Murine β-defensin-3 is an inducible peptide with limited tissue expression and broad-spectrum antimicrobial activity

Shock

Volumn 18, Issue 5, 2002, Pages 461-464

  Burd, Randall S ^a   Furrer, Jason L ^b   Sullivan, Janet ^b   Smith, Arnold L ^a  

^a ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^b University of Missouri   (United States)

Author keywords

Antibiotics; Gram negative bacterial infections; Peptide; Peptide synthesis

Indexed keywords

ANTIINFECTIVE AGENT; BETA DEFENSIN; BETA DEFENSIN 3; BETA-DEFENSIN 3; RECOMBINANT PROTEIN;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; BAGG ALBINO MOUSE; BIOSYNTHESIS; CANDIDA ALBICANS; DRUG EFFECT; ENTEROBACTER INFECTION; ESCHERICHIA COLI; FEMALE; GENE EXPRESSION; GENETICS; HUMAN; IMMUNOLOGY; MALE; MOLECULAR GENETICS; MOUSE; PSEUDOMONAS AERUGINOSA; SEPSIS; STAPHYLOCOCCUS AUREUS; TISSUE DISTRIBUTION;

AMINO ACID SEQUENCE; ANIMALS; ANTI-BACTERIAL AGENTS; ANTI-INFECTIVE AGENTS; BETA-DEFENSINS; CANDIDA ALBICANS; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTIONS; FEMALE; GENE EXPRESSION; HUMANS; MALE; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; PSEUDOMONAS AERUGINOSA; RECOMBINANT PROTEINS; SEPSIS; STAPHYLOCOCCUS AUREUS; TISSUE DISTRIBUTION;

EID: 0036834675     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/00024382-200211000-00013     Document Type: Article

References (21)

1. Huttner KM, Bevins CL: Antimicrobial peptides as mediators of epithelial host defense. Pediatr Res 45:785-794, 1999.
2. Valore EV, Ganz T: Laboratory production of antimicrobial peptides in native conformation. Methods Mol Biol 78:115-131, 1997.
3. Zhao C, Wang I, Lehrer RI: Widespread expression of β-defensin hBD-1 in human secretory glands and epithelial cells. FEBS Lett 396:319-322, 1996.
4. Valore EV, Park CH, Quayle AJ, Wiles KR, McCray PB Jr, Ganz T: Human β-defensin-1: an antimicrobial peptide of urogenital tissues. J Clin Invest 101: 1633-1642, 1998.
5. Bals R, Wang X, Wu Z, Freeman T, Bafna V, Zasloff M, Wilson JM: Human β-defensin 2 is a salt-sensitive peptide antibiotic expressed in human lung. J Clin Invest 102:874-880, 1998.
6. Liu L, Wang L, Jia HP, Zhao C, Heng HH, Schutte BC, McCray PB Jr, Ganz T: Structure and mapping of the human β-defensin HBD-2 gene and its expression at sites of inflammation. Gene 222:237-244, 1998.
7. Harder J, Bartels J, Christophers E, Schroder JM: Isolation and characterization of human β-defensin-3, a novel human inducible peptide antibiotic. J Biol Chem 276:5707-5713, 2001.
8. Garcia JR, Krause A, Schulz S, Rodriguez-Jimenez FJ, Kluver E, Adermann K, Forssmann U, Frimpong-Boateng A, Bals R, Forssmann WG: Human β-defensin 4: a novel inducible peptide with a specific salt-sensitive spectrum of antimicrobial activity. FASEB J 15:1819-1821, 2001.
9. Ganz T: Defensins and host defense. Science 286:420-421, 1999.
10. Huttner KM, Kozak CA, Bevins CL: The mouse genome encodes a single homolog of the antimicrobial peptide human β-defensin 1. FEBS Lett 413:45-49, 1997.
11. Bals R, Goldman MJ, Wilson JM: Mouse β-defensin 1 is a salt-sensitive antimicrobial peptide present in epithelia of the lung and urogenital tract. Infect Immun 66:1225-1232, 1998.
12. Morrison GM, Davidson DJ, Kilanowski FM, Borthwick DW, Crook K, Maxwell AI, Govan JR, Dorin JR: Mouse β-defensin-1 is a functional homolog of human β-defensin-1. Mamm Genome 9:453-457, 1998.
13. Morrison GM, Davidson DJ, Dorin JR: A novel mouse β-defensin, Defb2, which is upregulated in the airways by lipopolysaccharide. FEBS Lett 442:112-116, 1999.
14. Bals R, Wang X, Meegalla RL, Wattler S, Weiner DJ, Nehls MC, Wilson JM: Mouse β-defensin 3 is an inducible antimicrobial peptide expressed in the epithelia of multiple organs. Infect Immun 67:3542-3547, 1999.
15. Jia HP, Wowk SA, Schutte BC, Lee SK, Vivado A, Tack BF, Bevins CL, McCray PB Jr: A novel murine β-defensin expressed in tongue, esophagus, and trachea. J Biol Chem 275:33314-33320, 2000.
16. Yamaguchi Y, Fukuhara S, Nagase T, Tomita T, Hitomi S, Kimura S, Kurihara H, Ouchi Y: A novel mouse β-defensin, mBD-6, predominantly expressed in skeletal muscle. J Biol Chem 276:31510-31514, 2001.
17. Shi J, Zhang G, Wu H, Ross C, Blecha F, Ganz T: Porcine epithelial β-defensin 1 is expressed in the dorsal tongue at antimicrobial concentrations. Infect Immun 67:3121-3127, 1999.
18. Tarver AP, Clark DP, Diamond G, Russell JP, Erdjument-Bromage H, Tempst P, Cohen KS, Jones DE, Sweeney RW, Wines M, Hwang S, Bevins CL: Enteric β-defensin: molecular cloning and characterization of a gene with inducible intestinal epithelial cell expression associated with Cryptosporidium parvum infection. Infect Immun 66:1045-1056, 1998.
19. Stolzenberg ED, Anderson GM, Ackermann MR, Whitlock RH, Zasloff M: Epithelial antibiotic induced in states of disease. Proc Natl Acad Sci USA 94:8686-9086, 1997.
20. Lentner C: Geigy Scientific Tables. Basel, Switzerland: Ciba-Geigy, 1981, pp 114-122.
21. Schonwetter BS, Stolzenberg ED, Zasloff MA: Epithelial antibiotics induced at sites of inflammation. Science 267:1645-1648, 1995.