Dynamic control of neuroexocytosis by phosphoinositides in health and disease

Progress in Lipid Research

Volumn 50, Issue 1, 2011, Pages 52-61

  Wen, P J ^a   Osborne, S L ^a   Meunier, F A ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Actin; Exocytosis; Neurodegenerative diseases; Phosphoinositides; Phosphoinositides signalling

Indexed keywords

ACTIN; ION CHANNEL; NEUROTRANSMITTER; PHOSPHATASE; PHOSPHATIDYLINOSITIDE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PHOSPHOTRANSFERASE;

ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; BIPOLAR DISORDER; CELL MEMBRANE; CELL ORGANELLE; CENTRONUCLEAR MYOPATHY; CYTOSKELETON; DEGENERATIVE DISEASE; ENZYME ACTIVITY; EXOCYTOSIS; HEREDITARY MOTOR SENSORY NEUROPATHY; HUMAN; LIPID METABOLISM; LOWE SYNDROME; MENTAL DISEASE; MOLECULAR MECHANICS; NERVE CELL; NEUROSECRETORY CELL; NEUROTRANSMITTER RELEASE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REVIEW; SCHIZOPHRENIA; SIGNAL TRANSDUCTION; SURVIVAL;

ANIMALS; DISEASE; EXOCYTOSIS; HEALTH; HUMANS; NERVOUS SYSTEM; NEURODEGENERATIVE DISEASES; PHOSPHATIDYLINOSITOLS;

EID: 78650697678     PISSN: 01637827     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.plipres.2010.08.001     Document Type: Review

References (159)

1. M. Vicinanza, G. D'Angelo, A. Di Campli, and M.A. De Matteis Function and dysfunction of the PI system in membrane trafficking EMBO J 27 2008 2457 2470
2. T. Sasaki, S. Takasuga, J. Sasaki, S. Kofuji, S. Eguchi, and M. Yamazaki Mammalian phosphoinositide kinases and phosphatases Prog Lipid Res 48 2009 307 343
3. M.R. Hokin, L.E. Hokin, and W.D. Shelp The effects of acetylcholine on the turnover of phosphatidic acid and phosphoinositide in sympathetic ganglia, and in various parts of the central nervous system in vitro J Gen Physiol 44 1960 217 226
4. M.R. Hokin, and L.E. Hokin Effects of acetylcholine on phospholipids in the pancreas J Biol Chem 209 1954 549 558
5. L.E. Hokin, and M.R. Hokin Effects of acetylcholine on phosphate turnover in phospholipides of brain cortex in vitro Biochim Biophys Acta 16 1955 229 237
6. L.E. Hokin, and M.R. Hokin Effects of acetylcholine on the turnover of phosphoryl units in individual phospholipids of pancreas slices and brain cortex slices Biochim Biophys Acta 18 1955 102 110
7. Y. Nishizuka Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C Science 258 1992 607 614
8. Y. Nishizuka Studies and perspectives of protein kinase C Science 233 1986 305 312
9. 2+-mobilizing hormones Biochem J 212 1983 733 747
10. T.F. Martin Phosphoinositide lipids as signaling molecules: common themes for signal transduction, cytoskeletal regulation, and membrane trafficking Annu Rev Cell Dev Biol 14 1998 231 264
11. B. Vanhaesebroeck, J. Guillermet-Guibert, M. Graupera, and B. Bilanges The emerging mechanisms of isoform-specific PI3K signalling Nat Rev Mol Cell Biol 11 2010 329 341
12. B. Vanhaesebroeck, S.J. Leevers, K. Ahmadi, J. Timms, R. Katso, and P.C. Driscoll Synthesis and function of 3-phosphorylated inositol lipids Annu Rev Biochem 70 2001 535 602
13. D.A. Eberhard, C.L. Cooper, M.G. Low, and R.W. Holz Evidence that the inositol phospholipids are necessary for exocytosis. Loss of inositol phospholipids and inhibition of secretion in permeabilized cells caused by a bacterial phospholipase C and removal of ATP Biochem J 268 1990 15 25
14. J.C. Hay, P.L. Fisette, G.H. Jenkins, K. Fukami, T. Takenawa, and R.A. Anderson ATP-dependent inositide phosphorylation required for Ca(2+)-activated secretion Nature 374 1995 173 177
15. J.C. Hay, and T.F. Martin Resolution of regulated secretion into sequential MgATP-dependent and calcium-dependent stages mediated by distinct cytosolic proteins J Cell Biol 119 1992 139 151
16. J.C. Hay, and T.F. Martin Phosphatidylinositol transfer protein required for ATP-dependent priming of Ca(2+)-activated secretion Nature 366 1993 572 575
17. Balla T, Varnai P. Visualizing cellular phosphoinositide pools with GFP-fused protein-modules. Sci STKE 2002; PL3.
18. 2 synthesis in nerve terminals produces defects in synaptic vesicle trafficking Nature 431 2004 415 422
19. S.A. Watt, G. Kular, I.N. Fleming, C.P. Downes, and J.M. Lucocq Subcellular localization of phosphatidylinositol 4,5-bisphosphate using the pleckstrin homology domain of phospholipase C delta1 Biochem J 363 2002 657 666
20. 2 as being important in exocytosis J Biol Chem 275 2000 17878 17885
21. K.D. Micheva, R.W. Holz, and S.J. Smith Regulation of presynaptic phosphatidylinositol 4,5-biphosphate by neuronal activity J Cell Biol 154 2001 355 368
22. J.T. Lawrence, and M.J. Birnbaum ADP-ribosylation factor 6 regulates insulin secretion through plasma membrane phosphatidylinositol 4,5-bisphosphate Proc Natl Acad Sci USA 100 2003 13320 13325
23. G.R. Hammond, S.K. Dove, A. Nicol, J.A. Pinxteren, D. Zicha, and G. Schiavo Elimination of plasma membrane phosphatidylinositol (4,5)-bisphosphate is required for exocytosis from mast cells J Cell Sci 119 2006 2084 2094
24. D.J. James, C. Khodthong, J.A. Kowalchyk, and T.F. Martin Phosphatidylinositol 4,5-bisphosphate regulates SNARE-dependent membrane fusion J Cell Biol 182 2008 355 366
25. R.L. Doughman, A.J. Firestone, and R.A. Anderson Phosphatidylinositol phosphate kinases put PI4, 5P(2) in its place J Membr Biol 194 2003 77 89
26. S. McLaughlin, and D. Murray Plasma membrane phosphoinositide organization by protein electrostatics Nature 438 2005 605 611
27. S. McLaughlin, J. Wang, A. Gambhir, and D. Murray PIP(2) and proteins: interactions, organization, and information flow Annu Rev Biophys Biomol Struct 31 2002 151 175
28. P. Caroni New EMBO members' review: actin cytoskeleton regulation through modulation of PI(4,5)P(2) rafts EMBO J 20 2001 4332 4336
29. K. Aoyagi, T. Sugaya, M. Umeda, S. Yamamoto, S. Terakawa, and M. Takahashi The activation of exocytotic sites by the formation of phosphatidylinositol 4,5-bisphosphate microdomains at syntaxin clusters J Biol Chem 280 2005 17346 17352
30. T. Lang, D. Bruns, D. Wenzel, D. Riedel, P. Holroyd, and C. Thiele SNAREs are concentrated in cholesterol-dependent clusters that define docking and fusion sites for exocytosis Embo J 20 2001 2202 2213
31. C. Rickman, F.A. Meunier, T. Binz, and B. Davletov High affinity interaction of syntaxin and SNAP-25 on the plasma membrane is abolished by botulinum toxin E J Biol Chem 279 2004 644 651
32. L.E. Rameh, K.F. Tolias, B.C. Duckworth, and L.C. Cantley A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate Nature 390 1997 192 196
33. V. Carricaburu, K.A. Lamia, E. Lo, L. Favereaux, B. Payrastre, and L.C. Cantley The phosphatidylinositol (PI)-5-phosphate 4-kinase type II enzyme controls insulin signaling by regulating PI-3,4,5-trisphosphate degradation Proc Natl Acad Sci USA 100 2003 9867 9872
34. K.A. Lamia, O.D. Peroni, Y.B. Kim, L.E. Rameh, B.B. Kahn, and L.C. Cantley Increased insulin sensitivity and reduced adiposity in phosphatidylinositol 5-phosphate 4-kinase beta-/- mice Mol Cell Biol 24 2004 5080 5087
35. R.A. Anderson, I.V. Boronenkov, S.D. Doughman, J. Kunz, and J.C. Loijens Phosphatidylinositol phosphate kinases, a multifaceted family of signaling enzymes J Biol Chem 274 1999 9907 9910
36. H.L. Olsen, M. Hoy, W. Zhang, A.M. Bertorello, K. Bokvist, and K. Capito Phosphatidylinositol 4-kinase serves as a metabolic sensor and regulates priming of secretory granules in pancreatic beta cells Proc Natl Acad Sci USA 100 2003 5187 5192
37. L.W. Gong, G. Di Paolo, E. Diaz, G. Cestra, M.E. Diaz, and M. Lindau Phosphatidylinositol phosphate kinase type I gamma regulates dynamics of large dense-core vesicle fusion Proc Natl Acad Sci USA 102 2005 5204 5209
38. 2+-activated exocytosis J Biol Chem 272 1997 19637 19640
39. 2+-dependent activator protein for secretion 1 is critical for constitutive and regulated exocytosis but not for loading of transmitters into dense core vesicles J Biol Chem 282 2007 21392 21403
40. R.N. Grishanin, J.A. Kowalchyk, V.A. Klenchin, K. Ann, C.A. Earles, and E.R. Chapman CAPS acts at a prefusion step in dense-core vesicle exocytosis as a PIP2 binding protein Neuron 43 2004 551 562
41. H. de Wit, A.M. Walter, I. Milosevic, A. Gulyas-Kovacs, D. Riedel, and J.B. Sorensen Synaptotagmin-1 docks secretory vesicles to syntaxin-1/SNAP-25 acceptor complexes Cell 138 2009 935 946
42. G. Schiavo, Q.M. Gu, G.D. Prestwich, T.H. Sollner, and J.E. Rothman Calcium-dependent switching of the specificity of phosphoinositide binding to synaptotagmin Proc Natl Acad Sci USA 93 1996 13327 13332
43. J. Bai, W.C. Tucker, and E.R. Chapman PIP2 increases the speed of response of synaptotagmin and steers its membrane-penetration activity toward the plasma membrane Nat Struct Mol Biol 11 2004 36 44
44. W.C. Tucker, J.M. Edwardson, J. Bai, H.J. Kim, T.F. Martin, and E.R. Chapman Identification of synaptotagmin effectors via acute inhibition of secretion from cracked PC12 cells J Cell Biol 162 2003 199 209
45. S.L. Osborne, T.P. Wallis, J.L. Jimenez, J.J. Gorman, and F.A. Meunier Identification of secretory granule phosphatidylinositol 4,5-bisphosphate- interacting proteins using an affinity pulldown strategy Mol Cell Proteomic 6 2007 1158 1169
46. 2+ sensors for exocytosis in adrenal chromaffin cells Proc Natl Acad Sci USA 105 2008 3998 4003
47. S. Torii, T. Takeuchi, S. Nagamatsu, and T. Izumi Rab27 effector granuphilin promotes the plasma membrane targeting of insulin granules via interaction with syntaxin 1a J Biol Chem 279 2004 22532 22538
48. S. Torii, S. Zhao, Z. Yi, T. Takeuchi, and T. Izumi Granuphilin modulates the exocytosis of secretory granules through interaction with syntaxin 1a Mol Cell Biol 22 2002 5518 5526
49. 2+-inhibitory phospholipid-binding activity of the C2A domain Mol Biol Cell 18 2007 688 696
50. M. Okamoto, and T.C. Sudhof Mints, Munc18-interacting proteins in synaptic vesicle exocytosis J Biol Chem 272 1997 31459 31464
51. 2+-dependent manner. In vitro characteristics and possible significance J Biol Chem 273 1998 10240 10248
52. 2+ and phosphatidylinositol 4,5-bisphosphate binding by the C2A domain of rabphilin-3A J Biol Chem 283 2008 35918 35928
53. P. Montaville, N. Coudevylle, A. Radhakrishnan, A. Leonov, M. Zweckstetter, and S. Becker The PIP2 binding mode of the C2 domains of rabphilin-3A Protein Sci 17 2008 1025 1034
54. M.E. Burns, T. Sasaki, Y. Takai, and G.J. Augustine Rabphilin-3A: a multifunctional regulator of synaptic vesicle traffic J Gen Physiol 111 1998 243 255
55. O.M. Schluter, E. Schnell, M. Verhage, T. Tzonopoulos, R.A. Nicoll, and R. Janz Rabphilin knock-out mice reveal that rabphilin is not required for rab3 function in regulating neurotransmitter release J Neurosci 19 1999 5834 5846
56. F. Deak, O.H. Shin, J. Tang, P. Hanson, J. Ubach, and R. Jahn Rabphilin regulates SNARE-dependent re-priming of synaptic vesicles for fusion EMBO J 25 2006 2856 2866
57. P.A. Janmey, and T.P. Stossel Modulation of gelsolin function by phosphatidylinositol 4,5-bisphosphate Nature 325 1987 362 364
58. I. Lassing, and U. Lindberg Specific interaction between phosphatidylinositol 4,5-bisphosphate and profilactin Nature 314 1985 472 474
59. F. Chen, L. Ma, M.C. Parrini, X. Mao, M. Lopez, and C. Wu Cdc42 is required for PIP(2)-induced actin polymerization and early development but not for cell viability Curr Biol 10 2000 758 765
60. H.N. Higgs, and T.D. Pollard Activation by Cdc42 and PIP(2) of Wiskott-Aldrich syndrome protein (WASp) stimulates actin nucleation by Arp2/3 complex J Cell Biol 150 2000 1311 1320
61. 2 Biochemistry 46 2007 3494 3502
62. S. Benesch, S. Lommel, A. Steffen, T.E. Stradal, N. Scaplehorn, and M. Way Phosphatidylinositol 4,5-biphosphate (PIP2)-induced vesicle movement depends on N-WASP and involves Nck, WIP, and Grb2 J Biol Chem 277 2002 37771 37776
63. S. Gasman, S. Chasserot-Golaz, P. Hubert, D. Aunis, and M.F. Bader Identification of a potential effector pathway for the trimeric Go protein associated with secretory granules. Go stimulates a granule-bound phosphatidylinositol 4-kinase by activating RhoA in chromaffin cells J Biol Chem 273 1998 16913 16920
64. S. Gasman, S. Chasserot-Golaz, M. Malacombe, M. Way, and M.F. Bader Regulated exocytosis in neuroendocrine cells: a role for subplasmalemmal Cdc42/N-WASP-induced actin filaments Mol Biol Cell 15 2004 520 531
65. L. Yakir-Tamang, and J.E. Gerst A phosphatidylinositol-transfer protein and phosphatidylinositol-4-phosphate 5-kinase control Cdc42 to regulate the actin cytoskeleton and secretory pathway in yeast Mol Biol Cell 20 2009 3583 3597
66. M.A. Bittner, and R.W. Holz Phosphatidylinositol-4,5-bisphosphate: actin dynamics and the regulation of ATP-dependent and -independent secretion Mol Pharmacol 67 2005 1089 1098
67. S.J. Hong, and C.C. Chang Inhibition of quantal release from motor nerve by wortmannin Br J Pharmacol 128 1999 142 148
68. A. Warashina Mechanism of wortmannin-induced inhibition of secretory responses in rat adrenal medullary cells Life Sci 67 2000 2587 2593
69. D.A. Richards, S.O. Rizzoli, and W.J. Betz Effects of wortmannin and latrunculin A on slow endocytosis at the frog neuromuscular junction J Physiol 557 2004 77 91
70. K. Kumakura, K. Sasaki, T. Sakurai, M. Ohara-Imaizumi, H. Misonou, and S. Nakamura Essential role of myosin light chain kinase in the mechanism for MgATP-dependent priming of exocytosis in adrenal chromaffin cells J Neurosci 14 1994 7695 7703
71. I. Milosevic, J.B. Sorensen, T. Lang, M. Krauss, G. Nagy, and V. Haucke Plasmalemmal phosphatidylinositol-4,5-bisphosphate level regulates the releasable vesicle pool size in chromaffin cells J Neurosci 25 2005 2557 2565
72. J. Domin, F. Pages, S. Volinia, S.E. Rittenhouse, M.J. Zvelebil, and R.C. Stein Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin Biochem J 326 Pt 1 1997 139 147
73. F.A. Meunier, S.L. Osborne, G.R. Hammond, F.T. Cooke, P.J. Parker, and J. Domin Phosphatidylinositol 3-kinase C2alpha is essential for ATP-dependent priming of neurosecretory granule exocytosis Mol Biol Cell 16 2005 4841 4851
74. D.J. Gillooly, I.C. Morrow, M. Lindsay, R. Gould, N.J. Bryant, and J.M. Gaullier Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells Embo J 19 2000 4577 4588
75. K. Pattni, M. Jepson, H. Stenmark, and G. Banting A PtdIns(3)P-specific probe cycles on and off host cell membranes during Salmonella invasion of mammalian cells Curr Biol 11 2001 1636 1642
76. J.T. Murray, and J.M. Backer Analysis of hVps34/hVps15 interactions with Rab5 in vivo and in vitro Methods Enzymol 403 2005 789 799
77. J.T. Murray, C. Panaretou, H. Stenmark, M. Miaczynska, and J.M. Backer Role of Rab5 in the recruitment of hVps34/p150 to the early endosome Traffic 3 2002 416 427
78. S. Corvera, and M.P. Czech Direct targets of phosphoinositide 3-kinase products in membrane traffic and signal transduction Trends Cell Biol 8 1998 442 446
79. S. Corvera, A. D'Arrigo, and H. Stenmark Phosphoinositides in membrane traffic Curr Opin Cell Biol 11 1999 460 465
80. E.E. Johnson, J.H. Overmeyer, W.T. Gunning, and W.A. Maltese Gene silencing reveals a specific function of hVps34 phosphatidylinositol 3-kinase in late versus early endosomes J Cell Sci 119 2006 1219 1232
81. 2+/CaM signaling to hVps34 Cell Metab 7 2008 456 465
82. D.J. Klionsky, and Y. Ohsumi Vacuolar import of proteins and organelles from the cytoplasm Annu Rev Cell Dev Biol 15 1999 1 32
83. B. Levine, and D.J. Klionsky Development by self-digestion: molecular mechanisms and biological functions of autophagy Dev Cell 6 2004 463 477
84. M. Falasca, and T. Maffucci Rethinking phosphatidylinositol 3-monophosphate Biochim Biophys Acta 1793 2009 1795 1803
85. 2+-regulated pool of phosphatidylinositol-3-phosphate produced by phosphatidylinositol 3-kinase C2alpha on neurosecretory vesicles Mol Biol Cell 19 2008 5593 5603
86. M.A. Bittner, and R.W. Holz Kinetic analysis of secretion from permeabilized adrenal chromaffin cells reveals distinct components Journal of Biological Chemistry 267 1992 16219 16225
87. T. Maffucci, A. Brancaccio, E. Piccolo, R.C. Stein, and M. Falasca Insulin induces phosphatidylinositol-3-phosphate formation through TC10 activation Embo J 22 2003 4178 4189
88. C. Chaussade, G.W. Rewcastle, J.D. Kendall, W.A. Denny, K. Cho, and L.M. Gronning Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling Biochem J 404 2007 449 458
89. M. Falasca, W.E. Hughes, V. Dominguez, G. Sala, F. Fostira, and M.Q. Fang The role of phosphoinositide 3-kinase C2alpha in insulin signaling J Biol Chem 282 2007 28226 28236 (Pubitemid 47529549)
90. M.A. Cousin, C.S. Malladi, T.C. Tan, C.R. Raymond, K.J. Smillie, and P.J. Robinson Synapsin I-associated phosphatidylinositol 3-kinase mediates synaptic vesicle delivery to the readily releasable pool J Biol Chem 278 2003 29065 29071
91. D. Sbrissa, O.C. Ikonomov, and A. Shisheva Phosphatidylinositol 3-phosphate-interacting domains in PIKfyve. Binding specificity and role in PIKfyve. Endomenbrane localization J Biol Chem 277 2002 6073 6079
92. A. Cabezas, K. Pattni, and H. Stenmark Cloning and subcellular localization of a human phosphatidylinositol-3-phosphate 5-kinase, PIKfyve/Fab1 Gene 371 2006 34 41
93. 2 synthesis to regulate early endosome dynamics and fusion Am J Physiol Cell Physiol 291 2006 C393 404
94. A.C. Rutherford, C. Traer, T. Wassmer, K. Pattni, M.V. Bujny, and J.G. Carlton The mammalian phosphatidylinositol-3-phosphate 5-kinase (PIKfyve) regulates endosome-to-TGN retrograde transport J Cell Sci 119 2006 3944 3957
95. J. de Lartigue, H. Polson, M. Feldman, K. Shokat, S.A. Tooze, and S. Urbe PIKfyve regulation of endosome-linked pathways Traffic 10 2009 883 893
96. H.B. Jefferies, F.T. Cooke, P. Jat, C. Boucheron, T. Koizumi, and M. Hayakawa A selective PIKfyve inhibitor blocks PtdIns(3,5)P(2) production and disrupts endomembrane transport and retroviral budding EMBO Rep 9 2008 164 170
97. S.L. Osborne, P.J. Wen, C. Boucheron, H.N. Nguyen, M. Hayakawa, and H. Kaizawa PIKfyve negatively regulates exocytosis in neurosecretory cells Journal of Biological Chemistry 283 2008 2804 2813
98. A. Shisheva, B. Rusin, O.C. Ikonomov, C. DeMarco, and D. Sbrissa Localization and insulin-regulated relocation of phosphoinositide 5-kinase PIKfyve in 3T3-L1 adipocytes J Biol Chem 276 2001 11859 11869
99. O.C. Ikonomov, D. Sbrissa, R. Dondapati, and A. Shisheva ArPIKfyve-PIKfyve interaction and role in insulin-regulated GLUT4 translocation and glucose transport in 3T3-L1 adipocytes Exp Cell Res 313 2007 2404 2416
100. O.C. Ikonomov, D. Sbrissa, K. Mlak, and A. Shisheva Requirement for PIKfyve enzymatic activity in acute and long-term insulin cellular effects Endocrinology 143 2002 4742 4754
101. 3 Am J Physiol Endocrinol Metab 295 2008 E536 544
102. D. Sbrissa, and A. Shisheva Acquisition of unprecedented phosphatidylinositol 3,5-bisphosphate rise in hyperosmotically stressed 3T3-L1 adipocytes, mediated by ArPIKfyve-PIKfyve pathway J Biol Chem 280 2005 7883 7889
103. D.C. Berwick, G.C. Dell, G.I. Welsh, K.J. Heesom, I. Hers, and L.M. Fletcher Protein kinase B phosphorylation of PIKfyve regulates the trafficking of GLUT4 vesicles J Cell Sci 117 2004 5985 5993
104. S.G. Schwab, M. Knapp, P. Sklar, G.N. Eckstein, C. Sewekow, and M. Borrmann-Hassenbach Evidence for association of DNA sequence variants in the phosphatidylinositol-4-phosphate 5-kinase IIalpha gene (PIP5K2A) with schizophrenia Mol Psychiatry 11 2006 837 846
105. D.L. Thiselton, B.S. Maher, B.T. Webb, T.B. Bigdeli, F.A. O'Neill, and D. Walsh Association analysis of the PIP4K2A gene on chromosome 10p12 and schizophrenia in the Irish study of high density schizophrenia families (ISHDSF) and the Irish case-control study of schizophrenia (ICCSS) Am J Med Genet B Neuropsychiatr Genet 153B 2010 323 331
106. P. Stopkova, J. Vevera, I. Paclt, I. Zukov, and H.M. Lachman Analysis of SYNJ1, a candidate gene for 21q22 linked bipolar disorder: a replication study Psychiatry Res 127 2004 157 161
107. T. Sakisaka, T. Itoh, K. Miura, and T. Takenawa Phosphatidylinositol 4,5-bisphosphate phosphatase regulates the rearrangement of actin filaments Mol Cell Biol 17 1997 3841 3849
108. R. Woscholski, P.M. Finan, E. Radley, N.F. Totty, A.E. Sterling, and J.J. Hsuan Synaptojanin is the major constitutively active phosphatidylinositol-3,4, 5-trisphosphate 5-phosphatase in rodent brain J Biol Chem 272 1997 9625 9628
109. F. Herrera, Q. Chen, W.H. Fischer, P. Maher, and D.R. Schubert Synaptojanin-1 plays a key role in astrogliogenesis: possible relevance for Down's syndrome Cell Death Differ 16 2009 910 920
110. S.V. Voronov, S.G. Frere, S. Giovedi, E.A. Pollina, C. Borel, and H. Zhang Synaptojanin 1-linked phosphoinositide dyshomeostasis and cognitive deficits in mouse models of Down's syndrome Proc Natl Acad Sci USA 105 2008 9415 9420
111. T. Saito, F. Guan, D.F. Papolos, S. Lau, M. Klein, and C.S. Fann Mutation analysis of SYNJ1: a possible candidate gene for chromosome 21q22-linked bipolar disorder Mol Psychiatry 6 2001 387 395
112. O. Cremona, G. DiPaolo, M.R. Wenk, A. Luthi, W.T. Kim, and K. Takei Essential role of phosphoinositide metabolism in synaptic vesicle recycling Cell 99 1999 179 188
113. T.W. Harris, E. Hartwieg, H.R. Horvitz, and E.M. Jorgensen Mutations in synaptojanin disrupt synaptic vesicle recycling J Cell Biol 150 2000 589 599
114. D.E. Berman, C. Dall'Armi, S.V. Voronov, L.B. McIntire, H. Zhang, and A.Z. Moore Oligomeric amyloid-beta peptide disrupts phosphatidylinositol-4,5- bisphosphate metabolism Nat Neurosci 11 2008 547 554
115. P. Berger, S. Bonneick, S. Willi, M. Wymann, and U. Suter Loss of phosphatase activity in myotubularin-related protein 2 is associated with Charcot-Marie-Tooth disease type 4B1 Hum Mol Genet 11 2002 1569 1579
116. F. Blondeau, J. Laporte, S. Bodin, G. Superti-Furga, B. Payrastre, and J.L. Mandel Myotubularin, a phosphatase deficient in myotubular myopathy, acts on phosphatidylinositol 3-kinase and phosphatidylinositol 3-phosphate pathway Hum Mol Genet 9 2000 2223 2229
117. S.A. Kim, G.S. Taylor, K.M. Torgersen, and J.E. Dixon Myotubularin and MTMR2, phosphatidylinositol 3-phosphatases mutated in myotubular myopathy and type 4B Charcot-Marie-Tooth disease J Biol Chem 277 2002 4526 4531
118. A. Bolino, M. Muglia, F.L. Conforti, E. LeGuern, M.A. Salih, and D.M. Georgiou Charcot-Marie-Tooth type 4B is caused by mutations in the gene encoding myotubularin-related protein-2 Nat Genet 25 2000 17 19
119. M.E. Shy Charcot-Marie-Tooth disease: an update Curr Opin Neurol 17 2004 579 585
120. F.L. Robinson, I.R. Niesman, K.K. Beiswenger, and J.E. Dixon Loss of the inactive myotubularin-related phosphatase Mtmr13 leads to a Charcot-Marie-Tooth 4B2-like peripheral neuropathy in mice Proc Natl Acad Sci USA 105 2008 4916 4921
121. P. Berger, I. Berger, C. Schaffitzel, K. Tersar, B. Volkmer, and U. Suter Multi-level regulation of myotubularin-related protein-2 phosphatase activity by myotubularin-related protein-13/set-binding factor-2 Hum Mol Genet 15 2006 569 579
122. C.Y. Chow, Y. Zhang, J.J. Dowling, N. Jin, M. Adamska, and K. Shiga Mutation of FIG4 causes neurodegeneration in the pale tremor mouse and patients with CMT4J Nature 448 2007 68 72
123. Y. Zhang, S.N. Zolov, C.Y. Chow, S.G. Slutsky, S.C. Richardson, and R.C. Piper Loss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate, results in neurodegeneration in mice Proc Natl Acad Sci USA 104 2007 17518 17523
124. C.J. Bonangelino, E.M. Chavez, and J.S. Bonifacino Genomic screen for vacuolar protein sorting genes in Saccharomyces cerevisiae Mol Biol Cell 13 2002 2486 2501
125. A.S. Nicot, H. Fares, B. Payrastre, A.D. Chisholm, M. Labouesse, and J. Laporte The phosphoinositide kinase PIKfyve/Fab1p regulates terminal lysosome maturation in Caenorhabditis elegans Mol Biol Cell 17 2006 3062 3074
126. T.E. Rusten, L.M. Rodahl, K. Pattni, C. Englund, C. Samakovlis, and S. Dove Fab1 phosphatidylinositol-3-phosphate 5-kinase controls trafficking but not silencing of endocytosed receptors Mol Biol Cell 17 2006 3989 4001
127. O.C. Ikonomov, D. Sbrissa, and A. Shisheva Mammalian cell morphology and endocytic membrane homeostasis require enzymatically active phosphoinositide 5-kinase PIKfyve J Biol Chem 276 2001 26141 26147
128. F. Tsuruta, E.M. Green, M. Rousset, and R.E. Dolmetsch PIKfyve regulates CaV1.2 degradation and prevents excitotoxic cell death J Cell Biol 187 2009 279 294
129. 2 Hum Mol Genet 18 2009 4868 4878
130. 2 and autophagy in mouse models of neurodegeneration Autophagy 6 2010 170 171
131. S.A. Tooze, and G. Schiavo Liaisons dangereuses: autophagy, neuronal survival and neurodegeneration Curr Opin Neurobiol 18 2008 504 515
132. B. Barylko, S.H. Gerber, D.D. Binns, N. Grichine, M. Khvotchev, and T.C. Sudhof A novel family of phosphatidylinositol 4-kinases conserved from yeast to humans J Biol Chem 276 2001 7705 7708
133. S. Minogue, J.S. Anderson, M.G. Waugh, M. dos Santos, S. Corless, and R. Cramer Cloning of a human type II phosphatidylinositol 4-kinase reveals a novel lipid kinase family J Biol Chem 276 2001 16635 16640
134. L.E. Rameh, and L.C. Cantley The role of phosphoinositide 3-kinase lipid products in cell function J Biol Chem 274 1999 8347 8350
135. X. Zhang, A.B. Jefferson, V. Auethavekiat, and P.W. Majerus The protein deficient in Lowe syndrome is a phosphatidylinositol-4,5-bisphosphate 5-phosphatase Proc Natl Acad Sci USA 92 1995 4853 4856
136. F.A. Norris, V. Auethavekiat, and P.W. Majerus The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase J Biol Chem 270 1995 16128 16133
137. J.D. Gary, T.K. Sato, C.J. Stefan, C.J. Bonangelino, L.S. Weisman, and S.D. Emr Regulation of Fab1 phosphatidylinositol-3-phosphate 5-kinase pathway by Vac7 protein and FIG4, a polyphosphoinositide phosphatase family member Mol Biol Cell 13 2002 1238 1251
138. 2-specific phosphatase Mol Biol Cell 15 2004 24 36
139. S.K. Dove, R.K. McEwen, A. Mayes, D.C. Hughes, J.D. Beggs, and R.H. Michell Vac14 controls PtdIns(3,5)P(2) synthesis and Fab1-dependent protein trafficking to the multivesicular body Curr Biol 12 2002 885 893
140. S. Minogue, M.G. Waugh, M.A. De Matteis, D.J. Stephens, F. Berditchevski, and J.J. Hsuan Phosphatidylinositol 4-kinase is required for endosomal trafficking and degradation of the EGF receptor J Cell Sci 119 2006 571 581
141. S.F. Bairstow, K. Ling, X. Su, A.J. Firestone, C. Carbonara, and R.A. Anderson Type I gamma661 phosphatidylinositol phosphate kinase directly interacts with AP2 and regulates endocytosis J Biol Chem 281 2006 20632 20642
142. M. Krauss, V. Kukhtina, A. Pechstein, and V. Haucke Stimulation of phosphatidylinositol kinase type I-mediated phosphatidylinositol (4,5)-bisphosphate synthesis by AP-2mu-cargo complexes Proc Natl Acad Sci USA 103 2006 11934 11939
143. T. Itoh, T. Ijuin, and T. Takenawa A novel phosphatidylinositol-5- phosphate 4-kinase (phosphatidylinositol- phosphate kinase IIgamma) is phosphorylated in the endoplasmic reticulum in response to mitogenic signals J Biol Chem 273 1998 20292 20299
144. M.A. Dressman, I.M. Olivos-Glander, R.L. Nussbaum, and S.F. Suchy Ocrl1, a PtdIns(4,5)P(2) 5-phosphatase, is localized to the trans-Golgi network of fibroblasts and epithelial cells J Histochem Cytochem 48 2000 179 190
145. X. Zhang, P.A. Hartz, E. Philip, L.C. Racusen, and P.W. Majerus Cell lines from kidney proximal tubules of a patient with Lowe syndrome lack OCRL inositol polyphosphate 5-phosphatase and accumulate phosphatidylinositol 4,5-bisphosphate J Biol Chem 273 1998 1574 1582
146. O. Cremona, G. Di Paolo, M.R. Wenk, A. Luthi, W.T. Kim, and K. Takei Essential role of phosphoinositide metabolism in synaptic vesicle recycling Cell 99 1999 179 188
147. H.H. Nandurkar, M. Layton, J. Laporte, C. Selan, L. Corcoran, and K.K. Caldwell Identification of myotubularin as the lipid phosphatase catalytic subunit associated with the 3-phosphatase adapter protein, 3-PAP Proc Natl Acad Sci USA 100 2003 8660 8665
148. I. Ivetac, A.D. Munday, M.V. Kisseleva, X.M. Zhang, S. Luff, and T. Tiganis The type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane Mol Biol Cell 16 2005 2218 2233
149. R.J. Botelho, J.A. Efe, D. Teis, and S.D. Emr Assembly of a Fab1 phosphoinositide kinase signaling complex requires the FIG4 phosphoinositide phosphatase Mol Biol Cell 19 2008 4273 4286
150. D. Sbrissa, O.C. Ikonomov, Z. Fu, T. Ijuin, J. Gruenberg, and T. Takenawa Core protein machinery for mammalian phosphatidylinositol 3,5-bisphosphate synthesis and turnover that regulates the progression of endosomal transport. Novel Sac phosphatase joins the ArPIKfyve-PIKfyve complex J Biol Chem 282 2007 23878 23891
151. G. Narkis, R. Ofir, D. Landau, E. Manor, M. Volokita, and R. Hershkowitz Lethal contractual syndrome type 3 (LCCS3) is caused by a mutation in PIP5K1C, which encodes PIPKI gamma of the phophatidylinositol pathway Am J Hum Genet 81 2007 530 539
152. A.M. Leahey, L.R. Charnas, and R.L. Nussbaum Nonsense mutations in the OCRL-1 gene in patients with the oculocerebrorenal syndrome of Lowe Hum Mol Genet 2 1993 461 463
153. J. Laporte, C. Guiraud-Chaumeil, M.C. Vincent, J.L. Mandel, S.M. Tanner, and S. Liechti-Gallati Mutations in the MTM1 gene implicated in X-linked myotubular myopathy. ENMC International Consortium on Myotubular Myopathy. European Neuro-Muscular Center Hum Mol Genet 6 1997 1505 1511
154. C.Y. Chow, J.E. Landers, S.K. Bergren, P.C. Sapp, A.E. Grant, and J.M. Jones Deleterious variants of FIG4, a phosphoinositide phosphatase, in patients with ALS Am J Hum Genet 84 2009 85 88
155. J.P. Simons, R. Al-Shawi, S. Minogue, M.G. Waugh, C. Wiedemann, and S. Evangelou Loss of phosphatidylinositol 4-kinase 2alpha activity causes late onset degeneration of spinal cord axons Proc Natl Acad Sci USA 106 2009 11535 11539
156. Y. Wang, L. Lian, J.A. Golden, E.E. Morrisey, and C.S. Abrams PIP5KI gamma is required for cardiovascular and neuronal development Proc Natl Acad Sci USA 104 2007 11748 11753
157. P.A. Janne, S.F. Suchy, D. Bernard, M. MacDonald, J. Crawley, and A. Grinberg Functional overlap between murine Inpp5b and Ocrl1 may explain why deficiency of the murine ortholog for OCRL1 does not cause Lowe syndrome in mice J Clin Invest 101 1998 2042 2053
158. A. Buj-Bello, V. Laugel, N. Messaddeq, H. Zahreddine, J. Laporte, and J.F. Pellissier The lipid phosphatase myotubularin is essential for skeletal muscle maintenance but not for myogenesis in mice Proc Natl Acad Sci USA 99 2002 15060 15065
159. J. Sasaki, S. Kofuji, R. Itoh, T. Momiyama, K. Takayama, and H. Murakami The PtdIns(3,4)P(2) phosphatase INPP4A is a suppressor of excitotoxic neuronal death Nature 465 2010 497 501