Ability of macrophage subsets to transfer resistance to murine leishmaniasis is dependent on IL-12 production

European Journal of Immunology

Volumn 29, Issue 2, 1999, Pages 522-529

  Doherty, T Mark ^a,b   Coffman, Robert L ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b STATENS SERUM INSTITUT   (Denmark)

Author keywords

IL 12; Leishmania; Macrophage

Indexed keywords

ANTIGEN; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 12;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW; CELL ACTIVATION; CELL DIFFERENTIATION; CONTROLLED STUDY; DISEASE RESISTANCE; FATALITY; HELPER CELL; HYPERSENSITIVITY REACTION; LEISHMANIA MAJOR; LEISHMANIASIS; LETHAL DOSE; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SKIN LEISHMANIASIS;

ANIMALS; ANTIGEN PRESENTATION; ANTIGENS, PROTOZOAN; BONE MARROW CELLS; INTERLEUKIN-12; LEISHMANIA MAJOR; LEISHMANIASIS, CUTANEOUS; MACROPHAGE ACTIVATION; MACROPHAGES; MICE; MICE, INBRED BALB C;

EID: 0033028503     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199902)29:02<522::AID-IMMU522>3.0.CO;2-U     Document Type: Article

References (34)

1. Reiner, S. L. and Locksley, R. M., The regulation of immunity to Leishmania major. Annu. Rev. Immunol. 1995. 13: 151-177.
2. Scott, P., Pearce, E., Cheever, A. W., Coffman, R. L. and Sher, A., Role of cytokines and CD4 T-cell subsets in regulation of parasite immunity and disease, Immunol. Rev. 1989. 112: 161-182.
3. Howard, J. G., Immunological regulation and control of experimental leishmaniasis. Int. Rev. Exp. Pathol. 1986. 28: 79-116.
4. Heinzel, F. P., Sadick, M. D., Holaday, B. J., Coffman, R. L. and Locksley, R. M., Reciprocal expression of interferon gamma or IL-4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets. J. Exp. Med. 1989. 169: 59-72.
5. + T-cell subsets, Immunol. Rev. 1991. 123: 5-22.
6. Chatelain, R., Varkila, K. and Coffman, R. L, IL-4 induces a Th2 response in Leishmania mayor-infected mice. J. Immunol. 1992. 148: 1182-1187.
7. Keane, M. A. and Nickell, S. P., Role of IL-4 and IFN-gamma in modulation of immunity to Borrelia burgdorferi in mice. J. Immunol. 1995. 155: 2020-2028.
8. Fernandes, D. M., Jiang, X., Jung, J. H. and Baldwin, C. L., Comparison of T cell cytokines in resistant and susceptible mice infected with virulent Brucella abortus strain 2308. FEMS Immunol. Med. Microbiol. 1996. 16: 193-203.
9. Magee, D. M. and Cox, R. A., Interleukin-12 regulation of host defenses against Coccidioides immitis. Infect. Immun. 1996. 64: 3609-3613.
10. Titus, R. G., Ceredig, R., Cerottini, J. C. and Louis, J. A., Therapeutic effect of anti-L3T4 monoclonal antibody GK1.5 on cutaneous leishmaniasis in genetically-susceptible BALB/c mice. J. Immunol. 1985. 135: 2108-2114.
11. Sadick, M. D., Heinzel, F. P., Holaday, B. J., Pu, R. T., Dawkins, R. S. and Locksley, R. M., Cure of murine leishmaniasis with anti-interleukin-4 monoclonal antibody. Evidence for a T cell-dependent, interferon gamma-independent mechanism. J. Exp. Med. 1990. 171: 115-127.
12. Liew, F. Y., Hale, C. and Howard, J. G., Prophylactic immunization against experimental leishmaniasis. IV. Subcutaneous immunization prevents the induction of protective immunity against fatal Leishmania major infection. J. Immunol. 1985. 135: 2095-2101.
13. Gajewski, T. F., Pinnas, M., Wong, T. and Fitch, F. W., Murine Th1 and Th2 clones proliferate optimally in response to distinct antigen-presenting cell populations. J. Immunol. 1991. 146: 1750-1758.
14. Macatonia, S. E., Hsieh, C. S., Murphy, K. M. and O'Garra, A., Dendritic cells and macrophages are required for Th1 development of CD4+ T cells from alpha beta TCR transgenic mice: IL-12 substitution for macrophages to stimulate IFN-gamma production is IFN-gamma-dependent. Int. Immunol. 1993. 5: 1119-1128.
15. Doherty, T. M. and Coffman, R. L., Leishmania antigens presented by GM-CSF-derived macrophages protect susceptible mice against challenge with Leishmania major. J. Immunol. 1993. 150: 5476-5483.
16. Manetti, R., Parronchi, P., Giudizi, M. G., Piccinni, M. P., Maggi, E., Trinchieri, G. and Romagnani, S., Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells. J. Exp. Wed. 1993. 177: 1199-1204.
17. Hsieh, C. S., Macatonia, S. E., Tripp, C. S., Wolf, S. F., O'Garra, A. and Murphy, K. M., Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages. Science 1993. 260: 547-549.
18. Doherty, T. M., Bäckström, B. T., Love, S. G., Harding, D. R. K. and Watson, J. D., Identification of T cell stimulatory epitopes from the 18 kDa protein of Mycobacterium leprae. Int. Immunol. 1993. 5: 673-680.
19. Doherty, T. M., Love, S. G., Harding, D. R. and Watson, J. D., Reversal of T cell unresponsiveness by augmentation of antigen presenting cell function. Int. Immunol. 1994. 6: 761-768.
20. Scott, P., IFN-gamma modulates the early development of Th1 and Th2 responses in a murine model of cutaneous leishmaniasis. J. Immunol. 1991. 147: 3149-3155.
21. Doherty, T. M., Kastelein, R., Menon, S., Andrade, S. and Coffman, R. L., Modulation of murine macrophage function by IL-13. J. Immunol. 1993. 151: 7151-7160.
22. Sypek, J. P., Chung, C. L., Mayor, S. E., Subramanyam, J. M., Goldman, S. J., Sieburth, D. S., Wolf, S. F. and Schaub, R. G., Resolution of cutaneous leishmaniasis: interleukin 12 initiates a protective T helper type 1 immune response. J. Exp. Med. 1993. 177: 1797-1802.
23. Heinzel, F. P., Schoenhaut, D. S., Rerko, R. M., Rosser, L. E. and Gately, M. K., Recombinant interleukin 12 cures mice infected with Leishmania major. J. Exp. Med. 1993. 177: 1505-1509.
24. Murray, H. W. and Hariprashad, J., Interleukin 12 is effective treatment for an established systemic intracellular infection: experimental visceral leishmaniasis. J. Exp. Med. 1995. 181: 387-391.
25. Magram, J., Connaughton, S. E., Warrier, R. R., Carvajal, D. M., Wu, C. Y., Ferrante, J., Stewart, C., Sarmiento, U., Faherty, D. A. and Gately, M. K., IL-12-deficient mice are defective in IFN gamma production and type 1 cytokine responses. Immunity 1996. 4: 471-481.
26. Afonso, L. C. C., Scharton, T. M., Vieira, L. Q., Wysocka, M., Trinchieri, G. and Scott, P., The adjuvant effect of interleukin-12 in a vaccine against Leishmania major. Science 1994. 263: 235-237.
27. + T cells during initiation of infection. J. Exp. Med. 1994. 179: 447-456.
28. Germann, T., Mattner, F., Partenheimer, A., Schmitt, E., Reske-Kunz, A. B., Fischer, H. G. and Rüde, E., Different accessory cell function for Th1 cells of bone marrow-derived macrophages cultured in granulocyte-macrophage colony-stimulating factor or macrophage colony-stimulating factor. Int. Immunol. 1992. 4: 755.
29. Fischer, H. G., Nitzgen, B., Germann, T., Degitz, K., Daubener, W. and Hadding, U., Differentiation driven by granulocyte-macrophage colony-stimulating factor endows microglia with interferon-gamma-independent antigen presentation function. J. Neuroimmunol. 1993. 42: 87-95.
30. Nacy, C. A., Fortier, A. H., Pappas, M. G. and Henry, R. R., Susceptibility of inbred mice to Leishmania tropica infection: correlation of susceptibility with in vitro defective macrophage microbicidal activities. Cell. Immunol. 1983. 77: 298-307.
31. Fortier, A. H., Tong, A. and Nacy, C. A., Susceptibility of inbred mice to Leishmania major infection: genetic analysis of macrophage activation and innate resistance to disease in individual progeny of P/J (susceptible) and C3H/HeN (resistant) mice. Infect. Immun. 1990. 58: 4149-4152.
32. Whetton, A. D. and Dexter, T. M., Myeloid haemopoietic growth factors. Biochim. Biophys. Acta 1989. 989: 111-132.
33. Julius, M. H., Simpson, E. and Herzenberg, L. A., A rapid method for the isolation of functional thymus-derived murine lymphocytes. Eur. J. Immunol. 1973. 3: 645-649.
34. Doherty, T. M. and Sher, A., Defects in cell-mediated immunity affect chronic, but not innate, resistance of mice to Mycobacterium avium infection. J. Immunol. 1997. 158: 4822-4831.