The UL4 gene of pseudorabies virus encodes a minor infected-cell protein that is dispensable for virus replication

Journal of General Virology

Volumn 87, Issue 9, 2006, Pages 2517-2525

  Fuchs, Walter ^a   Granzow, Harald ^a   Klopfleisch, Robert ^a   Klupp, Barbara G ^a   Mettenleiter, Thomas C ^a  

^a FEDERAL RESEARCH INSTITUTE FOR ANIMAL HEALTH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; CELL PROTEIN; GENE PRODUCT; HYBRID PROTEIN; PROTEIN UL4; RABBIT ANTISERUM; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CODON; CONTROLLED STUDY; CORRELATION ANALYSIS; ELECTRON MICROSCOPY; ESCHERICHIA COLI; GENE MUTATION; GENETIC ANALYSIS; GENETIC CODE; HERPES SIMPLEX VIRUS 1; HERPES VIRUS; IMMUNOFLUORESCENCE; IN VITRO STUDY; IN VIVO STUDY; KIDNEY CELL; MOLECULAR CLONING; MOUSE; MUTAGENESIS; NONHUMAN; OPEN READING FRAME; PHENOTYPE; PLASMID; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STRUCTURE; PSEUDORABIES; PSEUDORABIES HERPETOVIRUS; SEQUENCE HOMOLOGY; SURVIVAL; VIRION; VIROGENESIS; VIRUS GENOME; VIRUS PARTICLE; VIRUS RECOMBINANT; VIRUS REPLICATION; VIRUS TITRATION; VIRUS VIRULENCE; WESTERN BLOTTING; WILD TYPE;

ANIMALS; CELL LINE; ESCHERICHIA COLI; GENES, VIRAL; HERPESVIRUS 1, SUID; MICROSCOPY, ELECTRON; MUTAGENESIS; OPEN READING FRAMES; PLASMIDS; RABBITS; TRANSFECTION; VIRAL PROTEINS; VIRULENCE; VIRUS REPLICATION;

BACTERIA (MICROORGANISMS); HUMAN HERPESVIRUS 1; ORYCTOLAGUS CUNICULUS; SUID HERPESVIRUS 1;

EID: 33747376814     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/vir.0.81813-0     Document Type: Article

References (34)

1. Babic, N., Klupp, B. G., Brack, A., Mettenleiter, T. C., Ugolini, G. & Flamand, A. (1996). Deletion of glycoprotein gE reduces the propagation of pseudorabies virus in the nervous system of mice after intranasal inoculation. Virology 219, 279-284.
2. Brideau, A. D., Eldridge, M. G. & Enquist L. W. (2000). Directional transneuronal infection by pseudorabies virus is dependent on an acidic internalization motif in the Us9 cytoplasmic tail. J Virol 74, 4549-4561.
3. R cassettes with the option of Flp-catalyzed excision of the antibiotic-resistance determinant. Gene 158, 9-14.
4. Crute, J. J., Tsurumi, T., Zhu, L., Weller, S. K., Olivo, P. D., Challberg, M. D., Mocarski, E. S. & Lehman, I. R. (1989). Herpes simplex virus 1 helicase-primase: a complex of three herpes-encoded gene products. Proc Natl Acad Sci U S A 86, 2186-2189.
5. Datsenko, K. A. & Wanner, B. L. (2000). One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products. Proc Natl Acad Sci U S A 97, 6640-6645.
6. Davison, A. J. & Scott, J. E. (1986). The complete DNA sequence of varicella-zoster virus. J Gen Virol 67, 1759-1816.
7. Davison, A. J., Eberle, R., Hayward, G. S., McGeoch, D. J., Minson, A. C., Pellet, P. E., Roizman, B., Studdert, M. J. & Thiry, E. (2005). Family Herpesviridae. In Virus Taxonomy. Eighth Report of the International Committee on Taxonomy of Viruses, pp. 193-212. Edited by C. M. Fauquet, M. A. Mayo, J. Maniloff, U. Desselberger & L. A. Ball. San Diego: Elsevier Academic Press.
8. Dean, H. J. & Cheung, A. K. (1993). A 3′ coterminal gene cluster in pseudorabies virus contains herpes simplex virus UL1, UL2, and UL3 gene homologs and a unique UL3.5 open reading frame. J Virol 67, 5955-5961.
9. Dean, H. J. & Cheung, A. K. (1994). Identification of the pseudorabies virus UL4 and UL5 (helicase) genes. Virology 202, 962-967.
10. Dietz, P., Klupp, B. G., Fuchs, W., Köllner, B., Weiland, E. & Mettenleiter, T. C. (2000). Pseudorabies virus glycoprotein K requires the UL20 gene product for processing. J Virol 74, 5083-5090.
11. Eide, T., Marsden, H. S., Leib, D. A., Cunningham, C., Davison, A. J., Langeland, N. & Haarr, L. (1998). Identification of the UL4 protein of herpes simplex virus type 1. J Gen Virol 79, 3033-3038.
12. Enquist, L. W. (2002). Exploiting circuit-specific spread of pseudorabies virus in the central nervous system: insights to pathogenesis and circuit tracers. J Infect Dis 186 (Suppl. 2), S209-S214.
13. Fuchs, W., Klupp, B. G., Granzow, H., Rziha, H. J. & Mettenleiter, T. C. (1996). Identification and characterization of the pseudorabies virus UL3.5 protein, which is involved in virus egress. J Virol 70, 3517-3527.
14. Fuchs, W., Klupp, B. G., Granzow, H., Osterrieder, N. & Mettenleiter, T. C. (2002). The interacting UL31 and UL34 gene products of pseudorabies virus are involved in egress from the host-cell nucleus and represent components of primary enveloped but not mature virions. J Virol 76, 364-378.
15. Graham, F. L. & van der Eb, A. J. (1973). A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 52, 456-467.
16. Jahedi, S., Markovitz, N. S., Filatov, F. & Roizman, B. (1999). Colocalization of the herpes simplex virus 1 UL4 protein with infected cell protein 22 in small, dense nuclear structures formed prior to onset of DNA synthesis. J Virol 73, 5132-5138.
17. Jun, P. Y., Strelow, L. I., Herman, R. C., Marsden, H. S., Eide, T., Haarr, L. & Leib, D. A. (1998). The UL4 gene of herpes simplex virus type 1 is dispensable for latency, reactivation and pathogenesis in mice. J Gen Virol 79, 1603-1611.
18. Kaplan, A. S. & Vatter, A. (1959). A comparison of herpes simplex and pseudorabies virus. Virology 7, 394-407.
19. Klopfleisch, R., Teifke, J. P., Fuchs, W., Kopp, M., Klupp, B. G., Mettenleiter, T. C. (2004). Influence of tegument proteins of pseudorabies virus on neuroinvasion and transneuronal spread in the nervous system of adult mice after intranasal inoculation. J Virol 78, 2956-2966.
20. Klopfleisch, R., Teifke, J. P., Fuchs, W., Kopp, M., Klupp, B. G. & Mettenleiter, T. C. (2006). Influence of pseudorabies virus proteins on neuroinvasion and neurovirulence in mice. J Virol 80, 5571-5576.
21. Klupp, B. G. & Mettenleiter, T. C. (1999). Glycoprotein gL-independent infectivity of pseudorabies virus is mediated by a gD-gH fusion protein. J Virol 73, 3014-3022.
22. Klupp, B. G., Granzow, H. & Mettenleiter, T. C. (2000). Primary envelopment of pseudorabies virus at the nuclear membrane requires the UL34 gene product. J Virol 74, 10063-10073.
23. Klupp, B. G., Hengartner, C. J., Mettenleiter, T. C. & Enquist, L. W. (2004). Complete, annotated sequence of the pseudorabies virus genome. J Virol 78, 424-440.
24. Kopp, M., Granzow, H., Fuchs, W., Klupp, B. G., Mundt, E., Karger, A. & Mettenleiter, T. C. (2003). The pseudorabies virus UL11 protein is a virion component involved in secondary envelopment in the cytoplasm. J Virol 77, 5339-5351.
25. Laemmli, U. K. (1970). Cleavage of structural proteins during assembly of the head of bacteriophage T4. Nature 277, 680-685.
26. McGeoch, D. J., Dalrymple, M. A., Davison, A. J., Dolan, A., Frame, M. C., McNab, D., Perry, L. J., Scott, J. E. & Taylor, P. (1988). The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1. J Gen Virol 69, 1531-1574.
27. Mettenleiter, T. C. (1989). Glycoprotein gIII deletion mutants of pseudorabies virus are impaired in virus entry. Virology 171, 623-625.
28. Mettenleiter, T. C. (2000). Aujeszky's disease (pseudorabies) virus: the virus and molecular pathogenesis - state of the art, June 1999. Vet Res 31, 99-115.
29. Mettenleiter, T. C. (2003). Pathogenesis of neurotropic herpesviruses: role of viral glycoproteins in neuroinvasion and transneuronal spread. Virus Res 92, 197-206.
30. Mettenleiter, T. C. (2004). Budding events in herpesvirus morphogenesis. Virus Res 106, 167-180.
31. Roizman, B. & Pellet, P. E. (2001). The family Herpesviridae: a brief introduction. In Fields Virology, 4th edn, pp. 2381-2397. Edited by D. M. Knipe & P. M. Howley. Philadelphia: Lippincott Williams & Wilkins.
32. Telford, E. A. R., Watson, M. S., McBride, K. & Davison, A. J. (1992). The DNA sequence of equine herpesvirus-1. Virology 189, 304-316.
33. Tulman, E. R., Alfonso, C. L., Lu, Z., Zsak, L., Rock, D. L. & Kutish, G. F. (2000). The genome of a very virulent Marek's disease virus. J Virol 74, 7980-7988.
34. Yamada, H., Jiang, Y. M., Oshima, S., Wada, K., Goshima, F., Daikoku, T. & Nishiyama, Y. (1998). Characterization of the UL4 gene product of herpes simplex virus type 2. Arch Virol 143, 1199-1207.