Characterization of central inhibitory muscarinic autoreceptors by the use of muscarinic acetylcholine receptor knock-out mice

Journal of Neuroscience

Volumn 22, Issue 5, 2002, Pages 1709-1717

  Zhang, Weilie ^a   Basile, Anthony S ^a   Gomeza, Jesus ^a,c   Volpicelli, Laura A ^b   Levey, Allan I ^b   Wess, Jürgen ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c MAX PLANCK INSTITUTE FOR BRAIN RESEARCH   (Germany)

Author keywords

Acetylcholine release; Autoreceptors; Knockout mice; Muscarinic receptors; Oxotremorine; Presynaptic receptors

Indexed keywords

CHOLINE; MUSCARINIC AGENT; MUSCARINIC M1 RECEPTOR; MUSCARINIC M2 RECEPTOR; MUSCARINIC M3 RECEPTOR; MUSCARINIC M4 RECEPTOR; MUSCARINIC M5 RECEPTOR; MUSCARINIC RECEPTOR; OXOTREMORINE;

ANIMAL TISSUE; ARTICLE; BRAIN SLICE; COGNITION; CONTROLLED STUDY; EXTRAPYRAMIDAL SYSTEM; HIPPOCAMPUS; KNOCKOUT MOUSE; MALE; MOTOR ACTIVITY; MOUSE; NEUROTRANSMITTER RELEASE; NONHUMAN; PRESYNAPTIC MEMBRANE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RECEPTOR OCCUPANCY; WILD TYPE;

EID: 0036522982     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.22-05-01709.2002     Document Type: Article

References (53)

1. Bernard V, Normand E, Bloch B (1992) Phenotypical characterization of the rat striatal neurons expressing muscarinic receptor genes. J Neurosci 12:3591-3600.
2. Bernard V, Laribi O, Levey AI, Bloch B (1998) Subcellular redistribution of m2 muscarinic acetylcholine receptors in striatal interneurons in vivo after acute cholinergic stimulation. J Neurosci 18:10207-10218.
3. Bernard V, Levey AI, Bloch B (1999) Regulation of the subcellular distribution of m4 muscarinic acetylcholine receptors in striatal neurons in vivo by the cholinergic environment: Evidence for regulation of cell surface receptors by endogenous and exogenous stimulation. J Neurosci 19:10237-10249.
4. 2 through a correlation of in vivo microdialysis and in vitro receptor binding data. J Pharmacol Exp Ther 273:273-279.
5. Buckley NJ, Bonner TI, Buckley CM, Brann MR (1989) Antagonist binding properties of five cloned muscarinic receptors expressed in CHO-K1 cells. Mol Pharmacol 35:469-476.
6. Büyükuysal RL, Ulus IH, Kiran BK (1998) Age-related alterations in pre-synaptic and receptor-mediated cholinergic functions in rat brain. Neurochem Res 23:719-726.
7. Caulfield MP (1993) Muscarinic receptors - Characterization, coupling and function. Pharmacol Ther 58:319-379.
8. Coyle JT, Price DL, DeLong MR (1983) Alzheimer's disease: A disorder of cortical cholinergic innervation. Science 219:1184-1190.
9. 3-like muscarinic autoreceptor regulates the in vivo release of acetylcholine in rat striatum. Eur J Pharmacol 179:167-172.
10. Di Chiara G, Morelli M, Consolo S (1994) Modulatory functions of neurotransmitters in the striatum: ACh/dopamine/NMDA interactions. Trends Neurosci 17:228-233.
11. 3H]acetylcholine release from rat striatum by muscarinic receptor agonists. Br J Pharmacol 124:1213-1218.
12. Dörje F, Wess J, Lambrecht G, Tacke R, Mutschler E, Brann M (1991) Antagonist binding profiles of five cloned human muscarinic receptor subtypes. J Pharmacol Exp Ther 256:727-733.
13. Fahn S, Burke R, Stern Y (1990) Antimuscarinic drugs in the treatment of movement disorders. Prog Brain Res 84:389-397.
14. Gilmor ML, Nash NR, Roghani A, Edwards RH, Yi H, Hersch SM, Levey AI (1996) Expression of the putative vesicular acetylcholine transporter in rat brain and localization in cholinergic synaptic vesicles. J Neurosci 16:2179-2190.
15. Gomeza J, Shannon H, Kostenis K, Felder C, Zhang L, Brodkin J, Grinberg A, Sheng H, Wess J (1999a) Pronounced pharmacologic deficits in M2 muscarinic acetylcholine receptor knock-out mice. Proc Natl Acad Sci USA 96:1692-1697.
16. 4 muscarinic acetylcholine receptor knock-out mice. Proc Natl Acad Sci USA 96:10483-10488.
17. Hamilton SE, Loose MD, Qi M, Levey AI, Hille B, McKnight GS, Idzerda RL, Nathanson NM (1997) Disruption of the m1 receptor gene ablates muscarinic receptor-dependent M current regulation and seizure activity in mice. Proc Natl Acad Sci USA 94:13311-13316.
18. Hersch SM, Gutekunst CA, Rees HD, Heilman CJ, Levey AI (1994) Distribution of m1-m4 muscarinic receptor proteins in the rat striatum: Light and electron microscopic immunocytochemistry using subtype-specific antibodies. J Neurosci 14:3351-3363.
19. Hornykiewicz O (1981) Brain neurotransmitter changes in Parkinson's disease. In: Movement Disorders (Marsden DC, Fahn S, eds), pp 41-58. Boston: Butterworth.
20. Hulme EC, Birdsall NJM, Buckley NJ (1990) Muscarinic receptor subtypes. Annu Rev Pharmacol Toxicol 30:633-673.
21. James MK, Cubeddu LS (1987) Pharmacologic characterization and functional role of muscarinic autoreceptors in the rabbit striatum. J Pharmacol Exp Ther 240:203-215.
22. Kawashima K, Hayakawa T, Kashima Y, Suzuki T, Fujimoto K, Oohata H (1991) Determination of acetylcholine release in the striatum of anesthetized rats using in vivo microdialysis and a radioimmunoassay. J Neurochem 57:882-887.
23. Kilbinger H (1984) Presynaptic muscarinic receptors modulating acetylcholine release. Trends Pharmacol Sci 7:103-105.
24. Kitaichi K, Hori T, Srivastava LK, Quirion R (1999) Antisense oligodeoxynucleotides against the muscarinic m2, but not m4, receptor supports its role as autoreceptors in the rat hippocampus. Brain Res Mol Brain Res 67:98-106.
25. 2 muscarinic antagonist, SCH 72788. Life Sci 68:2585-2592.
26. 3H]AF-DX 116 and effect of AF-DX 116 on endogenous acetylcholine release from rat brain slices. Brain Res 496:285-294.
27. Levey AI (1993) Immunological localization of m1-m5 muscarinic acetylcholine receptors in peripheral tissues and brain. Life Sci 52:441-448.
28. Levey AI, Kitt CA, Simonds WF, Price DL, Brann MR (1991) Identification and localization of muscarinic acetylcholine receptor proteins in brain with subtype-specific antibodies. J Neurosci 11:3218-3226.
29. Marchi M, Ruelle A, Andrioli GC, Raiteri M (1990) Pirenzepine-insensitive muscarinic autoreceptors regulate acetylcholine release in human neocortex. Brain Res 520:347-350.
30. Mash DC, Flynn DD, Potter LT (1985) Loss of M2 muscarine receptors in the cerebral cortex in Alzheimer's disease and experimental cholinergic denervation. Science 228:1115-1117.
31. McKinney M, Coyle JT (1991) The potential for muscarinic receptor subtype-specific pharmacotherapy for Alzheimer's disease. Mayo Clin Proc 66:1225-1237.
32. McKinney M, Miller JH, Aagaard PJ (1993) Pharmacological characterization of the rat hippocampal muscarinic autoreceptor. J Pharmacol Exp Ther 264:74-78.
33. Pedata F, Giovannelli L, De Sarno P, Pepeu G (1986) Effect of adenosine, adenosine derivatives, and caffeine on acetylcholine release from brain synaptosomes: Interaction with muscarinic autoregulatory mechanisms. J Neurochem 46:1593-1598.
34. Pittel Z, Heldman E, Rubinstein R, Cohen S (1990) Distinct muscarinic receptor subtypes differentially modulate acetylcholine release from corticocerebral synaptosomes. J Neurochem 55:665-672.
35. 3H]acetylcholine release from rat hippocampal slices. J Pharmacol Exp Ther 244:213-217.
36. Quirion R, Aubert I, Lapchak PA, Schaum RP, Teolis S, Gauthier S, Araujo DM (1989) Muscarinic receptor subtypes in human neurodegenerative disorders: Focus on Alzheimer's disease. Trends Pharmacol Sci Suppl:80-84.
37. 2-muscarinic receptor antagonist in aged memory-impaired rats. J Neurosci 15:1455-1462.
38. Raiteri M, Marchi M, Maura G, Bonanno G (1989) Presynaptic regulation of acetylcholine release in the CNS. Cell Biol Int Rep 13:1109-1118.
39. 2 muscarinic acetylcholine receptor protein in cholinergic and non-cholinergic terminals in rat hippocampus. Neurosci Lett 284:182-186.
40. Schnell SA, Staines WA, Wessendorf MW (1999) Reduction of lipofuscin-like autofluorescence in fluorescently labeled tissue. J Histochem Cytochem 47:719-730.
41. 2+ channels by using knock-out mice. Proc Natl Acad Sci USA 96:10899-10904.
42. Standaert DG, Young AB (1996) Treatment of central nervous system degenerative disorders. In: Goodman & Gilman's: The Pharmacological Basis of Therapeutics, Ed 9 (Hardman JG, Limbird LE, eds), pp 503-519. New York: McGraw-Hill.
43. Starke K, Gothert M, Kilbinger H (1989) Modulation of neurotransmitter release by presynaptic autoreceptors. Pharmacol Rev 69:864-989.
44. 2A/D-adrenoceptor-deficient mice. Naunyn Schmiedebergs Arch Pharmacol 360:540-551.
45. 2A/D-adrenoceptor-deficient mice. Naunyn Schmiedebergs Arch Pharmacol 363:110-119.
46. Vannucchi MG, Pepeu G (1995) Muscarinic receptor modulation of acetylcholine release from rat cerebral cortex and hippocampus. Neurosci Lett 190:53-56.
47. Vilaro MT, Mengod G, Palacios JM (1993) Advances and limitation of the molecular neuroanatomy of cholinergic receptors: The example of multiple muscarinic receptors. Prog Brain Res 98:95-101.
48. Vilaro MT, Palacios JM, Mengod G (1994) Multiplicity of muscarinic autoreceptor subtypes? Comparison of the distribution of cholinergic cells and cells containing mRNA for five subtypes of muscarinic receptors in the rat brain. Mol Brain Res 21:30-46.
49. Weiler M (1989) Muscarinic modulation of endogenous acetylcholine release in rat neostriatal slices. J Pharmacol Exp Ther 250:617-623.
50. Wess J (1996) Molecular biology of muscarinic acetylcholine receptors. Crit Rev Neurobiol 10:69-99.
51. 3H]acetylcholine release evoked from the myenteric plexus of the rat. Naunyn Schmiedebergs Arch Pharmacol 341:510-516.
52. Yamada M, Miyakawa T, Duttaroy A, Yamanaka A, Moriguchi T, Makita R, Ogawa M, Chou CJ, Xia B, Crawley JN, Felder C, Deng C, Wess J (2001) Mice lacking the M3 muscarinic acetylcholine receptor are hypophagic and lean. Nature 410:207-212.
53. 2+ currents in rat neostriatal cholinergic interneurons through a fast, membrane-delimited, G-protein pathway. J Neurosci 16:2592-2604.