-
1
-
-
0029118049
-
Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV
-
233314
-
233314 Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV. Kieffer TJ, McIntosh CH, Pederson RA Endocrinology 1995 136 8 3585-3596
-
(1995)
Endocrinology
, vol.136
, Issue.8
, pp. 3585-3596
-
-
Kieffer, T.J.1
McIntosh, C.H.2
Pederson, R.A.3
-
2
-
-
0027533758
-
Truncated GLP-1 (proglucagon 78-107-amide) inhibits gastric and pancreatic functions in man
-
233337
-
233337 Truncated GLP-1 (proglucagon 78-107-amide) inhibits gastric and pancreatic functions in man. Wettergren A, Schjoldager B, Mortensen PE, Myhre J, Christiansen J, Holst JJ Dig Dis Sci 1993 38 4 665-673
-
(1993)
Dig Dis Sci
, vol.38
, Issue.4
, pp. 665-673
-
-
Wettergren, A.1
Schjoldager, B.2
Mortensen, P.E.3
Myhre, J.4
Christiansen, J.5
Holst, J.J.6
-
3
-
-
0021782306
-
Serum albumin
-
240408
-
240408 Serum albumin. Peters T Jr Adv Protein Chem 1985 37 161-245
-
(1985)
Adv Protein Chem
, vol.37
, pp. 161-245
-
-
Peters Jr., T.1
-
4
-
-
13344282056
-
A role for glucagon-like peptide-1 in the central regulation of feeding
-
306810
-
306810 A role for glucagon-like peptide-1 in the central regulation of feeding. Turton MD, O'Shea D, Gunn I, Beak SA, Edwards CM, Meeran K, Choi SJ, Taylor GM, Health MM, Lambert PD, Wilding JP et al. Nature 1996 379 6560 69-72
-
(1996)
Nature
, vol.379
, Issue.6560
, pp. 69-72
-
-
Turton, M.D.1
O'Shea, D.2
Gunn, I.3
Beak, S.A.4
Edwards, C.M.5
Meeran, K.6
Choi, S.J.7
Taylor, G.M.8
Health, M.M.9
Lambert, P.D.10
Wilding, J.P.11
-
5
-
-
0031936954
-
Glucagon-like peptides
-
306812
-
306812 Glucagon-like peptides. Drucker DJ Diabetes 1998 47 2 159-169
-
(1998)
Diabetes
, vol.47
, Issue.2
, pp. 159-169
-
-
Drucker, D.J.1
-
6
-
-
0033175006
-
Glucagon-like peptide 1 (GLP-1): An intestinal hormone, signalling nutritional abundance, with an unusual therapeutic potential
-
362275
-
362275 Glucagon-like peptide 1 (GLP-1): An intestinal hormone, signalling nutritional abundance, with an unusual therapeutic potential. Holst JJ Trends Endocrinol Metab 1999 10 229-235
-
(1999)
Trends Endocrinol Metab
, vol.10
, Issue.8
, pp. 229-235
-
-
Holst, J.J.1
-
7
-
-
30844445321
-
Product pipeline
-
374863; 2000 July 18
-
374863 Product pipeline. Conjuchem Inc Company World Wide Web Site 2000 July 18
-
-
-
-
8
-
-
0242725082
-
ConjuChem Inc announces preclinical progression of its DAC:GLP-1 compound for type II diabetes
-
410194; May 23
-
410194 ConjuChem Inc announces preclinical progression of its DAC:GLP-1 compound for type II diabetes. ConjuChem Inc Press Release 2001 May 23
-
(2001)
ConjuChem Inc Press Release
-
-
-
9
-
-
0034857141
-
Development of glucagon-like peptide-1-based pharmaceuticals as therapeutic agents for the treatment of diabetes
-
439496
-
439496 Development of glucagon-like peptide-1-based pharmaceuticals as therapeutic agents for the treatment of diabetes. Ducker DJ Curr Pharm Design 2001 7 14 1399-1412
-
(2001)
Curr Pharm Design
, vol.7
, Issue.14
, pp. 1399-1412
-
-
Ducker, D.J.1
-
10
-
-
0002043269
-
CJC-1131, the novel long acting GLP-1 analogue, delays gastric emptying and demonstrates safety and tolerability in preclinical testing
-
454061; A340-OR
-
454061 CJC-1131, the novel long acting GLP-1 analogue, delays gastric emptying and demonstrates safety and tolerability in preclinical testing. Lawrence B, Wen SY, Jette L, Thibadeau K, Castaigne JP Diabetes 2002 51 2 A340-OR
-
(2002)
Diabetes
, vol.51
, Issue.2
-
-
Lawrence, B.1
Wen, S.Y.2
Jette, L.3
Thibadeau, K.4
Castaigne, J.P.5
-
11
-
-
0012980860
-
The long-acting GLP-1 agonist CJC-1131 exhibits high potency and extended pharmacokinetics in vivo
-
454095; A378-P
-
454095 The long-acting GLP-1 agonist CJC-1131 exhibits high potency and extended pharmacokinetics in vivo. Bridon DP, Thibaudeau K, Archeveque BP, Pham H, Robitaille MF, Drucker DJ, Leger R, Castaigne JP Diabetes 2002 51 2 A378-P
-
(2002)
Diabetes
, vol.51
, Issue.2
-
-
Bridon, D.P.1
Thibaudeau, K.2
Archeveque, B.P.3
Pham, H.4
Robitaille, M.F.5
Drucker, D.J.6
Leger, R.7
Castaigne, J.P.8
-
12
-
-
0010795476
-
Development and characterization of long-acting degradation resistant GLP-1-DAC compounds for the treatment of type 2 diabetes
-
454256; A471-P
-
454256 Development and characterization of long-acting degradation resistant GLP-1-DAC compounds for the treatment of type 2 diabetes. Thibaudeau K, Smith DC, Jette L, Castaigne JP, Bridon DP, Kim JG, Baggio LL, Drucker DJ Diabetes 2002 51 2 A471-P
-
(2002)
Diabetes
, vol.51
, Issue.2
-
-
Thibaudeau, K.1
Smith, D.C.2
Jette, L.3
Castaigne, J.P.4
Bridon, D.P.5
Kim, J.G.6
Baggio, L.L.7
Drucker, D.J.8
-
13
-
-
0001629458
-
The GLP-1-DAC analogue CJC-1131 upregulates insulin gene expression and exerts a memory effect on glycemic control in db/db mice
-
454479; A1391-P
-
454479 The GLP-1-DAC analogue CJC-1131 upregulates insulin gene expression and exerts a memory effect on glycemic control in db/db mice. Kim JG, Baggio LL, Drucker DJ Diabetes 2000 51 2 A1391-P
-
(2002)
Diabetes
, vol.51
, Issue.2
-
-
Kim, J.G.1
Baggio, L.L.2
Drucker, D.J.3
-
14
-
-
0242472310
-
ConjuChem announces start of phase I trial for DAC:GLP-1, a type II diabetes drug candidate
-
457323; July 08
-
457323 ConjuChem announces start of phase I trial for DAC:GLP-1, a type II diabetes drug candidate. ConjuChem Inc Press Release 2002 July 08
-
(2002)
ConjuChem Inc Press Release
-
-
-
15
-
-
0242725094
-
ConjuChem updates status of phase I trial for diabetes drug candidate
-
466084; October 07
-
466084 ConjuChem updates status of phase I trial for diabetes drug candidate. ConjuChem Inc Press Release October 07
-
(2002)
ConjuChem Inc Press Release
-
-
-
16
-
-
0036527096
-
Novel peptides under development for the treatment of type 1 and type 2 diabetes mellitus
-
478018
-
478018 Novel peptides under development for the treatment of type 1 and type 2 diabetes mellitus. Baron AD, Kim D, Weyer C Curr Drug Targets Immune Endocr Metabol Disord 2002 2 63-82
-
(2002)
Curr Drug Targets Immune Endocr Metabol Disord
, vol.2
, pp. 63-82
-
-
Baron, A.D.1
Kim, D.2
Weyer, C.3
-
17
-
-
0035340019
-
Insulinotropic actions of exendin-4 and glucagon-like peptide-1 in vivo and in vitro
-
478025
-
478025 Insulinotropic actions of exendin-4 and glucagon-like peptide-1 in vivo and in vitro. Parkes DG, Pittner R, Jodka C, Smith P, Young A Metabolism 2001 50 5 583-589
-
(2001)
Metabolism
, vol.50
, Issue.5
, pp. 583-589
-
-
Parkes, D.G.1
Pittner, R.2
Jodka, C.3
Smith, P.4
Young, A.5
-
18
-
-
0034507515
-
Glucagon-like peptide-1: A major regulator of pancreatic β-cell function
-
478028
-
478028 Glucagon-like peptide-1: A major regulator of pancreatic β-cell function. Perfetti R, Merkel P Eur J Endocrinol 2000 143 6 717-725
-
(2000)
Eur J Endocrinol
, vol.143
, Issue.6
, pp. 717-725
-
-
Perfetti, R.1
Merkel, P.2
-
19
-
-
0034967893
-
The entero-insular axis in type 2 diabetes - Incretins as therapeutic agents
-
478031
-
478031 The entero-insular axis in type 2 diabetes - Incretins as therapeutic agents. Creutzfeldt W Exp Clin Endocrinol Diabetes 2001 109 Suppl 2 S288-S303
-
(2001)
Exp Clin Endocrinol Diabetes
, vol.109
, Issue.SUPPL. 2
-
-
Creutzfeldt, W.1
-
20
-
-
0242472300
-
ConjuChem resumes DAC:GLP-1 clinical program, provides updates
-
479418; February 20
-
479418 ConjuChem resumes DAC:GLP-1 clinical program, provides updates. ConjuChem Inc Press Release 2003 February 20
-
(2003)
ConjuChem Inc Press Release
-
-
-
21
-
-
0242472301
-
ConjuChem's DAC:GLP-1 clinical program advances
-
482594; March 19
-
482594 ConjuChem's DAC:GLP-1 clinical program advances. ConjuChem Inc Press Release 2003 March 19
-
(2003)
ConjuChem Inc Press Release
-
-
-
22
-
-
0242640705
-
ConjuChem starts US trial for DAC(TM):GLP-1
-
488830; May 08
-
488830 ConjuChem starts US trial for DAC(TM):GLP-1. ConjuChem Inc Press Release 2003 May 08
-
(2003)
ConjuChem Inc Press Release
-
-
-
23
-
-
0242725075
-
CJC-1131, a long acting GLP-1 derivative, exhibits an extended pharmacokinetic profile in healthy human volunteers
-
492844; Abs 543-P
-
492844 CJC-1131, a long acting GLP-1 derivative, exhibits an extended pharmacokinetic profile in healthy human volunteers. Lawrence B, Dreyfus JF, Wen S, Guivarc'h PH, Drucker DJ, Castaigne J-P Diabetes 2003 52 Suppl 6 Abs 543-P
-
(2003)
Diabetes
, vol.52
, Issue.SUPPL. 6
-
-
Lawrence, B.1
Dreyfus, J.F.2
Wen, S.3
Guivarc'h, P.H.4
Drucker, D.J.5
Castaigne, J.-P.6
-
24
-
-
0242725076
-
ConjuChem reports positive preliminary DAC:GLP-1 results
-
493231; June 11
-
493231 ConjuChem reports positive preliminary DAC:GLP-1 results. ConjuChem Inc Press Release 2003 June 11
-
(2003)
ConjuChem Inc Press Release
-
-
-
25
-
-
0037339649
-
Development and characterization of a glucagon-like peptide 1-albumin conjugate: The ability to activate the glucagon-like peptide 1 receptor in vivo
-
498249
-
498249 Development and characterization of a glucagon-like peptide 1-albumin conjugate: The ability to activate the glucagon-like peptide 1 receptor in vivo. Jung-Guk K, Baggio LL, Bridon DP, Castaigne J-P, Robitaille MF, Jette L, Benquet C, Drucker DJ Diabetes 2003 52 3 751-759
-
(2003)
Diabetes
, vol.52
, Issue.3
, pp. 751-759
-
-
Jung-Guk, K.1
Baggio, L.L.2
Bridon, D.P.3
Castaigne, J.-P.4
Robitaille, M.F.5
Jette, L.6
Benquet, C.7
Drucker, D.J.8
-
26
-
-
0242472299
-
CJC-1131, a long-acting GLP-1 analogue, is well tolerated in rats up to 14 days
-
498254
-
498254 CJC-1131, a long-acting GLP-1 analogue, is well tolerated in rats up to 14 days. Lawrence B, Wen S, Dunn D, Iordanova V, Castaigne J Toxicol Sci 2003 72 S-1 49
-
(2003)
Toxicol Sci
, vol.72
, Issue.S-1
, pp. 49
-
-
Lawrence, B.1
Wen, S.2
Dunn, D.3
Iordanova, V.4
Castaigne, J.5
-
27
-
-
0242725079
-
CJC-1131, a long-acting GLP-1 analogue, exhibits safety and tolerability in dogs
-
498254 CJC-1131, a long-acting GLP-1 analogue, exhibits safety and tolerability in dogs. Wen S, Wilson S, Trebec D, Pham K, Castaigne J, Lawrence B Toxicol Sci 2003 72 S-1 48
-
(2003)
Toxicol Sci
, vol.72
, Issue.S-1
, pp. 48
-
-
Wen, S.1
Wilson, S.2
Trebec, D.3
Pham, K.4
Castaigne, J.5
Lawrence, B.6
-
28
-
-
0242725078
-
ConjuChem's strong clinical results hit primary endpoints in type 2 diabetes trials
-
502385; August 21
-
502385 ConjuChem's strong clinical results hit primary endpoints in type 2 diabetes trials. ConjuChem Inc Press Release 2003 August 21
-
(2003)
ConjuChem Inc Press Release
-
-
-
29
-
-
0242725078
-
ConjuChem's strong clinical results hit primary endpoints in type 2 diabetes trials
-
502385; August 21
-
502385 ConjuChem's strong clinical results hit primary endpoints in type 2 diabetes trials. ConjuChem Inc Press Release 2003 August 21
-
(2003)
ConjuChem Inc Press Release
-
-
-
30
-
-
0027215348
-
Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum
-
505939
-
505939 Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum. Mentlein R, Gallwitz B, Schmidt WE Eur J Biochem 1993 214 3 829-835
-
(1993)
Eur J Biochem
, vol.214
, Issue.3
, pp. 829-835
-
-
Mentlein, R.1
Gallwitz, B.2
Schmidt, W.E.3
-
31
-
-
0242640706
-
Analyst evaluation of ConjuChem Inc
-
506488; September 15
-
506488 Analyst evaluation of ConjuChem Inc. Dlouhy Merchant Group 2003 September 15 1-6
-
(2003)
Dlouhy Merchant Group
, pp. 1-6
-
-
Loe, D.W.1
|