Designed spiro-bicyclic analogues targeting the ribosomal decoding center

ChemBioChem

Volumn 12, Issue 1, 2011, Pages 71-87

  Cottin, Thomas ^a   Pyrkotis, Constantina ^a   Stathakis, Christos I ^a   Mavridis, Ioannis ^a   Katsoulis, Ioannis A ^a   Anastasopoulou, Panoula ^a   Kythreoti, Georgia ^a   Zografos, Alexandros L ^a   Nahmias, Victoria R ^a   Papakyriakou, Athanasios ^a   Vourloumis, Dionisios ^a  

^a Institute of Physical Chemistry   (Greece)

Author keywords

Aminoglycosides; Antibiotics; Ribosomal A site; Rigid scaffolds; RNA recognition

Indexed keywords

3,5 DIAMINO 7 OXASPIRO[5.6]DODEC 9 ENE 1,2 DIOL; 3,5 DIAMINO 7 OXASPIRO[5.6]DODECANE 1, DIOL; 3,5 DIAMINO 7 OXASPIRO[5.6]DODECANE 1,2,9,10 TETRAOL; 8,10 DIAMINO 1 OXASPIRO[4.5]DEC 3 ENE 6,7 DIOL; 8,10 DIAMINO 1 OXASPIRO[4.5]DECANE 3,4,6,7 TETRAOL; 8,10 DIAMINO 1 OXASPIRO[4.5]DECANE 6,7 DIOL; 9,11 DIAMINO 1 OXASPIRO[5.5]DODECANE 3,4,7,8 TETRAOL; 9,11 DIAMINO 1 OXASPIRO[5.5]UNDEC 3 ENE 7,8 DIOL; 9,11 DIAMINO 1 OXASPIRO[5.5]UNDECANE 3,4,7,8 TETRAOL; ANTIBIOTIC AGENT; FRAMYCETIN; N (9 AMINO 10,11 DIHYDROXY 1 OXASPIRO[5.5]UNDECAN 7 YL)ACETAMIDE; NEAMINE; SPIRO COMPOUND; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CONFORMATION; CONTROLLED STUDY; DIHYDROXYLATION; DRUG DESIGN; DRUG SYNTHESIS; IN VITRO STUDY; PREDICTION; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RIBOSOME; RING CLOSING METATHESIS; STRUCTURE ACTIVITY RELATION;

ALKENES; BASE SEQUENCE; DRUG DESIGN; GLYCOSIDES; HYDROXYLATION; KETONES; MODELS, MOLECULAR; MOLECULAR CONFORMATION; ORGANOMETALLIC COMPOUNDS; RNA, BACTERIAL; RNA, RIBOSOMAL; SPIRO COMPOUNDS; STATIC ELECTRICITY;

BACTERIA (MICROORGANISMS);

EID: 78650698483     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.201000591     Document Type: Article

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