Tacrolimus is not associated with gingival overgrowth in renal transplant patients

Journal of Clinical Periodontology

Volumn 28, Issue 9, 2001, Pages 848-852

  James, Jacqueline A ^a   Jamal, Sundos ^a   Hull, Peter S ^a   Macfarlane, Tatiana V ^a   Campbell, Babatunde A ^b   Johnson, Robert W G ^b   Short, Colin D ^b  

^a UNIVERSITY DENTAL HOSPITAL OF MANCHESTER   (United Kingdom)

^b MANCHESTER UNIVERSITY NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

Cyclosporin A; Gingival overgrowth; Renal allografts; Tacrolimus

Indexed keywords

ANTIHYPERTENSIVE AGENT; CALCIUM CHANNEL BLOCKING AGENT; IMMUNOSUPPRESSIVE AGENT; TACROLIMUS;

ADULT; ARTICLE; CASE CONTROL STUDY; FEMALE; GINGIVA OVERGROWTH; HUMAN; IMMUNOLOGY; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; TOOTH PLAQUE;

ADULT; ANTIHYPERTENSIVE AGENTS; CALCIUM CHANNEL BLOCKERS; CASE-CONTROL STUDIES; DENTAL PLAQUE INDEX; FEMALE; GINGIVAL OVERGROWTH; HUMANS; IMMUNOSUPPRESSIVE AGENTS; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; TACROLIMUS;

EID: 0035458327     PISSN: 03036979     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-051x.2001.028009848.x     Document Type: Article

References (19)

1. Adams, C. K. S. & Famili, P. (1991) A study of the effects of the drug FK506 on gingival tissues. Transplant Proceedings 23, 3193-3194.
2. Bader, G., Lejeune, S. & Messner, M. (1998) Reduction of cyclosporin-induced gingival overgrowth following a change to tacrolimus. A case history involving a liver transplant patient. Journal of Periodontology 69, 729-732.
3. Barclay, S., Thomason, J. M., Idle, J. R. & Seymour, R. A. (1992) The incidence and severity of gingival overgrowth. Journal of Clinical Periodontology 19, 311-314.
4. Bierer, B. E., Hollander, G., Fruman, D. & Burakoff, S. J. (1993) Cyclosporin A and FK506: Molecular mechanisms of immunosuppression and probes for transplantation biology. Current Opinions in Immunology 5, 763-773.
5. Busque, S., Demers, P., St-Louis, G., Boily, J. G., Tousoignant, J., Lemieux, F., Smeester, C., Corman, J. & Daloze, P. (1998) Conversion from Neoral (Cyclosporine) to tacrolimus of kidney transplant recipients for gingival hyperplasia or hypertrichosis. Transplantation Proceedings 30, 1247-1248.
6. James, J. A., Marley, J. J., Jamal, S., Campbel, B. A., Short, C. D., Johnson, R. W. G., Hull, P. S., Spratt, H., Irwin, C. R., Boomer, S., Maxwell, A. P. & Linden, G. J. (2000a) The calcium channel blocker used with cyclosporin has an effect on gingival overgrowth. Journal of Clinical Periodontolology 27, 109-115.
7. James, J. A., Boomer, S., Maxwell, A. P., Hull, P. S., Short, C. D., Campbel, B. A., Johnson, R. W. G., Hull, P. S., Irwin, C. R., Marley, J. J., Spratt, H. & Linden, G. J. (2000b) Reduction in gingival overgrowth associated with conversion from cyclosporin A to tacrolimus. Journal of Clinical Periodontology 27, 144-148.
8. Jorgensen, M. G. (1997) Prevalence of amlodipine-related gingival hyperplasia. Journal of Periodontology 68, 676-678.
9. Knoll, G. A. & Bell, R. C. (1999) Tacrolimus versus cyclosporin for immunosupression in renal transplantation: meta-analysis of randomised trials. British Medical Journal 318, 1104-1107.
10. Nash, M. M. & Zaltman, J. S. (1998) Efficacy of azithiomycin in the treatment of cyclosporine-induced gingival hyperplasia in renal transplant recipients. Transplantation 65, 1661-1615.
11. Seymour, R. A. (1991) Calcium channel blockers and gingival overgrowth. British Dental Journal 170, 376-379.
12. Seymour, R. A. & Jacobs, D. J. (1992) Cyclosporin A and the gingival tissues. Journal of Clinical Periodontology 19, 1-11.
13. Seymour, R. A. & Smith, D. G. (1991) The effect of a plaque control programme on the incidence and severity of cyclosporin induced gingival changes. Journal of Clinical Periodontolology 18, 107-110.
14. Seymour, R. A., Smith, D. G. & Turnbull, D. N. (1985) The effects of phenytoin and sodium valporate on the periodontal health of adult epileptic patients. Journal of Clinical Periodontology 12, 413-419.
15. Shield, C. F. III, McGrath, M. M. & Goss, T. F. (1997) Assessment of health related quality of life in kidney transplant patients receiving tacrolimus (FK506)-based versus cyclosporine-based immunosuppression. Transplantation 64, 1738-1743.
16. Silness, P. & Loe, H. (1964) Periodontal disease in pregnancy. Acta Odontologica Scandinavia 22, 121-135.
17. Thomason, J. M., Kelly, P. & Seymour, R. A. (1996) The distribution of gingival overgrowth in organ transplant patients. Journal of Clinical Periodontology 23, 367-371.
18. Thomason, J. M., Seymour, R. A., Ellis, J. S., Kelly, P. J., Pany, G., Dark, J. & Idle, J. R. (1995) Iatrogenic gingival overgrowth in cardiac transplantation. Journal of Periodontology 66, 742-746.
19. Tyldesley, W. R. & Rotter, E. (1984) Gingival hyperplasia induced by cyclosporin-A. British Dental Journal 157, 305-309.