Structure, interactions, and antibacterial activities of MSI-594 derived mutant peptide MSI-594F5A in lipopolysaccharide micelles: Role of the helical hairpin conformation in outer-membrane permeabilization

Journal of the American Chemical Society

Volumn 132, Issue 51, 2010, Pages 18417-18428

  Domadia, Prerna N ^a   Bhunia, Anirban ^a   Ramamoorthy, Ayyalusamy ^b   Bhattacharjya, Surajit ^a  

^a NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3D STRUCTURE; AMPHIPATHIC; ANTI-BACTERIAL ACTIVITY; ANTIMICROBIAL PEPTIDE; ATOMIC-RESOLUTION; BINDING AFFINITIES; CATIONIC ANTIMICROBIAL PEPTIDES; CYTOPLASMIC MEMBRANE; GAINING ACCESS; GRAM-NEGATIVE BACTERIA; GRAM-NEGATIVE PATHOGENS; HELICAL HAIRPINS; HELICAL SEGMENTS; HELICAL STRUCTURES; HOST DEFENSE; INNER MEMBRANES; INTERHELICAL INTERACTIONS; LIPOPOLYSACCHARIDES; MEMBRANE PERMEABILIZATION; NMR SPECTROSCOPY; OUTER MEMBRANE; PERMEABILITY BARRIERS; PERMEABILIZATION;

ATOMIC SPECTROSCOPY; BACTERIA; BACTERIOLOGY; BINDING ENERGY; CELL MEMBRANES; CONFORMATIONS; DRUG INTERACTIONS; MICELLES; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PEPTIDES; POLYPEPTIDES; VIRUSES;

MEMBRANES;

ALANINE; MSI 594; MSI 594F5A; PHENYLALANINE; POLYPEPTIDE ANTIBIOTIC AGENT; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; BACTERIAL CELL; BINDING AFFINITY; CELL MEMBRANE; CONTROLLED STUDY; ENTEROBACTER; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; KLEBSIELLA PNEUMONIAE; MICELLE; MOLECULAR INTERACTION; NONHUMAN; OUTER MEMBRANE; PERMEABILITY BARRIER; PSEUDOMONAS AERUGINOSA; SALMONELLA ENTERITIDIS; STAPHYLOCOCCUS AUREUS;

ANTI-BACTERIAL AGENTS; CELL MEMBRANE PERMEABILITY; CIRCULAR DICHROISM; ESCHERICHIA COLI; GRAM-POSITIVE BACTERIA; LIPOPOLYSACCHARIDES; LIPOSOMES; MICELLES; MOLECULAR SEQUENCE DATA; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PEPTIDES; PROTEIN STRUCTURE, SECONDARY; THERMODYNAMICS;

EID: 78650599747     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja1083255     Document Type: Article

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