ANTIMICROBIAL PROTEIN 18; GROWTH FACTOR; LIPOCALIN; PEPTIDE; POLYPEPTIDE; SECRETORY LEUKOCYTE PROTEINASE INHIBITOR; SOMATOMEDIN C; TRANSFORMING GROWTH FACTOR ALPHA; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; HOST RESISTANCE; HUMAN; HUMAN CELL; INFECTION; KERATINOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; PSORIASIS; SKIN; SKIN DISEASE; TISSUE REGENERATION; WOUND HEALING;

EID: 0038189571     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.170.11.5583     Document Type: Article

References (45)

1. Hoffmann, J. A., F. C. Kafatos, C. A. Janeway, and R. B. Ezekowitz. 1999. Phylogenetic perspectives in innate immunity. Science 284:1313.
2. Zasloff, M. 2002. Antimicrobial peptides of multicellular organisms. Nature 415:389.
3. Boman, H. G. 2000. Innate immunity and the normal microflora. Immunol. Rev. 173:5.
4. Fulton, C., G. M. Anderson, M. Zasloff, R. Bull, and A. G. Quinn. 1997. Expression of natural peptide antibiotics in human skin. Lancet 350:1750.
5. Harder, J., J. Bartels, E. Christophers, and J.-M. Schröder. 1997. A peptide antibiotic from human skin. Nature 387:861.
6. Harder, J., J. Bartels, E. Christophers, and J. M. Schroder. 2001. Isolation and characterization of human β-defensin-3, a novel human inducible peptide antibiotic. J Biol. Chem. 276:5707.
7. Frohm, M., B. Agerberth, G. Ahangari, M. Ståhle-Bäckdahl, S. Lidén, H. Wigzell. and G. H. Gudmundsson. 1997. The expression of the gene coding for the antibacterial peptide LL-37 is induced in human keratinocytes during inflammatory disorders. J Biol. Chem. 272:15258.
8. Dorschner. R. A., V. K. Pestonjamasp, S. Tamakuwala, T. Ohtake, J. Rudisill, V. Nizet, B. Agerberth, G. H. Gudmundsson, and R. L. Gallo. 2001. Cutaneous injury induces the release of cathelicidin anti-microbial peptides active against group A streptococcus. J. Invest. Dermatol. 117:91.
9. Nizet, V., T. Ohtake, X. Lauth, J. Trowbridge, J. Rudisill, R. A. Dorschner, V. Pestonjamasp. J. Piraino, K. Huttner, and R. L. Gallo. 2001. Innate antimicrobial peptide protects the skin from invasive bacterial infection. Nature 414:454.
10. Wingens, M., B. H. van Bergen, P. S. Hiemstra, J. F. Meis, W. I. van-Vlijmen, P. L. Zeeuwen, J. Mulder, H. A. Kramps, R. F. van Ruissen, and J. Schalkwijk. 1998. Induction of SLPI (ALP/HUSI-I) in epidermal keratmocytes. J. Invest. Dermatol. 111:996.
11. Mallbris, L., K. P. O'Brien, A. Hulthen, B. Sandstedt, J. B. Cowland. N. Borregaard, and M. Ståhle-Bäckdahl. 2002. Neutrophil gelatinase-associated lipocalin is a marker for dysregulated keratinocyte differentiation in human skin. Exp. Dermatol. 11:584.
12. Hiemstra, P. S., R. J. Maassen, J. Stolk, R. Heinzel-Wieland, G. J. Steffens, and J. H. Dijkman. 1996. Antibacterial activity of antileukoprotease. Infect. Immun. 64:4520.
13. McNeely, T. B., M. Dealy, D. J. Dripps, J. M. Orenstein, S. P. Eisenberg, and S. M. Wahl. 1995. Secretory leukocyte protease inhibitor: a human saliva protein exhibiting anti-human immunodeficiency virus I activity in vitro. J. Clin. Invest. 96:456.
14. Goetz, D. H., M. A. Holmes, N. Borregaard, M. E. Bluhm, K. N. Raymond, and R. K. Strong. 2002. The neutrophil lipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition. Mol. Cell 10:1033.
15. Kjeldsen, L., C. Koch, K. Amljots, and N. Borregaard. 1996. Characterization of two ELISAs for NGAL, a newly described lipocalin in human neutrophils. J. Immunol. Methods 198:155.
16. Sørensen, O., J. B. Cowland, J. Askaa. and N. Borregaard. 1997. An ELISA for hCAP-18, the cathelicidin present in human neutrophils and plasma. J. Immunol. Methods 206:53.
17. Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680.
18. Towbin, H., T. Staehelin, and J. Gordon. 1979. Electrophoretic transfer of proteins from polyacrylamide gets to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad. Sci. USA 76:4350.
19. Bundgaard, J. R., H. Sengelov, N. Borregaard, and L. Kjeldsen. 1994. Molecular cloning and expression of a cDNA encoding NGAL: a lipocalin expressed in human neutrophils. Biochem. Biophys. Res. Commun. 202:1468,
20. Cowland, J. B., and N. Borregaard. 1999. The individual regulation of granule protein mRNA levels during neutrophil maturation explains the heterogeneity of neutrophil granules. J. Leukocyte Biol. 66:989.
21. Liu, L., L. Wang, H. P. Jia, C. Zhao, H. Q. Heng, B. C. Schutte, J. McCray-PB, and T. Ganz. 1998. Structure and mapping of the human β-defensin HBD-2 gene and its expression at sites of inflammation. Gene 222:237.
22. Liu, A. Y., D. Destoumieux, A. V. Wong, C. H. Park, E. V. Valore, L. Liu, and T. Ganz. 2002. Human β-defensin-2 production in keratinocytes is regulated by interleukin-1, bacteria, and the state of differentiation. J. Invest. Dermatol. 118:275.
23. Zhao, C., I. Wang, and R. I. Lehrer. 1996. Widespread expression of β-defensin hBD-1 in human scretory glands and epithelial cells. FEBS Lett. 396:319.
24. Roudabush, F. L., K. L. Pierce, S. Maudsley, K. D. Khan, and L. M. Luttrell. 2000. Transactivation of the EGF receptor mediates IGF-I-stimulated she phosphorylation and ERKI/2 activation in COS-7 cells. J. Biol. Chem. 275:22583.
25. Krane, J. F., D. P. Murphy, D. M. Carter, and J. G. Krueger. 1991. Synergistic effects of epidermal growth factor (EGF) and insulin-like growth factor I/somatomedin C (IGF-I) on keratinocyte proliferation may be mediated by IGF-I transmodulation of the EGF receptor. J. Invest. Dermatol. 96:419.
26. Garcia, J. R., A. Krause, S. Schulz, F. J. Rodriguez-Jimenez, E. Kluver, K. Adermann, U. Forssmann, A. Frimpong-Boateng, R. Bals. and W. G. Forssmann. 2001. Human β-defensin 4: a novel inducible peptide with a specific salt-sensitive spectrum of antimicrobial activity. FASEB J. 15:1819.
27. Wiedow, O., J. Harder, J. Bartels, V. Streit, and E. Christophers. 1998. Antileukoprotease in human skin: an antibiotic peptide constitutively produced by keratinocytes. Biochem. Biophys. Res. Commun. 248:904.
28. Sallenave, J. M., J. Shulmann, J. Crossley, M. Jordana, and J. Gauldie. 1994. Regulation of secretory leukocyte proteinase inhibitor (SLPI) and elastase-specific inhibitor (ESI/elafin) in human airway epithelial cells by cytokines and neutrophilic enzymes. Am. J. Respir. Cell Mol. Biol. 11:733.
29. Oren, A., T. Ganz, L. Liu, and T. Meerloo. In human epidermis, β-defensin 2 is packaged in lamellar bodies. Exp. Mol. Pathol. In press.
30. Singer, A. J., and R. A. Clark. 1999. Cutaneous wound healing. N. Engl. J. Med. 341:738.
31. Costigan, D. C., H. J. Guyda, and B. 1. Posner. 1988. Free insulin-like growth factor I (IGF-I) and IGF-II in human saliva. J Clin. Endocrinol. Metab 66:1014.
32. Mogi, M., H. Inagaki, K. Kojima, M. Minami, and M. Harada. 1995. Transforming growth factor-α in human submandibular gland and saliva. J. Immunoassay 16:379.
33. Kumar, V., S. A. Bustin, and I. A. McKay. 1995. Transforming growth factor α. Cell Biol. Int. 19:273.
34. Elder, J. T., G. J. Fisher, P. B. Lindquist, G. L. Bennett, M. R. Pittelkow, J. Coffey-RJ, L. Ellingsworth, R. Derynck, and J. J. Voorhees. 1989. Overexpression of transforming growth factor a in psoriatic epidermis. Science 243:811.
35. Krane, J. F., A. B. Gottlieb, D. M. Carter, and J. G. Krueger. 1992. The insulin-like growth factor I receptor is overexpressed in psoriatic epidermis, but is differentially regulated from the epidermal growth factor receptor. J. Exp. Med. 175:1081.
36. Gartner, M. H., J. D. Benson, and M. D. Caldwell. 1992. Insulin-like growth factors I and II expression in the healing wound. J. Surg. Res. 52:389.
37. Rappolee, D. A., D. Mark, M. J. Banda, and Z. Werb. 1988. Wound macrophages express TGF-α and other growth factors in vivo: analysis by mRNA phenotyping. Science 241:708.
38. Calafat, J., H. Janssen, M. Ståhle-Bäckdahl, A. E. M. Zuurbier, E. F. Knol, and A. Egesten. 1997. Human monocytes and neutrophils store transforming growth factor-α in a subpopulation of cytoplasmatic granules. Blood 90:1255.
39. Egesten, A., J. Calafat, E. F. Knol, H. Janssen, and T. M. Walz. 1996. Subcellular localization of transforming growth factor-a in human eosinophil granulocytes. Blood 87:3910.
40. Madtes, D. K., E. W. Raines, K. S. Sakariassen, R. K. Assoian, M. B. Spom, G. I. Bell, and R. Ross. 1988. Induction of transforming growth factor-α in activated human alveolar macrophages. Cell 53:285.
41. Wu, L. P., and K. V. Anderson. 1997. Related signaling networks in Drosophila that control dorsoventral patterning in the embryo and the immune response. Cold Spring Harb. Symp. Quant. Biol. 62:97.
42. Liu, J. P., J. Baker, A. S. Perkins, E. J. Robertson, and A. Efstratiadis. 1993. Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1). Cell 75:59.
43. Threadgill, D. W., A. A. Dlugosz, L. A. Hansen, T. Tennenbaum, U. Lichti, D. Yee, C. LaMantia, T. Mourton, K. Herrup, R. C. Harris, et al. 1995. Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype. Science 269:230.
44. Vogt, P. M., M. Lehnhardt, D. Wagner, and H. U. Steinau. 1998. Growth factors and insulin-like growth factor binding proteins in acute wound fluid. Growth Horm. IGF. Res. 8(Suppl. B):107.
45. Erdag, G., and J. R. Morgan. 2002. Interleukin-1α and interleukin-6 enhance the antibacterial properties of cultured composite keratinocyte grafts. Ann. Surg. 235:113.