A live guinea pig cytomegalovirus vaccine deleted of three putative immune evasion genes is highly attenuated but remains immunogenic in a vaccine/challenge model of congenital cytomegalovirus infection

Vaccine

Volumn 27, Issue 31, 2009, Pages 4209-4218

  Crumpler, Megan M ^a   Choi, K Yeon ^c   McVoy, Michael A ^b   Schleiss, Mark R ^c  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

Animal models; Congenital cytomegalovirus infection; Cytomegalovirus vaccines; Guinea pig cytomegalovirus; MHC class I homolog; Viral immune evasion

Indexed keywords

CYTOMEGALOVIRUS VACCINE; GAMMA INTERFERON; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; INTERLEUKIN 12; LIVE VACCINE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MESSENGER RNA; NEUTRALIZING ANTIBODY;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ANTIBODY TITER; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOMEGALOVIRUS INFECTION; DRUG EFFICACY; DRUG SAFETY; FEMALE; GENE DELETION; GUINEA PIG; HUMORAL IMMUNITY; IMMUNOGENICITY; IMMUNOMODULATION; IN VIVO STUDY; MORTALITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PREGNANCY; PRIORITY JOURNAL; VACCINATION; VIRUS GENOME; VIRUS LOAD; VIRUS VIRULENCE; WILD TYPE;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, VIRAL; CYTOKINES; CYTOMEGALOVIRUS INFECTIONS; CYTOMEGALOVIRUS VACCINES; FEMALE; GENE DELETION; GUINEA PIGS; MOLECULAR SEQUENCE DATA; NEUTRALIZATION TESTS; PREGNANCY; ROSEOLOVIRUS; SEQUENCE ALIGNMENT; VACCINES, ATTENUATED; VIRAL PROTEINS; VIRULENCE FACTORS;

EID: 67349171033     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2009.04.036     Document Type: Article

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