Herpesvirus BACs: Past, present, and future

Journal of Biomedicine and Biotechnology

Volumn 2011, Issue , 2011, Pages

  Warden, Charles ^a   Tang, Qiyi ^b   Zhu, Hua ^c  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^b PONCE SCHOOL OF MEDICINE   (Puerto Rico)

^c RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HERPESVIRUS VECTOR; VACCINE; RECOMBINANT DNA;

BACTERIAL ARTIFICIAL CHROMOSOME; GENE THERAPY; HERPES VIRUS; HOMOLOGOUS RECOMBINATION; MUTAGENESIS; NONHUMAN; REVIEW; SITE DIRECTED MUTAGENESIS; TRANSPOSON MUTAGENESIS; VIRUS GENOME; VIRUS MUTANT; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MOLECULAR CLONING; VIROLOGY;

BACTERIA (MICROORGANISMS); DNA VIRUSES; HERPESVIRIDAE;

CHROMOSOMES, ARTIFICIAL, BACTERIAL; CLONING, MOLECULAR; DNA, RECOMBINANT; HERPESVIRIDAE; MUTAGENESIS; VIROLOGY;

EID: 78650730818     PISSN: 11107243     EISSN: 11107251     Source Type: Journal    
DOI: 10.1155/2011/124595     Document Type: Review

References (150)

1. Murray P. R., Rosenthal K. S., Pfaller M. A., Medical Microbiology 2002 St. Louis, Mo, USA Mosby
2. Pellett P. E., Roizman B., Knipe D. M., Howley P. M., The family ferpesviridae: a brief introduction Field's Virology 2007 5th Philadelphia, Pa, USA Lippincott Williams Wilkins
3. Roizman B., Knipe D. M., Whitley R., Knipe D. M., Howley P. M., Herpes simplex viruses Field's Virology 2007 5th Philadelphia, Pa, USA Lippincott Williams Wilkins
4. Cohen J. I., Straus S. E., Arvin A., Knipe D. M., Howley P. M., Varicella-zoster virus replication, pathogenesis, and management Field's Virology 2007 5th Philadelphia, Pa, USA Lippincott Williams Wilkins
5. Mocarski E. S., Shenk T., Pass R. F., Knipe D. M., Howley P. M., Cytomegaloviruses Field's Virology 2007 5th Philadelphia, Pa, USA Lippincott Williams Wilkins
6. Yamanishi K., Mori Y., Pellett P. E., Knipe D. M., Howley P. M., Human herpesviruses 6 and 7 Field's Virology 2007 5th Philadelphia, Pa, USA Lippincott Williams Wilkins
7. Rickinson A. B., Kieff E., Knipe D. M., Howley P. M., Epstein-Barr virus Field's Virology 2007 5th Philadelphia, Pa, USA Lippincott Williams Wilkins
8. Ganem D., Knipe D. M., Howley P. M., Kaposi's sarcoma-associated herpesvirus Field's Virology 2007 5th Philadelphia, Pa, USA Lippincott Williams Wilkins
9. Britt W. J., Infectious clones of herpesviruses: a new approach for understanding viral gene function Trends in Microbiology 2000 8 6 262 265
10. Brune W., Messerle M., Koszinowski U. H., Forward with BACsnew tools for herpesvirus genomics Trends in Genetics 2000 16 6 254 259
11. McGregor A., Schleiss M. R., Recent advances in Herpesvirus genetics using bacterial artificial chromosomes Molecular Genetics and Metabolism 2001 72 1 8 14
12. Messerle M., Crnkovic I., Hammerschmidt W., Ziegler H., Koszinowski U. H., Cloning and mutagenesis of a herpesvirus genome as an infectious bacterial artificial chromosome Proceedings of the National Academy of Sciences of the United States of America 1997 94 26 14759 14763
13. Wagner M., Ruzsics Z., Koszinowski U. H., Herpesvirus genetics has come of age Trends in Microbiology 2002 10 7 318 324
14. Schalkwyk L. C., Francis F., Lehrach H., Techniques in mammalian genome mapping Current Opinion in Biotechnology 1995 6 1 37 43
15. Shizuya H., Birren B., Kim U.-J., Mancino V., Slepak T., Tachiiri Y., Simon M., Cloning and stable maintenance of 300-kilobase-pair fragments of human DNA in Escherichia coli using an F-factor-based vector Proceedings of the National Academy of Sciences of the United States of America 1992 89 18 8794 8797
16. Ali A. K. M., Saito S., Shibata S., Takada K., Kanda T., Distinctive effects of the Epstein-Barr virus family of repeats on viral latent gene promoter activity and B-lymphocyte transformation Journal of Virology 2009 83 18 9163 9174
17. Horsburgh B. C., Hubinette M. M., Qiang D., MacDonald M. L. E., Tufaro F., Allele replacement: an application that permits rapid manipulation of herpes simplex virus type 1 genomes Gene Therapy 1999 6 5 922 930
18. Saeki Y., Ichikawa T., Saeki A., Chiocca E. A., Tobler K., Ackermann M., Breakefield X. O., Fraefel C., Herpes simplex virus type 1 DNA amplified as bacterial artificial chromosome in Escherichia coli: rescue of replication-competent virus progeny and packaging of amplicon vectors Human Gene Therapy 1998 9 18 2787 2794
19. Stavropoulos T. A., Strathdee C. A., An enhanced packaging system for helper-dependent herpes simplex virus vectors Journal of Virology 1998 72 9 7137 7143
20. Meseda C. A., Schmeisser F., Pedersen R., Woerner A., Weir J. P., DNA immunization with a herpes simplex virus 2 bacterial artificial chromosome Virology 2004 318 1 420 428
21. Nagaike K., Mori Y., Gomi Y., Yoshii H., Takahashi M., Wagner M., Koszinowski U., Yamanishi K., Cloning of the varicella-zoster virus genome as an infectious bacterial artificial chromosome in Escherichia coli Vaccine 2004 22 29-30 4069 4074
22. Zhang Z., Rowe J., Wang W., Sommer M., Arvin A., Moffat J., Zhu H., Genetic analysis of varicella-zoster virus ORF0 to ORF4 by use of a novel luciferase bacterial artificial chromosome system Journal of Virology 2007 81 17 9024 9033
23. Wussow F., Fickenscher H., Tischer B. K., Red-mediated transposition and final release of the mini-f vector of a cloned infectious herpesvirus genome PLoS ONE 2009 4 12 1 9
24. Delecluse H.-J., Hilsendegen T., Pich D., Zeidler R., Hammerschmidt W., Propagation and recovery of intact, infectious Epstein-Barr virus from prokaryotic to human cells Proceedings of the National Academy of Sciences of the United States of America 1998 95 14 8245 8250
25. Borst E.-M., Hahn G., Koszinowski U. H., Messerle M., Cloning of the human cytomegalovirus (HCMV) genome as an infectious bacterial artificial chromosome in Escherichia coli: a new approach for construction of HCMV mutants Journal of Virology 1999 73 10 8320 8329
26. Marchini A., Liu H., Zhu H., Human cytomegalovirus with IE-2 (UL122) deleted fails to express early lytic genes Journal of Virology 2001 75 4 1870 1878
27. Hahn G., Khan H., Baldanti F., Koszinowski U. H., Revello M. G., Gerna G., The human cytomegalovirus ribonucleotide reductase homolog UL45 is dispensable for growth in endothelial cells, as determined by a BAC-cloned clinical isolate of human cytomegalovirus with preserved wild-type characteristics Journal of Virology 2002 76 18 9551 9555
28. Murphy E., Yu D., Grimwood J., Schmutz J., Dickson M., Jarvis M. A., Hahn G., Nelson J. A., Myers R. M., Shenk T. E., Coding potential of laboratory and clinical strains of human cytomegalovirus Proceedings of the National Academy of Sciences of the United States of America 2003 100 25 14976 14981
29. Sinzger C., Hahn G., Digel M., Katona R., Sampaio K. L., Messerle M., Hengel H., Koszinowski U., Brune W., Adler B., Cloning and sequencing of a highly productive, endotheliotropic virus strain derived from human cytomegalovirus TB40/E Journal of General Virology 2008 89 2 359 368
30. Dulal K., Zhang Z., Zhu H., Development of a gene capture method to rescue a large deletion mutant of human cytomegalovirus Journal of Virological Methods 2009 157 2 180 187
31. Borenstein R., Frenkel N., Cloning human herpes virus 6A genome into bacterial artificial chromosomes and study of DNA replication intermediates Proceedings of the National Academy of Sciences of the United States of America 2009 106 45 19138 19143
32. Delecluse H.-J., Kost M., Feederle R., Wilson L., Hammerschmidt W., Spontaneous activation of the lytic cycle in cells infected with a recombinant Kaposi's sarcoma-associated virus Journal of Virology 2001 75 6 2921 2928
33. Zhou F.-C., Zhang Y.-J., Deng J.-H., Wang X.-P., Pan H.-Y., Hettler E., Gao S.-J., Efficient infection by a recombinant Kaposi's sarcoma-associated herpesvirus cloned in a bacterial artificial chromosome: application for genetic analysis Journal of Virology 2002 76 12 6185 6196
34. Mahony T. J., McCarthy F. M., Gravel J. L., West L., Young P. L., Construction and manipulation of an infectious clone of the bovine herpesvirus 1 genome maintained as a bacterial artificial chromosome Journal of Virology 2002 76 13 6660 6668
35. Robinson K. E., Meers J., Gravel J. L., McCarthy F. M., Mahony T. J., The essential and non-essential genes of Bovine herpesvirus 1 Journal of General Virology 2008 89 11 2851 2863
36. Rudolph J., O'Callaghan D. J., Osterrieder N., Cloning of the genomes of equine herpesvirus type 1 (EHV-1) strains KyA and racL11 as bacterial artificial chromosomes (BAC) Journal of Veterinary Medicine. B 2002 49 1 31 36
37. Costes B., Thirion M., Dewals B., Mast J., Ackermann M., Markine-Goriaynoff N., Gillet L., Vanderplasschen A., Felid herpesvirus 1 glycoprotein G is a structural protein that mediates the binding of chemokines on the viral envelope Microbes and Infection 2006 8 11 2657 2667
38. McGregor A., Schleiss M. R., Molecular cloning of the guinea pig cytomegalovirus (GPCMV) genome as an infectious bacterial artificial chromosome (BAC) in Escherichia coli Molecular Genetics and Metabolism 2001 72 1 15 26
39. White R. E., Calderwood M. A., Whitehouse A., Generation and precise modification of a herpesvirus saimiri bacterial artificial chromosome demonstrates that the terminal repeats are required for both virus production and episomal persistence Journal of General Virology 2003 84 12 3393 3403
40. Costes B., Fournier G., Michel B., Delforge C., Stalin Raj V., Dewals B., Gillet L., Drion P., Body A., Schynts F., Lieffrig F., Vanderplasschen A., Cloning of the koi herpesvirus genome as an infectious bacterial artificial chromosome demonstrates that disruption of the thymidine kinase locus induces partial attenuation in Cyprinus carpio koi Journal of Virology 2008 82 10 4955 4964
41. Schumacher D., Tischer B. K., Fuchs W., Osterrieder N., Reconstitution of marek's disease virus serotype 1 (MDV-1) from DNA cloned as a bacterial artificial chromosome and characterization of a glycoprotein B-negative MDV-1 mutant Journal of Virology 2000 74 23 11088 11098
42. Brune W., Mnard C., Hobom U., Odenbreit S., Messerle M., Koszinowski U. H., Rapid identification of essential and nonessential herpesvirus genes by direct transposon mutagenesis Nature Biotechnology 1999 17 4 360 364
43. Bubeck A., Wagner M., Ruzsics Z., Ltzerich M., Iglesias M., Singh I. R., Koszinowski U. H., Comprehensive mutational analysis of a herpesvirus gene in the viral genome context reveals a region essential for virus replication Journal of Virology 2004 78 15 8026 8035
44. Adler H., Messerle M., Wagner M., Koszinowski U. H., Cloning and mutagenesis of the murine gammaherpesvirus 68 genome as an infectious bacterial artificial chromosome Journal of Virology 2000 74 15 6964 6974
45. Song M. J., Hwang S., Wong W. H., Wu T.-T., Lee S., Liao H.-I., Sun R., Identification of viral genes essential for replication of murine -herpesvirus 68 using signature-tagged mutagenesis Proceedings of the National Academy of Sciences of the United States of America 2005 102 10 3805 3810
46. Smith G. A., Enquist L. W., Construction and transposon mutagenesis in Escherichia coli of a full- length infectious clone of pseudorabies virus, an alphaherpesvirus Journal of Virology 1999 73 8 6405 6414
47. Chang W. L. W., Barry P. A., Cloning of the full-length rhesus cytomegalovirus genome as an infectious and self-excisable bacterial artificial chromosome for analysis of viral pathogenesis Journal of Virology 2003 77 9 5073 5083
48. Estep R. D., Powers M. F., Yen B. K., Li H., Wong S. W., Construction of an infectious rhesus rhadinovirus bacterial artificial chromosome for the analysis of Kaposi's sarcoma-associated herpesvirus-related disease development Journal of Virology 2007 81 6 2957 2969
49. Baigent S. J., Petherbridge L. J., Smith L. P., Zhao Y., Chesters P. M., Nair V. K., Herpesvirus of turkey reconstituted from bacterial artificial chromosome clones induces protection against Marek's disease Journal of General Virology 2006 87 4 769 776
50. Yu D., Smith G. A., Enquist L. W., Shenk T., Construction of a self-excisable bacterial artificial chromosome containing the human cytomegalovirus genome and mutagenesis of the diploid TRL/IRL13 gene Journal of Virology 2002 76 5 2316 2328
51. Wagner M., Jonji S., Koszinowski U. H., Messerle M., Systematic excision of vector sequences from the BAC-cloned herpesvirus genome during virus reconstitution Journal of Virology 1999 73 8 7056 7060
52. Dunn W., Chou C., Li H., Hai R., Patterson D., Stolc V., Zhu H., Liu F., Functional profiling of a human cytomegalovirus genome Proceedings of the National Academy of Sciences of the United States of America 2003 100 2 14223 14228
53. Zhang Z., Selariu A., Warden C., Huang G., Huang Y., Genome-wide mutagenesis reveals that ORF7 is a novel VZV skin-tropic factor PLoS Pathogens 2010 6, article no. e1000971
54. Cohen J. I., Seidel K. E., Generation of varicella-zoster virus (VZV) and viral mutants from cosmid DNAs: VZV thymidylate synthetase is not essential for replication in vitro Proceedings of the National Academy of Sciences of the United States of America 1993 90 15 7376 7380
55. Cunningham C., Davison A. J., A cosmid-based system for constructing mutants of herpes simplex virus type 1 Virology 1993 197 1 116 124
56. Kemble G., Duke G., Winter R., Spaete R., Defined large-scale alteration of the human cytomegalovirus genome constructed by cotransfection of overlapping cosmids Journal of Virology 1996 70 3 2044 2048
57. Tomkinson B., Robertson E., Yalamanchili R., Longnecker R., Kieff E., Epstein-Barr virus recombinants from overlapping cosmid fragments Journal of Virology 1993 67 12 7298 7306 (Pubitemid 23343857)
58. Niizuma T., Zerboni L., Sommer M. H., Ito H., Hinchliffe S., Arvin A. M., Construction of varicella-zoster virus recombinants from parent oka cosmids and demonstration that ORF65 protein is dispensable for infection of human skin and T cells in the SCID-hu mouse model Journal of Virology 2003 77 10 6062 6065
59. Zhang Z., Huang Y., Zhu H., A highly efficient protocol of generating and analyzing VZV ORF deletion mutants based on a newly developed luciferase VZV BAC system Journal of Virological Methods 2008 148 1-2 197 204
60. Terada K., Wakimoto H., Tyminski E., Chiocca E. A., Saeki Y., Development of a rapid method to generate multiple oncolytic HSV vectors and their in vivo evaluation using syngeneic mouse tumor models Gene Therapy 2006 13 8 705 714
61. Magin-Lachman C., Kotzamanis G., D'Aiuto L., Wagner E., Huxley C., Retrofitting BACs with G418 resistance, luciferase, and oriP and EBNA-1new vectors for in vitro and in vivo delivery BMC Biotechnology 2003 3, article no. 2
62. Olivo P. D., Detection of herpes simplex virus by measurement of luciferase activity in an infected-cell lysate Journal of Virological Methods 1994 47 1-2 117 128
63. Lee E.-C., Yu D., Martinez De Velasco J., Tessarollo L., Swing D. A., Court D. L., Jenkins N. A., Copeland N. G., A highly efficient Escherichia coli -based chromosome engineering system adapted for recombinogenic targeting and subcloning of BAC DNA Genomics 2001 73 1 56 65
64. Yu D., Ellis H. M., Lee E.-C., Jenkins N. A., Copeland N. G., Court D. L., An efficient recombination system for chromosome engineering in Escherichia coli Proceedings of the National Academy of Sciences of the United States of America 2000 97 11 5978 5983
65. Carter D. M., Radding C. M., The role of exonuclease and beta protein of phage lambda in genetic recombination. II. Substrate specificity and the mode of action of lambda exonuclease Journal of Biological Chemistry 1971 246 8 2502 2512
66. Little J. W., An exonuclease induced by bacteriophage lambda. II. Nature of the enzymatic reaction Journal of Biological Chemistry 1967 242 4 679 686
67. Datsenko K. A., Wanner B. L., One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products Proceedings of the National Academy of Sciences of the United States of America 2000 97 12 6640 6645
68. Tischer B. K., Von Einem J., Kaufer B., Osterrieder N., Two-step red-mediated recombination for versatile high-efficiency markerless DNA manipulation in Escherichia coli BioTechniques 2006 40 2 191 197
69. Warming S., Costantino N., Court D. L., Jenkins N. A., Copeland N. G., Simple and highly efficient BAC recombineering using galK selection Nucleic acids research 2005 33 4, article no. e36
70. Rijsewijk F. A. M., Kaashoek M. J., Langeveld J. P. M., Meloen R., Judek J., Biekowska-Szewczyk K., Maris-Veldhuis M. A., Van Oirschot J. T., Epitopes on glycoprotein C of bovine herpesvirus-1 (BHV-1) that allow differentiation between BHV-1.1 and BHV-1.2 strains Journal of General Virology 1999 80 6 1477 1483
71. Smith G. A., Enquist L. W., A self-recombining bacterial artificial chromosome and its application for analysis of herpesvirus pathogenesis Proceedings of the National Academy of Sciences of the United States of America 2000 97 9 4873 4878
72. Glass M., Busche A., Wagner K., Messerle M., Borst E. M., Conditional and reversible disruption of essential herpesvirus proteins Nature Methods 2009 6 8 577 579
73. Heermann R., Zeppenfeld T., Jung K., Simple generation of site-directed point mutations in the Escherichia coli chromosome using Red /ET recombination Microbial Cell Factories 2008 7, article no. 14
74. Stanton R. J., McSharry B. P., Armstrong M., Tomasec P., Wilkinson G. W. G., Re-engineering adenovirus vector systems to enable high-throughput analyses of gene function BioTechniques 2008 45 6 659 668
75. Devito J. A., Recombineering with tolC as a Selectable/Counter-selectable Marker: remodeling the rRNA Operons of Escherichia coli Nucleic Acids Research 2008 36 1, article no. e4
76. Haas R., Kahrs A. F., Facius D., Allmeier H., Schmitt R., Meyer T. F., TnMaxa versatile mini-transposon for the analysis of cloned genes and shuttle mutagenesis Gene 1993 130 1 23 31
77. Hobom U., Brune W., Messerle M., Hahn G., Koszinowski U. H., Fast screening procedures for random transposon libraries of cloned herpesvirus genomes: mutational analysis of human cytomegalovirus envelope glycoprotein genes Journal of Virology 2000 74 17 7720 7729
78. Kahrs A. F., Odenbreit S., Schmitt W., Heuermann D., Meyer T. F., Haas R., An improved TnMax mini-transposon system suitable for sequencing, shuttle mutagenesis and gene fusions Gene 1995 167 1-2 53 57
79. Adamson W. E., McNab D., Preston V. G., Rixon F. J., Mutational analysis of the herpes simplex virus triplex protein VP19C Journal of Virology 2006 80 3 1537 1548
80. Leege T., Fuchs W., Granzow H., Kopp M., Klupp B. G., Mettenleiter T. C., Effects of simultaneous deletion of pUL11 and glycoprotein M on virion maturation of herpes simplex virus type 1 Journal of Virology 2009 83 2 896 907
81. O'Hara M., Rixon F. J., Stow N. D., Murray J., Murphy M., Preston V. G., Mutational analysis of the herpes simplex virus type 1 UL25 DNA packaging protein reveals regions that are important after the viral DNA has been packaged Journal of Virology 2010 84 9 4252 4263
82. Roberts A. P. E., Abaitua F., O'Hare P., McNab D., Rixon F. J., Pasdeloup D., Differing roles of inner tegument proteins pUL36 and pUL37 during entry of herpes simplex virus type Journal of Virology 2009 83 1 105 116
83. Sciortino M. T., Taddeo B., Giuffr-Cuculletto M., Medici M. A., Mastino A., Roizman B., Replication-competent herpes simplex virus 1 isolates selected from cells transfected with a bacterial artificial chromosome DNA lacking only the U L49 gene vary with respect to the defect in the UL41 gene encoding host shutoff RNase Journal of Virology 2007 81 20 10924 10932
84. Tong L., Stow N. D., Analysis of herpes simplex virus type 1 DNA packaging signal mutations in the context of the viral genome Journal of Virology 2010 84 1 321 329
85. Boutell C., Sadis S., Everett R. D., Herpes simplex virus type 1 immediate-early protein ICP0 and its isolated RING finger domain act as ubiquitin E3 ligases in vitro Journal of Virology 2002 76 2 841 850
86. Morimoto T., Arii J., Tanaka M., Sata T., Akashi H., Yamada M., Nishiyama Y., Uema M., Kawaguchi Y., Differences in the regulatory and functional effects of the Us3 protein kinase activities of herpes simplex virus 1 and 2 Journal of Virology 2009 83 22 11624 11634
87. Fuchs W., Granzow H., Klopfleisch R., Klupp B. G., Mettenleiter T. C., The UL4 gene of pseudorabies virus encodes a minor infected-cell protein that is dispensable for virus replication Journal of General Virology 2006 87 9 2517 2525
88. Fuchs W., Klupp B. G., Granzow H., Leege T., Mettenleiter T. C., Characterization of Pseudorabies Virus (PrV) cleavage-encapsidation proteins and functional complementation of PrV pUL32 by the homologous protein of herpes simplex virus type 1 Journal of Virology 2009 83 8 3930 3943
89. Kopp M., Granzow H., Fuchs W., Klupp B., Mettenleiter T. C., simultaneous deletion of pseudorabies virus tegument protein ul11 and glycoprotein m severely impairs secondary envelopment Journal of Virology 2004 78 6 3024 3034
90. Dolan A., Cunningham C., Hector R. D., Hassan-Walker A. F., Lee L., Addison C., Dargan D. J., McGeoch D. J., Gatherer D., Emery V. C., Griffiths P. D., Sinzger C., McSharry B. P., Wilkinson G. W. G., Davison A. J., Genetic content of wild-type human cytomegalovirus Journal of General Virology 2004 85 5 1301 1312
91. Britt W. J., Jarvis M., Seo J.-Y., Drummond D., Nelson J., Rapid genetic engineering of human cytomegalovirus by using a lambda phage linear recombination system: demonstration that pp28 (ul99) is essential for production of infectious virus Journal of Virology 2004 78 1 539 543
92. Hahn G., Rose D., Wagner M., Rhiel S., McVoy M. A., Cloning of the genomes of human cytomegalovirus strains Toledo, TownevarRIT3, and Townelong as BACs and site-directed mutagenesis using a PCR-based technique Virology 2003 307 1 164 177
93. Spaderna S., Kropff B., Kdel Y., Shen S., Coley S., Lu S., Britt W., Mach M., Deletion of gpUL132, a structural component of human cytomegalovirus, results in impaired virus replication in fibroblasts Journal of Virology 2005 79 18 11837 11847
94. Yu D., Silva M. C., Shenk T., Functional map of human cytomegalovirus AD169 defined by global mutational analysis Proceedings of the National Academy of Sciences of the United States of America 2003 100 21 12396 12401
95. Cicin-Sain L., Brune W., Bubic I., Jonjic S., Koszinowski U. H., Vaccination of mice with bacteria carrying a cloned herpesvirus genome reconstituted in vivo Journal of Virology 2003 77 15 8249 8255
96. Cicin-Sain L., Bubi I., Schnee M., Ruzsics Z., Mohr C., Jonji S., Koszinowski U. H., Targeted deletion of regions rich in immune-evasive genes from the cytomegalovirus genome as a novel vaccine strategy Journal of Virology 2007 81 24 13825 13834
97. Mnard C., Wagner M., Ruzsics Z., Holak K., Brune W., Campbell A. E., Koszinowski U. H., Role of murine cytomegalovirus US22 gene family members in replication in macrophages Journal of Virology 2003 77 10 5557 5570
98. Lilja A. E., Chang W. L. W., Barry P. A., Becerra S. P., Shenk T. E., Functional genetic analysis of rhesus cytomegalovirus: Rh01 is an epithelial cell tropism factor Journal of Virology 2008 82 5 2170 2181
99. Rue C. A., Jarvis M. A., Knoche A. J., Meyers H. L., DeFilippis V. R., Hansen S. G., Wagner M., Frh K., Anders D. G., Wong S. W., Barry P. A., Nelson J. A., A cyclooxygenase-2 homologue encoded by rhesus cytomegalovirus is a determinant for endothelial cell tropism Journal of Virology 2004 78 22 12529 12536
100. Schleiss M. R., Comparison of vaccine strategies against congenital CMV infection in the guinea pig model Journal of Clinical Virology 2008 41 3 224 230
101. Crumpler M. M., Choi K. Y., McVoy M. A., Schleiss M. R., A live guinea pig cytomegalovirus vaccine deleted of three putative immune evasion genes is highly attenuated but remains immunogenic in a vaccine/challenge model of congenital cytomegalovirus infection Vaccine 2009 27 31 4209 4218
102. Ahsan N., Kanda T., Nagashima K., Takada K., Epstein-Barr virus transforming protein LMP1 plays a critical role in virus production Journal of Virology 2005 79 7 4415 4424
103. Anderton E., Yee J., Smith P., Crook T., White R. E., Allday M. J., Two Epstein-Barr virus (EBV) oncoproteins cooperate to repress expression of the proapoptotic tumour-suppressor Bim: clues to the pathogenesis of Burkitt's lymphoma Oncogene 2008 27 4 421 433
104. Chau C. M., Zhang X.-Y., McMahon S. B., Lieberman P. M., Regulation of Epstein-Barr virus latency type by the chromatin boundary factor CTCF Journal of Virology 2006 80 12 5723 5732
105. Chen A., DiVisconte M., Jiang X., Quink C., Wang F., Epstein-Barr virus with the latent infection nuclear antigen 3B completely deleted is still competent for B-cell growth transformation in vitro Journal of Virology 2005 79 7 4506 4509
106. Delecluse H.-J., Hammerschmidt W., The genetic approach to the Epstein-Barr virus: from basic virology to gene therapy Journal of Clinical Pathology 2000 53 5 270 279
107. Kanda T., Yajima M., Ahsan N., Tanaka M., Takada K., Production of high-titer Epstein-Barr virus recombinants derived from Akata cells by using a bacterial artificial chromosome system Journal of Virology 2004 78 13 7004 7015
108. Pavlova I. V., Virgin H. W. IV, Speck S. H., Disruption of gammaherpesvirus 68 gene 50 demonstrates that Rta is essential for virus replication Journal of Virology 2003 77 10 5731 5739
109. Calderwood M., White R. E., Griffiths R. A., Whitehouse A., Open reading frame 73 is required for herpesvirus saimiri A11-S4 episomal persistence Journal of General Virology 2005 86 10 2703 2708
110. Lu F., Stedman W., Yousef M., Renne R., Lieberman P. M., Epigenetic regulation of Kaposi's sarcoma-associated herpesvirus latency by virus-encoded microRNAs that target Rta and the cellular Rbl2-DNMT pathway Journal of Virology 2010 84 6 2697 2706
111. Luna R. E., Zhou F., Baghian A., Chouljenko V., Forghani B., Gao S.-J., Kousoulas K. G., Kaposi's sarcoma-associated herpesvirus glycoprotein K8.1 is dispensable for virus entry Journal of Virology 2004 78 12 6389 6398
112. Majerciak V., Pripuzova N., McCoy J. P., Gao S.-J., Zheng Z.-M., Targeted disruption of Kaposi's sarcoma-associated herpesvirus ORF57 in the viral genome is detrimental for the expression of ORF59, K8, and K8.1 and the production of infectious virus Journal of Virology 2007 81 3 1062 1071
113. Xu Y., AuCoin D. P., Rodriguez Huete A., Cei S. A., Hanson L. J., Pari G. S., A kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 ORF50 deletion mutant is defective for reactivation of latent virus and DNA replication Journal of Virology 2005 79 6 3479 3487
114. Xu Y., Rodriguez-Huete A., Pari G. S., Evaluation of the lytic origins of replication of Kaposi's sarcoma-associated virus/human herpesvirus 8 in the context of the viral genome Journal of Virology 2006 80 19 9905 9909
115. Fan X. Z., Li X., Zhou F., Gao S.-J., Yuan Y., Functional characterization of Kaposi's sarcoma-associated herpesvirus ORF45 by bacterial artificial chromosome-based mutagenesis Journal of Virology 2006 80 24 12187 12196
116. Lukac D. M., Garibyan L., Kirshner J. R., Palmeri D., Ganem D., DNA binding by Kaposi's sarcoma-associated herpesvirus lytic switch protein is necessary for transcriptional activation of two viral delayed early promoters Journal of Virology 2001 75 15 6786 6799
117. Zhou F., Li Q., Wong S. W., Gao S.-J., Autoexcision of bacterial artificial chromosome facilitated by terminal repeat-mediated homologous recombination: a novel approach for generating traceless genetic mutants of herpesviruses Journal of Virology 2010 84 6 2871 2880
118. Yoshii H., Sadaoka K., Matsuura M., Nagaike K., Takahashi M., Yamanishi K., Mori Y., Varicella-zoster virus ORF 58 gene is dispensable for viral replication in cell culture Virology Journal 2008 5, article no. 54
119. Borenstein R., Zeigerman H., Frenkel N., The DR1 and DR6 first exons of human herpesvirus 6A are not required for virus replication in culture and are deleted in virus stocks that replicate well in T-cell lines The Journal of Virology 2010 84 2648 2656
120. Gabev E., Fraefel C., Ackermann M., Tobler K., Cloning of Bovine herpesvirus type 1 and type 5 as infectious bacterial artifical chromosomes BMC Research Notes 2009 2
121. Trapp S., Osterrieder N., Keil G. M., Beer M., Mutagenesis of a bovine herpesvirus type 1 genome cloned as an infectious bacterial artificial chromosome: analysis of glycoprotein E and G double deletion mutants Journal of General Virology 2003 84 2 301 306
122. Goodman L. B., Loregian A., Perkins G. A., Nugent J., Buckles E. L., Mercorelli B., Kydd J. H., Pal G., Smith K. C., Osterrieder N., Davis-Poynter N., A point mutation in a herpesvirus polymerase determines neuropathogenicity PLoS Pathogens 2007 3 11 1583 1592
123. Rudolph J., Osterrieder N., Equine herpesvirus type 1 devoid of gM and gp2 is severely impaired in virus egress but not direct cell-to-cell spread Virology 2002 293 2 356 367
124. Yao H., Osterrieder N., O'Callaghan D. J., Generation and characterization of an EICP0 null mutant of equine herpesvirus 1 Virus Research 2003 98 2 163 172
125. Tai S. H. S., Niikura M., Cheng H. H., Kruger J. M., Wise A. G., Maes R. K., Complete genomic sequence and an infectious BAC clone of feline herpesvirus-1 (FHV-1) Virology 2010 401 2 215 227
126. Richter M., Schudel L., Tobler K., Matheis F., Vgtlin A., Vanderplasschen A., Costes B., Spiess B., Ackermann M., Clinical, virological, and immunological parameters associated with superinfection of latently with FeHV-1 infected cats Veterinary Microbiology 2009 138 3-4 205 216
127. Costes B., Raj V. S., Michel B., Fournier G., Thirion M., Gillet L., Mast J., Lieffrig F., Bremont M., Vanderplasschen A., The major portal of entry of koi herpesvirus in cyprinus carpio is the skin Journal of Virology 2009 83 7 2819 2830
128. Petherbridge L., Howes K., Baigent S. J., Sacco M. A., Evans S., Osterrieder N., Nair V., Replication-competent bacterial artificial chromosomes of Marek's disease virus: novel tools for generation of molecularly defined herpesvirus vaccines Journal of Virology 2003 77 16 8712 8718
129. Zhao Y., Petherbridge L., Smith L. P., Baigent S., Nair V., Self-excision of the BAC sequences from the recombinant Marek's disease virus genome increases replication and pathogenicity Virology Journal 2008 5, article no. 19
130. Hansen K., Napier I., Koen M., Bradford S., Messerle M., Bell E., Seshadri L., Stokes H. W., Birch D., Whalley J. M., In vitro transposon mutagenesis of an equine herpesvirus 1 genome cloned as a bacterial artificial chromosome Archives of Virology 2006 151 12 2389 2405
131. Glass M., Busche A., Wagner K., Messerle M., Borst E. M., Conditional and reversible disruption of essential herpesvirus proteins Nature Methods 2009 6 8 577 579
132. Wagner M., Koszinowski U. H., Mutagenesis of viral BACs with linear PCR fragments (ET recombination) Methods in Molecular Biology 2004 256 257 268
133. Schmeisser F., Weir J. P., Incorporation of a lambda phage recombination system and EGFP detection to simplify mutagenesis of Herpes simplex virus bacterial artificial chromosomes BMC Biotechnology 2007 7, article no. 22
134. Kunec D., van Haren S., Burgess S. C., Hanson L. A., A Gateway recombination herpesvirus cloning system with negative selection that produces vectorless progeny Journal of Virological Methods 2009 155 1 82 86
135. Neubauer A., Rudolph J., Brandmller C., Just F. T., Osterrieder N., The equine herpesvirus 1 UL34 gene product is involved in an early step in virus egress and can be efficiently replaced by a UL34-GFP fusion protein Virology 2002 300 2 189 204
136. Antinone S. E., Smith G. A., Two modes of herpesvirus trafficking in neurons: membrane acquisition directs motion Journal of Virology 2006 80 22 11235 11240
137. White R. E., Carline L., Allday M. J., Mutagenesis of the herpesvirus saimiri terminal repeat region reveals important elements for virus production Journal of Virology 2007 81 12 6765 6770
138. Sharon-Friling R., Goodhouse J., Colberg-Poley A. M., Shenk T., Human cytomegalovirus pUL37x1 induces the release of endoplasmic reticulum calcium stores Proceedings of the National Academy of Sciences of the United States of America 2006 103 50 19117 19122
139. Schnee M., Ruzsics Z., Bubeck A., Koszinowski U. H., Common and specific properties of herpesvirus UL34/UL31 protein family members revealed by protein complementation assay Journal of Virology 2006 80 23 11658 11666
140. Schleiss M. R., Stroup G., Pogorzelski K., McGregor A., Protection against congenital cytomegalovirus (CMV) disease, conferred by a replication-disabled, bacterial artificial chromosome (BAC)-based DNA vaccine Vaccine 2006 24 3739 6175 6186
141. Suter M., Lew A. M., Grob P., Adema G. J., Ackermann M., Shortman K., Fraefel C., BAC-VAC, a novel generation of (DNA) vaccines: a bacterial artificial chromosome (BAC) containing a replication-competent, packaging-defective virus genome induces protective immunity against herpes simplex virus 1 Proceedings of the National Academy of Sciences of the United States of America 1999 96 22 12697 12702
142. Marconi P., Argnani R., Epstein A. L., Manservigi R., HSV as a vector in vaccine development and gene therapy Advances in Experimental Medicine and Biology 2009 655 118 144
143. Redwood A. J., Messerle M., Harvey N. L., Hardy C. M., Koszinowski U. H., Lawson M. A., Shellam G. R., Use of a murine cytomegalovirus K181-derived bacterial artificial chromosome as a vaccine vector for immunocontraception Journal of Virology 2005 79 5 2998 3008
144. Hansen S. G., Powers C. J., Richards R., Ventura A. B., Ford J. C., Siess D., Axthelm M. K., Nelson J. A., Jarvis M. A., Picker L. J., Frh K., Evasion of CD8 + T cells is critical for superinfection by cytomegalovirus Science 2010 328 5974 102 106
145. Rosas C. T., Tischer B. K., Perkins G. A., Wagner B., Goodman L. B., Osterrieder N., Live-attenuated recombinant equine herpesvirus type 1 (EHV-1) induces a neutralizing antibody response against West Nile virus (WNV) Virus Research 2007 125 1 69 78
146. Rosas C. T., Knig P., Beer M., Dubovi E. J., Tischer B. K., Osterrieder N., Evaluation of the vaccine potential of an equine herpesvirus type 1 vector expressing bovine viral diarrhea virus structural proteins Journal of General Virology 2007 88 3 748 757
147. Rosas C. T., Paessler S., Ni H., Osterrieder N., Protection of mice by equine herpesvirus type 1-based experimental vaccine against lethal Venezuelan equine encephalitis virus infection in the absence of neutralizing antibodies American Journal of Tropical Medicine and Hygiene 2008 78 1 83 92
148. Kuroda T., Martuza R. L., Todo T., Rabkin S. D., Flip-flop HSV-BAC: bacterial artificial chromosome based system for rapid generation of recombinant herpes simplex virus vectors using two independent site-specific recombinases BMC Biotechnology 2006 6, article no. 40
149. Xing W., Baylink D., Kesavan C., Mohan S., HSV-1 amplicon-mediated transfer of 128-kb BMP-2 genomic locus stimulates osteoblast differentiation in vitro Biochemical and Biophysical Research Communications 2004 319 3 781 786
150. Hettich E., Janz A., Zeidler R., Pich D., Hellebrand E., Weissflog B., Moosmann A., Hammerschmidt W., Genetic design of an optimized packaging cell line for gene vectors transducing human B cells Gene Therapy 2006 13 10 844 856