GRK5 deficiency leads to reduced hippocampal acetylcholine level via impaired presynaptic M2/M4 autoreceptor desensitization

Journal of Biological Chemistry

Volumn 284, Issue 29, 2009, Pages 19564-19571

  Liu, Jun ^a,b   Rasul, Imtiaz ^a   Sun, Yuning ^a,c   Wu, Guisheng ^a   Li, Longxuan ^a,d   Premont, Richard T ^e   Suo, William Z ^a,f  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b SUN YAT SEN UNIVERSITY   (China)

^c NINGXIA MEDICAL UNIVERSITY   (China)

^d GUANGDONG MEDICAL UNIVERSITY   (China)

^e DUKE UNIVERSITY MEDICAL CENTER   (United States)

^f UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; COGNITIVE DECLINE; CULTURED CELL; DEGENERATIVE CHANGES; DOMINANT-NEGATIVE MUTANTS; G PROTEIN-COUPLED RECEPTOR KINASE; HIPPOCAMPAL SLICE; IMMUNOREACTIVITY; KNOCK OUTS; MUSCARINIC RECEPTOR; NEURONAL CELL; OVER-EXPRESSION; PERTUSSIS TOXIN; PLASMA MEMBRANES; PRESYNAPTIC; WESTERN BLOTTING; WILD TYPES;

CELL CULTURE; POTASSIUM;

CELL MEMBRANES;

ACETYLCHOLINE; ATROPINE; AUTORECEPTOR; G PROTEIN COUPLED RECEPTOR KINASE 5; METHOCTRAMINE; MUSCARINIC M2 RECEPTOR; MUSCARINIC M4 RECEPTOR; OXOTREMORINE M; PERTUSSIS TOXIN; POTASSIUM;

ACETYLCHOLINE RELEASE; ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CELL LINE; CELL MEMBRANE; CHOLINERGIC NERVE; CHOLINERGIC NERVE CELL; COGNITIVE DEFECT; CONTROLLED STUDY; ENZYME DEFICIENCY; GENE MUTATION; GENE OVEREXPRESSION; HIPPOCAMPUS; IMMUNOREACTIVITY; INTERNALIZATION; KNOCKOUT MOUSE; MOUSE; NERVE DEGENERATION; NONHUMAN; PATHOGENESIS; PRESYNAPTIC NERVE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION; WESTERN BLOTTING; WILD TYPE;

ACETYLCHOLINE; ANIMALS; AUTORECEPTORS; BLOTTING, WESTERN; CELL LINE; ENDOCYTOSIS; G-PROTEIN-COUPLED RECEPTOR KINASE 5; GENE EXPRESSION; GREEN FLUORESCENT PROTEINS; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; OXOTREMORINE; PERTUSSIS TOXIN; POTASSIUM; RECEPTOR, MUSCARINIC M2; RECEPTOR, MUSCARINIC M4; RECOMBINANT FUSION PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SYNAPSES; TRANSFECTION;

MUS;

EID: 67749145689     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.005959     Document Type: Article

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