Design and in vivo evaluation of a patch delivery system for insulin based on thiolated polymers

International Journal of Pharmaceutics

Volumn 348, Issue 1-2, 2008, Pages 169-174

  Grabovac, Vjera ^a   Föger, Florian ^a   Bernkop Schnürch, Andreas ^a  

^a UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

Intestinal absorption; Oral delivery; Oral insulin; Oral peptide delivery; Polymer

Indexed keywords

BOVINE INSULIN; EUDRAGIT; GLUCOSE; GLUTATHIONE; INSULIN; MANNITOL; POLYCARBOPHIL; POLYMER;

AQUEOUS SOLUTION; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG COATING; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG RELEASE; GLUCOSE BLOOD LEVEL; IN VIVO STUDY; INSULIN BLOOD LEVEL; INTESTINE FLUID; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STOMACH JUICE; TRANSDERMAL PATCH;

ACRYLIC RESINS; ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; BLOOD GLUCOSE; CATTLE; CELLULOSE; CYSTEINE; DELAYED-ACTION PREPARATIONS; DRUG DELIVERY SYSTEMS; DRUG EVALUATION, PRECLINICAL; HYPOGLYCEMIC AGENTS; INSULIN; MALE; PHARMACEUTIC AIDS; RATS; RATS, SPRAGUE-DAWLEY; SULFHYDRYL COMPOUNDS; TABLETS, ENTERIC-COATED;

EID: 37249047365     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2007.06.052     Document Type: Article

References (29)

1. Achleitner, B., 1995. bioadhäsive Arzneiformulierungen. freisetzung, stabilität und dotierung mit fimbrien, Diplomathesis University of Vienna.
2. Bai J.P.F., Chang L.L., and Guo J.H. Effects of polyacrylic polymers on the degradation of insulin and peptide drugs by chymotrypsin and trypsin. J. Pharm. Pharmacol. 48 (1996) 17-21
3. Bernkop-Schnürch A., Schwarz V., and Steininger S. Polymers with thiol groups: a new generation of mucoadhesive polymers?. Pharm. Res. 16 (1999) 876-881
4. Bernkop-Schnürch A., and Steininger S. Synthesis and characterisation of mucoadhesive thiolated polymers. Int. J. Pharm. 194 (2000) 239-247
5. Bernkop-Schnürch A., and Thaler S. Polycarbophil-cysteine conjugates as platforms for oral (poly)peptide delivery systems. J. Pharm. Sci. 89 (2000) 901-909
6. Bernkop-Schnürch A. Thiomers: a new generation of mucoadhesive polymers. Adv. Drug. Deliv. Rev. 57 (2005) 1569-1582
7. Burkman R.T. Transdermal contraceptive systems. Am. J. Obstet. Gynecol. 190 (2004) 49-53
8. Clausen A.E., Kast C.E., and Bernkop-Schnürch A. The role of glutathione in the permeation enhancing effect of thiolated polymers. Pharm. Res. 19 (2002) 602-608
9. De Jaeghere F., Allémann E., Kubel F., Galli B., Doelker E., and Gurny R. pH-Sensitive microparticles as oral delivery systems for antiinfective agents of poor water solubility. Proceedings of the 2nd World Meeting APGI/APV 2 (1998) 559-560
10. Eaimtrakarn S., Itoh Y., Kishimoto J., Yoshikawa Y., Shibata N., Murakami M., and Takada K. Gastrointestinal mucoadhesive patch system (GI-MAPS) for oral administration of G-CSF, a model protein. Biomaterials 23 (2002) 145-152
11. Eaimtrakarn S., Prasad Y.V.R., Puthli S.P., Yoshikawa Y., Shibata N., and Takada K. Possibility of a patch system as a new oral delivery system. Int. J. Pharm. 250 (2003) 111-117
12. Foulds J., Steinberg M.B., Williams J.M., and Ziedonis D.M. Developments in pharmacotherapy for tobacco dependence: past, present and future. Drug Alcohol Rev. 25 (2006) 59-71
13. Hosny E.A., Ghilzai N.M.K., and Elmaza M.M. Promotion of oral insulin absorption in diabetic rabbits using pH-dependent coated capsules containing sodium cholate. Pharm. Acta Helvetiae 72 (2006) 203-207
14. Krauland A.H., Guggi D., and Bernkop-Schnürch A. Oral insulin delivery: the potential of thiolated chitosan-insulin tablets on non-diabetic rats. J. Control. Rel. 95 (2004) 547-555
15. Lehr C.-M., Poelma F.G.J., Junginger H.E., and Tukker J.J. An estimate of turnover time of intestinal mucus gel layer in the rat in situ loop. Int. J. Pharm. 70 (1991) 235-240
16. Leroux J.C., Cozens R., Roesel J.L., Galli B., Kubel F., Doelker E., and Gurny R. Pharmacokinetics of a novel HIV-1 protease inhibitor incorporated into biodegradable or enteric nanoparticles following intravenous and oral administration to mice. J. Pharm. Sci. 84 (1995) 1387-1391
17. Li C., Bhatt P.P., and Johnston T.P. Evaluation of a mucoadhesive buccal patch for delivery of peptides: in vitro screening of bioadhesion. Drug Dev. Ind. Pharm. 24 (1998) 919-926
18. Luessen H.L., Bohner V., Perard D., Langguth P., Verhoef J.C., de Boer A.G., Merkle H.P., and Junginger H.E. Mucoadhesive polymers in peroral peptide drug delivery. V. Effect of poly(acrylates) on the enzymatic degradation of peptide drugs by intestinal brush border membrane vesicles. Int. J. Pharm. 141 (1996) 39-52
19. Luessen H.L., de Leeuw B.J., Perard D., Lehr C.-M., de Boer A.G., Verhoef J.C., and Junginger H.E. Mucoadhesive polymers in peroral peptide drug delivery. I. Influence of mucoadhesive excipients on the proteolytic activity of intestinal enzymes. Eur. J. Pharm. Sci. 4 (1996) 117-128
20. Luessen H.L., Rentel C.O., Kotzé A.F., Lehr C.-M., deBoer A.G., Verhoef J.C., and Junginger H.E. Mucoadhesive polymers in peroral peptide drug delivery. IV. Polycarbophil and chitosan are potent enhancers of peptide transport across intestinal mucosae in vitro. J. Control. Rel. 45 (1997) 15-23
21. Marschütz M.K., and Bernkop-Schnürch A. Oral peptide drug delivery: polymer-inhibitor conjugates protecting insulin from enzymatic degradation in vitro. Biomaterials 21 (2000) 1499-1507
22. Marschütz M.K., Caliceti P., and Bernkop-Schnürch A. Design and in vivo evaluation of an oral delivery system for insulin. Pharm. Res. 17 (2000) 1468-1474
23. Mathiowitz E., Jacob J.S., Jong Y.S., Carino G.P., Chickering D.E., Chaturvedi P., Santos C.A., Vijayaraghavan K., Montgomery S., Bassett M., and Morrell C. Biologically erodable microspheres as potential oral drug delivery systems. Nature 386 (1997) 410-414
24. Schmitz T., Leitner V.M., and Bernkop-Schnürch A. Oral heparin delivery: design and in vivo evaluation of a stomach-targeted mucoadhesive delivery system. J. Pharm. Sci. 94 (2005) 966-973
25. Shen Z.C., and Mitragotri S. Intestinal patches for oral drug delivery. Pharm. Res. 19 (2002) 391-395
26. Skaer T.L. Transdermal opioids for cancer pain. Health Qual. Life Outcomes 4 (2006) 24
27. Takeuchi H., Yamamoto H., Niwa T., Hino T., and Kawashima Y. Enteral absorption of insulin in rats from mucoadhesive chitosan-coated liposomes. Pharm. Res. 13 (1996) 896-901
28. Vogelson C.T. Innovative pharmaceutical treatments require innovative methods of administrations. Modern Drug Discov. 4 (2001) 49-50
29. Woodley J.F. Enzymatic barriers for GI peptide and protein delivery. Crit. Rev. Ther. Drug Carrier Syst. 11 (1994) 61-95