Immune and non-immune functions of the (not so) neonatal Fc receptor, FcRn

Seminars in Immunopathology

Volumn 31, Issue 2, 2009, Pages 223-236

  Baker, Kristi ^a,b   Qiao, Shuo Wang ^c,d   Kuo, Timothy ^a,b   Kobayashi, Kanna ^a,b   Yoshida, Masaru ^e   Lencer, Wayne I ^b,f,g   Blumberg, Richard S ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c OSLO UNIVERSITY HOSPITAL   (Norway)

^d UNIVERSITY OF OSLO   (Norway)

^e KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^f HARVARD UNIVERSITY   (United States)

^g BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

Albumin; Gastrointestinal tract; Immune complexes; Immunoglobulin G; Neonatal Fc receptor

Indexed keywords

ALBUMIN; FC RECEPTOR; IMMUNOGLOBULIN G; PROTEIN FCRN; UNCLASSIFIED DRUG;

ADULT; FEMALE; GASTROINTESTINAL TRACT; HOMEOSTASIS; HUMAN; IMMUNE RESPONSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REVIEW; TRANSCYTOSIS;

ANIMALS; ANTIGEN-ANTIBODY COMPLEX; FEMALE; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; IMMUNOGLOBULIN G; INTESTINES; MATERNAL-FETAL EXCHANGE; PREGNANCY; PROTEIN TRANSPORT; RECEPTORS, FC; SERUM ALBUMIN;

EID: 70349275220     PISSN: 18632297     EISSN: 18632300     Source Type: Journal    
DOI: 10.1007/s00281-009-0160-9     Document Type: Review

References (109)

1. DC Roopenian S Akilesh 2007 FcRn: the neonatal Fc receptor comes of age Nat Rev Immunol 7 715 725 doi: 10.1038/nri2155 17703228 1:CAS:528: DC%2BD2sXpsV2qtbw%3D (Pubitemid 47327396)
2. FWR Brambell 1966 The transmission of immunity from mother to young and the catabolism of immunoglobulins Lancet 288 1087 1093 doi: 10.1016/S0140- 6736(66) 92190-8
3. FWR Brambell R Halliday IG Morris 1958 Interference by human and bovine serum and serum protein fractions with the absorption of antibodies by suckling rats and mice Proc R Soc Lond B Biol Sci 149 1 11 doi: 10.1098/rspb.1958.0046 13554426 1:STN:280:DyaG1c%2FpslCmtg%3D%3D
4. R Rodewald 1976 pH-Dependent binding of immunoglobulins to intestinal cells of the neonatal rat J Cell Biol 71 666 669 doi: 10.1083/jcb.71.2.666 11223 1:STN:280:DyaE2s%2FltFCgsQ%3D%3D
5. R Rodewald JP Kraehenbuhl 1984 Receptor-mediated transport of IgG J Cell Biol 99 159s 164 doi: 10.1083/jcb.99.1.159s 6235233 1:STN:280: DyaL2c3msVOmtg%3D%3D
6. NE Simister AR Rees 1985 Isolation and characterization of an Fc receptor from neonatal rat small intestine Eur J Immunol 15 733 738 doi: 10.1002/eji.1830150718 2988974 1:CAS:528:DyaL2MXltVeis78%3D (Pubitemid 15028949)
7. NE Simister KE Mostov 1989 An Fc receptor structurally related to MHC class I antigens Nature 337 184 187 doi: 10.1038/337184a0 2911353 1:CAS:528:DyaL1MXltFegtr8%3D (Pubitemid 19025381)
8. NE Simister KE Mostov 1989 Cloning and expression of the neonatal rat intestinal Fc receptor, a major histocompatibility complex class I antigen homolog Cold Spring Harb Symp Quant Biol 54 Pt 1 571 580 2534798 1:CAS:528:DyaK3MXktVGntQ%3D%3D
9. WL Martin AP West Jr L Gan PJ Bjorkman 2001 Crystal structure at 2.8 A of an FcRn/heterodimeric Fc complex: mechanism of pH-dependent binding Mol Cell 7 867 877 doi: 10.1016/S1097-2765(01)00230-1 11336709 1:CAS:528: DC%2BD3MXjsVentLc%3D (Pubitemid 32436446)
10. WP Burmeister LN Gastinel NE Simister ML Blum PJ Bjorkman 1994 Crystal structure at 2.2 A resolution of the MHC-related neonatal Fc receptor Nature 372 336 343 doi: 10.1038/372336a0 7969491 1:CAS:528:DyaK2MXitlOrsLc%3D (Pubitemid 24363433)
11. WP Burmeister AH Huber PJ Bjorkman 1994 Crystal structure of the complex of rat neonatal Fc receptor with Fc Nature 372 379 383 doi: 10.1038/372379a0 7969498 1:CAS:528:DyaK2MXitlOrtrw%3D (Pubitemid 24363442)
12. SM Claypool BL Dickinson M Yoshida WI Lencer RS Blumberg 2002 Functional reconstitution of human FcRn in Madin-Darby canine kidney cells requires co-expressed human beta 2-microglobulin J Biol Chem 277 28038 28050 doi: 10.1074/jbc.M202367200 12023961 1:CAS:528:DC%2BD38XlvFKgtbw%3D (Pubitemid 34966755)
13. A Praetor W Hunziker 2002 beta(2)-Microglobulin is important for cell surface expression and pH-dependent IgG binding of human FcRn J Cell Sci 115 2389 2397 12006623 1:CAS:528:DC%2BD38XltF2ksr0%3D
14. E Kandil M Egashira O Miyoshi N Niikawa T Ishibashi M Kasahara 1996 The human gene encoding the heavy chain of the major histocompatibility complex class I-like Fc receptor (FCGRT) maps to 19q13.3 Cytogenet Cell Genet 73 97 98 doi: 10.1159/000134316 8646894 1:CAS:528:DyaK28XkvVarurs%3D
15. JJ Ahouse CL Hagerman P Mittal DJ Gilbert NG Copeland NA Jenkins NE Simister 1993 Mouse MHC class I-like Fc receptor encoded outside the MHC J Immunol 151 6076 6088 7504013 1:CAS:528:DyaK2cXhtlWkt7k%3D
16. NE Simister JC Ahouse 1996 The structure and evolution of FcRn Res Immunol 147 333 337 doi: 10.1016/0923-2494(96)89647-7 8876062 1:CAS:528:DyaK28XlvVWhuro%3D discussion 353 (Pubitemid 26258846)
17. AP West Jr PJ Bjorkman 2000 Crystal structure and immunoglobulin G binding properties of the human major histocompatibility complex-related Fc receptor(,) Biochemistry 39 9698 9708 doi: 10.1021/bi000749m 10933786 1:CAS:528:DC%2BD3cXkvVWgsbY%3D (Pubitemid 30626819)
18. I Kacskovics Z Wu NE Simister LV Frenyo L Hammarstrom 2000 Cloning and characterization of the bovine MHC class I-like Fc receptor J Immunol 164 1889 1897 10657638 1:CAS:528:DC%2BD3cXhtlymtLo%3D
19. Kuo TT, de Muinck EJ, Claypool SM, Yoshida M, Nagaishi T, Aveson VG, Lencer WI, Blumberg RS (2009) N-glycan moieties in FcRn determine steady-state membrane distribution and directional transport of IgG. J Biol Chem: M805877200. doi:doi: 10.1074/jbc.M805877200.
20. RJ Ober CG Radu V Ghetie ES Ward 2001 Differences in promiscuity for antibody-FcRn interactions across species: implications for therapeutic antibodies Int Immunol 13 1551 1559 doi: 10.1093/intimm/13.12.1551 11717196 1:CAS:528:DC%2BD3MXptVKmt7o%3D
21. JE Mikulska NE Simister 2000 Analysis of the promoter region of the human FcRn gene Biochim Biophys Acta 1492 180 184 11004487 1:CAS:528: DC%2BD3cXltVCqtro%3D
22. B Tiwari RP Junghans 2005 Functional analysis of the mouse Fcgrt 5' proximal promoter Biochim Biophys Acta 1681 88 98 15627500 1:CAS:528: DC%2BD2cXhtFGhtbbJ
23. JL Leach DD Sedmak JM Osborne B Rahill MD Lairmore CL Anderson 1996 Isolation from human placenta of the IgG transporter, FcRn, and localization to the syncytiotrophoblast: implications for maternal-fetal antibody transport J Immunol 157 3317 3322 8871627 1:CAS:528:DyaK28XmtlagsLs%3D
24. F Antohe L Radulescu A Gafencu V Ghetie M Simionescu 2001 Expression of functionally active FcRn and the differentiated bidirectional transport of IgG in human placental endothelial cells Hum Immunol 62 93 105 doi: 10.1016/S0198-8859(00) 00244-5 11182218 1:CAS:528:DC%2BD3MXhtFeisL8%3D
25. RJ Ober C Martinez C Vaccaro J Zhou ES Ward 2004 Visualizing the site and dynamics of IgG salvage by the MHC class I-related receptor, FcRn J Immunol 172 2021 2029 14764666 1:CAS:528:DC%2BD2cXpslWgsw%3D%3D
26. M Sakagami Y Omidi L Campbell LE Kandalaft CJ Morris J Barar M Gumbleton 2006 Expression and transport functionality of FcRn within rat alveolar epithelium: a study in primary cell culture and in the isolated perfused lung Pharm Res 23 270 279 doi: 10.1007/s11095-005-9226-0 16382279 1:CAS:528:DC%2BD28XhsVSnu7k%3D (Pubitemid 43237858)
27. P Cianga C Cianga L Cozma ES Ward E Carasevici 2003 The MHC class I related Fc receptor, FcRn, is expressed in the epithelial cells of the human mammary gland Hum Immunol 64 1152 1159 doi: 10.1016/j.humimm.2003.08.025 14630397 1:CAS:528:DC%2BD3sXptVGru7c%3D (Pubitemid 37475276)
28. S Akilesh TB Huber H Wu G Wang B Hartleben JB Kopp JH Miner DC Roopenian ER Unanue AS Shaw 2008 Podocytes use FcRn to clear IgG from the glomerular basement membrane Proc Natl Acad Sci USA 105 967 972 doi: 10.1073/pnas. 0711515105 18198272 1:CAS:528:DC%2BD1cXht1Onu7Y%3D (Pubitemid 351282065)
29. M Yoshida SM Claypool JS Wagner E Mizoguchi A Mizoguchi DC Roopenian WI Lencer RS Blumberg 2004 Human neonatal Fc receptor mediates transport of IgG into luminal secretions for delivery of antigens to mucosal dendritic cells Immunity 20 769 783 doi: 10.1016/j.immuni.2004.05.007 15189741 1:CAS:528:DC%2BD2cXltlKisb0%3D (Pubitemid 38757446)
30. X Zhu G Meng BL Dickinson X Li E Mizoguchi L Miao Y Wang C Robert B Wu PD Smith WI Lencer RS Blumberg 2001 MHC class I-related neonatal Fc receptor for IgG is functionally expressed in monocytes, intestinal macrophages, and dendritic cells J Immunol 166 3266 3276 11207281 1:CAS:528:DC%2BD3MXhs1Oju70%3D
31. W Mi S Wanjie ST Lo Z Gan B Pickl-Herk RJ Ober ES Ward 2008 Targeting the neonatal fc receptor for antigen delivery using engineered fc fragments J Immunol 181 7550 7561 19017944 1:CAS:528:DC%2BD1cXhtl2gs7bN
32. WL Martin PJ Bjorkman 1999 Characterization of the 2:1 complex between the class I MHC-related Fc receptor and its Fc ligand in solution Biochemistry 38 12639 12647 doi: 10.1021/bi9913505 10504233 1:CAS:528:DyaK1MXls1ahtbc%3D (Pubitemid 29463259)
33. GM Spiekermann PW Finn ES Ward J Dumont BL Dickinson RS Blumberg WI Lencer 2002 Receptor-mediated immunoglobulin G transport across mucosal barriers in adult life: functional expression of FcRn in the mammalian lung J Exp Med 196 303 310 doi: 10.1084/jem.20020400 12163559 1:CAS:528:DC%2BD38XmtVOhtL4%3D (Pubitemid 34875660)
34. M Raghavan VR Bonagura SL Morrison PJ Bjorkman 1995 Analysis of the pH dependence of the neonatal Fc receptor/immunoglobulin G interaction using antibody and receptor variants Biochemistry 34 14649 14657 doi: 10.1021/bi00045a005 7578107 1:CAS:528:DyaK2MXovFSrtrg%3D
35. M Raghavan LN Gastinel PJ Bjorkman 1993 The class I major histocompatibility complex related Fc receptor shows pH-dependent stability differences correlating with immunoglobulin binding and release Biochemistry 32 8654 8660 doi: 10.1021/bi00084a037 8357807 1:CAS:528:DyaK3sXltFGjtLs%3D
36. C Chaudhury CL Brooks DC Carter JM Robinson CL Anderson 2006 Albumin binding to FcRn: distinct from the FcRn-IgG interaction Biochemistry 45 4983 4990 doi: 10.1021/bi052628y 16605266 1:CAS:528:DC%2BD28Xis1Kitbc%3D
37. C Chaudhury S Mehnaz JM Robinson WL Hayton DK Pearl DC Roopenian CL Anderson 2003 The major histocompatibility complex-related Fc receptor for IgG (FcRn) binds albumin and prolongs its lifespan J Exp Med 197 315 322 doi: 10.1084/jem.20021829 12566415 1:CAS:528:DC%2BD3sXhtVWms78%3D (Pubitemid 36184238)
38. M Berryman R Rodewald 1995 Beta 2-microglobulin co-distributes with the heavy chain of the intestinal IgG-Fc receptor throughout the transepithelial transport pathway of the neonatal rat J Cell Sci 108 2347 2360 7673354 1:CAS:528:DyaK2MXmsFOnsr0%3D
39. BL Dickinson K Badizadegan Z Wu JC Ahouse X Zhu NE Simister RS Blumberg WI Lencer 1999 Bidirectional FcRn-dependent IgG transport in a polarized human intestinal epithelial cell line J Clin Invest 104 903 911 doi: 10.1172/JCI6968 10510331 1:CAS:528:DyaK1MXmsVClsb0%3D
40. X Zhu J Peng R Raychowdhury A Nakajima WI Lencer RS Blumberg 2002 The heavy chain of neonatal Fc receptor for IgG is sequestered in endoplasmic reticulum by forming oligomers in the absence of beta2-microglobulin association Biochem J 367 703 714 doi: 10.1042/BJ20020200 12162790 1:CAS:528: DC%2BD38XotFWlu7w%3D (Pubitemid 35305709)
41. X Zhu J Peng D Chen X Liu L Ye H Iijima K Kadavil WI Lencer RS Blumberg 2005 Calnexin and ERp57 facilitate the assembly of the neonatal Fc receptor for IgG with beta 2-microglobulin in the endoplasmic reticulum J Immunol 175 967 976 16002696 1:CAS:528:DC%2BD2MXlvFSjt78%3D
42. SM Claypool BL Dickinson JS Wagner FE Johansen N Venu JA Borawski WI Lencer RS Blumberg 2004 Bidirectional transepithelial IgG transport by a strongly polarized basolateral membrane Fcgamma-receptor Mol Biol Cell 15 1746 1759 doi: 10.1091/mbc.E03-11-0832 14767057 1:CAS:528:DC%2BD2cXivFals7s%3D (Pubitemid 38401824)
43. U Shah BL Dickinson RS Blumberg NE Simister WI Lencer WA Walker 2003 Distribution of the IgG Fc receptor, FcRn, in the human fetal intestine Pediatr Res 53 295 301 12538789 1:CAS:528:DC%2BD3sXivVylsw%3D%3D
44. KM McCarthy M Lam L Subramanian R Shakya Z Wu EE Newton NE Simister 2001 Effects of mutations in potential phosphorylation sites on transcytosis of FcRn J Cell Sci 114 1591 1598 11282034 1:CAS:528:DC%2BD3MXjsVyhsro%3D
45. KM McCarthy Y Yoong NE Simister 2000 Bidirectional transcytosis of IgG by the rat neonatal Fc receptor expressed in a rat kidney cell line: a system to study protein transport across epithelia J Cell Sci 113 Pt 7 1277 1285 10704378 1:CAS:528:DC%2BD3cXjtFyls7s%3D
46. EE Newton Z Wu NE Simister 2005 Characterization of basolateral-targeting signals in the neonatal Fc receptor J Cell Sci 118 2461 2469 doi: 10.1242/jcs.02367 15923659 1:CAS:528:DC%2BD2MXlslequrw%3D (Pubitemid 40873086)
47. NL Wernick V Haucke NE Simister 2005 Recognition of the tryptophan-based endocytosis signal in the neonatal Fc receptor by the mu subunit of adaptor protein-2 J Biol Chem 280 7309 7316 doi: 10.1074/jbc.M410752200 15598658 1:CAS:528:DC%2BD2MXhsFSjsrY%3D (Pubitemid 40341289)
48. Z Wu NE Simister 2001 Tryptophan- and dileucine-based endocytosis signals in the neonatal Fc receptor J Biol Chem 276 5240 5247 doi: 10.1074/jbc. M006684200 11096078 1:CAS:528:DC%2BD3MXhtlyjs7k%3D
49. 2+∈- dependent calmodulin binding to FcRn affects immunoglobulin G transport in the transcytotic pathway Mol Biol Cell 19 414 423 doi: 10.1091/mbc.E07-07-0658 18003977 1:CAS:528:DC%2BD1cXlslent7s%3D (Pubitemid 351186164)
50. S Tzaban RH Massol E Yen W Hamman SR Frank LA Lapierre SH Hansen JR Goldenring RS Blumberg WI Lencer 2009 The recycling and transcytotic pathways for IgG transport by FcRn are distinct and display an inherent polarity J Cell Biol 185 673 684 19451275 1:CAS:528:DC%2BD1MXmtlGru7g%3D
51. ES Ward C Martinez C Vaccaro J Zhou Q Tang RJ Ober 2005 From sorting endosomes to exocytosis: association of Rab4 and Rab11 GTPases with the Fc receptor, FcRn, during recycling Mol Biol Cell 16 2028 2038 doi: 10.1091/mbc.E04-08-0735 15689494 1:CAS:528:DC%2BD2MXjt1Kqur8%3D (Pubitemid 40471968)
52. W He MS Ladinsky KE Huey-Tubman GJ Jensen JR McIntosh PJ Bjorkman 2008 FcRn-mediated antibody transport across epithelial cells revealed by electron tomography Nature 455 542 546 doi: 10.1038/nature07255 18818657 1:CAS:528:DC%2BD1cXhtFKhtbjJ
53. RJ Ober C Martinez X Lai J Zhou ES Ward 2004 Exocytosis of IgG as mediated by the receptor, FcRn: an analysis at the single-molecule level Proc Natl Acad Sci USA 101 11076 11081 doi: 10.1073/pnas.0402970101 15258288 1:CAS:528:DC%2BD2cXmsVCmtL0%3D (Pubitemid 38989586)
54. WI Lencer RS Blumberg 2005 A passionate kiss, then run: exocytosis and recycling of IgG by FcRn Trends Cell Biol 15 5 9 doi: 10.1016/j.tcb.2004.11.004 15653072 1:CAS:528:DC%2BD2MXkslOrsA%3D%3D (Pubitemid 40094675)
55. SW Qiao K Kobayashi FE Johansen LM Sollid JT Andersen E Milford DC Roopenian WI Lencer RS Blumberg 2008 Dependence of antibody-mediated presentation of antigen on FcRn Proc Natl Acad Sci USA 105 9337 9342 doi: 10.1073/pnas.0801717105 18599440 1:CAS:528:DC%2BD1cXosFakur4%3D
56. DC Roopenian GJ Christianson TJ Sproule AC Brown S Akilesh N Jung S Petkova L Avanessian EY Choi DJ Shaffer PA Eden CL Anderson 2003 The MHC class I-like IgG receptor controls perinatal IgG transport, IgG homeostasis, and fate of IgG-Fc-coupled drugs J Immunol 170 3528 3533 12646614 1:CAS:528: DC%2BD3sXitFKltr0%3D
57. J Kim CL Bronson WL Hayton MD Radmacher DC Roopenian JM Robinson CL Anderson 2006 Albumin turnover: FcRn-mediated recycling saves as much albumin from degradation as the liver produces Am J Physiol Gastrointest Liver Physiol 290 G352 G360 doi: 10.1152/ajpgi.00286.2005 16210471 1:CAS:528: DC%2BD28XhsFKhtb8%3D
58. CL Anderson C Chaudhury J Kim CL Bronson MA Wani S Mohanty 2006 Perspective-FcRn transports albumin: relevance to immunology and medicine Trends Immunol 27 343 348 doi: 10.1016/j.it.2006.05.004 16731041 1:CAS:528: DC%2BD28XmsFSrt7Y%3D (Pubitemid 43963476)
59. S Akilesh GJ Christianson DC Roopenian AS Shaw 2007 Neonatal FcR expression in bone marrow-derived cells functions to protect serum IgG from catabolism J Immunol 179 4580 4588 17878355 1:CAS:528:DC%2BD2sXhtVCrur%2FM
60. SW Qiao WI Lencer RS Blumberg 2007 How the controller is controlled - neonatal Fc receptor expression and immunoglobulin G homeostasis Immunology 120 145 147 doi: 10.1111/j.1365-2567.2006.02507.x 17140402 1:CAS:528: DC%2BD2sXhsVSru7w%3D (Pubitemid 46046314)
61. C Montoyo HcPr Vaccaro M Hafner RJ Ober W Mueller ES Ward 2009 Conditional deletion of the MHC class I-related receptor FcRn reveals the sites of IgG homeostasis in mice Proc Natl Acad Sci 106 2788 2793
62. M Yoshida A Masuda TT Kuo K Kobayashi SM Claypool T Takagawa H Kutsumi T Azuma WI Lencer RS Blumberg 2006 IgG transport across mucosal barriers by neonatal Fc receptor for IgG and mucosal immunity Springer Semin Immunopathol 28 397 403 doi: 10.1007/s00281-006-0054-z 17051393 1:CAS:528:DC%2BD28Xht1KgtrfF (Pubitemid 44900578)
63. J Kim CL Bronson MA Wani TM Oberyszyn S Mohanty C Chaudhury WL Hayton JM Robinson CL Anderson 2008 Beta 2-microglobulin deficient mice catabolize IgG more rapidly than FcRn- alpha-chain deficient mice Exp Biol Med (Maywood) 233 603 609 10.3181/0710-RM-270 1:CAS:528:DC%2BD1cXlsF2htrw%3D (Pubitemid 351657361)
64. TA Waldmann WD Terry 1990 Familial hypercatabolic hypoproteinemia. A disorder of endogenous catabolism of albumin and immunoglobulin J Clin Invest 86 2093 2098 doi: 10.1172/JCI114947 2254461 1:STN:280:DyaK3M%2Fnt1Kruw%3D%3D
65. MA Wani LD Haynes J Kim CL Bronson C Chaudhury S Mohanty TA Waldmann JM Robinson CL Anderson 2006 Familial hypercatabolic hypoproteinemia caused by deficiency of the neonatal Fc receptor, FcRn, due to a mutant beta2-microglobulin gene Proc Natl Acad Sci USA 103 5084 5089 doi: 10.1073/pnas.0600548103 16549777 1:CAS:528:DC%2BD28XjsVGlsbc%3D
66. NE Simister 2003 Placental transport of immunoglobulin G Vaccine 21 3365 3369 doi: 10.1016/S0264-410X(03) 00334-7 12850341 1:CAS:528:DC%2BD3sXlt1eisLw%3D
67. M Firan R Bawdon C Radu RJ Ober D Eaken F Antohe V Ghetie ES Ward 2001 The MHC class I-related receptor, FcRn, plays an essential role in the maternofetal transfer of gamma-globulin in humans Int Immunol 13 993 1002 doi: 10.1093/intimm/13.8.993 11470769 1:CAS:528:DC%2BD3MXmt1aitrc%3D
68. J Kim S Mohanty LP Ganesan K Hua D Jarjoura WL Hayton JM Robinson CL Anderson 2009 FcRn in the yolk sac endoderm of mouse is required for igg transport to fetus J Immunol 182 2583 2589 10.4049/jimmunol.0803247 19234152 1:CAS:528:DC%2BD1MXitFKhtrs%3D
69. Petru Cianga CMJARVGESW 1999 Identification and function of neonatal Fc receptor in mammary gland of lactating mice Eur J Immunol 29 2515 2523 doi: 10.1002/(SICI) 1521-4141(199908) 29:08<2515::AID-IMMU2515>3.0. CO;2-D
70. W Lu Z Zhao Y Zhao S Yu Y Zhao B Fan I Kacskovics L Hammarstrom N Li 2007 Over-expression of the bovine FcRn in the mammary gland results in increased IgG levels in both milk and serum of transgenic mice Immunology 122 401 408 doi: 10.1111/j.1365-2567.2007.02654.x 17608809 1:CAS:528:DC%2BD2sXht12jtrbO (Pubitemid 47556477)
71. EA Jones TA Waldmann 1972 The mechanism of intestinal uptake and transcellular transport of IgG in the neonatal rat J Clin Invest 51 2916 2927 doi: 10.1172/JCI107116 5080417 1:CAS:528:DyaE38Xls1aqsb0%3D
72. CM Stirling B Charleston H Takamatsu S Claypool W Lencer RS Blumberg TE Wileman 2005 Characterization of the porcine neonatal Fc receptor-potential use for trans-epithelial protein delivery Immunology 114 542 553 doi: 10.1111/j.1365-2567.2004.02121.x 15804291 1:CAS:528:DC%2BD2MXjtFeqtbs%3D (Pubitemid 40478148)
73. PA Kozlowski S Cu-Uvin MR Neutra TP Flanigan 1997 Comparison of the oral, rectal, and vaginal immunization routes for induction of antibodies in rectal and genital tract secretions of women Infect Immun 65 1387 1394 9119478 1:CAS:528:DyaK2sXit12is7k%3D
74. R Rojas G Apodaca 2002 Immunoglobulin transport across polarized epithelial cells Nat Rev Mol Cell Biol 3 944 955 doi: 10.1038/nrm972 12461560 1:CAS:528:DC%2BD38XptFKnt7o%3D (Pubitemid 35477372)
75. AJ Macpherson KD McCoy FE Johansen P Brandtzaeg 2008 The immune geography of IgA induction and function Mucosal Immunol 1 11 22 doi: 10.1038/mi.2007.6 19079156 1:CAS:528:DC%2BD1cXhtlWgsQ%3D%3D
76. EG Pamer 2007 Immune responses to commensal and environmental microbes Nat Immunol 8 1173 1178 doi: 10.1038/ni1526 17952042 1:CAS:528: DC%2BD2sXhtF2itbvI (Pubitemid 350011753)
77. L Bry MB Brenner 2004 Critical role of T cell-dependent serum antibody, but not the gut-associated lymphoid tissue, for surviving acute mucosal infection with Citrobacter rodentium, an attaching and effacing pathogen J Immunol 172 433 441 14688352 1:CAS:528:DC%2BD3sXpvFehu7w%3D
78. AJ Bitonti JA Dumont 2006 Pulmonary administration of therapeutic proteins using an immunoglobulin transport pathway Adv Drug Deliv Rev 58 1106 1118 doi: 10.1016/j.addr.2006.07.015 16997417 1:CAS:528:DC%2BD28Xht1Sht7jP (Pubitemid 44709269)
79. B Mayer Z Kis G Kajan LV Frenyo L Hammarstrom I Kacskovics 2004 The neonatal Fc receptor (FcRn) is expressed in the bovine lung Vet Immunol Immunopathol 98 85 89 doi: 10.1016/j.vetimm.2003.10.010 15127845 1:CAS:528:DC%2BD2cXhtV2ntbc%3D (Pubitemid 38209993)
80. KJ Kim TE Fandy VH Lee DK Ann Z Borok ED Crandall 2004 Net absorption of IgG via FcRn-mediated transcytosis across rat alveolar epithelial cell monolayers Am J Physiol Lung Cell Mol Physiol 287 L616 L622 doi: 10.1152/ajplung.00121.2004 15169676 1:CAS:528:DC%2BD2cXnvVeitrc%3D (Pubitemid 39095919)
81. R Deane A Sagare K Hamm M Parisi B LaRue H Guo Z Wu DM Holtzman BV Zlokovic 2005 IgG-assisted age-dependent clearance of Alzheimer's amyloid beta peptide by the blood-brain barrier neonatal Fc receptor J Neurosci 25 11495 11503 doi: 10.1523/JNEUROSCI.3697-05.2005 16354907 1:CAS:528: DC%2BD28XhsVeluw%3D%3D (Pubitemid 43102486)
82. F Schlachetzki C Zhu WM Pardridge 2002 Expression of the neonatal Fc receptor (FcRn) at the blood-brain barrier J Neurochem 81 203 206 doi: 10.1046/j.1471-4159.2002.00840.x 12067234 1:CAS:528:DC%2BD38XivVentr4%3D (Pubitemid 34808868)
83. H Kim RN Fariss C Zhang SB Robinson M Thill KG Csaky 2008 Mapping of the neonatal Fc receptor in the rodent eye Invest Ophthalmol Vis Sci 49 2025 2029 doi: 10.1167/iovs.07-0871 18436836
84. L Ye X Liu SN Rout Z Li Y Yan L Lu T Kamala NK Nanda W Song SK Samal X Zhu 2008 The MHC class II-associated invariant chain interacts with the neonatal Fc gamma receptor and modulates its trafficking to endosomal/lysosomal compartments J Immunol 181 2572 2585 18684948 1:CAS:528:DC%2BD1cXptlKqu7c%3D
85. C Mueller AJ Macpherson 2006 Layers of mutualism with commensal bacteria protect us from intestinal inflammation Gut 55 276 284 doi: 10.1136/gut.2004. 054098 16407387 1:CAS:528:DC%2BD28XhsFaqsLc%3D (Pubitemid 43117289)
86. LV Hooper 2004 Bacterial contributions to mammalian gut development Trends Microbiol 12 129 134 doi: 10.1016/j.tim.2004.01.001 15001189 1:CAS:528:DC%2BD2cXhslelsbk%3D (Pubitemid 38314756)
87. M Rescigno 2008 The pathogenic role of intestinal flora in IBD and colon cancer Curr Drug Targets 9 395 403 10.2174/138945008784221125 18473768 1:CAS:528:DC%2BD1cXkvFelsb4%3D (Pubitemid 352025214)
88. BL Kelsall F Leon 2005 Involvement of intestinal dendritic cells in oral tolerance, immunity to pathogens, and inflammatory bowel disease Immunol Rev 206 132 148 doi: 10.1111/j.0105-2896.2005.00292.x 16048546 1:CAS:528: DC%2BD2MXhtVWjsb%2FO (Pubitemid 41105167)
89. X Bossuyt 2006 Serologic markers in inflammatory bowel disease Clin Chem 52 171 181 doi: 10.1373/clinchem.2005.058560 16339302 1:CAS:528: DC%2BD28Xht1Kkur8%3D (Pubitemid 43185477)
90. RJ Adams SP Heazlewood KS Gilshenan M O'Brien MA McGuckin TH Florin 2008 IgG antibodies against common gut bacteria are more diagnostic for Crohn's disease than IgG against mannan or flagellin Am J Gastroenterol 103 386 396 doi: 10.1111/j.1572-0241.2007.01577.x 17924999 (Pubitemid 351248712)
91. E Furrie S Macfarlane JH Cummings GT Macfarlane 2004 Systemic antibodies towards mucosal bacteria in ulcerative colitis and Crohn's disease differentially activate the innate immune response Gut 53 91 98 doi: 10.1136/gut.53.1.91 14684582 1:CAS:528:DC%2BD2cXptlKqtA%3D%3D (Pubitemid 38083016)
92. MJ Lodes Y Cong CO Elson R Mohamath CJ Landers SR Targan M Fort RM Hershberg 2004 Bacterial flagellin is a dominant antigen in Crohn disease J Clin Invest 113 1296 1306 15124021 1:CAS:528:DC%2BD2cXjvVOqs78%3D
93. P Brandtzaeg TS Halstensen K Kett P Krajci D Kvale TO Rognum H Scott LM Sollid 1989 Immunobiology and immunopathology of human gut mucosa: humoral immunity and intraepithelial lymphocytes Gastroenterology 97 1562 1584 2684725 1:STN:280:DyaK3c%2FmtVGqug%3D%3D
94. Kobayashi K, Qiao SW, Yoshida M, Baker K, Lencer WI, Blumberg RS (2009) FcRn-dependent pathogenic role of anti-flagellin antibody in an IgG-mediated colitis mouse model. Gastroenterology (in press)
95. F Nimmerjahn JV Ravetch 2008 Anti-inflammatory actions of intravenous immunoglobulin Annu Rev Immunol 26 513 533 doi: 10.1146/annurev.immunol.26. 021607.090232 18370923 1:CAS:528:DC%2BD1cXltlWktr0%3D (Pubitemid 351600384)
96. R Clynes 2007 Protective mechanisms of IVIG Curr Opin Immunol 19 646 651 doi: 10.1016/j.coi.2007.09.004 18032008 1:CAS:528:DC%2BD2sXhsVCksb%2FN (Pubitemid 350236813)
97. PR Hinton MG Johlfs JM Xiong K Hanestad KC Ong C Bullock S Keller MT Tang JY Tso M Vasquez N Tsurushita 2004 Engineered human IgG antibodies with longer serum half-lives in primates J Biol Chem 279 6213 6216 doi: 10.1074/jbc. C300470200 14699147 1:CAS:528:DC%2BD2cXht1Cls7k%3D (Pubitemid 38248752)
98. C Vaccaro J Zhou RJ Ober ES Ward 2005 Engineering the Fc region of immunoglobulin G to modulate in vivo antibody levels Nat Biotechnol 23 1283 1288 doi: 10.1038/nbt1143 16186811 1:CAS:528:DC%2BD2MXhtVOhu7nM (Pubitemid 41486856)
99. AR Mezo KA McDonnell A Castro C Fraley 2008 Structure-activity relationships of a peptide inhibitor of the human FcRn:human IgG interaction Bioorg Med Chem 16 6394 6405 doi: 10.1016/j.bmc.2008.05.004 18501614 1:CAS:528:DC%2BD1cXntlagtLk%3D (Pubitemid 351783417)
100. AR Mezo KA McDonnell CA Hehir SC Low VJ Palombella JM Stattel GD Kamphaus C Fraley Y Zhang JA Dumont AJ Bitonti 2008 Reduction of IgG in nonhuman primates by a peptide antagonist of the neonatal Fc receptor FcRn Proc Natl Acad Sci USA 105 2337 2342 doi: 10.1073/pnas.0708960105 18272495 1:CAS:528:DC%2BD1cXis1Kiu70%3D
101. JS Jaggi JA Carrasquillo SV Seshan P Zanzonico E Henke A Nagel J Schwartz B Beattie BJ Kappel D Chattopadhyay J Xiao G Sgouros SM Larson DA Scheinberg 2007 Improved tumor imaging and therapy via i.v. IgG-mediated time-sequential modulation of neonatal Fc receptor J Clin Invest 117 2422 2430 doi: 10.1172/JCI32226 17717602 1:CAS:528:DC%2BD2sXhtVCms7vN (Pubitemid 47494344)
102. A Sesarman AG Sitaru F Olaru D Zillikens C Sitaru 2008 Neonatal Fc receptor deficiency protects from tissue injury in experimental epidermolysis bullosa acquisita J Mol Med 86 951 959 doi: 10.1007/s00109-008-0366-7 18542899 1:CAS:528:DC%2BD1cXptVCntbs%3D
103. L Liu AM Garcia H Santoro Y Zhang K McDonnell J Dumont A Bitonti 2007 Amelioration of experimental autoimmune myasthenia gravis in rats by neonatal FcR blockade J Immunol 178 5390 5398 17404325 1:CAS:528:DC%2BD2sXjslWjtbY%3D
104. S Petkova TJ Sproule DJ Shaffer GJ Christianson D Roopenian 2004 The MHC class I-like Fc receptor promotes humorally mediated autoimmune disease J Clin Invest 113 1328 1333 15124024
105. J Zhou LM Pop V Ghetie 2005 Hypercatabolism of IgG in mice with lupus-like syndrome Lupus 14 458 466 doi: 10.1191/0961203305lu2129oa 16038110 1:CAS:528:DC%2BD2MXnsVCis7g%3D (Pubitemid 40961320)
106. JT Andersen S Justesen G Berntzen TE Michaelsen V Lauvrak B Fleckenstein S Buus I Sandlie 2008 A strategy for bacterial production of a soluble functional human neonatal Fc receptor J Immunol Methods 331 39 49 18155020 1:CAS:528:DC%2BD1cXitVegu7o%3D
107. JT Andersen S Justesen B Fleckenstein TE Michaelsen G Berntzen VE Kenanova MB Daba V Lauvrak S Buus I Sandlie 2008 Ligand binding and antigenic properties of a human neonatal Fc receptor with mutation of two unpaired cysteine residues FEBS J 275 4097 4110 doi: 10.1111/j.1742-4658.2008.06551.x 18637944 1:CAS:528:DC%2BD1cXhtVCltr%2FL
108. AJ Bitonti JA Dumont SC Low RT Peters KE Kropp VJ Palombella JM Stattel Y Lu CA Tan JJ Song AM Garcia NE Simister GM Spiekermann WI Lencer RS Blumberg 2004 Pulmonary delivery of an erythropoietin Fc fusion protein in non-human primates through an immunoglobulin transport pathway Proc Natl Acad Sci USA 101 9763 9768 doi: 10.1073/pnas.0403235101 15210944 1:CAS:528:DC%2BD2cXlvVaht7o%3D (Pubitemid 38869310)
109. JA Dumont AJ Bitonti D Clark S Evans M Pickford SP Newman 2005 Delivery of an erythropoietin-Fc fusion protein by inhalation in humans through an immunoglobulin transport pathway J Aerosol Med 18 294 303 doi: 10.1089/jam.2005.18.294 16181004 1:CAS:528:DC%2BD2MXhtVehs7bF (Pubitemid 41395731)