GRK5 deficiency accelerates β-amyloid accumulation in Tg2576 mice via impaired cholinergic activity

Journal of Biological Chemistry

Volumn 285, Issue 53, 2010, Pages 41541-41548

  Cheng, Shaowu ^a   Li, Longxuan ^a,c   He, Shuangteng ^a   Liu, Jun ^a,d   Sun, Yuning ^a   He, Minchao ^a,e   Grasing, Kenneth ^a   Premont, Richard T ^f   Suo, William Z ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^c GUANGDONG MEDICAL UNIVERSITY   (China)

^d SUN YAT SEN UNIVERSITY   (China)

^e NINGXIA MEDICAL UNIVERSITY   (China)

^f DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEINS; G PROTEIN-COUPLED RECEPTOR KINASE; INTERSTITIAL FLUIDS; LYSATES; MODIFYING EFFECTS; PRESYNAPTIC; TRANSGENIC MICE;

ANIMALS; GLYCOPROTEINS; PATHOLOGY;

DISEASES;

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; G PROTEIN COUPLED RECEPTOR KINASE 5; METHOCTRAMINE; PHYSOSTIGMINE;

ALZHEIMER DISEASE; AMYLOID PLAQUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN TISSUE; CHOLINERGIC ACTIVITY; CONTROLLED STUDY; ENZYME DEFICIENCY; FEMALE; GENE INACTIVATION; GENE MUTATION; GENE OVEREXPRESSION; INTERSTITIAL FLUID; MOUSE; NEUROPATHOLOGY; NONHUMAN; PRESYNAPTIC POTENTIAL; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN PROCESSING; TRANSGENIC MOUSE;

AMYLOID BETA-PEPTIDES; ANIMALS; APOPTOSIS; FEMALE; G-PROTEIN-COUPLED RECEPTOR KINASE 5; GENOTYPE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MICROSCOPY, FLUORESCENCE; MODELS, BIOLOGICAL; PHOSPHORYLATION; RECEPTORS, CHOLINERGIC; RECEPTORS, MUSCARINIC;

ANIMALIA; MUS; MUS MUSCULUS;

EID: 78650631014     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.170894     Document Type: Article

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