The regulation of Th1 responses by the p38 MAPK

Journal of Immunology

Volumn 185, Issue 10, 2010, Pages 6205-6213

  Yang, Ziyan ^a   Zhang, Xia ^a   Darrah, Patricia A ^b   Mosser, David M ^a  

^a Bldg 142   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 4 [4 (4 FLUOROPHENYL) 5 (2 METHOXY 4 PYRIMIDINYL) 1 IMIDAZOLYL]CYCLOHEXANOL; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 12P70; INTERLEUKIN 23; INTERLEUKIN 23P10; INTERLEUKIN 4; INTERLEUKIN 5; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTING CELL; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOKINE PRODUCTION; EXPERIMENTAL MODEL; IMMUNE RESPONSE; IMMUNITY; IMMUNOREGULATION; IMMUNOSTIMULATION; LEISHMANIA MAJOR; LEISHMANIASIS; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVIEW; RNA ISOLATION; RNA STABILITY; TH1 CELL; VACCINATION; WESTERN BLOTTING;

ANIMALS; ANTIGEN-PRESENTING CELLS; BLOTTING, WESTERN; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; IMIDAZOLES; INTERLEUKIN-12; LEISHMANIASIS; LEISHMANIASIS VACCINES; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PYRIDINES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; TRANSFECTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 78650656137     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1000243     Document Type: Review

References (40)

1. Trinchieri, G. 2003. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat. Rev. Immunol. 3:133-146.
2. Hunter, C. A. 2005. New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions. Nat. Rev. Immunol. 5:521-531.
3. Cooper, A. M., and S. A. Khader. 2007. IL-12p40: an inherently agonistic cytokine. Trends Immunol. 28:33-38.
4. Trinchieri, G. 1995. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu. Rev. Immunol. 13:251-276.
5. Gaestel, M. 2006. MAPKAP kinases-MKs-two's company, three's a crowd. Nat. Rev. Mol. Cell Biol. 7:120-130.
6. Dunn, K. L., P. S. Espino, B. Drobic, S. He, and J. R. Davie. 2005. The Ras-MAPK signal transduction pathway, cancer and chromatin remodeling. Biochem. Cell Biol. 83:1-14.
7. + T cells. Immunol. Rev. 192:131-142.
8. Kotlyarov, A., A. Neininger, C. Schubert, R. Eckert, C. Birchmeier, H. D. Volk, and M. Gaestel. 1999. MAPKAP kinase 2 is essential for LPS-induced TNF-a biosynthesis. Nat. Cell Biol. 1:94-97.
9. Rincón, M., H. Enslen, J. Raingeaud, M. Recht, T. Zapton, M. S. Su, L. A. Penix, R. J. Davis, and R. A. Flavell. 1998. Interferon-γ expression by Th1 effector T cells mediated by the p38 MAP kinase signaling pathway. EMBO J. 17:2817-2829.
10. Hotez, P. J., J. H. Remme, P. Buss, G. Alleyne, C. Morel, and J. G. Breman. 2004. Combating tropical infectious diseases: report of the Disease Control Priorities in Developing Countries Project. Clin. Infect. Dis. 38:871-878.
11. Mattner, F., J. Magram, J. Ferrante, P. Launois, K. di Padova, R. Behin, M. K. Gately, J. A. Louis, and G. Alber. 1996. Genetically resistant mice lacking interleukin-12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response. Eur. J. Immunol. 26:1553-1559.
12. Heinzel, F. P., D. S. Schoenhaut, R. M. Rerko, L. E. Rosser, and M. K. Gately. 1993. Recombinant interleukin 12 cures mice infected with Leishmania major. J. Exp. Med. 177:1505-1509.
13. Junghae, M., and J. G. Raynes. 2002. Activation of p38 mitogen-activated protein kinase attenuates Leishmania donovani infection in macrophages. Infect. Immun. 70:5026-5035.
14. Zhang, X., J. P. Edwards, and D. M. Mosser. 2006. Dynamic and transient remodeling of the macrophage IL-10 promoter during transcription. J. Immunol. 177:1282-1288.
15. Yang, Z., D. M. Mosser, and X. Zhang. 2007. Activation of the MAPK, ERK, following Leishmania amazonensis infection of macrophages. J. Immunol. 178:1077-1085.
16. Lutz, M. B., N. Kukutsch, A. L. Ogilvie, S. Rössner, F. Koch, N. Romani, and G. Schuler. 1999. An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow. J. Immunol. Methods 223:77-92.
17. Edwards, J. P., X. Zhang, K. A. Frauwirth, and D. M. Mosser. 2006. Biochemical and functional characterization of three activated macrophage populations. J. Leukoc. Biol. 80:1298-1307.
18. Mahtani, K. R., M. Brook, J. L. Dean, G. Sully, J. Saklatvala, and A. R. Clark. 2001. Mitogen-activated protein kinase p38 controls the expression and posttranslational modification of tristetraprolin, a regulator of tumor necrosis factor a mRNA stability. Mol. Cell. Biol. 21:6461-6469.
19. McCluskie, M. J., and A. M. Krieg. 2006. Enhancement of infectious disease vaccines through TLR9-dependent recognition of CpG DNA. Curr. Top. Microbiol. Immunol. 311:155-178.
20. Hemmi, H., O. Takeuchi, T. Kawai, T. Kaisho, S. Sato, H. Sanjo, M. Matsumoto, K. Hoshino, H. Wagner, K. Takeda, and S. Akira. 2000. A Toll-like receptor recognizes bacterial DNA. Nature 408:740-745.
21. + T cell responses and protection against Leishmania major infection. J. Exp. Med. 195:1565-1573.
22. Saccani, S., S. Pantano, and G. Natoli. 2002. p38-Dependent marking of inflammatory genes for increased NF-kB recruitment. Nat. Immunol. 3:69-75.
23. Salmon, R. A., X. Guo, H. S. Teh, and J. W. Schrader. 2001. The p38 mitogenactivated protein kinases can have opposing roles in the antigen-dependent or endotoxin-stimulated production of IL-12 and IFN-γ. Eur. J. Immunol. 31:3218-3227.
24. Kim, C., Y. Sano, K. Todorova, B. A. Carlson, L. Arpa, A. Celada, T. Lawrence, K. Otsu, J. L. Brissette, J. S. Arthur, and J. M. Park. 2008. The kinase p38α serves cell type-specific inflammatory functions in skin injury and coordinates pro-and anti-inflammatory gene expression. Nat. Immunol. 9:1019-1027.
25. Kang, Y. J., J. Chen, M. Otsuka, J. Mols, S. Ren, Y. Wang, and J. Han. 2008. Macrophage deletion of p38α partially impairs lipopolysaccharide- induced cellular activation. J. Immunol. 180:5075-5082.
26. Gaestel, M., A. Mengel, U. Bothe, and K. Asadullah. 2007. Protein kinases as small molecule inhibitor targets in inflammation. Curr. Med. Chem. 14:2214-2234.
27. Kotlyarov, A., and M. Gaestel. 2002. Is MK2 (mitogen-activated protein kinaseactivated protein kinase 2) the key for understanding post-transcriptional regulation of gene expression? Biochem. Soc. Trans. 30:959-963.
28. Lu, H. T., D. D. Yang, M. Wysk, E. Gatti, I. Mellman, R. J. Davis, and R. A. Flavell. 1999. Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice. EMBO J. 18:1845-1857.
29. Zhu, J., X. Wu, S. Goel, N. M. Gowda, S. Kumar, G. Krishnegowda, G. Mishra, R. Weinberg, G. Li, M. Gaestel, et al. 2009. MAPK-activated protein kinase 2 differentially regulates Plasmodium falciparum glycosylphosphatidylinositolinduced production of tumor necrosis factor-α and interleukin-12 in macrophages. J. Biol. Chem. 284:15750-15761.
30. Yu, J. J., C. S. Tripp, and J. H. Russell. 2003. Regulation and phenotype of an innate Th1 cell: role of cytokines and the p38 kinase pathway. J. Immunol. 171:6112-6118.
31. Berenson, L. S., J. Yang, B. P. Sleckman, T. L. Murphy, and K. M. Murphy. 2006. Selective requirement of p38α MAPK in cytokine-dependent, but not antigen receptor-dependent, Th1 responses. J. Immunol. 176:4616-4621.
32. Salvador, J. M., P. R. Mittelstadt, G. I. Belova, A. J. Fornace, Jr., and J. D. Ashwell. 2005. The autoimmune suppressor Gadd45a inhibits the T cell alternative p38 activation pathway. Nat. Immunol. 6:396-402.
33. Jirmanova, L., D. Jankovic, A. J. Fornace, Jr., and J. D. Ashwell. 2007. Gadd45α regulates p38-dependent dendritic cell cytokine production and Th1 differentiation. J. Immunol. 178:4153-4158.
34. Sun, L., G. Stoecklin, S. Van Way, V. Hinkovska-Galcheva, R. F. Guo, P. Anderson, and T. P. Shanley. 2007. Tristetraprolin (TTP)-14-3-3 complex formation protects TTP from dephosphorylation by protein phosphatase 2a and stabilizes tumor necrosis factor-α mRNA. J. Biol. Chem. 282:3766-3777.
35. Matsushita, K., O. Takeuchi, D. M. Standley, Y. Kumagai, T. Kawagoe, T. Miyake, T. Satoh, H. Kato, T. Tsujimura, H. Nakamura, and S. Akira. 2009. Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay. Nature 458:1185-1190.
36. Konecny, P., A. J. Stagg, H. Jebbari, N. English, R. N. Davidson, and S. C. Knight. 1999. Murine dendritic cells internalize Leishmania major promastigotes, produce IL-12 p40 and stimulate primary T cell proliferation in vitro. Eur. J. Immunol. 29:1803-1811.
37. von Stebut, E., Y. Belkaid, T. Jakob, D. L. Sacks, and M. C. Udey. 1998. Uptake of Leishmania major amastigotes results in activation and interleukin 12 release from murine skin-derived dendritic cells: implications for the initiation of anti-Leishmania immunity. J. Exp. Med. 188:1547-1552.
38. Doherty, T. M., and R. L. Coffman. 1999. Ability of macrophage subsets to transfer resistance to murine leishmaniasis is dependent on IL-12 production. Eur. J. Immunol. 29:522-529.
39. Liu, L., L. Wang, Y. Zhao, Y. Wang, Z. Wang, and Z. Qiao. 2006. Testosterone attenuates p38 MAPK pathway during Leishmania donovani infection of macrophages. Parasitol. Res. 99:189-193.
40. Fukao, T., M. Tanabe, Y. Terauchi, T. Ota, S. Matsuda, T. Asano, T. Kadowaki, T. Takeuchi, and S. Koyasu. 2002. PI3K-mediated negative feedback regulation of IL-12 production in DCs. Nat. Immunol. 3:875-881.