Allergy prevention starts before conception: Maternofetal transfer of tolerance protects against the development of asthma

Journal of Allergy and Clinical Immunology

Volumn 122, Issue 5, 2008, Pages

  Polte, Tobias ^a,b,c   Hennig, Christian ^a   Hansen, Gesine ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^c UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

Asthma; pregnancy; primary prevention; tolerance

Indexed keywords

ANTIGEN; CYTOKINE; GAMMA INTERFERON; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN G1; OVALBUMIN;

ALLERGIC ASTHMA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; CONCEPTION; CONTROLLED STUDY; DISEASE COURSE; FEMALE; FETOMATERNAL TRANSFUSION; HISTOPATHOLOGY; IMMUNOLOGICAL TOLERANCE; LUNG LAVAGE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROGENY; PROPHYLAXIS; WEANING;

EID: 55449099354     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2008.09.014     Document Type: Article

References (39)

1. Umetsu D.T., McIntire J.J., Akbari O., Macaubas C., and DeKruyff R.H. Asthma: an epidemic of dysregulated immunity. Nat Immunol 3 (2002) 715-720
2. Ball T.M., Castro-Rodriguez J.A., Griffith K.A., Holberg C.J., Martinez F.D., and Wright A.L. Siblings, day-care attendance, and the risk of asthma and wheezing during childhood. N Engl J Med 343 (2000) 538-543
3. Celedon J.C., Wright R.J., Litonjua A.A., Sredl D., Ryan L., Weiss S.T., et al. Day care attendance in early life, maternal history of asthma, and asthma at the age of 6 years. Am J Respir Crit Care Med 167 (2003) 1239-1243
4. Illi S., von Mutius E., Lau S., Nickel R., Niggemann B., Sommerfeld C., et al. The pattern of atopic sensitization is associated with the development of asthma in childhood. J Allergy Clin Immunol 108 (2001) 709-714
5. Ege M.J., Bieli C., Frei R., van Strien R.T., Riedler J., Ublagger E., et al. Prenatal farm exposure is related to the expression of receptors of the innate immunity and to atopic sensitization in school-age children. J Allergy Clin Immunol 117 (2006) 817-823
6. Stern D.A., Riedler J., Nowak D., Braun-Fahrlander C., Swoboda I., Balic N., et al. Exposure to a farming environment has allergen-specific protective effects on TH2-dependent isotype switching in response to common inhalants. J Allergy Clin Immunol 119 (2007) 351-358
7. Gerhold K., Avagyan A., Seib C., Frei R., Steinle J., Ahrens B., et al. Prenatal initiation of endotoxin airway exposure prevents subsequent allergen-induced sensitization and airway inflammation in mice. J Allergy Clin Immunol 118 (2006) 666-673
8. Pincus-Knackstedt M.K., Joachim R.A., Blois S.M., Douglas A.J., Orsal A.S., Klapp B.F., et al. Prenatal stress enhances susceptibility of murine adult offspring toward airway inflammation. J Immunol 177 (2006) 8484-8492
9. Ruiz R.G., Kemeny D.M., and Price J.F. Higher risk of infantile atopic dermatitis from maternal atopy than from paternal atopy. Clin Exp Allergy 22 (1992) 762-766
10. Litonjua A.A., Carey V.J., Burge H.A., Weiss S.T., and Gold D.R. Parental history and the risk for childhood asthma. Does mother confer more risk than father?. Am J Respir Crit Care Med 158 (1998) 176-181
11. Polte T., Foell J., Werner C., Hoymann H.G., Braun A., Burdach S., et al. CD137-mediated immunotherapy for allergic asthma. J Clin Invest 116 (2006) 1025-1036
12. Hansen G., Berry G., DeKruyff R.H., and Umetsu D.T. Allergen-specific Th1 cells fail to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation. J Clin Invest 103 (1999) 175-183
13. Schonberger H.J., Dompeling E., Knottnerus J.A., Kuiper S., van Weel C., and Schayck C.P. Prenatal exposure to mite and pet allergens and total serum IgE at birth in high-risk children. Pediatr Allergy Immunol 16 (2005) 27-31
14. Kihlstrom A., Lilja G., Pershagen G., and Hedlin G. Exposure to high doses of birch pollen during pregnancy, and risk of sensitization and atopic disease in the child. Allergy 58 (2003) 871-877
15. Zinkernagel R.M. Maternal antibodies, childhood infections, and autoimmune diseases. N Engl J Med 345 (2001) 1331-1335
16. Jarrett E., and Hall E. Selective suppression of IgE antibody responsiveness by maternal influence. Nature 280 (1979) 145-147
17. Seeger M., Thierse H.J., Lange H., Shaw L., Hansen H., and Lemke H. Antigen-independent suppression of the IgE immune response to bee venom phospholipase A2 by maternally derived monoclonal IgG antibodies. Eur J Immunol 28 (1998) 2124-2130
18. Roopenian D.C., Christianson G.J., Sproule T.J., Brown A.C., Akilesh S., Jung N., et al. The MHC class I-like IgG receptor controls perinatal IgG transport, IgG homeostasis, and fate of IgG-Fc-coupled drugs. J Immunol 170 (2003) 3528-3533
19. Medesan C., Radu C., Kim J.K., Ghetie V., and Ward E.S. Localization of the site of the IgG molecule that regulates maternofetal transmission in mice. Eur J Immunol 26 (1996) 2533-2536
20. Verhasselt V., Milcent V., Cazareth J., Kanda A., Fleury S., Dombrowicz D., et al. Breast milk-mediated transfer of antigen induces tolerance and protection from allergic asthma. Nat Med 14 (2008) 170-175
21. Adkins B., Leclerc C., and Marshall-Clarke S. Neonatal adaptive immunity comes of age. Nat Rev Immunol 4 (2004) 553-564
22. Wu L., and Dakic A. Development of dendritic cell system. Cell Mol Immunol 1 (2004) 112-118
23. Lack G., Bradley K.L., Hamelmann E., Renz H., Loader J., Leung D.Y., et al. Nebulized IFN-gamma inhibits the development of secondary allergic responses in mice. J Immunol 157 (1996) 1432-1439
24. Li X.M., Chopra R.K., Chou T.Y., Schofield B.H., Wills-Karp M., and Huang S.K. Mucosal IFN-gamma gene transfer inhibits pulmonary allergic responses in mice. J Immunol 157 (1996) 3216-3219
25. Cohn L., Homer R.J., Niu N., and Bottomly K. T helper 1 cells and interferon gamma regulate allergic airway inflammation and mucus production. J Exp Med 190 (1999) 1309-1318
26. Huang T.J., MacAry P.A., Eynott P., Moussavi A., Daniel K.C., Askenase P.W., et al. Allergen-specific Th1 cells counteract efferent Th2 cell-dependent bronchial hyperresponsiveness and eosinophilic inflammation partly via IFN-gamma. J Immunol 166 (2001) 207-217
27. De Rose V., Cappello P., Sorbello V., Ceccarini B., Gani F., Bosticardo M., et al. IFN-gamma inhibits the proliferation of allergen-activated T lymphocytes from atopic, asthmatic patients by inducing Fas/FasL-mediated apoptosis. J Leukoc Biol 76 (2004) 423-432
28. Matson A.P., Zhu L., Lingenheld E.G., Schramm C.M., Clark R.B., Selander D.M., et al. Maternal transmission of resistance to development of allergic airway disease. J Immunol 179 (2007) 1282-1291
29. Lima C., Souza V.M., Faquim-Mauro E.L., Hoshida M.S., Bevilacqua E., Macedo M.S., et al. Modulation of the induction of lung and airway allergy in the offspring of IFN-gamma-treated mother mice. J Immunol 175 (2005) 3554-3559
30. McGee H.S., and Agrawal D.K. TH2 cells in the pathogenesis of airway remodeling: regulatory T cells a plausible panacea for asthma. Immunol Res 35 (2006) 219-232
31. Bacchetta R., Gambineri E., and Roncarolo M.G. Role of regulatory T cells and FOXP3 in human diseases. J Allergy Clin Immunol 120 (2007) 227-237
32. Umetsu D.T. Understanding the immunological basis of asthma; immunotherapy and regulatory T cells. Arb Paul Ehrlich Inst Bundesamt Sera Impfstoffe Frankf A M (2006) 211-216
33. Umetsu D.T., and DeKruyff R.H. The regulation of allergy and asthma. Immunol Rev 212 (2006) 238-255
34. Kramer M.S., Chalmers B., Hodnett E.D., Sevkovskaya Z., Dzikovich I., Shapiro S., et al. Promotion of Breastfeeding Intervention Trial (PROBIT): a randomized trial in the Republic of Belarus. JAMA 285 (2001) 413-420
35. Oddy W.H., Peat J.K., and de Klerk N.H. Maternal asthma, infant feeding, and the risk of asthma in childhood. J Allergy Clin Immunol 110 (2002) 65-67
36. Kull I., Almqvist C., Lilja G., Pershagen G., and Wickman M. Breast-feeding reduces the risk of asthma during the first 4 years of life. J Allergy Clin Immunol 114 (2004) 755-760
37. Sears M.R., Greene J.M., Willan A.R., Taylor D.R., Flannery E.M., Cowan J.O., et al. Long-term relation between breastfeeding and development of atopy and asthma in children and young adults: a longitudinal study. Lancet 360 (2002) 901-907
38. Bergmann R.L., Diepgen T.L., Kuss O., Bergmann K.E., Kujat J., Dudenhausen J.W., et al. Breastfeeding duration is a risk factor for atopic eczema. Clin Exp Allergy 32 (2002) 205-209
39. Leme A.S., Hubeau C., Xiang Y., Goldman A., Hamada K., Suzaki Y., et al. Role of breast milk in a mouse model of maternal transmission of asthma susceptibility. J Immunol 176 (2006) 762-769