Biopositive effects of low-dose UVB on epidermis: Coordinate upregulation of antimicrobial peptides and permeability barrier reinforcement

Journal of Investigative Dermatology

Volumn 128, Issue 12, 2008, Pages 2880-2887

  Hong, Seung P ^a   Kim, Min J ^a   Jung, Min Young ^a   Jeon, Hyerin ^a   Goo, Jawoong ^a   Ahn, Sung K ^a   Lee, Seung H ^b   Elias, Peter M ^c   Choi, Eung H ^a  

^a Yonsei University Wonju College of Medicine   (South Korea)

^b Yonsei University College of Medicine   (South Korea)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 ALPHA HYDROXYLASE; 1 ALPHA, 25 DIHYDROXYVITAMIN D3; BETA DEFENSIN 2; BETA DEFENSIN 3; CATHELIN RELATED ANTIMICROBIAL PEPTIDE; DEFENSIN; DIHYDROXYCOLECALCIFEROL; INVOLUCRIN; KETOCONAZOLE; MESSENGER RNA; OXYGENASE; POLYPEPTIDE ANTIBIOTIC AGENT; UNCLASSIFIED DRUG; VITAMIN D RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATOPIC DERMATITIS; CELL DIFFERENTIATION; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; EPIDERMIS; FEMALE; IMMUNOHISTOCHEMISTRY; LIPOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIATION DOSE; RADIATION EXPOSURE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ULTRAVIOLET B RADIATION; UPREGULATION; WESTERN BLOTTING;

ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; CELL DIFFERENTIATION; CHOLECALCIFEROL; EPIDERMIS; FEMALE; IMMUNOHISTOCHEMISTRY; KETOCONAZOLE; LIPIDS; MICE; MICE, HAIRLESS; MODELS, BIOLOGICAL; PERMEABILITY; RECEPTORS, CALCITRIOL; ULTRAVIOLET RAYS;

EID: 57349167517     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2008.169     Document Type: Article

References (33)

1. Aberg KM, Man MQ, Gallo RL, Ganz T, Crumrine D, Brown BE et al. (2008) Co-regulation and interdependence of the mammalian epidermal permeability and antimicrobial barriers. J Invest Dermatol 128:917-25
2. Bikle DD (2004) Vitamin D regulated keratinocyte differentiation. J Cell Biochem 92:436-44
3. Bikle DD, Chang S, Crumrine D, Elalieh H, Man MQ, Choi EH et al. (2004a) 25 Hydroxyvitamin D 1 alpha-hydroxylase is required for optimal epidermal differentiation and permeability barrier homeostasis. J Invest Dermatol 122:984-92
4. Bikle DD, Chang S, Crumrine D, Elalieh H, Man MQ, Dardenne O et al. (2004b) Mice lacking 25OHD 1alpha-hydroxylase demonstrate decreased epidermal differentiation and barrier function. J Steroid Biochem Mol Biol 89-90:347-53
5. Braff MH, Nardo AD, Gallo RL (2005) Keratinocytes store the antimicrobial peptide cathelicidin in lamellar bodies. J Invest Dermatol 124:394-400
6. de Jongh GJ, Zeeuwen PL, Kucharekova M, Pfundt R, van der Valk PG, Blokx W et al. (2005) High expression levels of keratinocyte antimicrobial proteins in psoriasis compared with atopic dermatitis. J Invest Dermatol 125:1163-73
7. Elias PM (2007) The skin barrier as an innate immune element. Semin Immunopathol 29:3-14
8. Elias PM, Choi EH (2005) Interactions among stratum corneum defensive functions. Exp Dermatol 14:719-26
9. Farrell AM, Uchida Y, Nagiec MM, Harris IR, Dickson RC, Elias PM et al. (1998) UVB irradiation up-regulates serine palmitoyltransferase in cultured human keratinocytes. J Lipid Res 39:2031-8
10. Gambichler T, Skrygan M, Tomi NS, Altmeyer P, Kreuter A (2006) Changes of antimicrobial peptide mRNA expression in atopic eczema following phototherapy. Br J Dermatol 155:1275-8
11. Haratake A, Uchida Y, Schmuth M, Tanno O, Yasuda R, Epstein JH et al. (1997) UVB-induced alterations in permeability barrier function: roles for epidermal hyperproliferation and thymocyte-mediated response. J Invest Dermatol 108:769-75
12. Holick MF (1981) The cutaneous photosynthesis of previtamin D3: a unique photoendocrine system. J Invest Dermatol 77:51-8
13. Holleran WM, Uchida Y, Halkier-Sorensen L, Haratake A, Hara M, Epstein JH et al. (1997) Structural and biochemical basis for the UVB-induced alterations in epidermal barrier function. Photodermatol Photoimmunol Photomed 13:117-28
14. Jekler J, Larko O (1988) UVB phototherapy of atopic dermatitis. Br J Dermatol 119:697-705
15. Lamaud E, Schalla W (1984) Influence of UV irradiation on penetration of hydrocortisone. In vivo study in hairless rat skin. Br J Dermatol 111(Suppl 27):152-7
16. Leenutaphong V, Nimkulrat P, Sudtim S (2000) Comparison of phototherapy two times and four times a week with low doses of narrow-band ultraviolet B in Asian patients with psoriasis. Photodermatol Photoimmunol Photomed 16:202-6
17. Lehmann B (2005) The vitamin D3 pathway in human skin and its role for regulation of biological processes. Photochem Photobiol 81:1246-51
18. Lehmann B, Sauter W, Knuschke P, Dressler S, Meurer M (2003) Demonstration of UVB-induced synthesis of 1 alpha,25-dihydroxyvitamin D3 (calcitriol) in human skin by microdialysis. Arch Dermatol Res 295:24-8
19. Lehmann P, Holzle E, Melnik B, Plewig G (1991) Effects of ultraviolet A and B on the skin barrier: a functional, electron microscopic and lipid biochemical study. Photodermatol Photoimmunol Photomed 8:129-34
20. Liu AY, Destoumieux D, Wong AV, Park CH, Valore EV, Liu L et al. (2002) Human beta-defensin-2 production in keratinocytes is regulated by interleukin-1, bacteria, and the state of differentiation. J Invest Dermatol 118:275-81
21. Mallbris L, Edstrom DW, Sundblad L, Granath F, Stahle M (2005) UVB upregulates the antimicrobial protein hCAP18 mRNA in human skin. J Invest Dermatol 125:1072-4
22. Narbutt J, Lesiak A, Sysa-Jedrzejowska A, Wozniacka A, Cierniewska-Cieslak A, Boncela J et al. (2007) Repeated low-dose ultraviolet (UV) B exposures of humans induce limited photoprotection against the immune effects of erythemal UVB radiation. Br J Dermatol 156:539-47
23. Oh Y, Kim M, Jeon H, Choi EH (2007) Topical vitamin D improves impairment of epidermal barrier induced by topical steroid. J Invest Dermatol 127:S76, (abstr no. 456)
24. Ong PY, Ohtake T, Brandt C, Strickland I, Boguniewicz M, Ganz T et al. (2002) Endogenous antimicrobial peptides and skin infections in atopic dermatitis. N Engl J Med 347:1151-60
25. Oren A, Ganz T, Liu L, Meerloo T (2003) In human epidermis, [beta]-defensin 2 is packaged in lamellar bodies. Exp Mol Pathol 74:180-2
26. Schauber J, Dorschner RA, Coda AB, Buchau AS, Liu PT, Kiken D et al. (2007) Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D-dependent mechanism. J Clin Invest 117:803-11
27. Seo SJ, Ahn SW, Hong CK, Ro BI (2001) Expressions of beta-defensins in human keratinocyte cell lines. J Dermatol Sci 27:183-91
28. 2 vitamin D3 in cultured human keratinocytes. Arch Dermatol Res 289:367-72
29. Takagi Y, Nakagawa H, Kondo H, Takema Y, Imokawa G (2004) Decreased levels of covalently bound ceramide are associated with ultraviolet B-induced perturbation of the skin barrier. J Invest Dermatol 123:1102-9
30. Wang TT, Nestel FP, Bourdeau V, Nagai Y, Wang Q, Liao J et al. (2004) Cutting edge: 1,25-dihydroxyvitamin D3 is a direct inducer of antimicrobial peptide gene expression. J Immunol 173:2909-12
31. Weber G, Heilborn JD, Chamorro Jimenez CI, Hammarsjo A, Torma H, Stahle M (2005) Vitamin D induces the antimicrobial protein hCAP18 in human skin. J Invest Dermatol 124:1080-2
32. Wefers H, Melnik BC, Flur M, Bluhm C, Lehmann P, Plewig G (1991) Influence of UV irradiation on the composition of human stratum corneum lipids. J Invest Dermatol 96:959-62
33. Wulf HC, Bech-Thomsen N (1998) A UVB phototherapy protocol with very low dose increments as a treatment of atopic dermatitis. Photodermatol Photoimmunol Photomed 14:1-6